{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:26:28Z","timestamp":1773865588467,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asian Journal of Psychiatry"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ajp.2022.103089","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T11:38:17Z","timestamp":1648208297000},"page":"103089","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Comparing retinal changes measured by optical coherence tomography in patients with schizophrenia and their siblings with healthy controls: Are retinal findings potential endophenotype candidates?"],"prefix":"10.1016","volume":"72","author":[{"given":"Hatice","family":"Kaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batuhan","family":"Ay\u0131k","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumeysa","family":"Tasdelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neslihan","family":"Sevimli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erhan","family":"Ertekin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ajp.2022.103089_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neucli.2009.12.001","article-title":"Correlation between functional and structural assessments of the optic nerve and retina in multiple sclerosis patients","volume":"40","author":"Almarcegui","year":"2010","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.ajp.2022.103089_bib2","series-title":"American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"issue":"3","key":"10.1016\/j.ajp.2022.103089_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/S0920-9964(01)00278-X","article-title":"Duration of untreated psychosis and cognitive deterioration in first-episode schizophrenia","volume":"54","author":"Amminger","year":"2002","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.ajp.2022.103089_bib4","doi-asserted-by":"crossref","DOI":"10.4321\/S0213-61632010000400005","article-title":"Retinal nerve fiber layer thickness measured by optical coherence tomography in patients with schizophrenia: a short report","author":"Ascaso","year":"2010","journal-title":"Eur. J. Psychiatry"},{"issue":"11","key":"10.1016\/j.ajp.2022.103089_bib5","doi-asserted-by":"crossref","DOI":"10.1001\/archneurol.2009.230","article-title":"Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis","volume":"66","author":"Burkholder","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ajp.2022.103089_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/j.1755-3768.2012.T123.x","article-title":"Optical coherence tomography: a window into the brain of schizophrenic patients","author":"Cabezon","year":"2012","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.ajp.2022.103089_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpsy.2015.10.006","article-title":"Decreases in ganglion cell layer and inner plexiform layer volumes correlate better with disease severity in schizophrenia patients than retinal nerve fiber layer thickness: findings from spectral optic coherence tomography","author":"Celik","year":"2016","journal-title":"Eur. Psychiatry"},{"issue":"1","key":"10.1016\/j.ajp.2022.103089_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscychresns.2011.08.011","article-title":"A window into the brain: an in vivo study of the retina in schizophrenia using optical coherence tomography","volume":"203","author":"Chu","year":"2012","journal-title":"Psychiatry Res. Neuroimaging"},{"issue":"2","key":"10.1016\/j.ajp.2022.103089_bib9","doi-asserted-by":"crossref","DOI":"10.1007\/s11910-017-0725-2","article-title":"Trans-synaptic retrograde degeneration in the human visual system: slow, silent, and real","volume":"17","author":"Dinkin","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"12","key":"10.1016\/j.ajp.2022.103089_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/ncpneuro0950","article-title":"Optical coherence tomography: a window into the mechanisms of multiple sclerosis","volume":"4","author":"Frohman","year":"2008","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"10.1016\/j.ajp.2022.103089_bib11","first-page":"219","article-title":"Retinal function anomalies in young offspring at genetic risk of schizophrenia and mood disorder: the meaning for the illness pathophysiology","author":"Gagn\u00e9","year":"2020","journal-title":"Schizophr. Res."},{"issue":"1","key":"10.1016\/j.ajp.2022.103089_bib12","doi-asserted-by":"crossref","DOI":"10.1007\/s13311-010-0005-1","article-title":"Optical coherence tomography (OCT): imaging the visual pathway as a model for neurodegeneration","volume":"8","author":"Galetta","year":"2011","journal-title":"Neurotherapeutics"},{"issue":"16","key":"10.1016\/j.ajp.2022.103089_bib13","doi-asserted-by":"crossref","DOI":"10.1212\/01.wnl.0000295995.46586.ae","article-title":"Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis","volume":"69","author":"Gordon-Lipkin","year":"2007","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.ajp.2022.103089_bib14","doi-asserted-by":"crossref","DOI":"10.1093\/schbul\/sbl055","article-title":"The consortium on the genetics of schizophrenia: neurocognitive endophenotypes","volume":"33","author":"Gur","year":"2007","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.ajp.2022.103089_bib15","doi-asserted-by":"crossref","unstructured":"Guy, W., 1976. ECDEU Assessment Manual for Psuchopharmacology Revised: Clinical Global Impression. NIMH.","DOI":"10.1037\/e591322011-001"},{"issue":"24","key":"10.1016\/j.ajp.2022.103089_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.visres.2004.06.009","article-title":"Retinal nerve fiber layer thinning in Parkinson disease","volume":"44","author":"Inzelberg","year":"2004","journal-title":"Vis. Res."