{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:52:45Z","timestamp":1767790365680,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["111\\u20132314-B-182A-027 -"],"award-info":[{"award-number":["111\\u20132314-B-182A-027 -"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["CMRPG8P0631"],"award-info":[{"award-number":["CMRPG8P0631"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["109\\u20132314-B-182A-009-MY2"],"award-info":[{"award-number":["109\\u20132314-B-182A-009-MY2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["CMRPG8N0881"],"award-info":[{"award-number":["CMRPG8N0881"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112\\u20132314-B-182\\u2013070-MY3"],"award-info":[{"award-number":["112\\u20132314-B-182\\u2013070-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CORPG8P0561"],"award-info":[{"award-number":["CORPG8P0561"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["BMRPJ30"],"award-info":[{"award-number":["BMRPJ30"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asian Journal of Psychiatry"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ajp.2025.104591","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T02:40:22Z","timestamp":1750300822000},"page":"104591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dose-effect trajectory of lumateperone in schizophrenia: Evidence from a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-9175","authenticated-orcid":false,"given":"Yang-Chieh Brian","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-4060","authenticated-orcid":false,"given":"Chih-Wei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-8085","authenticated-orcid":false,"given":"Kuo-Chuan","family":"Hung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Sung","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Tao","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Kang","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajp.2025.104591_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajp.2023.103717","article-title":"Trajectory of changes in depressive symptoms after acute repetitive transcranial magnetic stimulation: A meta-analysis of follow-up effects","volume":"88","author":"Brian Chen","year":"2023","journal-title":"Asian J. Psychiatr."},{"key":"10.1016\/j.ajp.2025.104591_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101678","article-title":"Comparative effectiveness of valproic acid in different serum concentrations for maintenance treatment of bipolar disorder: A retrospective cohort study using target trial emulation framework","volume":"54","author":"Chen","year":"2022","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.ajp.2025.104591_bib3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2147\/NDT.S225643","article-title":"Negative Symptoms in Schizophrenia: A Review and Clinical Guide for Recognition, Assessment, and Treatment","volume":"16","author":"Correll","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.ajp.2025.104591_bib4","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1001\/jamapsychiatry.2019.4379","article-title":"Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial","volume":"77","author":"Correll","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ajp.2025.104591_bib5","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1177\/0962280218773122","article-title":"One-stage dose-response meta-analysis for aggregated data","volume":"28","author":"Crippa","year":"2019","journal-title":"Stat. Methods Med Res"},{"key":"10.1016\/j.ajp.2025.104591_bib6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/sim.3841","article-title":"Dose-response analyses using restricted cubic spline functions in public health research","volume":"29","author":"Desquilbet","year":"2010","journal-title":"Stat. Med"},{"key":"10.1016\/j.ajp.2025.104591_bib7","unstructured":"Evaluation, F.D.A.C.f.D., Research, 2018. NDA 209500 Multi-Disciplinary Review and Evaluation: Caplyta (lumateperone). U.S. Food and Drug Administration."},{"key":"10.1016\/j.ajp.2025.104591_bib8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/cts.12087","article-title":"Publishing \"Invisible\" and \"Abandoned\" clinical trials: a commitment for CTS","volume":"6","author":"Feldman","year":"2013","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.ajp.2025.104591_bib9","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1093\/oxfordjournals.aje.a116237","article-title":"Methods for trend estimation from summarized dose-response data, with applications to meta-analysis","volume":"135","author":"Greenland","year":"1992","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ajp.2025.104591_bib10","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1248\/bpb.b13-Foreword","article-title":"Recent advances in 5-hydroxytryptamine (5-HT) receptor research: how many pathophysiological roles does 5-HT play via its multiple receptor subtypes? Foreword","volume":"36","author":"Hirafuji","year":"2013","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ajp.2025.104591_bib11","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/acps.13346","article-title":"Lithium concentration and recurrence risk during maintenance treatment of bipolar disorder: Multicenter cohort and meta-analysis","volume":"144","author":"Hsu","year":"2021","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.ajp.2025.104591_bib12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.euroneuro.2022.01.112","article-title":"Differences in the prophylactic effect of serum lithium levels on depression and mania in bipolar disorder: A dose-response meta-analysis","volume":"58","author":"Hsu","year":"2022","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.ajp.2025.104591_bib13","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1176\/appi.ajp.2019.19010034","article-title":"Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia","volume":"177","author":"Leucht","year":"2020","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ajp.2025.104591_bib14","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.biopsych.2015.08.026","article-title":"ITI-007 for the Treatment of Schizophrenia: A 4-Week Randomized, Double-Blind, Controlled Trial","volume":"79","author":"Lieberman","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ajp.2025.104591_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102308","article-title":"Efficacy