{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:26:52Z","timestamp":1793950012460,"version":"4.8.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["ajogmfm.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Obstetrics &amp; Gynecology MFM"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ajogmf.2026.101963","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:30:50Z","timestamp":1775575850000},"page":"101963","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral calcium carbonate as an adjunct to oxytocin infusion for labor induction: a randomized controlled pilot study on feasibility and acceptability"],"prefix":"10.1016","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2968-6779","authenticated-orcid":false,"given":"Julia Romina M.","family":"Boers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirely","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Voegtline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moeun","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ajogmf.2026.101963_bib0001","first-page":"1","article-title":"Births: final data for 2019","volume":"70","author":"Martin","year":"2021","journal-title":"Natl Vital Stat Rep"},{"issue":"2","key":"10.1016\/j.ajogmf.2026.101963_bib0002","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0021-9258(18)49238-1","article-title":"The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin","volume":"205","author":"Du Vigneaud","year":"1953","journal-title":"J Biol Chem"},{"issue":"2 Pt 1","key":"10.1016\/j.ajogmf.2026.101963_bib0003","first-page":"386","article-title":"ACOG Practice Bulletin No. 107: Induction of labor","volume":"114","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2026.101963_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.srhc.2021.100648","article-title":"Induction of labour as compared with spontaneous labour in low-risk women: a multicenter study in Catalonia","volume":"29","author":"Espada-Trespalacios","year":"2021","journal-title":"Sex Reprod Healthc"},{"issue":"2","key":"10.1016\/j.ajogmf.2026.101963_bib0005","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s13224-020-01395-5","article-title":"To study the maternal and neonatal outcome in postdated women undergoing induction of labour versus spontaneous labour","volume":"71","author":"Dagli","year":"2021","journal-title":"J Obstet Gynecol India"},{"issue":"6","key":"10.1016\/j.ajogmf.2026.101963_bib0006","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-047040","article-title":"Intrapartum interventions and outcomes for women and children following induction of labour at term in uncomplicated pregnancies: a 16-year population-based linked data study","volume":"11","author":"Dahlen","year":"2021","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.ajogmf.2026.101963_bib0007","doi-asserted-by":"crossref","first-page":"35.e1","DOI":"10.1016\/j.ajog.2008.06.010","article-title":"Oxytocin: new perspectives on an old drug","volume":"200","author":"Clark","year":"2009","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ajogmf.2026.101963_bib0008","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1677\/joe.0.1540007","article-title":"The desensitization of oxytocin receptors in human myometrial cells is accompanied by down-regulation of oxytocin receptor messenger RNA","volume":"154","author":"Phaneuf","year":"1997","journal-title":"J Endocrinol"},{"issue":"5","key":"10.1016\/j.ajogmf.2026.101963_bib0009","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/humupd\/4.5.625","article-title":"Desensitization of oxytocin receptors in human myometrium","volume":"4","author":"Phaneuf","year":"1998","journal-title":"Hum Reprod Update"},{"issue":"2","key":"10.1016\/j.ajogmf.2026.101963_bib0010","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1067\/mob.2003.22","article-title":"Oxytocin-induced desensitization of the oxytocin receptor","volume":"188","author":"Robinson","year":"2003","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.ajogmf.2026.101963_bib0011","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1113\/expphysiol.2007.038125","article-title":"Insights into the uterus","volume":"92","author":"Wray","year":"2007","journal-title":"Exp Physiol"},{"issue":"4","key":"10.1016\/j.ajogmf.2026.101963_bib0012","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1028-4559(09)60005-X","article-title":"Fetal acidosis from obstetric interventions during the first vaginal delivery","volume":"47","author":"Su","year":"2008","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ajogmf.2026.101963_bib0013","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0029-7844(97)00177-4","article-title":"Risk factors for acidemia at birth","volume":"90","author":"Herbst","year":"1997","journal-title":"Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.ajogmf.2026.101963_bib0014","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1080\/00016340802220352","article-title":"Acidemia at birth, related to obstetric characteristics and to oxytocin use, during the last two hours of labor","volume":"87","author":"Jonsson","year":"2008","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"3","key":"10.1016\/j.ajogmf.2026.101963_bib0015","doi-asserted-by":"crossref","first-page":"S740","DOI":"10.1016\/j.ajog.2023.04.011","article-title":"The