{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:49:47Z","timestamp":1781045387844,"version":"3.54.1"},"reference-count":76,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":3056,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100010648","name":"Cancer and Polio Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.ajpath.2011.04.022","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T21:00:01Z","timestamp":1308862801000},"page":"1061-1072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Statistical Association of Basal Cell Keratins with Metastasis-Inducing Proteins in a Prognostically Unfavorable Group of Sporadic Breast Cancers"],"prefix":"10.1016","volume":"179","author":[{"given":"Suzete","family":"de Silva Rudland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Platt-Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.R.","family":"Winstanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel J.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Barraclough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Rudland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2011.04.022_bib1","first-page":"231","article-title":"An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions","volume":"55","author":"Wellings","year":"1975","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ajpath.2011.04.022_bib2","series-title":"Diagnostic Histopathology of the Breast","author":"Page","year":"1988"},{"key":"10.1016\/j.ajpath.2011.04.022_bib3","doi-asserted-by":"crossref","first-page":"8418","DOI":"10.1073\/pnas.0932692100","article-title":"Repeated observation of breast tumor subtypes in independent gene expression data sets","volume":"100","author":"Sorlie","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2011.04.022_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(82)90400-7","article-title":"The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells","volume":"31","author":"Moll","year":"1982","journal-title":"Cell"},{"issue":"8531","key":"10.1016\/j.ajpath.2011.04.022_bib5","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(87)92129-5","article-title":"Monoclonal marker that predicts early recurrence of breast cancer","volume":"1","author":"Dairkee","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2011.04.022_bib6","first-page":"4763","article-title":"Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast disease","volume":"42","author":"Gusterson","year":"1982","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib7","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1177\/41.4.8450194","article-title":"Immunocytochemical identification of cell types in benign and malignant breast diseases: variations in cell markers accompany the malignant state","volume":"41","author":"Rudland","year":"1993","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.ajpath.2011.04.022_bib8","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/path.1559","article-title":"Expression of luminal and basal cytokeratins in human breast carcinoma","volume":"203","author":"Abd El-Rehim","year":"2004","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib9","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.1158\/1078-0432.CCR-04-0220","article-title":"Immunohistochemical and clinical characterisation of the basal-like subtype of invasive breast carcinoma","volume":"10","author":"Nielsen","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s004280050226","article-title":"Biological and prognostic significance of stratified epithelial cytokeratins in infiltrating breast carcinomas","volume":"433","author":"Malzahn","year":"1998","journal-title":"Virchows Arch"},{"key":"10.1016\/j.ajpath.2011.04.022_bib11","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/S0002-9440(10)64476-8","article-title":"Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome","volume":"161","author":"van de Rijn","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib12","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1056\/NEJMoa052933","article-title":"Concordance among gene-expression-based predictors for breast cancer","volume":"355","author":"Fan","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2011.04.022_bib13","first-page":"1227","article-title":"Phenotypic instability of rat mammary tumor epithelial cells","volume":"71","author":"Dunnington","year":"1983","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ajpath.2011.04.022_bib14","first-page":"999","article-title":"Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka, a rat calcium-binding protein, but not with the oncogene EJ-ras-1","volume":"8","author":"Davies","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2011.04.022_bib15","first-page":"97","article-title":"The identification of osteopontin as a metastasis-related gene product in a rodent mammary tumour model","volume":"13","author":"Oates","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2011.04.022_bib16","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1158\/0008-5472.CAN-04-3823","article-title":"Human homologue of cement gland protein, a novel metastasis inducer associated with breast carcinomas","volume":"65","author":"Liu","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib17","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1158\/0008-5472.CAN-05-2605","article-title":"Induction of metastasis by S100P in a rat mammary model and its association with poor survival of breast cancer patients","volume":"66","author":"Wang","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib18","first-page":"1595","article-title":"Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer","volume":"60","author":"Rudland","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib19","first-page":"3417","article-title":"Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer","volume":"62","author":"Rudland","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib20","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.2353\/ajpath.2009.090246","article-title":"The metastasis-associated anterior gradient 2 protein is correlated with poor survival of breast cancer patients","volume":"175","author":"Barraclough","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib21","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrg2159","article-title":"Emergence of DNA-damage response network consisting of Fanconi anemia and BRCA proteins","volume":"8","author":"Wang","year":"2007","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ajpath.2011.04.022_bib22","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.2353\/ajpath.2010.090779","article-title":"Significance of the Fanconi anemia FANCD2 protein in sporadic and metastatic human breast cancer","volume":"176","author":"Rudland","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1242\/jcs.97.1.39","article-title":"Antibody markers of basal cells in complex epithelia","volume":"97","author":"Purkis","year":"1990","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2011.04.022_bib24","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1158\/1078-0432.CCR-05-1580","article-title":"Association of S100A4 and osteopontin with specific prognostic factors and survival of patients with minimally invasive breast cancer","volume":"12","author":"de Silva Rudland","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/(SICI)1097-0215(20000320)89:2<198::AID-IJC16>3.0.CO;2-L","article-title":"Comparison of the metastasis-inducing protein S100A4 (p9Ka) with other prognostic markers