{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:11:51Z","timestamp":1787893911485,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD067541"],"award-info":[{"award-number":["HD067541"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL143459"],"award-info":[{"award-number":["HL143459"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL51971"],"award-info":[{"award-number":["HL51971"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20-GM104357"],"award-info":[{"award-number":["P20-GM104357"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20-GM121334"],"award-info":[{"award-number":["P20-GM121334"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-HL105324"],"award-info":[{"award-number":["T32-HL105324"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajogmfm.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics & Gynecology MFM"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.ajogmf.2023.100945","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T12:20:42Z","timestamp":1679919642000},"page":"100945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Inhibition of angiotensin II type 1 receptor agonistic autoantibodies by direct binding does not impact reduced uterine perfusion pressure offspring birthweight and blood pressure at adulthood"],"prefix":"10.1016","volume":"5","author":[{"given":"Dylan","family":"Solise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Herrock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breland","family":"Crudup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Mallette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Willis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam Z.","family":"Rawls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ty","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Cockrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangeline","family":"Deer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara T.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babbette","family":"Lamarca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajogmf.2023.100945_bib0001","first-page":"1","article-title":"ACOG Practice Bulletin No. 202: gestational hypertension and preeclampsia","volume":"133","year":"2019","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0002","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10654-013-9762-6","article-title":"Cardiovascular disease risk in women with pre-eclampsia: systematic review and meta-analysis","volume":"28","author":"Brown","year":"2013","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0004","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/01.HYP.38.3.718","article-title":"Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction","volume":"38","author":"Granger","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0005","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0006","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s11906-007-0088-1","article-title":"Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia","volume":"9","author":"LaMarca","year":"2007","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0007","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bcp.2015.04.012","article-title":"Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia","volume":"95","author":"Shah","year":"2015","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0008","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1172\/JCI4106","article-title":"Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor","volume":"103","author":"Wallukat","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0009","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2174\/1389201019666180925121254","article-title":"The role of agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) in pathophysiology of preeclampsia","volume":"19","author":"Campbell","year":"2018","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0010","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.preghy.2018.11.004","article-title":"Renal natural killer cell activation and mitochondrial oxidative stress; new mechanisms in AT1-AA mediated hypertensive pregnancy","volume":"15","author":"Cunningham","year":"2019","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0011","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/HYPERTENSIONAHA.117.10681","article-title":"AT1-AA (angiotensin II type 1 receptor agonistic autoantibody) blockade prevents preeclamptic symptoms in placental ischemic rats","volume":"71","author":"Cunningham","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0012","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12012-013-9229-8","article-title":"Autoantibodies isolated from preeclamptic patients induce endothelial dysfunction via interaction with the angiotensin II AT1 receptor","volume":"14","author":"Yang","year":"2014","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0013","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/HYPERTENSIONAHA.113.01648","article-title":"Endothelin-1, oxidative stress, and endogenous angiotensin II: mechanisms of angiotensin II type I receptor autoantibody-enhanced renal and blood pressure response during pregnancy","volume":"62","author":"Brewer","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0014","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.genm.2011.04.003","article-title":"Angiotensin II type 1 autoantibody induced hypertension during pregnancy is associated with renal endothelial dysfunction","volume":"8","author":"Parrish","year":"2011","journal-title":"Gend Med"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0015","doi-asserted-by":"crossref","first-page":"R670","DOI":"10.1152\/ajpregu.00122.2022","article-title":"Inhibition of the AT1R agonistic autoantibody in a rat model of preeclampsia improves fetal growth in late gestation","volume":"323","author":"Ashraf","year":"2022","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0016","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.earlhumdev.2016.09.007","article-title":"Preeclampsia; short and long-term consequences for mother and neonate","volume":"102","author":"Bokslag","year":"2016","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0017","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/jech.58.2.114","article-title":"Developmental origins of adult health and disease","volume":"58","author":"Barker","year":"2004","journal-title":"J Epidemiol Community Health"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0018","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00003081-200606000-00009","article-title":"Adult consequences of fetal growth restriction","volume":"49","author":"Barker","year":"2006","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0019","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/01.HYP.0000053448.95913.3D","article-title":"Placental insufficiency leads to development of hypertension in growth-restricted offspring","volume":"41","author":"Alexander","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0020","doi-asserted-by":"crossref","first-page":"R1131","DOI":"10.1152\/ajpregu.00037.2003","article-title":"Modest maternal protein restriction fails to program adult hypertension in female rats","volume":"289","author":"Woods","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0021","first-page":"950","article-title":"Preeclampsia