physiology and pharmacology of oxytocin in labor and in the peripartum period","volume":"230","author":"Uvn\u00e4s-Moberg","year":"2024","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ajogmf.2026.101963_bib0016","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1213\/ANE.0000000000001264","article-title":"The effect of extracellular calcium on oxytocin-induced contractility in naive and oxytocin-pretreated human myometrium in vitro","volume":"122","author":"Talati","year":"2016","journal-title":"Anesth Analg"},{"issue":"2","key":"10.1016\/j.ajogmf.2026.101963_bib0017","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0002-9378(99)70580-6","article-title":"Intracellular calcium stores and agonist-induced contractions in isolated human myometrium","volume":"181","author":"Luckas","year":"1999","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ajogmf.2026.101963_bib0018","first-page":"174","article-title":"Oxytocin-induced oscillations of cytoplasmic Ca 2+ in human myometrial cells","volume":"79","author":"Fu","year":"2000","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"2","key":"10.1016\/j.ajogmf.2026.101963_bib0019","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0002-9378(99)70573-9","article-title":"Oxytocin-stimulated capacitative calcium entry in human myometrial cells","volume":"181","author":"Monga","year":"1999","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ajogmf.2026.101963_bib0020","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1095\/biolreprod40.5.942","article-title":"Effects of external calcium, magnesium, and temperature on spontaneous contractions of pregnant human myometrium","volume":"40","author":"Kawarabayashi","year":"1989","journal-title":"Biol Reprod"},{"issue":"1","key":"10.1016\/j.ajogmf.2026.101963_bib0021","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejogrb.2003.11.032","article-title":"Calcium levels during the initiation of labor","volume":"115","author":"Papandreou","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"1","key":"10.1016\/j.ajogmf.2026.101963_bib0022","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/AOG.0000000000005441","article-title":"Intravenous calcium to decrease blood loss during intrapartum cesarean delivery: a randomized controlled trial","volume":"143","author":"Ansari","year":"2024","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajogmf.2026.101963_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinane.2022.110796","article-title":"Calcium chloride for the prevention of uterine atony during cesarean delivery: a pilot randomized controlled trial and pharmacokinetic study","volume":"80","author":"Ansari","year":"2022","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.ajogmf.2026.101963_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijoa.2025.104704","article-title":"Effect of prophylactic intravenous calcium gluconate on uterine atony during intrapartum cesarean delivery with spinal anesthesia: a placebo controlled, randomized clinical trial","volume":"63","author":"Abirami","year":"2025","journal-title":"Int J Obstet Anesth"},{"issue":"1","key":"10.1016\/j.ajogmf.2026.101963_bib0025","doi-asserted-by":"crossref","first-page":"101541","DOI":"10.1016\/j.ajogmf.2024.101541","article-title":"Role of prophylactic intravenous calcium in prevention of postspinal hypotension among women with preeclampsia undergoing cesarean delivery: a placebo controlled randomized clinical trial","volume":"7","author":"Yadav","year":"2025","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"01","key":"10.1016\/j.ajogmf.2026.101963_bib0026","doi-asserted-by":"crossref","first-page":"89","DOI":"10.33314\/jnhrc.v20i01.3882","article-title":"Effect of intravenous calcium gluconate on prevention of post spinal hypotension during spinal anaesthesia for caesarean section: a randomized double-blind controlled study","volume":"20","author":"Agarwal","year":"2022","journal-title":"J Nepal Health Res Counc"},{"issue":"4","key":"10.1016\/j.ajogmf.2026.101963_bib0027","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/01.AOG.0000118306.82556.43","article-title":"Dysfunctional labor and myometrial lactic acidosis","volume":"103","author":"Quenby","year":"2004","journal-title":"Obstet Gynecol"},{"issue":"17","key":"10.1016\/j.ajogmf.2026.101963_bib0028","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1080\/14767058.2017.1339268","article-title":"A randomized controlled trial of a new treatment for labor dystocia","volume":"31","author":"Wiberg-Itzel","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ajogmf.2026.101963_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2288-10-1","article-title":"A tutorial on pilot studies: the what, why and how","volume":"10","author":"Thabane","year":"2010","journal-title":"BMC Med Res Methodol"},{"issue":"5","key":"10.1016\/j.ajogmf.2026.101963_bib0030","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.bja.2020.11.020","article-title":"Association between ionised calcium and severity of postpartum haemorrhage: a retrospective cohort study","volume":"126","author":"Epstein","year":"2021","journal-title":"Br J Anaesth"},{"issue":"4","key":"10.1016\/j.ajogmf.2026.101963_bib0031","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000355526","article-title":"What is hypercalcemia? The