in human breast cancer","volume":"89","author":"Platt-Higgins","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2011.04.022_bib26","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1136\/jcp.53.8.634","article-title":"Immunohistochemical detection of steroid receptors in breast cancer: a working protocol","volume":"53","author":"Leake","year":"2000","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib27","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1136\/jcp.2007.054866","article-title":"HER2 testing in the UK: further update to recommendations","volume":"61","author":"Walker","year":"2008","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib28","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.ejca.2005.03.032","article-title":"REporting recommendations for tumour MARKer prognostic studies (REMARK)","volume":"41","author":"McShane","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ajpath.2011.04.022_bib29","series-title":"Practical Nonparametric Statistics","author":"Conover","year":"1999"},{"key":"10.1016\/j.ajpath.2011.04.022_bib30","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1158\/1078-0432.CCR-08-2132","article-title":"Triple negative breast cancer: distinguishing between basal and nonbasal subtypes","volume":"15","author":"Rakha","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib31","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1177\/34.7.2423579","article-title":"Characterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithelial from luminal epithelial cells","volume":"34","author":"Nagle","year":"1986","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.ajpath.2011.04.022_bib32","first-page":"751","article-title":"Basal cell-specific and hyperproliferation-related keratins in human cancer","volume":"138","author":"Wetzels","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib33","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1158\/1078-0432.CCR-04-2424","article-title":"Breast Cancer Linkage Consortium: Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype","volume":"11","author":"Lakhani","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib34","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1365-2559.2006.02453.x","article-title":"Specific morphological features predictive for the basal phenotype in grade 3 invasive ductal carcinoma of breast","volume":"49","author":"Fulford","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.ajpath.2011.04.022_bib35","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1158\/1078-0432.CCR-07-1658","article-title":"Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype","volume":"14","author":"Cheang","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib36","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1200\/JCO.2007.13.1748","article-title":"Basal-like breast cancer: a critical review","volume":"26","author":"Rakha","year":"2008","journal-title":"J Clin Oncol"},{"issue":"Suppl 1","key":"10.1016\/j.ajpath.2011.04.022_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0959-8049(09)70013-9","article-title":"Triple negative breast cancers: clinical and prognostic implications","volume":"45","author":"Dawson","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ajpath.2011.04.022_bib38","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1093\/jnci\/djg050","article-title":"Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer","volume":"95","author":"Foulkes","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ajpath.2011.04.022_bib39","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1200\/JCO.2007.15.5986","article-title":"Prognostic significance of the Nottingham histologic grade in invasive breast carcinoma","volume":"26","author":"Rakha","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib40","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/bjc.1982.106","article-title":"The Cancer Research Campaign (King's\/Cambridge) Trial for early breast cancer: clinico-pathological aspects","volume":"45","author":"Elston","year":"1982","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajpath.2011.04.022_bib41","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/bjc.1991.103","article-title":"The long term prognostic significance of c-erbB-2 in primary breast cancer","volume":"63","author":"Winstanley","year":"1991","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajpath.2011.04.022_bib42","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ijc.23479","article-title":"Expression and splicing of the unfolded response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer","volume":"123","author":"Davies","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2011.04.022_bib43","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.molonc.2010.04.006","article-title":"Triple-negative breast cancer: present challenges and new perspectives","volume":"4","author":"Podo","year":"2010","journal-title":"Mol Oncol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib44","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1182\/blood-2002-01-0278","article-title":"S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51","volume":"100","author":"Taniguchi","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2011.04.022_bib45","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1054\/bjoc.2001.1869","article-title":"CGH analysis of ductal carcinoma of the breast with basaloid\/myoepithelial cell differentiation","volume":"85","author":"Jones","year":"2001","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajpath.2011.04.022_bib46","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1097\/01.LAB.0000038508.86221.B3","article-title":"Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast differentiation into cytogenetic pathways of breast carcinogenesis","volume":"82","author":"Korsching","year":"2002","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2011.04.022_bib47","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","article-title":"Molecular portraits of human breast tumours","volume":"406","author":"Perou","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2011.04.022_bib48","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1073\/pnas.191367098","article-title":"Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications","volume":"98","author":"S\u00f8rlie","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2011.04.022_bib49","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/415530a","article-title":"Gene expression profiling predicts clinical outcome of breast cancer","volume":"415","author":"van 't Veer","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2011.04.022_bib50","first-page":"87","article-title":"Microarray analysis of suppression subtracted hybridisation libraries identifies genes associated with breast cancer progression","volume":"32","author":"Barraclough","year":"2010","journal-title":"Cell Oncol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib51","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1177\/37.7.2471725","article-title":"Immunocytochemical identification of cell types in human mammary gland: variations in cellular markers are dependent on glandular topography and differentiation","volume":"37","author":"Rudland","year":"1989","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.ajpath.2011.04.022_bib52","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1177\/39.11.1918925","article-title":"Histochemical organization and cellular composition