{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:07:30Z","timestamp":1787069250836,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajogmfm.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics &amp; Gynecology MFM"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ajogmf.2026.101910","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T01:14:16Z","timestamp":1770254056000},"page":"101910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Selective serotonin reuptake inhibitor use during pregnancy and maternal depression\u2014a nationwide birth cohort study on risks to the mother and the newborn"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5986-6640","authenticated-orcid":false,"given":"Heli","family":"Malm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3892-2073","authenticated-orcid":false,"given":"Alan S.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7945-407X","authenticated-orcid":false,"given":"Keely","family":"Cheslack-Postava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8254-7525","authenticated-orcid":false,"given":"Mika","family":"Gissler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-9805","authenticated-orcid":false,"given":"David","family":"Gyllenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6105-2150","authenticated-orcid":false,"given":"Emmi","family":"Heinonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-9196","authenticated-orcid":false,"given":"Susanna","family":"Hinkka-Yli-Salom\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-7217","authenticated-orcid":false,"given":"Ian W.","family":"McKeague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5713-5692","authenticated-orcid":false,"given":"Aleksi","family":"Tornio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6126-5561","authenticated-orcid":false,"given":"Subina","family":"Upadhyaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0361-7244","authenticated-orcid":false,"given":"Andre","family":"Sourander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajogmf.2026.101910_bib0001","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s11920-022-01372-x","article-title":"Selective serotonin reuptake inhibitors (SSRIs) in pregnancy: an updated review on risks to mother, fetus, and child","volume":"24","author":"Lebin","year":"2022","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0002","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/AOG.0000000000004538","article-title":"Associations between maternal depression, antidepressant use during pregnancy, and adverse pregnancy outcomes: an individual participant data meta-analysis","volume":"138","author":"Vlenterie","year":"2021","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0003","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jpsychires.2020.02.023","article-title":"Use of antidepressants during pregnancy and neonatal outcomes: an umbrella review of meta-analyses of observational studies","volume":"124","author":"Biffi","year":"2020","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0004","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/acps.13120","article-title":"In utero exposure to antidepressant medication and neonatal and child outcomes: a systematic review","volume":"141","author":"Fitton","year":"2020","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0005","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/JCP.0b013e3182490eaf","article-title":"Pregnancy outcome after exposure to antidepressants and the role of maternal depression: results from the Norwegian Mother and Child Cohort Study","volume":"32","author":"Nordeng","year":"2012","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0006","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1176\/appi.ajp.2015.14121575","article-title":"Pregnancy complications following prenatal exposure to SSRIs or maternal psychiatric disorders: results from population-based national register data","volume":"172","author":"Malm","year":"2015","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0007","doi-asserted-by":"crossref","first-page":"e309","DOI":"10.4088\/JCP.12r07967","article-title":"The effect of Prenatal antidepressant exposure on neonatal adaptation: a systematic review and meta-analysis","volume":"74","author":"Grigoriadis","year":"2013","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0008","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1136\/archdischild-2023-326049","article-title":"Maternal treatment with selective serotonin reuptake inhibitors during pregnancy and delayed neonatal adaptation: a population-based cohort study","volume":"109","author":"Cornet","year":"2024","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2023.108365","article-title":"Maternal SSRI use during pregnancy and offspring depression or anxiety disorders: a review of the literature and description of a study protocol for a register-based cohort study","volume":"118","author":"Upadhyaya","year":"2023","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0010","unstructured":"Anatomical therapeutic classification of drugs, WHO. At: https:\/\/www.who.int\/standards\/classifications\/other-classifications\/the-anatomical-therapeutic-chemical-classification-system-with-defined-daily-doses. Accessed February 23, 2026."},{"key":"10.1016\/j.ajogmf.2026.101910_bib0011","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0140-6736(24)00825-0","article-title":"Epidemiology and management of gestational diabetes","volume":"404","author":"Sweeting","year":"2024","journal-title":"Lancet"},{"issue":"Suppl_1","key":"10.1016\/j.ajogmf.2026.101910_bib0012","first-page":"S27","article-title":"Diagnosis and classification of diabetes: standards of care in diabetes","volume":"48","year":"2025","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0013","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.2337\/dc13-0560","article-title":"Antidepressant medication as a risk factor for type 2 diabetes and impaired glucose regulation: systematic review","volume":"36","author":"Barnard","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0014","doi-asserted-by":"crossref","DOI":"10.1080\/14767058.2022.2162817","article-title":"Antidepressant use during pregnancy and the risk for