importance of fasting samples","volume":"3","author":"Siyam","year":"2013","journal-title":"Cardiorenal Med"},{"issue":"4","key":"10.1016\/j.ajogmf.2026.101963_bib0032","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ecl.2021.07.009","article-title":"Hypercalcemia in pregnancy","volume":"50","author":"Dandurand","year":"2021","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.ajogmf.2026.101963_bib0033","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1753-4887.2012.00491.x","article-title":"Role of calcium during pregnancy: maternal and fetal needs","volume":"70","author":"Hacker","year":"2012","journal-title":"Nutr Rev"},{"key":"10.1016\/j.ajogmf.2026.101963_bib0034","unstructured":"Calcium blood test: MedlinePlus medical test. Accessed October 12, 2024. https:\/\/medlineplus.gov\/lab-tests\/calcium-blood-test\/"},{"issue":"3","key":"10.1016\/j.ajogmf.2026.101963_bib0035","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/00365518209168085","article-title":"The concentration of free calcium ions and total calcium in pregnancies at term","volume":"42","author":"Wandrup","year":"1982","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.ajogmf.2026.101963_bib0036","unstructured":"Reference values for calcium, total in pregnancy. Accessed October 2, 2024.https:\/\/www.perinatology.com\/Reference\/Reference\/20Ranges\/Calcium,total.htm"},{"issue":"6","key":"10.1016\/j.ajogmf.2026.101963_bib0037","doi-asserted-by":"crossref","first-page":"453","DOI":"10.5001\/omj.2018.85","article-title":"Hypocalcemia in pregnancy: a clinical review update","volume":"33","author":"Almaghamsi","year":"2018","journal-title":"Oman Med J"},{"key":"10.1016\/j.ajogmf.2026.101963_bib0038","unstructured":"DailyMed\u2014calcium carbonate 500MG tablet, Chewable. Accessed August 8, 2024.https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=26bba88a-7db2-4cef-b6b9-03183ee85152"},{"key":"10.1016\/j.ajogmf.2026.101963_bib0039","series-title":"StatPearls","article-title":"Calcium carbonate","author":"Fritz","year":"2024"},{"key":"10.1016\/j.ajogmf.2026.101963_bib0040","unstructured":"PubChem. Calcium carbonate. Accessed March 17, 2026. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/10112"},{"issue":"3","key":"10.1016\/j.ajogmf.2026.101963_bib0041","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1177\/0962280215588241","article-title":"Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable","volume":"25","author":"Whitehead","year":"2016","journal-title":"Stat Methods Med Res"},{"key":"10.1016\/j.ajogmf.2026.101963_bib0042","series-title":"SAS\/STAT software. version 9.4","year":"2023"},{"issue":"2","key":"10.1016\/j.ajogmf.2026.101963_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2022.100575","article-title":"Intrapartum nipple stimulation therapy for labor induction: a randomized controlled external pilot study of acceptability and feasibility","volume":"4","author":"Stark","year":"2022","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"5","key":"10.1016\/j.ajogmf.2026.101963_bib0044","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1055\/a-2419-8476","article-title":"A pilot study using continuous glucose monitoring among patients with a low 1-hour glucose challenge test result versus controls to detect maternal hypoglycemia","volume":"42","author":"Ding","year":"2025","journal-title":"Am J Perinatol"},{"issue":"2","key":"10.1016\/j.ajogmf.2026.101963_bib0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168783","article-title":"Early skin-to-skin contact after cesarean section: a randomized clinical pilot study","volume":"12","author":"Kollmann","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.ajogmf.2026.101963_bib0046","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1471-0528.2004.00132.x","article-title":"A pilot study for a randomised controlled trial of waterbirth versus land birth","volume":"111","author":"Woodward","year":"2004","journal-title":"BJOG"},{"issue":"6","key":"10.1016\/j.ajogmf.2026.101963_bib0047","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jogc.2017.08.046","article-title":"Accelerated titration of oxytocin in nulliparous women with labour dystocia: results of the ACTION pilot randomized controlled trial","volume":"40","author":"Dy","year":"2018","journal-title":"J Obstet Gynaecol Can"}],"container-title":["American Journal of Obstetrics &amp; Gynecology MFM"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933326000649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589933326000649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:42:35Z","timestamp":1793947355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589933326000649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2589933326000649"],"URL":"https:\/\/doi.org\/10.1016\/j.ajogmf.2026.101963","relation":{},"ISSN":["2589-9333"],"issn-type":[{"value":"2589-9333","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral calcium carbonate as an adjunct to oxytocin infusion for labor induction: a randomized controlled pilot study on feasibility and acceptability","name":"articletitle","label":"Article Title"},{"value":"American Journal of Obstetrics & Gynecology MFM","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajogmf.2026.101963","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101963"}}