{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T02:44:39Z","timestamp":1783824279312,"version":"3.55.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2025A03J3468"],"award-info":[{"award-number":["2025A03J3468"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2024A04J4178"],"award-info":[{"award-number":["2024A04J4178"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2023B03J1300"],"award-info":[{"award-number":["2023B03J1300"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271564"],"award-info":[{"award-number":["82271564"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401795"],"award-info":[{"award-number":["82401795"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFB4500600"],"award-info":[{"award-number":["2022YFB4500600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asian Journal of Psychiatry"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ajp.2025.104660","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T06:45:35Z","timestamp":1755153935000},"page":"104660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Neuroimaging biomarkers distinguishing medication-na\u00efve adolescents with major depressive disorder and bipolar disorder during depressive episodes"],"prefix":"10.1016","volume":"111","author":[{"given":"Shijie","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunkai","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuran","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajp.2025.104660_bib1","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.2741\/4636","article-title":"Choline, the brain and neurodegeneration: insights from epigenetics","volume":"23","author":"Bekdash","year":"2018","journal-title":"Front. Biosci."},{"key":"10.1016\/j.ajp.2025.104660_bib2","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1212\/01.wnl.0000311267.63292.6c","article-title":"N-acetylaspartate and N-acetylaspartylglutamate: neurobiology and clinical significance","volume":"70","author":"Benarroch","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.ajp.2025.104660_bib3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/wps.21300","article-title":"Bipolar II disorder: a state-of-the-art review","volume":"24","author":"Berk","year":"2025","journal-title":"World Psychiatry"},{"key":"10.1016\/j.ajp.2025.104660_bib4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1017\/S0033291723003410","article-title":"Distinct neurofunctional alterations during motivational and hedonic processing of natural and monetary rewards in depression - a neuroimaging meta-analysis","volume":"54","author":"Bore","year":"2024","journal-title":"Psychol. Med"},{"key":"10.1016\/j.ajp.2025.104660_bib5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/bdi.12782","article-title":"Neurophysiological effects of multiple mood episodes in bipolar disorder","volume":"21","author":"Borgelt","year":"2019","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2019.03.081","article-title":"Corrigendum to \"altered White matter volumes in first-episode depression: evidence from cross-sectional and longitudinal voxel-based analyses\" journal of affective disorders 245 (2019) 971-977","volume":"253","author":"Carceller-Sindreu","year":"2019","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23168974","article-title":"Glutamatergic and N-Acetylaspartate metabolites in bipolar disorder: a systematic review and Meta-Analysis of proton magnetic resonance spectroscopy studies","volume":"23","author":"Chabert","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ajp.2025.104660_bib8","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/jora.12928","article-title":"Positioning adolescence in the developmental timeline","volume":"34","author":"Chaku","year":"2024","journal-title":"J. Res Adolesc."},{"key":"10.1016\/j.ajp.2025.104660_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajp.2024.103958","article-title":"The prevalence and clinical correlates of suicide attempts in patients with bipolar disorder misdiagnosed with major depressive disorder: results from a national survey in China","volume":"93","author":"Chen","year":"2024","journal-title":"Asian J. Psychiatr."},{"key":"10.1016\/j.ajp.2025.104660_bib10","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/jamapsychiatry.2024.1133","article-title":"Adolescent and adult transitions from major depressive disorder to bipolar disorder","volume":"81","author":"Desai Bostr\u00f6m","year":"2024","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ajp.2025.104660_bib11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ejrad.2003.08.009","article-title":"High-field proton MRS of human brain","volume":"48","author":"Di Costanzo","year":"2003","journal-title":"Eur. J. Radio."},{"key":"10.1016\/j.ajp.2025.104660_bib12","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s00213-019-05344-7","article-title":"The potential of (1)H-MRS in CNS drug development","volume":"238","author":"Egerton","year":"2021","journal-title":"Psychopharmacol. (Berl. )"},{"key":"10.1016\/j.ajp.2025.104660_bib13","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.jad.2018.12.104","article-title":"Reward-circuit biomarkers of risk and resilience in adolescent depression","volume":"246","author":"Fischer","year":"2019","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib14","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-073591","article-title":"Diagnosis and management of bipolar disorders","volume":"381","author":"Goes","year":"2023","journal-title":"Bmj"},{"key":"10.1016\/j.ajp.2025.104660_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jad.2022.09.016","article-title":"A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults","volume":"319","author":"Goldman","year":"2022","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejrad.2008.03.002","article-title":"Introduction to clinical in vivo MR spectroscopy","volume":"67","author":"Hajek","year":"2008","journal-title":"Eur. J. Radio."