{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:34:46Z","timestamp":1794011686100,"version":"4.8.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJCR22P3"],"award-info":[{"award-number":["JPMJCR22P3"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJMS2292"],"award-info":[{"award-number":["JPMJMS2292"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K02379"],"award-info":[{"award-number":["24K02379"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JSPS KAKENHI Grant Number 23H04979"],"award-info":[{"award-number":["JSPS KAKENHI Grant Number 23H04979"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["25wm0625219"],"award-info":[{"award-number":["25wm0625219"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["25wm0625417"],"award-info":[{"award-number":["25wm0625417"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21dm0307008"],"award-info":[{"award-number":["21dm0307008"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007173","name":"Bio-oriented Technology Research Advancement Institution","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asian Journal of Psychiatry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ajp.2026.105161","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:33:16Z","timestamp":1789831996000},"page":"105161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Differing effects of methylphenidate on attention-related behavior and brain activity in medication-naive and non-naive ADHD adults"],"prefix":"10.1016","volume":"125","author":[{"given":"Masaaki","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Itahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5732-9833","authenticated-orcid":false,"given":"Yumi","family":"Shikauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1082-7533","authenticated-orcid":false,"given":"Hironobu","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7289-6553","authenticated-orcid":false,"given":"Shunsuke","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genichi","family":"Sugihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2830-3049","authenticated-orcid":false,"given":"Motoaki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajp.2026.105161_bib1","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1037\/neu0000707","article-title":"The role of top-down attentional control and attention-deficit\/hyperactivity disorder symptoms in predicting future motor vehicle crash risk","volume":"34","author":"Aduen","year":"2020","journal-title":"Neuropsychology"},{"key":"10.1016\/j.ajp.2026.105161_bib2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1037\/a0032371","article-title":"Attention-deficit\/hyperactivity disorder (ADHD) and working memory in adults: a meta-analytic review","volume":"27","author":"Alderson","year":"2013","journal-title":"Neuropsychology"},{"key":"10.1016\/j.ajp.2026.105161_bib3","doi-asserted-by":"crossref","first-page":"12582","DOI":"10.18632\/aging.103515","article-title":"Modulation of attention networks serving reorientation in healthy aging","volume":"12","author":"Arif","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.ajp.2026.105161_bib4","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1126\/science.1138071","article-title":"Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices","volume":"315","author":"Buschman","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ajp.2026.105161_bib5","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1523\/JNEUROSCI.3890-14.2015","article-title":"Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2\/3 receptor availability in the striatum","volume":"35","author":"Caprioli","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ajp.2026.105161_bib6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s40263-017-0487-z","article-title":"Cognitive function of children and adolescents with attention-deficit\/hyperactivity disorder in a 2-year open-label study of lisdexamfetamine dimesylate","volume":"32","author":"Coghill","year":"2018","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ajp.2026.105161_bib7","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.biopsych.2013.10.005","article-title":"Effects of methylphenidate on cognitive functions in children and adolescents with attention-deficit\/hyperactivity disorder: evidence from a systematic review and a meta-analysis","volume":"76","author":"Coghill","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib8","first-page":"24","article-title":"Rating scales in attention-deficit\/hyperactivity disorder: use in assessment and treatment monitoring","author":"Conners","year":"1998","journal-title":"J. Clin. Psychiatry 59"},{"key":"10.1016\/j.ajp.2026.105161_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41386-021-01100-8","article-title":"Neuromodulation of prefrontal cortex cognitive function in primates: the powerful roles of monoamines and acetylcholine","volume":"47","author":"Cools","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ajp.2026.105161_bib10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn755","article-title":"Control of goal-directed and stimulus-driven attention in the brain","volume":"3","author":"Corbetta","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ajp.2026.105161_bib11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/HRP.0b013e318293749e","article-title":"Areas of the brain modulated by single-dose methylphenidate treatment in youth with ADHD during task-based fMRI: a systematic review","volume":"21","author":"Czerniak","year":"2013","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib12","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/cercor\/bhp215","article-title":"Neural correlates of the spatial and expectancy components of endogenous and stimulus-driven orienting of attention in the Posner task","volume":"20","author":"Doricchi","year":"2010","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.ajp.2026.105161_bib13","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/ane.12955","article-title":"Increase of frontal neuronal activity in chronic neglect after training in virtual reality","volume":"138","author":"Ekman","year":"2018","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.ajp.2026.105161_bib14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41592-018-0235-4","article-title":"fMRIPrep: a robust preprocessing pipeline for functional MRI","volume":"16","author":"Esteban","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ajp.2026.105161_bib15","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neubiorev.2021.01.022","article-title":"The world federation of ADHD international consensus statement: 208 evidence-based conclusions about the disorder","volume":"128","author":"Faraone","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ajp.2026.105161_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00787-009-0054-3","article-title":"Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis","volume":"19","author":"Faraone","year":"2010","journal-title":"Eur. Child. Adolesc. