{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:54:30Z","timestamp":1791204870859,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":3268,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000221","name":"Canadian Lung Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000019","name":"Crohn's and Colitis Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000194","name":"Nova Scotia Health Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.ajpath.2010.11.041","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T04:24:00Z","timestamp":1296102240000},"page":"150-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Tissue Eosinophilia in a Mouse Model of Colitis Is Highly Dependent on TLR2 and Independent of Mast Cells"],"prefix":"10.1016","volume":"178","author":[{"given":"Eric J.","family":"Albert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Duplisea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Dawicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D.","family":"Haidl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean S.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2010.11.041_bib1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2010.11.041_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1600-065X.2001.790114.x","article-title":"Gastrointestinal eosinophils","volume":"179","author":"Rothenberg","year":"2001","journal-title":"Immunol Rev"},{"key":"10.1016\/j.ajpath.2010.11.041_bib3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/BF01307568","article-title":"Colonic mucosal mast cell distribution at line of demarcation of active ulcerative colitis","volume":"37","author":"King","year":"1992","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.ajpath.2010.11.041_bib4","first-page":"678","article-title":"Different distribution of mast cells and macrophages in colonic mucosa of patients with collagenous colitis and inflammatory bowel disease","volume":"49","author":"Nishida","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.ajpath.2010.11.041_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0952-7915(94)90038-8","article-title":"Eosinophils: structure and functions","volume":"6","author":"Weller","year":"1994","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev.iy.02.040184.002241","article-title":"Immunobiology of eosinophils","volume":"2","author":"Gleich","year":"1984","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.24.021605.090720","article-title":"The eosinophil","volume":"24","author":"Rothenberg","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1084\/jem.167.1.219","article-title":"Recombinant human interleukin 5 is a selective activator of human eosinophil function","volume":"167","author":"Lopez","year":"1988","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2010.11.041_bib9","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1084\/jem.182.4.1169","article-title":"Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo","volume":"182","author":"Collins","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2010.11.041_bib10","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1084\/jem.172.5.1425","article-title":"Eosinophilia in transgenic mice expressing interleukin 5","volume":"172","author":"Dent","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2010.11.041_bib11","doi-asserted-by":"crossref","first-page":"13901","DOI":"10.1016\/S0021-9258(18)68329-2","article-title":"Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte\/macrophage colony stimulating factor","volume":"263","author":"Rothenberg","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2010.11.041_bib12","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1034\/j.1398-9995.2000.00786.x","article-title":"MBP deposition in eosinophilic gastroenteritis","volume":"55","author":"Koga","year":"2000","journal-title":"Allergy"},{"key":"10.1016\/j.ajpath.2010.11.041_bib13","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1111\/j.1572-0241.1999.01641.x","article-title":"Immunnohistological assessment of intestinal eosinophil activation in patients with eosinophilic gastroenteritis and inflammatory bowel disease","volume":"94","author":"Bischoff","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/00004836-200302000-00006","article-title":"Immunohistochemical study of intestinal eosinophils in inflammatory bowel disease","volume":"36","author":"Carvalho","year":"2003","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2559.1996.262309.x","article-title":"Quantitative assessment of intestinal eosinophils and mast cells in inflammatory bowel disease","volume":"28","author":"Bischoff","year":"1996","journal-title":"Histopathology"},{"key":"10.1016\/j.ajpath.2010.11.041_bib16","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.4049\/jimmunol.172.9.5664","article-title":"Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase","volume":"172","author":"Forbes","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.gene.6363654","article-title":"Eosinophilia is attenuated in experimental colitis induced in IL-5 deficient mice","volume":"1","author":"Stevceva","year":"2000","journal-title":"Genes Immun"},{"key":"10.1016\/j.ajpath.2010.11.041_bib18","doi-asserted-by":"crossref","first-page":"7390","DOI":"10.4049\/jimmunol.181.10.7390","article-title":"Intestinal macrophage\/epithelial cell-derived CCL11\/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis","volume":"181","author":"Ahrens","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1365-2249.2007.03531.x","article-title":"Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease","volume":"151","author":"Szebeni","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1053\/j.gastro.2005.05.013","article-title":"Characteristics of intestinal dendritic cells in inflammatory bowel diseases","volume":"129","author":"Hart","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2010.11.041_bib21","doi-asserted-by":"crossref","first-page":"966","DOI":"10.4049\/jimmunol.164.2.966","article-title":"Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors","volume":"164","author":"Cario","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib22","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.4049\/jimmunol.174.8.4453","article-title":"TLR