},{"key":"10.1016\/j.ajp.2025.104660_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102265","article-title":"Functional expression of choline transporters in the Blood-Brain barrier","volume":"11","author":"Inazu","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.ajp.2025.104660_bib18","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3109\/15622975.2014.885659","article-title":"A review of fMRI studies during visual emotive processing in major depressive disorder","volume":"16","author":"Jaworska","year":"2015","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.ajp.2025.104660_bib19","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41398-023-02607-y","article-title":"Association of polygenic risk for bipolar disorder with grey matter structure and White matter integrity in youth","volume":"13","author":"Jiang","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.ajp.2025.104660_bib20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S2215-0366(14)00081-9","article-title":"Changes in the adolescent brain and the pathophysiology of psychotic disorders","volume":"1","author":"Keshavan","year":"2014","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.ajp.2025.104660_bib21","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/s41380-018-0032-6","article-title":"Correction to: the pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI","volume":"24","author":"Kraus","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ajp.2025.104660_bib22","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41386-022-01463-6","article-title":"Effects of short-term quetiapine and lithium therapy for acute manic or mixed episodes on the limbic system and emotion regulation circuitry in youth with bipolar disorder","volume":"48","author":"Lei","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ajp.2025.104660_bib23","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/npp.2014.310","article-title":"Myelin vs axon abnormalities in White matter in bipolar disorder","volume":"40","author":"Lewandowski","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ajp.2025.104660_bib24","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jad.2023.05.070","article-title":"Morphological abnormalities in youth with bipolar disorder and their relationship to clinical characteristics","volume":"338","author":"Li","year":"2023","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib25","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.bbi.2019.10.010","article-title":"Inflammation, brain structure and cognition interrelations among individuals with differential risks for bipolar disorder","volume":"83","author":"Lin","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ajp.2025.104660_bib26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jad.2017.01.009","article-title":"A comparison of neurometabolites between remitted bipolar disorder and depressed bipolar disorder: a proton magnetic resonance spectroscopy study","volume":"211","author":"Liu","year":"2017","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib27","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jad.2023.01.049","article-title":"Gray matter alterations in adolescent major depressive disorder and adolescent bipolar disorder","volume":"325","author":"Long","year":"2023","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib28","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.nicl.2016.04.008","article-title":"The volumetric and shape changes of the putamen and thalamus in first episode, untreated major depressive disorder","volume":"11","author":"Lu","year":"2016","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.ajp.2025.104660_bib29","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jad.2021.08.129","article-title":"Correlations between facial emotion processing and biochemical abnormalities in untreated adolescent patients with major depressive disorder: a proton magnetic resonance spectroscopy study","volume":"296","author":"Lv","year":"2022","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib30","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/bdi.13367","article-title":"The diagnosis of bipolar disorder in children and adolescents: past, present and future","volume":"25","author":"Malhi","year":"2023","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/pcn.12372","article-title":"Correlation between neurochemical metabolism and memory function in adolescent patients with depression: a multi-voxel \u00b9H magnetic resonance spectroscopy study","volume":"70","author":"Mao","year":"2016","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.ajp.2025.104660_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2025.108823","article-title":"Biomarker identification in bipolar disorder","volume":"268","author":"Martella","year":"2025","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.ajp.2025.104660_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2023.1221709","article-title":"Obesity, inflammation, and depression in adolescents","volume":"14","author":"McLachlan","year":"2023","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.ajp.2025.104660_bib34","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3109\/15622970802123695","article-title":"Increased xanthine oxidase in the thalamus and putamen in depression","volume":"11","author":"Michel","year":"2010","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.ajp.2025.104660_bib35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pneurobio.2006.12.003","article-title":"N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology","volume":"81","author":"Moffett","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ajp.2025.104660_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2024.105766","article-title":"Inflammatory and oxidative stress biomarkers in children and adolescents with bipolar disorder - a systematic review and meta-analysis","volume":"163","author":"Munkholm","year":"2024","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.ajp.2025.104660_bib37","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jad.2023.03.025","article-title":"Brain functional activation and first mood episode in youth at risk for bipolar disorder","volume":"331","author":"Nery","year":"2023","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib38","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1159\/000284673","article-title":"The importance of karl leonhard's classification of endogenous psychoses","volume":"23","author":"Perris","year":"1990","journal-title":"Psychopathology"},{"key":"10.1016\/j.ajp.2025.104660_bib39","doi-asserted-by":"crossref","first-page":"7805","DOI":"10.1017\/S0033291723001848","article-title":"Predictors of diagnostic conversion from major depression to bipolar disorder: a Swedish national longitudinal