{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:06:06Z","timestamp":1762081566176,"version":"build-2065373602"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":3663,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007465","name":"Universitetet i Troms\u00f8","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003063","name":"Erna and Olav Aakre Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008730","name":"Kreftforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.ajpath.2011.01.022","type":"journal-article","created":{"date-parts":[[2011,4,24]],"date-time":"2011-04-24T17:41:15Z","timestamp":1303666875000},"page":"2389-2396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["S100A4 Expression in Xenograft Tumors of Human Carcinoma Cell Lines Is Induced by the Tumor Microenvironment"],"prefix":"10.1016","volume":"178","author":[{"given":"Hilde Ljones","family":"Wetting","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elin","family":"Hadler-Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Synn\u00f8ve","family":"Magnussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oddveig","family":"Rikardsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja E.","family":"Steigen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Sundkvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thrina","family":"Loennechen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Premasany","family":"Kanapathippillai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanne","family":"Kildalsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Olof","family":"Winberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Uhlin-Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunbj\u00f8rg","family":"Svineng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2011.01.022_bib1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrc1477","article-title":"Friends or foes: bipolar effects of the tumour stroma in cancer","volume":"4","author":"Mueller","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ajpath.2011.01.022_bib2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrc1877","article-title":"Fibroblasts in cancer","volume":"6","author":"Kalluri","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ajpath.2011.01.022_bib3","first-page":"1595","article-title":"Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer","volume":"60","author":"Rudland","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2011.01.022_bib4","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1053\/gast.2002.36606","article-title":"Prognostic significance of calcium-binding protein S100A4 in colorectal cancer","volume":"123","author":"Gongoll","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2011.01.022_bib5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1074\/jbc.R500017200","article-title":"S100A4, a mediator of metastasis","volume":"281","author":"Garrett","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2011.01.022_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.canlet.2008.10.037","article-title":"Metastasis promoter S100A4 is a potentially valuable molecular target for cancer therapy","volume":"280","author":"Sherbet","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ajpath.2011.01.022_bib7","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1101\/gad.3.7.1086","article-title":"Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family","volume":"3","author":"Ebralidze","year":"1989","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2011.01.022_bib8","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1349-7006.2006.00295.x","article-title":"Nuclear expression of S100A4 is associated with aggressive behavior of epithelial ovarian carcinoma: an important autocrine\/paracrine factor in tumor progression","volume":"97","author":"Kikuchi","year":"2006","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ajpath.2011.01.022_bib9","doi-asserted-by":"crossref","first-page":"24498","DOI":"10.1074\/jbc.M400441200","article-title":"Functional significance of metastasis-inducing S100A4(Mts1) in tumor-stroma interplay","volume":"279","author":"Schmidt-Hansen","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2011.01.022_bib10","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/ijc.22850","article-title":"Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer","volume":"121","author":"Cabezon","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2011.01.022_bib11","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1158\/0008-5472.CAN-04-4510","article-title":"Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene","volume":"65","author":"Grum-Schwensen","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2011.01.022_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/hed.10004","article-title":"Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report","volume":"24","author":"Funk","year":"2002","journal-title":"Head Neck"},{"key":"10.1016\/j.ajpath.2011.01.022_bib13","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0190-9622(08)81509-5","article-title":"Nonmelanoma skin cancer in the United States: incidence","volume":"30","author":"Miller","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.ajpath.2011.01.022_bib14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.amjoto.2008.03.002","article-title":"Nonmelanoma skin cancer of the head and neck, I: histopathology and clinical behavior","volume":"30","author":"McGuire","year":"2009","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.ajpath.2011.01.022_bib15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00428-010-0980-y","article-title":"Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts","volume":"457","author":"Hadler-Olsen","year":"2010","journal-title":"Virchows Arch"},{"key":"10.1016\/j.ajpath.2011.01.022_bib16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ejca.2010.09.006","article-title":"Organ specific regulation of tumour invasiveness and gelatinolytic activity at the invasive front","volume":"47","author":"Hadler-Olsen","year":"2011","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ajpath.2011.01.022_bib17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/03008200802143125","article-title":"Dysregulation of matrix metalloproteinases and their tissue inhibitors by S100A4","volume":"49","author":"Elenjord","year":"2008","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.ajpath.2011.01.022_bib18","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1001\/archotol.1992.01880050096023","article-title":"UT-MUC-1, a new mucoepidermoid carcinoma cell line, and its