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib17","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2165\/00148581-200911030-00005","article-title":"Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents: a review of its use in attention-deficit hyperactivity disorder in children and adolescents","volume":"11","author":"Garnock-Jones","year":"2009","journal-title":"Paediatr. Drugs"},{"key":"10.1016\/j.ajp.2026.105161_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52460","article-title":"Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network","volume":"9","author":"Hart","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.ajp.2026.105161_bib19","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1469-8749.2001.tb00157.x","article-title":"Is increased D2 receptor availability associated with response to stimulant medication in ADHD","volume":"43","author":"Ilgin","year":"2001","journal-title":"Dev. Med. Child. Neurol."},{"key":"10.1016\/j.ajp.2026.105161_bib20","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/1073858413514136","article-title":"Bottom-up and top-down attention: different processes and overlapping neural systems: different processes and overlapping neural systems","volume":"20","author":"Katsuki","year":"2014","journal-title":"Neuroscientist"},{"key":"10.1016\/j.ajp.2026.105161_bib21","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ejpn.2008.10.008","article-title":"Effects of methylphenidate on working memory functioning in children with attention deficit\/hyperactivity disorder","volume":"13","author":"Kobel","year":"2009","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"10.1016\/j.ajp.2026.105161_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2021.102600","article-title":"Brain\/MINDS beyond human brain MRI project: a protocol for multi-level harmonization across brain disorders throughout the lifespan","volume":"30","author":"Koike","year":"2021","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.ajp.2026.105161_bib23","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/hbm.23068","article-title":"The right temporoparietal junction in attention and social interaction: a transcranial magnetic stimulation study: RTPJ-TMS in Attention and Social Interaction","volume":"37","author":"Krall","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.ajp.2026.105161_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.148144","article-title":"Top-down auditory attention modulates neural responses more strongly in neurotypical than ADHD young adults","volume":"1798","author":"Kwasa","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.ajp.2026.105161_bib25","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1111\/ejn.13086","article-title":"The effect of oppositional parietal transcranial direct current stimulation on lateralized brain functions","volume":"42","author":"Li","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ajp.2026.105161_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.642798","article-title":"Intentional discontinuation of psychostimulants used to treat ADHD in youth: a review and analysis","volume":"12","author":"Lohr","year":"2021","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib27","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.eurpsy.2010.08.013","article-title":"Low self-awareness of ADHD in adults using a self-report screening questionnaire","volume":"27","author":"Manor","year":"2012","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib28","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/s42003-022-03434-5","article-title":"Cortical D1 and D2 dopamine receptor availability modulate methylphenidate-induced changes in brain activity and functional connectivity","volume":"5","author":"Manza","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ajp.2026.105161_bib29","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2423785122","article-title":"Neural basis for individual differences in the attention-enhancing effects of methylphenidate","volume":"122","author":"Manza","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ajp.2026.105161_bib30","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/01.chi.0000153228.72591.73","article-title":"A meta-analysis of working memory impairments in children with attention-deficit\/hyperactivity disorder","volume":"44","author":"Martinussen","year":"2005","journal-title":"J. Am. Acad. Child. Adolesc. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib31","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1176\/appi.ajp.2019.18111296","article-title":"Continued benefits of methylphenidate in ADHD after 2 years in clinical practice: a randomized placebo-controlled discontinuation study","volume":"176","author":"Matthijssen","year":"2019","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib32","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.neuroimage.2004.06.027","article-title":"Neural networks underlying endogenous and exogenous visual-spatial orienting","volume":"23","author":"Mayer","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.ajp.2026.105161_bib33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/cercor\/bhz078","article-title":"Dopamine receptor expression among local and visual cortex-projecting frontal eye field neurons","volume":"30","author":"Mueller","year":"2020","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.ajp.2026.105161_bib34","doi-asserted-by":"crossref","first-page":"16443","DOI":"10.1523\/JNEUROSCI.2625-13.2013","article-title":"Frontal and parietal cortical interactions with distributed visual representations during selective attention and action selection","volume":"33","author":"Nelissen","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ajp.2026.105161_bib35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.conb.2010.02.003","article-title":"Top-down control of visual attention","volume":"20","author":"Noudoost","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ajp.2026.105161_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2023.1173989","article-title":"The association between different sources of distraction and symptoms of attention deficit hyperactivity disorder","volume":"14","author":"Osborne","year":"2023","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/00335558008248231","article-title":"Orienting of attention","volume":"32","author":"Posner","year":"1980","journal-title":"Q. J. Exp. Psychol."