and fetal growth","volume":"96","author":"\u00d8deg\u00e5rd","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0022","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.preghy.2018.06.013","article-title":"Prenatal exposure to preeclampsia as an independent risk factor for long-term cardiovascular morbidity of the offspring","volume":"13","author":"Nahum Sacks","year":"2018","journal-title":"Pregnancy Hypertens"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0023","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/HYPERTENSIONAHA.107.091785","article-title":"Estrogen protects against increased blood pressure in postpubertal female growth restricted offspring","volume":"50","author":"Ojeda","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0024","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/CS20150702","article-title":"The role of inflammation in the pathology of preeclampsia","volume":"130","author":"Harmon","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0025","doi-asserted-by":"crossref","first-page":"5106","DOI":"10.1002\/jcp.27315","article-title":"The imbalance of Th17\/Treg axis involved in the pathogenesis of preeclampsia","volume":"234","author":"Eghbal-Fard","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0026","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.mam.2007.02.006","article-title":"The role of the immune system in preeclampsia","volume":"28","author":"Saito","year":"2007","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0027","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1046\/j.1525-1373.1999.d01-139.x","article-title":"Oxidative stress in the pathogenesis of preeclampsia","volume":"222","author":"Hubel","year":"1999","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0028","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.biopsych.2018.08.018","article-title":"Inflammation: a proposed intermediary between maternal stress and offspring neuropsychiatric risk","volume":"85","author":"Hantsoo","year":"2019","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0029","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ijdevneu.2007.08.017","article-title":"The effects of maternal inflammation on neuronal development: possible mechanisms","volume":"25","author":"Jonakait","year":"2007","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0030","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.HYP.0000257797.49289.71","article-title":"Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia","volume":"49","author":"Herse","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0031","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11906-019-0969-0","article-title":"Low birth weight, blood pressure and renal susceptibility","volume":"21","author":"Coats","year":"2019","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0032","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1161\/HYPERTENSIONAHA.116.06603","article-title":"Developmental programming of hypertension: physiological mechanisms","volume":"68","author":"Dasinger","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0033","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.coph.2011.01.003","article-title":"Role of angiotensin II type I receptor agonistic autoantibodies (AT1-AA) in preeclampsia","volume":"11","author":"LaMarca","year":"2011","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0034","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2147\/IJICMR.S22329","article-title":"Hypertension in response to IL-6 during pregnancy: role of AT1-receptor activation","volume":"2011","author":"LaMarca","year":"2011","journal-title":"Int J Interferon Cytokine Mediat Res"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0035","doi-asserted-by":"crossref","first-page":"H1923","DOI":"10.1152\/ajpheart.00033.2021","article-title":"Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric intrauterine growth restriction or cardiovascular risk induced by placental ischemia in the rat","volume":"320","author":"Coats","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0036","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/01.HYP.28.4.635","article-title":"Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy","volume":"28","author":"Booz","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0037","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jri.2018.05.008","article-title":"Auto-antibodies against the angiotensin II type I receptor in women with uteroplacental acute atherosis and preeclampsia at delivery and several years postpartum","volume":"128","author":"Rieber-Mohn","year":"2018","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0038","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1161\/01.HYP.0000256565.20983.d4","article-title":"Agonistic angiotensin II type 1 receptor autoantibodies in postpartum women with a history of preeclampsia","volume":"49","author":"Hubel","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0039","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1056\/NEJMe048335","article-title":"Agonistic autoantibodies and rejection of renal allografts","volume":"352","author":"Ingelfinger","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0040","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/00004872-200018070-00017","article-title":"Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension","volume":"18","author":"Fu","year":"2000","journal-title":"J Hypertens"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2021.102683","article-title":"Autoantibodies against ACE2 and angiotensin type-1 receptors increase severity of COVID-19","volume":"122","author":"Rodriguez-Perez","year":"2021","journal-title":"J Autoimmun"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0042","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3864941","article-title":"The role of inflammation in the pathogenesis of preeclampsia","volume":"2020","author":"Michalczyk","year":"2020","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.ajogmf.2023.100945_bib0043","doi-asserted-by":"crossref","first-page":"H475","DOI":"10.1152\/ajpheart.00382.2021","article-title":"Getting it right: preventing drift in baseline cardiovascular phenotype when using Sprague-Dawley rats","volume":"321","author":"Banek","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["American Journal of Obstetrics & Gynecology MFM"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933323000873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933323000873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:51:52Z","timestamp":1762905112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589933323000873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S2589933323000873"],"URL":"https:\/\/doi.org\/10.1016\/j.ajogmf.2023.100945","relation":{},"ISSN":["2589-9333"],"issn-type":[{"value":"2589-9333","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of angiotensin II type 1 receptor agonistic autoantibodies by direct binding does not impact reduced uterine perfusion pressure offspring birthweight and blood pressure at adulthood","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics & Gynecology MFM","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajogmf.2023.100945","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100945"}}