{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:53:42Z","timestamp":1791917622028,"version":"4.3.4"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asian Journal of Psychiatry"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.ajp.2016.05.007","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T22:55:24Z","timestamp":1463871324000},"page":"74-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Effectiveness of add-on l-methylfolate therapy in a complex psychiatric illness with MTHFR C677 T genetic polymorphism"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5831-9327","authenticated-orcid":false,"given":"Shailesh","family":"Jha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajp.2016.05.007_bib0005","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S0899-9007(00)00327-0","article-title":"Nutrition and depression: focus on folate","volume":"16","author":"Alpert","year":"2000","journal-title":"Nutrition"},{"key":"10.1016\/j.ajp.2016.05.007_bib0010","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/archpsyc.60.6.618","article-title":"Folate, vitamin B12, homocystein, and the MTHFR 677-4 polymorphism in anxiety and depression: the Hordaland Homocysteine Study","volume":"60","author":"Bjelland","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"issue":"7","key":"10.1016\/j.ajp.2016.05.007_bib0015","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.pnpbp.2005.06.021","article-title":"Homocysteine and folate metabolism in depression","volume":"29","author":"Bottiglieri","year":"2005","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ajp.2016.05.007_bib0020","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/aje\/kwm140","article-title":"Methylenetetrahydrofolate reductase C677 T polymorphism and cognitive function in older women","volume":"166","author":"Elkins","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ajp.2016.05.007_bib0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/10673220701551136","article-title":"The role of one-carbon metabolism in schizophrenia and depression","volume":"15","author":"Frankenburg","year":"2007","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.ajp.2016.05.007_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/aje\/kwj347","article-title":"Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review","volume":"165","author":"Gilbody","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ajp.2016.05.007_bib0035","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/jech.2004.027078","article-title":"Impact of voluntary folate fortification on plasma homocysteine and serum folate in Australia from 1995 to 2001: a population based cohort study","volume":"59","author":"Hickling","year":"2005","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.ajp.2016.05.007_bib0040","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0140-6736(96)12049-3","article-title":"Thermolabile variant of 5,10-red-cell folates: implications for folate intake recommendations","volume":"349","author":"Molloy","year":"1997","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.ajp.2016.05.007_bib0045","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1176\/appi.ajp.2012.11071114","article-title":"l-Methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials","volume":"169","author":"Papakostas","year":"2012","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ajp.2016.05.007_bib0050","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jad.2014.03.008","article-title":"Association analysis of COMT\/MTHFR polymorphisms and major depressive disorder in Chinese Han population","volume":"161","author":"Shen","year":"2014","journal-title":"J. Affect. Disord."}],"container-title":["Asian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187620181530068X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187620181530068X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T16:27:58Z","timestamp":1761755278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187620181530068X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":10,"alternative-id":["S187620181530068X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajp.2016.05.007","relation":{},"ISSN":["1876-2018"],"issn-type":[{"value":"1876-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of add-on l-methylfolate therapy in a complex psychiatric illness with MTHFR C677 T genetic polymorphism","name":"articletitle","label":"Article Title"},{"value":"Asian Journal of Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajp.2016.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}