},{"key":"10.1016\/j.ajp.2026.105161_bib38","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00913468","article-title":"Effects of methylphenidate (Ritalin) on information processing in hyperactive children","volume":"12","author":"Reid","year":"1984","journal-title":"J. Abnorm. Child. Psychol."},{"key":"10.1016\/j.ajp.2026.105161_bib39","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00702-017-1680-4","article-title":"Chronic oral methylphenidate treatment reversibly increases striatal dopamine transporter and dopamine type 1 receptor binding in rats","volume":"124","author":"Robison","year":"2017","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ajp.2026.105161_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1501672","article-title":"Dopamine D1 signaling organizes network dynamics underlying working memory","volume":"2","author":"Roffman","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ajp.2026.105161_bib41","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fnhum.2018.00100","article-title":"Cognitive neuroscience of attention deficit hyperactivity disorder (ADHD) and its clinical translation","volume":"12","author":"Rubia","year":"2018","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.ajp.2026.105161_bib42","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.biopsych.2011.04.018","article-title":"Methylphenidate normalizes frontocingulate underactivation during error processing in attention-deficit\/hyperactivity disorder","volume":"70","author":"Rubia","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib43","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1093\/cercor\/bhx179","article-title":"Local-global parcellation of the human cerebral cortex from intrinsic functional connectivity MRI","volume":"28","author":"Schaefer","year":"2018","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.ajp.2026.105161_bib44","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cortex.2018.01.021","article-title":"Distraction by salient stimuli in adults with attention-deficit\/hyperactivity disorder: Evidence for the role of task difficulty in bottom-up and top-down processing","volume":"101","author":"Schneidt","year":"2018","journal-title":"Cortex"},{"key":"10.1016\/j.ajp.2026.105161_bib45","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1001\/archgenpsychiatry.2011.2053","article-title":"Common and unique therapeutic mechanisms of stimulant and nonstimulant treatments for attention-deficit\/hyperactivity disorder","volume":"69","author":"Schulz","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib46","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.biopsych.2004.07.011","article-title":"Effect of methylphenidate on executive functioning in adults with attention-deficit\/hyperactivity disorder: normalization of behavior but not related brain activity","volume":"56","author":"Schweitzer","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib47","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/cne.903530210","article-title":"Topography of projections to posterior cortical areas from the macaque frontal eye fields","volume":"353","author":"Stanton","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ajp.2026.105161_bib48","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1177\/1087054714530782","article-title":"Self-awareness of Executive Functioning deficits in adolescents with ADHD","volume":"21","author":"Steward","year":"2017","journal-title":"J. Atten. Disord."},{"key":"10.1016\/j.ajp.2026.105161_bib49","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/002221949102400406","article-title":"Effects of stimulant medication on learning in children with ADHD","volume":"24","author":"Swanson","year":"1991","journal-title":"J. Learn. Disabil."},{"key":"10.1016\/j.ajp.2026.105161_bib50","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ridd.2018.08.017","article-title":"The effectiveness of methylphenidate in the management of attention deficit hyperactivity disorder (ADHD) in people with intellectual disabilities: a systematic review","volume":"83","author":"Tarrant","year":"2018","journal-title":"Res. Dev. Disabil."},{"key":"10.1016\/j.ajp.2026.105161_bib51","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.pbb.2007.05.020","article-title":"Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents","volume":"87","author":"Thanos","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ajp.2026.105161_bib52","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00787-023-02176-x","article-title":"Methylphenidate dose-response in children with ADHD: evidence from a double-blind, randomized placebo-controlled titration trial","volume":"33","author":"Vertessen","year":"2024","journal-title":"Eur. Child. Adolesc. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib53","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1055\/s-2003-39602","article-title":"Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD)","volume":"34","author":"Vles","year":"2003","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.ajp.2026.105161_bib54","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1176\/appi.ajp.160.11.1909","article-title":"Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD","volume":"160","author":"Volkow","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ajp.2026.105161_bib55","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1523\/JNEUROSCI.4461-11.2012","article-title":"Methylphenidate-elicited dopamine increases in ventral striatum are associated with long-term symptom improvement in adults with attention deficit hyperactivity disorder","volume":"32","author":"Volkow","year":"2012","journal-title":"J. Neurosci."}],"container-title":["Asian Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876201826003345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876201826003345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:11:37Z","timestamp":1794010297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876201826003345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":55,"alternative-id":["S1876201826003345"],"URL":"https:\/\/doi.org\/10.1016\/j.ajp.2026.105161","relation":{},"ISSN":["1876-2018"],"issn-type":[{"value":"1876-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differing effects of methylphenidate on attention-related behavior and brain activity in medication-naive and non-naive ADHD adults","name":"articletitle","label":"Article Title"},{"value":"Asian Journal of Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajp.2026.105161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105161"}}