{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:59:59Z","timestamp":1791075599505,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":3237,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003461","name":"Gunnar Nilssons Cancerstiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003461","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011077","name":"Sk\u00e5nes universitetssjukhus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.ajpath.2010.10.026","type":"journal-article","created":{"date-parts":[[2011,1,29]],"date-time":"2011-01-29T04:17:08Z","timestamp":1296274628000},"page":"828-837","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":232,"title":["Isolation and Characterization of Progenitor-Like Cells from Human Renal Proximal Tubules"],"prefix":"10.1016","volume":"178","author":[{"given":"David","family":"Lindgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Karin","family":"Bostr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Sj\u00f6lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Jirstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Landberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Axelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E.","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2010.10.026_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1681\/ASN.2008070795","article-title":"Recruitment of podocytes from glomerular parietal epithelial cells","volume":"20","author":"Appel","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib2","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1681\/ASN.2008070709","article-title":"Regeneration of glomerular podocytes by human renal progenitors","volume":"20","author":"Ronconi","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib3","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1681\/ASN.2006010089","article-title":"Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys","volume":"17","author":"Sagrinati","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib4","doi-asserted-by":"crossref","first-page":"C807","DOI":"10.1152\/ajpcell.00301.2006","article-title":"Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney","volume":"292","author":"Vogetseder","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib5","doi-asserted-by":"crossref","first-page":"C22","DOI":"10.1152\/ajpcell.00227.2007","article-title":"Proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells","volume":"294","author":"Vogetseder","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib6","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S0140-6736(10)60237-1","article-title":"Kidney regeneration","volume":"375","author":"Benigni","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2010.10.026_bib7","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1172\/JCI22593","article-title":"Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells","volume":"115","author":"Duffield","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2010.10.026_bib8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.stem.2008.01.014","article-title":"Intrinsic epithelial cells repair the kidney after injury","volume":"2","author":"Humphreys","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2010.10.026_bib9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ctrv.2006.12.005","article-title":"Renal cell carcinoma: current status and emerging therapies","volume":"33","author":"Nelson","year":"2007","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.ajpath.2010.10.026_bib10","doi-asserted-by":"crossref","first-page":"11707","DOI":"10.1073\/pnas.0603806103","article-title":"Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells","volume":"103","author":"Chute","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2010.10.026_bib11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1089\/scd.2008.0055","article-title":"ALDH1 as a functional marker of cancer stem and progenitor cells","volume":"18","author":"Douville","year":"2009","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.ajpath.2010.10.026_bib12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1172\/JCI32086","article-title":"Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo","volume":"118","author":"Sjolund","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2010.10.026_bib13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/modpathol.3880508","article-title":"Quantification of MYCN, DDX1, and NAG gene copy number in neuroblastoma using a real-time quantitative PCR assay","volume":"15","author":"De Preter","year":"2002","journal-title":"Mod Pathol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/1471-2105-10-330","article-title":"BASE: 2nd generation software for microarray data management and analysis","volume":"10","author":"Vallon-Christersson","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.ajpath.2010.10.026_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: nCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2010.10.026_bib16","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2010.10.026_bib17","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2010.10.026_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10048-006-0032-6","article-title":"Gene expression analyses reveal molecular relationships among 20 regions of the human CNS","volume":"7","author":"Roth","year":"2006","journal-title":"Neurogenetics"},{"key":"10.1016\/j.ajpath.2010.10.026_bib19","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1158\/1078-0432.CCR-04-2225","article-title":"Gene signatures of progression and metastasis in renal cell cancer","volume":"11","author":"Jones","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2010.10.026_bib20","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.1158\/0008-5472.CAN-05-0533","article-title":"A molecular classification of papillary renal cell carcinoma","volume":"65","author":"Yang","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2010.10.026_bib21","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.bcp.2006.03.016","article-title":"Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1\u03b1","volume":"72","author":"Maher","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0092-8674(00)81033-8","article-title":"Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome","volume":"84","author":"Pontoglio","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2010.10.026_bib23","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1124\/jpet.107.128249","article-title":"Transcriptional regulation of human and mouse organic anion transporter 1 by hepatocyte nuclear factor 1 \u03b1\/\u03b2","volume":"324","author":"Saji","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.ajpath.2010.10.026_bib24","doi-asserted-by":"crossref","first-page":"C484","DOI":"10.1152\/ajpcell.00498.2008","article-title":"Myoferlin is critical for endocytosis in endothelial cells","volume":"297","author":"Bernatchez","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00428-003-0948-2","article-title":"Keratin immunohistochemistry in renal cell carcinoma subtypes and renal oncocytomas: a systematic analysis of 233 tumors","volume":"444","author":"Langner","year":"2004","journal-title":"Virchows Arch"},{"key":"10.1016\/j.ajpath.2010.10.026_bib26","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/01.pas.0000163362.78475.63","article-title":"Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors","volume":"29","author":"Skinnider","year":"2005","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.humpath.2006.07.016","article-title":"Renal papillary adenoma: a putative precursor of papillary renal cell carcinoma","volume":"38","author":"Wang","year":"2007","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib28","first-page":"74","article-title":"Expression of intermediate filament proteins in fetal and adult human kidney: modulations of intermediate filament patterns during development and in damaged tissue","volume":"65","author":"Moll","year":"1991","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2010.10.026_bib29","first-page":"1","article-title":"Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney","volume":"129","author":"Grone","year":"1987","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib30","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0002-9440(10)62276-6","article-title":"Isolation of renal progenitor cells from adult human kidney","volume":"166","author":"Bussolati","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib31","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1096\/fj.09-136481","article-title":"TLR2 plays a role in the activation of human resident renal stem\/progenitor cells","volume":"24","author":"Sallustio","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2010.10.026_bib32","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1369\/jhc.2008.951897","article-title":"The stem cell marker CD133 (Prominin-1) is expressed in various human glandular epithelia","volume":"56","author":"Karbanova","year":"2008","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.ajpath.2010.10.026_bib33","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1172\/JCI37829","article-title":"Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models","volume":"119","author":"Brooks","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2010.10.026_bib34","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0092-8674(93)80065-M","article-title":"Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair","volume":"75","author":"Veis","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2010.10.026_bib35","doi-asserted-by":"crossref","first-page":"F243","DOI":"10.1152\/ajprenal.00236.2006","article-title":"Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells","volume":"292","author":"Brooks","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ajpath.2010.10.026_bib36","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.1072530","article-title":"\u201cStemness\u201d: transcriptional profiling of embryonic and adult stem cells","volume":"298","author":"Ramalho-Santos","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2010.10.026_bib37","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/35102174","article-title":"The development of neural stem cells","volume":"414","author":"Temple","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2010.10.026_bib38","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ki.2010.39","article-title":"Ontogeny of CD24 in the human kidney","volume":"77","author":"Ivanova","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2010.10.026_bib39","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1002\/stem.140","article-title":"Toward the identification of a \u201crenopoietic system\u201d?","volume":"27","author":"Romagnani","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.ajpath.2010.10.026_bib40","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1172\/JCI20921","article-title":"The renal papilla is a niche for adult kidney stem cells","volume":"114","author":"Oliver","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2010.10.026_bib41","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nature01602","article-title":"Adaptation of core mechanisms to generate cell polarity","volume":"422","author":"Nelson","year":"2003","journal-title":"Nature"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010001197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010001197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:47:22Z","timestamp":1762080442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010001197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0002944010001197"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2010.10.026","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isolation and Characterization of Progenitor-Like Cells from Human Renal Proximal Tubules","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2010.10.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}