radiosensitivity","volume":"118","author":"Grenman","year":"1992","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ajpath.2011.01.022_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1369\/jhc.2009.954354","article-title":"Gelatin in situ zymography on fixed, paraffin-embedded tissue: zinc and ethanol fixation preserve enzyme activity","volume":"58","author":"Hadler-Olsen","year":"2010","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.ajpath.2011.01.022_bib20","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s00428-004-1095-0","article-title":"Epithelial hyaluronic acid and CD44v6 are mutually involved in invasion of colorectal adenocarcinomas and linked to patient prognosis","volume":"445","author":"Kobel","year":"2004","journal-title":"Virchows Arch"},{"key":"10.1016\/j.ajpath.2011.01.022_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-\u0394\u0394C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ajpath.2011.01.022_bib22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0002-9440(10)64347-7","article-title":"Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation","volume":"160","author":"Rosty","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2011.01.022_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0167-4781(95)00013-7","article-title":"Transcriptional regulation of the mts1 gene in human lymphoma cells: the role of DNA-methylation","volume":"1261","author":"Tulchinsky","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2011.01.022_bib24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/pros.20401","article-title":"DNA methylation and immunohistochemical analysis of the S100A4 calcium binding protein in human prostate cancer","volume":"67","author":"Rehman","year":"2007","journal-title":"Prostate"},{"key":"10.1016\/j.ajpath.2011.01.022_bib25","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/modpathol.3800940","article-title":"Hypomethylation-induced expression of S100A4 in endometrial carcinoma","volume":"20","author":"Xie","year":"2007","journal-title":"Mod Pathol"},{"key":"10.1016\/j.ajpath.2011.01.022_bib26","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1002\/ijc.23893","article-title":"Relationship of SNCG, S100A4, S100A9 and LCN2 gene expression and DNA methylation in bladder cancer","volume":"123","author":"Dokun","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2011.01.022_bib27","first-page":"143","article-title":"The role of DNA methylation in cancer development","volume":"44","author":"Luczak","year":"2006","journal-title":"Folia Histochem Cytobiol"},{"key":"10.1016\/j.ajpath.2011.01.022_bib28","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nbt.1678","article-title":"Epigenetic modifications as therapeutic targets","volume":"28","author":"Kelly","year":"2010","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.ajpath.2011.01.022_bib29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2407-4-52","article-title":"Sensitization of interferon-\u03b3 induced apoptosis in human osteosarcoma cells by extracellular S100A4","volume":"4","author":"Pedersen","year":"2004","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ajpath.2011.01.022_bib30","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/sj.bjc.6603852","article-title":"Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma","volume":"97","author":"Lindsey","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajpath.2011.01.022_bib31","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0092-8674(90)90015-7","article-title":"High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines","volume":"62","author":"Antequera","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2011.01.022_bib32","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/hmg\/10.13.1413","article-title":"Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies","volume":"10","author":"Smiraglia","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ajpath.2011.01.022_bib33","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1600-0625.2009.00922.x","article-title":"Methylation-associated silencing of S100A4 expression in human epidermal cancers","volume":"18","author":"Li","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajpath.2011.01.022_bib34","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.1158\/1078-0432.CCR-08-2783","article-title":"Targeting DNA methylation","volume":"15","author":"Issa","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2011.01.022_bib35","first-page":"F563","article-title":"Early role of Fsp1 in epithelial-mesenchymal transformation","volume":"273","author":"Okada","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ajpath.2011.01.022_bib36","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1046\/j.1523-1755.2002.00333.x","article-title":"Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation","volume":"61","author":"Strutz","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2011.01.022_bib37","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1101\/gad.14.2.163","article-title":"Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-\u03b2 and promotes tumor invasion and angiogenesis","volume":"14","author":"Yu","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2011.01.022_bib38","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1387\/ijdb.041811af","article-title":"Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies","volume":"48","author":"Folgueras","year":"2004","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.ajpath.2011.01.022_bib39","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1006\/bbrc.1994.1898","article-title":"Expression of a calcium binding protein pEL98 (mts1) during differentiation of human promyelocytic leukemia HL-60 cells","volume":"202","author":"Takenaga","year":"1994","journal-title":"Biochem Biophys Res Commun"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011001313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011001313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:01:16Z","timestamp":1762081276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944011001313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0002944011001313"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.01.022","relation":{},"ISSN":["0002-9440"],"issn-type":[{"type":"print","value":"0002-9440"}],"subject":[],"published":{"date-parts":[[2011,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S100A4 Expression in Xenograft Tumors of Human Carcinoma Cell Lines Is Induced by the Tumor Microenvironment","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.01.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}