study","volume":"53","author":"Rhee","year":"2023","journal-title":"Psychol. Med"},{"key":"10.1016\/j.ajp.2025.104660_bib40","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jad.2024.03.150","article-title":"Proton magnetic resonance spectroscopy of N-acetyl aspartate in first depressive episode and chronic major depressive disorder: a systematic review and meta-analysis","volume":"355","author":"Saccaro","year":"2024","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib41","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.cmet.2019.03.011","article-title":"Choline uptake and metabolism modulate macrophage IL-1\u03b2 and IL-18 production","volume":"29","author":"Sanchez-Lopez","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.ajp.2025.104660_bib42","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/bdi.12395","article-title":"Deficits in axon-associated proteins in prefrontal White matter in bipolar disorder but not schizophrenia","volume":"18","author":"Shao","year":"2016","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib43","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41583-023-00701-0","article-title":"The impact of the human thalamus on brain-wide information processing","volume":"24","author":"Shine","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ajp.2025.104660_bib44","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/bjc.12333","article-title":"Global prevalence of depression and elevated depressive symptoms among adolescents: a systematic review and meta-analysis","volume":"61","author":"Shorey","year":"2022","journal-title":"Br. J. Clin. Psychol."},{"key":"10.1016\/j.ajp.2025.104660_bib45","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/bdi.13439","article-title":"Distinguishing bipolar depression, bipolar mania, and major depressive disorder by gut microbial characteristics","volume":"26","author":"Sun","year":"2024","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib46","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jad.2021.10.021","article-title":"Dynamical regional activity in putamen distinguishes bipolar type I depression and unipolar depression","volume":"297","author":"Sun","year":"2022","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib47","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.biopsych.2022.06.035","article-title":"Putamen structure and function in familial risk for depression: a multimodal imaging study","volume":"92","author":"Talati","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ajp.2025.104660_bib48","first-page":"1","article-title":"Larger putamen in individuals at risk and with manifest bipolar disorder","author":"Thomas-Odenthal","year":"2024","journal-title":"Psychol. Med"},{"key":"10.1016\/j.ajp.2025.104660_bib49","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.18r12180","article-title":"Updated Meta-Analysis of epidemiologic studies of pediatric bipolar disorder","volume":"80","author":"Van Meter","year":"2019","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.ajp.2025.104660_bib50","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.neubiorev.2018.06.004","article-title":"Puberty and the human brain: insights into adolescent development","volume":"92","author":"Vijayakumar","year":"2018","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.ajp.2025.104660_bib51","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1176\/appi.ajp.2013.13070920","article-title":"Structural brain development and depression onset during adolescence: a prospective longitudinal study","volume":"171","author":"Whittle","year":"2014","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ajp.2025.104660_bib52","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41380-023-02327-1","article-title":"The neural signature of psychomotor disturbance in depression","volume":"29","author":"W\u00fcthrich","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ajp.2025.104660_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2022.103295","article-title":"The thalamus is the causal hub of intervention in patients with major depressive disorder: evidence from the granger causality analysis","volume":"37","author":"Yang","year":"2023","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.ajp.2025.104660_bib54","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jad.2021.10.132","article-title":"Associations between executive function impairment and biochemical abnormalities in depressed adolescents with non-suicidal self-injury","volume":"298","author":"Zhang","year":"2022","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib55","article-title":"Microstructural alterations in superficial White matter associated with anhedonia and suicidal ideation in major depressive disorder","author":"Zhang","year":"2025","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"10.1016\/j.ajp.2025.104660_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.119747","article-title":"Magnetic resonance spectroscopy studies in children and adolescents with depression: a systematic review and meta-analysis","author":"Zhou","year":"2025","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ajp.2025.104660_bib57","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.5498\/wjp.v14.i11.1652","article-title":"Application of proton magnetic resonance spectroscopy in metabolic alterations of prefrontal White and gray matter in depression adolescents","volume":"14","author":"Zou","year":"2024","journal-title":"World J. Psychiatry"}],"container-title":["Asian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187620182500303X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187620182500303X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:42:50Z","timestamp":1772894570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187620182500303X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":57,"alternative-id":["S187620182500303X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajp.2025.104660","relation":{},"ISSN":["1876-2018"],"issn-type":[{"value":"1876-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroimaging biomarkers distinguishing medication-na\u00efve adolescents with major depressive disorder and bipolar disorder during depressive episodes","name":"articletitle","label":"Article Title"},{"value":"Asian Journal of Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajp.2025.104660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104660"}}