and safety of zuranolone in major depressive disorder: a meta-analysis of factor effect and dose-response analyses","volume":"66","author":"Lin","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.ajp.2025.104591_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/bmjment-2024-301165","article-title":"Efficacy and acceptability of lurasidone for bipolar depression: a systematic review and dose-response meta-analysis","volume":"27","author":"Lin","year":"2024","journal-title":"BMJ Ment. Health"},{"key":"10.1016\/j.ajp.2025.104591_bib17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/jamapsychiatry.2019.3360","article-title":"Schizophrenia-An Overview","volume":"77","author":"McCutcheon","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ajp.2025.104591_bib18","unstructured":"NCT02469155, 2015. A Randomized, Double-Blind, Placebo- and Active-Controlled, Multi-Center Study to Assess the Antipsychotic Efficacy of ITI-007 After 6 Weeks of Treatment in Patients With Schizophrenia."},{"key":"10.1016\/j.ajp.2025.104591_bib19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/aje\/kwr265","article-title":"Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software","volume":"175","author":"Orsini","year":"2012","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ajp.2025.104591_bib20","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.ajp.2025.104591_bib21","first-page":"638","article-title":"Schizophrenia: overview and treatment options","volume":"39","author":"Patel","year":"2014","journal-title":"P T"},{"key":"10.1016\/j.ajp.2025.104591_bib22","first-page":"27","article-title":"Efficacy and safety of lumateperone for bipolar depression and schizophrenia: a systematic review and meta-analysis","author":"Peng","year":"2024","journal-title":"Int J. Neuropsychopharmacol."},{"key":"10.1016\/j.ajp.2025.104591_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41537-021-00171-2","article-title":"Antipsychotics for negative and positive symptoms of schizophrenia: dose-response meta-analysis of randomized controlled acute phase trials","volume":"7","author":"Sabe","year":"2021","journal-title":"NPJ Schizophr."},{"key":"10.1016\/j.ajp.2025.104591_bib24","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.22r14490","article-title":"Comparative Effects of 11 Antipsychotics on Weight Gain and Metabolic Function in Patients With Acute Schizophrenia: A Dose-Response Meta-Analysis","volume":"84","author":"Sab\u00e9","year":"2023","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.ajp.2025.104591_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/cld.388","article-title":"LiverTox: An online information resource and a site for case report submission on drug-induced liver injury","volume":"4","author":"Serrano","year":"2014","journal-title":"Clin. Liver Dis. (Hoboken)"},{"key":"10.1016\/j.ajp.2025.104591_bib26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00213-014-3704-1","article-title":"Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission","volume":"232","author":"Snyder","year":"2015","journal-title":"Psychopharmacol. (Berl. )"},{"key":"10.1016\/j.ajp.2025.104591_bib27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/bs.apha.2020.09.001","article-title":"A review of the pharmacology and clinical profile of lumateperone for the treatment of schizophrenia","volume":"90","author":"Snyder","year":"2021","journal-title":"Adv. Pharm."},{"key":"10.1016\/j.ajp.2025.104591_bib28","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.1038\/s41380-023-02138-4","article-title":"Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019","volume":"28","author":"Solmi","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ajp.2025.104591_bib29","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1093\/schbul\/sbac039","article-title":"Optimal Doses of Specific Antipsychotics for Relapse Prevention in a Nationwide Cohort of Patients with Schizophrenia","volume":"48","author":"Taipale","year":"2022","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.ajp.2025.104591_bib30","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1093\/schbul\/sbx021.043","article-title":"24. The Clinical Development of Lumateperone (ITI-007) for the Treatment of Schizophrenia","volume":"43","author":"Vanover","year":"2017","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.ajp.2025.104591_bib31","doi-asserted-by":"crossref","first-page":"S351","DOI":"10.1093\/schbul\/sbz020.662","article-title":"S117. FAVORABLE LONG-TERM SAFETY PROFILE OF LUMATEPERONE IITI-007): RESULTS FROM A 12 MONTH OPEN LABEL SAFETY STUDY FOR LUMATEPERONE IN PATIENTS WITH STABLE SYMPTOMS OF SCHIZOPHRENIA","volume":"45","author":"Vanover","year":"2019","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.ajp.2025.104591_bib32","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/s41386-018-0251-1","article-title":"Dopamine D(2) receptor occupancy of lumateperone (ITI-007): a Positron Emission Tomography Study in patients with schizophrenia","volume":"44","author":"Vanover","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ajp.2025.104591_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajp.2024.104172","article-title":"Long-term metabolic side effects of second-generation antipsychotics in Chinese patients with schizophrenia: A within-subject approach with modelling of dosage effects","volume":"100","author":"Wong","year":"2024","journal-title":"Asian J. Psychiatr."}],"container-title":["Asian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876201825002345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876201825002345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:10:17Z","timestamp":1767773417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876201825002345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":33,"alternative-id":["S1876201825002345"],"URL":"https:\/\/doi.org\/10.1016\/j.ajp.2025.104591","relation":{},"ISSN":["1876-2018"],"issn-type":[{"value":"1876-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose-effect trajectory of lumateperone in schizophrenia: Evidence from a systematic review and meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"Asian Journal of Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajp.2025.104591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104591"}}