{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:31:59Z","timestamp":1793215919569,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018961","name":"Health and Health Services Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018961","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005407","name":"Food and Health Bureau","doi-asserted-by":"publisher","award":["SMH-28"],"award-info":[{"award-number":["SMH-28"]}],"id":[{"id":"10.13039\/501100005407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asian Journal of Psychiatry"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ajp.2022.103087","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T01:16:05Z","timestamp":1647134165000},"page":"103087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Longitudinal relapse pattern of patients with first-episode schizophrenia-spectrum disorders and its predictors and outcomes: A 10-year follow-up study"],"prefix":"10.1016","volume":"71","author":[{"given":"Sherry Kit Wa","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hei Yan Veronica","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Nam","family":"Suen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy Lai Ming","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Chung","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin Ho Ming","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Yu Hai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajp.2022.103087_bib1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0920-9964(92)90003-N","article-title":"Reliability and validity of a depression rating scale for schizophrenics","volume":"6","author":"Addington","year":"1992","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.ajp.2022.103087_bib2","series-title":"Scale for the Assessment of Negative Symptoms (SANS)","author":"Andreasen","year":"1984"},{"key":"10.1016\/j.ajp.2022.103087_bib3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1176\/appi.ajp.162.3.441","article-title":"Remission in schizophrenia: proposed criteria and rationale for consensus","volume":"162","author":"Andreasen","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib4","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1176\/appi.ajp.2013.12050674","article-title":"Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study","volume":"170","author":"Andreasen","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/09540261.2019.1643704","article-title":"A systematic review of long-term outcomes of patients with psychosis who received early intervention services","volume":"31","author":"Chan","year":"2019","journal-title":"Int. Rev. Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib6","article-title":"Predictors of treatment-resistant and clozapine-resistant schizophrenia: a 12-year follow-up study of first-episode schizophrenia-spectrum disorders","author":"Chan","year":"2020","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.ajp.2022.103087_bib7","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1001\/jamapsychiatry.2018.0185","article-title":"Association of an early intervention service for psychosis with suicide rate among patients with first-episode schizophrenia-spectrum disorders","volume":"75","author":"Chan","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.schres.2018.08.022","article-title":"Ten-year follow up of patients with first-episode schizophrenia spectrum disorder from an early intervention service: predictors of clinical remission and functional recovery","volume":"204","author":"Chan","year":"2019","journal-title":"Schizophr. Res."},{"issue":"3","key":"10.1016\/j.ajp.2022.103087_bib9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1192\/bjp.2019.161","article-title":"Ten-year employment patterns of patients with first-episode schizophrenia-spectrum disorders: comparison of early intervention and standard care services","volume":"217","author":"Chan","year":"2020","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib10","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1017\/S0033291714002220","article-title":"10-year outcome study of an early intervention program for psychosis compared with standard care service","volume":"45","author":"Chan","year":"2015","journal-title":"Psychol. Med."},{"key":"10.1016\/j.ajp.2022.103087_bib11","doi-asserted-by":"crossref","DOI":"10.1001\/jamapsychiatry.2018.0623","article-title":"Comparison of early intervention services vs treatment as usual for early-phase psychosis: a systematic review, meta-analysis, and meta-regression","author":"Correll","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/wps.20516","article-title":"What is the risk-benefit ratio of long-term antipsychotic treatment in people with schizophrenia?","volume":"17","author":"Correll","year":"2018","journal-title":"World Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib13","unstructured":"Diagnostic, A., 2000. Statistical manual of mental disorders DSM-IV-TR, American Psychiatric Association Task Force on DSM-IV."},{"key":"10.1016\/j.ajp.2022.103087_bib14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.schres.2013.05.016","article-title":"The evidence for illness progression after relapse in schizophrenia","volume":"148","author":"Emsley","year":"2013","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.ajp.2022.103087_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-244X-13-50","article-title":"The nature of relapse in schizophrenia","volume":"13","author":"Emsley","year":"2013","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00756338","article-title":"Assessing levels of adaptive functioning: the role functioning scale","volume":"29","author":"Goodman","year":"1993","journal-title":"Community Ment. Health J."},{"key":"10.1016\/j.ajp.2022.103087_bib17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1034\/j.1600-0447.107.s416.5.x","article-title":"The Clinical Global Impression\u2013Schizophrenia scale: a simple instrument to measure the diversity of symptoms present in schizophrenia","volume":"107","author":"Haro","year":"2003","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.ajp.2022.103087_bib18","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1192\/bjp.bp.110.082065","article-title":"Cross-national clinical and functional remission rates: Worldwide Schizophrenia Outpatient Health Outcomes (W-SOHO) study","volume":"199","author":"Haro","year":"2011","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib19","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1017\/S0033291718003070","article-title":"Predicting first-episode psychosis patients who will never relapse over 10 years","volume":"49","author":"Hui","year":"2019","journal-title":"Psychol. Med."