signaling in the gut in health and disease","volume":"174","author":"Abreu","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib23","doi-asserted-by":"crossref","first-page":"G1055","DOI":"10.1152\/ajpgi.00328.2004","article-title":"Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis","volume":"288","author":"Fukata","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib24","doi-asserted-by":"crossref","first-page":"25179","DOI":"10.1074\/jbc.M400967200","article-title":"MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells","volume":"279","author":"Rhee","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2010.11.041_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","article-title":"Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis","volume":"118","author":"Rakoff-Nahoum","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2010.11.041_bib26","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1189\/jlb.0807557","article-title":"Aging in the absence of TLR2 is associated with reduced IFN-gamma responses in the large intestine and increased severity of induced colitis","volume":"83","author":"Albert","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib27","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1053\/j.gastro.2007.02.056","article-title":"Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function","volume":"132","author":"Cario","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2010.11.041_bib28","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1128\/IAI.01326-06","article-title":"Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy","volume":"75","author":"D'Avila","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2010.11.041_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF02991210","article-title":"The mucosal mast cell and its role in gastrointestinal allergic diseases","volume":"2","author":"Barrett","year":"1984","journal-title":"Clin Rev Allergy"},{"key":"10.1016\/j.ajpath.2010.11.041_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/381077a0","article-title":"Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha","volume":"381","author":"Malaviya","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2010.11.041_bib31","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/312450a0","article-title":"Mucosal mast cells are functionally active during spontaneous expulsion of intestinal nematode infections in rat","volume":"312","author":"Woodbury","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2010.11.041_bib32","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1128\/IAI.73.4.1978-1985.2005","article-title":"Mast cells limit systemic bacterial dissemination but not colitis in response to Citrobacter rodentium","volume":"73","author":"Wei","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2010.11.041_bib33","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.4049\/jimmunol.167.4.2250","article-title":"Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4","volume":"167","author":"Supajatura","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib34","doi-asserted-by":"crossref","first-page":"7761","DOI":"10.1073\/pnas.1231488100","article-title":"Mast cells disrupt epithelial barrier function during enteric nematode infection","volume":"100","author":"McDermott","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2010.11.041_bib35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0016-5085(90)91238-2","article-title":"Enhancement of human intestinal mast cell mediator release in active ulcerative colitis","volume":"99","author":"Fox","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2010.11.041_bib36","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1136\/gut.31.7.791","article-title":"Histamine release from gut mast cells from patients with inflammatory bowel diseases","volume":"31","author":"Nolte","year":"1990","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2010.11.041_bib37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nri2018","article-title":"Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data","volume":"7","author":"Bischoff","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib38","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1053\/j.gastro.2004.08.015","article-title":"Gastrointestinal food allergy: new insights into pathophysiology and clinical perspectives","volume":"128","author":"Bischoff","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2010.11.041_bib39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-065X.2007.00519.x","article-title":"Differential release of mast cell mediators and the pathogenesis of inflammation [Erratum appeared in Immunol Rev 2007;219:204]","volume":"217","author":"Theoharides","year":"2007","journal-title":"Immunol Rev"},{"key":"10.1016\/j.ajpath.2010.11.041_bib40","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/(SICI)1521-4141(199905)29:05<1496::AID-IMMU1496>3.0.CO;2-5","article-title":"Human intestinal mast cells produce IL-5 in vitro upon IgE receptor cross-linking and in vivo in the course of intestinal inflammatory disease","volume":"29","author":"Lorentz","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib41","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1172\/JCI0214704","article-title":"Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity","volume":"109","author":"Supajatura","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2010.11.041_bib42","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.4049\/jimmunol.170.4.1625","article-title":"Cutting edge: distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells","volume":"170","author":"McCurdy","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib43","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jaci.2006.06.008","article-title":"Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism","volume":"118","author":"Olynych","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib44","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0002-9440(10)62055-X","article-title":"Mast