of ductal buds in developing human breasts: evidence for cytological intermediates between epithelial and myoepithelial cells","volume":"39","author":"Rudland","year":"1991","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.ajpath.2011.04.022_bib53","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/bcr1041","article-title":"Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer","volume":"7","author":"Gusterson","year":"2005","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib54","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/01.LAB.0000017371.72714.C5","article-title":"Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept","volume":"82","author":"B\u00f6cker","year":"2002","journal-title":"Lab Invest"},{"issue":"Suppl 1","key":"10.1016\/j.ajpath.2011.04.022_bib55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1046\/j.1365-2184.36.s.1.7.x","article-title":"Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept","volume":"36","author":"Boecker","year":"2003","journal-title":"Cell Prolif"},{"key":"10.1016\/j.ajpath.2011.04.022_bib56","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0012-1606(89)90139-5","article-title":"Isolation of simian virus 40-transformed human mammary epithelial stem cell lines that can differentiate to myoepithelial-like cells in culture and in vivo","volume":"136","author":"Rudland","year":"1989","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib57","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.yexcr.2004.03.029","article-title":"Growth and differentiation of progenitor\/stem cells derived from the human mammary gland","volume":"297","author":"Clayton","year":"2004","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib58","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nm.2000","article-title":"Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers","volume":"15","author":"Lim","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2011.04.022_bib59","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0092-8674(78)90104-6","article-title":"A possible mammary stem cell line","volume":"15","author":"Bennett","year":"1978","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2011.04.022_bib60","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/aja.1001700408","article-title":"Cellular composition and organisation of ductal buds in developing rat mammary glands: evidence for morphological intermediates between epithelial and myoepithelial cells","volume":"170","author":"Ormerod","year":"1984","journal-title":"Am J Anat"},{"key":"10.1016\/j.ajpath.2011.04.022_bib61","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/jnci\/djj267","article-title":"Steroid hormone receptor status of mouse mammary stem cells","volume":"98","author":"Asselin-Labat","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ajpath.2011.04.022_bib62","first-page":"385","article-title":"Epithelial stem cells and their possible role in the development of the normal and diseased breast","volume":"8","author":"Rudland","year":"1993","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib63","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/carcin\/bgh293","article-title":"Will cancer stem cells provide new therapeutic targets?","volume":"26","author":"Behbod","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ajpath.2011.04.022_bib64","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nrc2212","article-title":"Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis","volume":"7","author":"Stingl","year":"2007","journal-title":"Nat Rev Cancer"},{"issue":"Suppl 1","key":"10.1016\/j.ajpath.2011.04.022_bib65","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2184.36.s.1.4.x","article-title":"Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasia","volume":"36","author":"Petersen","year":"2003","journal-title":"Cell Prolif"},{"key":"10.1016\/j.ajpath.2011.04.022_bib66","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ydbio.2004.07.044","article-title":"A putative breast stem cell population is enriched for steroid receptor-positive cells","volume":"277","author":"Clarke","year":"2005","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib67","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1797","article-title":"The origin of vimentin expression in invasive cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential?","volume":"206","author":"Korsching","year":"2005","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2011.04.022_bib68","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1158\/1078-0432.1154.11.3","article-title":"Prevalence of CD44+\/CD24-\/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis","volume":"11","author":"Abraham","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib69","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.stem.2007.08.014","article-title":"ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome","volume":"1","author":"Ginestier","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2011.04.022_bib70","doi-asserted-by":"crossref","first-page":"R10","DOI":"10.1186\/bcr1855","article-title":"Brca1 breast tumors contain distinct CD44 +\/CD24- and CD133+ cells with cancer stem cell characteristics","volume":"10","author":"Wright","year":"2008","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.ajpath.2011.04.022_bib71","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.stem.2010.07.010","article-title":"BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells","volume":"7","author":"Molyneux","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2011.04.022_bib72","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1093\/jnci\/djm207","article-title":"Molecular basis for estrogen receptor alpha deficiency on BRCA1-linked breast cancer","volume":"99","author":"Hosey","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ajpath.2011.04.022_bib73","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s10549-009-0565-0","article-title":"BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer","volume":"122","author":"Gorski","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ajpath.2011.04.022_bib74","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1073\/pnas.0711613105","article-title":"BRCA1 regulates human mammary stem cell progenitor cell fate","volume":"105","author":"Liu","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2011.04.022_bib75","doi-asserted-by":"crossref","first-page":"26587","DOI":"10.1074\/jbc.M604403200","article-title":"BRCA1 suppresses osteopontin-mediated breast cancer","volume":"281","author":"El-Tanani","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2011.04.022_bib76","first-page":"147","article-title":"Mammary stem cells in normal development and cancer","author":"Rudland","year":"1996"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011004287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011004287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:32:55Z","timestamp":1757601175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944011004287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0002944011004287"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.04.022","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Statistical Association of Basal Cell Keratins with Metastasis-Inducing Proteins in a Prognostically Unfavorable Group of Sporadic Breast Cancers","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.04.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}