},{"key":"10.1016\/j.ajp.2022.103087_bib20","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S2215-0366(18)30090-7","article-title":"Long-term effects of discontinuation from antipsychotic maintenance following first-episode schizophrenia and related disorders: a 10 year follow-up of a randomised, double-blind trial","volume":"5","author":"Hui","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/09540261.2019.1613965","article-title":"A systematic review of clinical guidelines on choice, dose, and duration of antipsychotics treatment in first- and multi-episode schizophrenia","volume":"31","author":"Hui","year":"2019","journal-title":"Int. Rev. Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0264180100000904","article-title":"Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study","volume":"20","author":"Jablensky","year":"1992","journal-title":"Psychol. Med. Monogr. Suppl."},{"key":"10.1016\/j.ajp.2022.103087_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2147\/NDT.S96392","article-title":"Long-term outcomes of antipsychotic treatment in patients with first-episode schizophrenia: a systematic review","volume":"12","author":"Karson","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.ajp.2022.103087_bib24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.ajp.2022.103087_bib25","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1017\/S0033291710002023","article-title":"Early detection of psychosis: positive effects on 5-year outcome","volume":"41","author":"Larsen","year":"2011","journal-title":"Psychol. Med."},{"issue":"3","key":"10.1016\/j.ajp.2022.103087_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.psychres.2008.06.043","article-title":"Effectiveness of a psychosocial intervention for relapse prevention in patients with schizophrenia receiving risperidone via long-acting injection","volume":"175","author":"Lee","year":"2010","journal-title":"Psychiatry Res."},{"issue":"3","key":"10.1016\/j.ajp.2022.103087_bib27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1017\/S0033291721000209","article-title":"The predictive power of expressed emotion and its components in relapse of schizophrenia: a meta-analysis and mete-regression","volume":"51","author":"Ma","year":"2021","journal-title":"Psychol. Med."},{"key":"10.1016\/j.ajp.2022.103087_bib28","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/YIC.0b013e328303ac75","article-title":"Is the defined daily dose system a reliable tool for standardizing antipsychotic dosages?","volume":"23","author":"Nos\u00e8","year":"2008","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.ajp.2022.103087_bib29","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s40273-017-0515-3","article-title":"The cost of relapse in schizophrenia","volume":"35","author":"Pennington","year":"2017","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.ajp.2022.103087_bib30","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3109\/13651501.2016.1149195","article-title":"Clinical factors related to schizophrenia relapse","volume":"20","author":"Porcelli","year":"2016","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"10.1016\/j.ajp.2022.103087_bib31","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/schbul\/sbi017","article-title":"Predicting recovery from schizophrenia: a retrospective comparison of characteristics at onset of people with single and multiple episodes","volume":"31","author":"Rosen","year":"2005","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.ajp.2022.103087_bib32","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1751-7893.2010.00193.x","article-title":"Early intervention for psychosis in Hong Kong--the EASY programme","volume":"4","author":"Tang","year":"2010","journal-title":"Early Interv. Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib33","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/sj.npp.1301347","article-title":"Focal gray matter changes in schizophrenia across the course of the illness: a 5-year follow-up study","volume":"32","author":"van Haren","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ajp.2022.103087_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/oxfordjournals.schbul.a033315","article-title":"Natural course of schizophrenic disorders: a 15-year followup of a Dutch incidence cohort","volume":"24","author":"Wiersma","year":"1998","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.ajp.2022.103087_bib35","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/jamapsychiatry.2013.19","article-title":"Recovery in remitted first-episode psychosis at 7 years of follow-up of an early dose reduction\/discontinuation or maintenance treatment strategy: long-term follow-up of a 2-year randomized clinical trial","volume":"70","author":"Wunderink","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ajp.2022.103087_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.schres.2020.02.009","article-title":"You say \u201cschizophrenia\u201d and I say \u201cpsychosis\u201d: Just tell me when I can come off this medication","author":"Zipursky","year":"2020","journal-title":"Schizophr. Res."}],"container-title":["Asian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876201822000855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876201822000855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T16:41:58Z","timestamp":1761756118000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876201822000855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":36,"alternative-id":["S1876201822000855"],"URL":"https:\/\/doi.org\/10.1016\/j.ajp.2022.103087","relation":{},"ISSN":["1876-2018"],"issn-type":[{"value":"1876-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal relapse pattern of patients with first-episode schizophrenia-spectrum disorders and its predictors and outcomes: A 10-year follow-up study","name":"articletitle","label":"Article Title"},{"value":"Asian Journal of Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajp.2022.103087","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103087"}}