cell-deficient W-sash c-kit mutant KitW-sh\/W-sh mice as a model for investigating mast cell biology in vivo","volume":"167","author":"Grimbaldeston","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib45","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1758-2229.2008.00006.x","article-title":"The gut microbiota of toll-like receptor 2-deficient mice exhibits lineage-specific modifications","volume":"1","author":"Albert","year":"2009","journal-title":"Environ Microbiol Rep"},{"key":"10.1016\/j.ajpath.2010.11.041_bib46","first-page":"788","article-title":"Long-term in vitro culture of murine mast cells","volume":"127","author":"Tertian","year":"1981","journal-title":"I. Description of a growth factor-dependent culture technique. J Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib47","first-page":"1025","article-title":"Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W\/Wv mice","volume":"162","author":"Nakano","year":"1985","journal-title":"Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells. J Exp Med"},{"key":"10.1016\/j.ajpath.2010.11.041_bib48","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/jcp.34.8.851","article-title":"Human intestinal mucosal mast cells: evaluation of fixation and staining techniques","volume":"34","author":"Strobel","year":"1981","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib49","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/eji.200324723","article-title":"The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils","volume":"34","author":"Zhang","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib50","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1097\/01.TP.0000158714.09346.A6","article-title":"Evidence that T-helper type 2 cell-derived cytokines and eosinophils contribute to acute rejection of orthotopic corneal xenografts in mice","volume":"79","author":"Tanaka","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.ajpath.2010.11.041_bib51","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature05746","article-title":"Chitin induces accumulation in tissue of innate immune cells associated with allergy","volume":"447","author":"Reese","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2010.11.041_bib52","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/path.904","article-title":"Distribution and activation of eosinophils in inflammatory bowel disease using an improved immunohistochemical technique","volume":"194","author":"Jeziorska","year":"2001","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib53","first-page":"31936","article-title":"Mast cell tryptase controls paracellular permeability of the intestine","volume":"280","author":"Jacob","year":"2005","journal-title":"Role of protease-activated receptor 2 and beta-arrestins. J Biol Chem"},{"key":"10.1016\/j.ajpath.2010.11.041_bib54","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/BF01540344","article-title":"Intestinal mucosal injury is associated with mast cell activation and leukotriene generation during Nippostrongylus-induced inflammation in the rat","volume":"34","author":"Perdue","year":"1989","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.ajpath.2010.11.041_bib55","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1034\/j.1600-065X.2001.790107.x","article-title":"Role of mast cells in intestinal mucosal function: studies in models of hypersensitivity and stress","volume":"179","author":"Yu","year":"2001","journal-title":"Immunol Rev"},{"key":"10.1016\/j.ajpath.2010.11.041_bib56","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.4049\/jimmunol.161.5.2561","article-title":"The influence of mast cells on pathways of transepithelial antigen transport in rat intestine","volume":"161","author":"Berin","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib57","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1136\/gut.41.6.785","article-title":"Mast cell mediated ion transport in intestine from patients with and without inflammatory bowel disease","volume":"41","author":"Crowe","year":"1997","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2010.11.041_bib58","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1172\/JCI25702","article-title":"Mast cells can promote the development of multiple features of chronic asthma in mice","volume":"116","author":"Yu","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2010.11.041_bib59","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jaci.2007.11.029","article-title":"The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis","volume":"121","author":"Mrabet-Dahbi","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib60","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaci.2003.12.583","article-title":"The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype","volume":"113","author":"Ahmad-Nejad","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2010.11.041_bib61","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jaci.2003.12.374","article-title":"ALEX Study Team: Toll-like receptor 2 as a major gene for asthma in children of European farmers","volume":"113","author":"Eder","year":"2004","journal-title":"J Allergy Clin Immunol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294401000088X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294401000088X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:46:33Z","timestamp":1762080393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000294401000088X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S000294401000088X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2010.11.041","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tissue Eosinophilia in a Mouse Model of Colitis Is Highly Dependent on TLR2 and Independent of Mast Cells","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2010.11.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}