},{"key":"10.1016\/j.ajp.2022.103089_bib17","doi-asserted-by":"crossref","DOI":"10.5505\/kpd.2017.69077","article-title":"Psychiatric disorders and eye: optical coherent tomography in psychiatry aspect","author":"Karada\u011f","year":"2017","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.ajp.2022.103089_bib18","doi-asserted-by":"crossref","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","author":"Kay","year":"1987","journal-title":"Schizophr. Bull."},{"issue":"2","key":"10.1016\/j.ajp.2022.103089_bib19","doi-asserted-by":"crossref","DOI":"10.1007\/s10519-015-9765-z","article-title":"A danish twin study of schizophrenia liability: investigation from interviewed twins for genetic links to affective psychoses and for cross-cohort comparisons","volume":"46","author":"Kl\u00e4ning","year":"2016","journal-title":"Behav. Genet."},{"key":"10.1016\/j.ajp.2022.103089_bib20","article-title":"An investigation of retinal layer thicknesses in unaffected first-degree relatives of schizophrenia patients","author":"Kurtulmus","year":"2020","journal-title":"Schizophr. Res."},{"issue":"12","key":"10.1016\/j.ajp.2022.103089_bib21","article-title":"Retinal nerve fiber layer structure abnormalities in schizophrenia and its relationship to disease state: evidence from optical coherence tomography","volume":"54","author":"Lee","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ajp.2022.103089_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/schbul\/sbz029","article-title":"A meta-analysis of retinal cytoarchitectural abnormalities in schizophrenia and bipolar disorder","author":"Lizano","year":"2020","journal-title":"Schizophr. Bull."},{"issue":"1","key":"10.1016\/j.ajp.2022.103089_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2010.06.006","article-title":"Retinal nerve fiber layer structure abnormalities in early Alzheimer\u2019s disease: evidence in optical coherence tomography","volume":"480","author":"Lu","year":"2010","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.ajp.2022.103089_bib24","doi-asserted-by":"crossref","DOI":"10.1192\/bjp.bp.113.127753","article-title":"Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis","volume":"205","author":"Penttil\u00e4","year":"2014","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.ajp.2022.103089_bib25","doi-asserted-by":"crossref","DOI":"10.1177\/1352458511418630","article-title":"Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than peripapillary retinal nerve fiber layer thickness","author":"Saidha","year":"2011","journal-title":"Mult. Scler. J."},{"issue":"4","key":"10.1016\/j.ajp.2022.103089_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/schbul\/sbx130","article-title":"Retinal layer abnormalities as biomarkers of schizophrenia","volume":"44","author":"Samani","year":"2018","journal-title":"Schizophr. Bull."},{"issue":"3","key":"10.1016\/j.ajp.2022.103089_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/bjophthalmol-2013-304152","article-title":"Retinal thinning and correlation with functional disability in patients with Parkinson\u2019s disease","volume":"98","author":"Satue","year":"2014","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.ajp.2022.103089_bib28","article-title":"From imaging the brain to imaging the retina: optical coherence tomography (OCT) in schizophrenia","volume":"42","author":"Sch\u00f6nfeldt-Lecuona","year":"2016","journal-title":"Schizophr. Bull."},{"issue":"4","key":"10.1016\/j.ajp.2022.103089_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2011.12.015","article-title":"Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia","volume":"36","author":"Shepherd","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ajp.2022.103089_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.scog.2015.03.004","article-title":"Schizophrenia and the eye","author":"Silverstein","year":"2015","journal-title":"Schizophr. Res. Cogn."},{"issue":"7","key":"10.1016\/j.ajp.2022.103089_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0020212","article-title":"The genetics of schizophrenia","volume":"2","author":"Sullivan","year":"2005","journal-title":"PLoS Med."},{"issue":"7","key":"10.1016\/j.ajp.2022.103089_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/ajmg.b.32170","article-title":"A review of neuroimaging studies of young relatives of individuals with schizophrenia: a developmental perspective from schizotaxia to schizophrenia","volume":"162","author":"Thermenos","year":"2013","journal-title":"Am. J. Med. Genet. Part B: Neuropsychiatr. Genet."}],"container-title":["Asian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876201822000879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876201822000879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T16:42:55Z","timestamp":1761756175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876201822000879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":32,"alternative-id":["S1876201822000879"],"URL":"https:\/\/doi.org\/10.1016\/j.ajp.2022.103089","relation":{},"ISSN":["1876-2018"],"issn-type":[{"value":"1876-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparing retinal changes measured by optical coherence tomography in patients with schizophrenia and their siblings with healthy controls: Are retinal findings potential endophenotype candidates?","name":"articletitle","label":"Article Title"},{"value":"Asian Journal of Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajp.2022.103089","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103089"}}