gestational diabetes: a systematic review and meta-analysis","volume":"36","author":"Wang","year":"2023","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182088","article-title":"The risk of new-onset diabetes in antidepressant users\u2014a systematic review and meta-analysis","volume":"12","author":"Salvi","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0016","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/pds.5388","article-title":"Association between antidepressant use in pregnancy and gestational diabetes mellitus: results from the Norwegian Mother, Father and Child Cohort Study","volume":"31","author":"Lupattelli","year":"2022","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0017","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-025908","article-title":"Antidepressant use during pregnancy and the risk of gestational diabetes mellitus: a nested case-control study","volume":"9","author":"Dandjinou","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0018","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/pds.4799","article-title":"Antidepressant continuation in pregnancy and risk of gestational diabetes","volume":"28","author":"Wartko","year":"2019","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0019","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1111\/bcp.13382","article-title":"Maternal SSRI discontinuation, use, psychiatric disorder and the risk of autism in children: a meta-analysis of cohort studies","volume":"83","author":"Kaplan","year":"2017","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0020","doi-asserted-by":"crossref","DOI":"10.1093\/ije\/dyaa039","article-title":"Cohort profile: the Finnish Gestational Diabetes (FinnGeDi) Study","volume":"49","author":"Keikkala","year":"2020","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0021","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2021-067946","article-title":"Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis","volume":"377","author":"Ye","year":"2022","journal-title":"BMJ"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0022","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1210\/endrev\/bnac003","article-title":"A clinical update on gestational diabetes mellitus","volume":"43","author":"Sweeting","year":"2022","journal-title":"Endocr Rev"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0023","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/biolre\/ioad046","article-title":"Maternal serotonin: implications for the use of selective serotonin reuptake inhibitors during gestation\u2020","volume":"109","author":"Domingues","year":"2023","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0024","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.genhosppsych.2013.08.002","article-title":"A meta-analysis of the relationship between antidepressant use in pregnancy and the risk of preterm birth and low birth weight","volume":"36","author":"Huang","year":"2014","journal-title":"Gen Hosp Psychiatry"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0025","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1001\/archpsyc.60.7.720","article-title":"Effects of exposure to selective serotonin reuptake inhibitors during pregnancy on serotonergic symptoms in newborns and cord blood monoamine and prolactin concentrations","volume":"60","author":"Laine","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0026","doi-asserted-by":"crossref","first-page":"L937","DOI":"10.1152\/ajplung.00198.2011","article-title":"Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus","volume":"301","author":"Delaney","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0027","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/bdr2.1085","article-title":"New insights into how serotonin selective reuptake inhibitors shape the developing brain","volume":"109","author":"Gingrich","year":"2017","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0028","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/1471-0528.16210","article-title":"SSRI use during pregnancy and risk for postpartum haemorrhage: a national register-based cohort study in Sweden","volume":"127","author":"Skalkidou","year":"2020","journal-title":"BJOG"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0029","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/ppe.12660","article-title":"Patterns of prenatal antidepressant exposure and risk of preeclampsia and postpartum haemorrhage","volume":"34","author":"Palmsten","year":"2020","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0030","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1089\/jwh.2024.0033","article-title":"The risk of postpartum hemorrhage with selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors: preliminary results from the Massachusetts General Hospital National Pregnancy Registry for Psychiatric Medications","volume":"33","author":"Viguera","year":"2024","journal-title":"J Womens Health (Larchmt)"},{"key":"10.1016\/j.ajogmf.2026.101910_bib0031","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.preghy.2022.08.001","article-title":"Selective serotonin reuptake inhibitors and preeclampsia: a quality assessment and meta-analysis","volume":"30","author":"Gumusoglu","year":"2022","journal-title":"Pregnancy Hypertens"}],"container-title":["American Journal of Obstetrics &amp; Gynecology MFM"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933326000212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933326000212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:43:11Z","timestamp":1782189791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589933326000212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S2589933326000212"],"URL":"https:\/\/doi.org\/10.1016\/j.ajogmf.2026.101910","relation":{},"ISSN":["2589-9333"],"issn-type":[{"value":"2589-9333","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective serotonin reuptake inhibitor use during pregnancy and maternal depression\u2014a nationwide birth cohort study on risks to the mother and the newborn","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics & Gynecology MFM","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajogmf.2026.101910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101910"}}