{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:56:36Z","timestamp":1791618996543,"version":"4.3.4"},"reference-count":58,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":2995,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK073495"],"award-info":[{"award-number":["DK073495"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK089394"],"award-info":[{"award-number":["DK089394"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007519","name":"Nephcure Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007519","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PBZHP3-128278"],"award-info":[{"award-number":["PBZHP3-128278"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002997","name":"Nierstichting","doi-asserted-by":"publisher","award":["KJPB 07.0001"],"award-info":[{"award-number":["KJPB 07.0001"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.ajpath.2011.06.033","type":"journal-article","created":{"date-parts":[[2011,8,23]],"date-time":"2011-08-23T15:26:59Z","timestamp":1314113219000},"page":"1719-1732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":185,"title":["Angiotensin II Contributes to Podocyte Injury by Increasing TRPC6 Expression via an NFAT-Mediated Positive Feedback Signaling Pathway"],"prefix":"10.1016","volume":"179","author":[{"given":"Tom","family":"Nijenhuis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis J.","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost G.J.","family":"Hoenderop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Flesche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"van Goor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas D.","family":"Kistler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinka","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene J.M.","family":"Bindels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf A.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens C.","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Hamming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerjan","family":"Navis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack F.M.","family":"Wetzels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo H.M.","family":"Berden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Reiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Faul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"van der Vlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2011.06.033_bib1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.tcb.2007.06.006","article-title":"Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton","volume":"17","author":"Faul","year":"2007","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/ng1592","article-title":"TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function","volume":"37","author":"Reiser","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajpath.2011.06.033_bib3","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1106215","article-title":"A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis","volume":"308","author":"Winn","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2011.06.033_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1681\/ASN.2006091010","article-title":"Induction of TRPC6 channel in acquired forms of proteinuric kidney disease","volume":"18","author":"Moller","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib5","doi-asserted-by":"crossref","first-page":"e12859","DOI":"10.1371\/journal.pone.0012859","article-title":"Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease","volume":"5","author":"Krall","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2011.06.033_bib6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature02196","article-title":"TRP channels as cellular sensors","volume":"426","author":"Clapham","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2011.06.033_bib7","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.bbadis.2007.02.001","article-title":"TRP channels in kidney disease","volume":"1772","author":"Hsu","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2011.06.033_bib8","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI24134","article-title":"Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia","volume":"115","author":"Nijenhuis","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2011.06.033_bib9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrneph.2009.100","article-title":"The role of transient receptor potential channels in kidney disease","volume":"5","author":"Woudenberg-Vrenken","year":"2009","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib10","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1681\/ASN.2008030329","article-title":"Sensitizing the slit diaphragm with TRPC6 ion channels","volume":"20","author":"Moller","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mrfmmm.2008.11.021","article-title":"Identification and functional analysis of a novel TRPC6 mutation associated with late onset familial focal segmental glomerulosclerosis in Chinese patients","volume":"664","author":"Zhu","year":"2009","journal-title":"Mutat Res"},{"key":"10.1016\/j.ajpath.2011.06.033_bib12","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1093\/ndt\/gfp229","article-title":"TRPC6 mutational analysis in a large cohort of patients with focal segmental glomerulosclerosis","volume":"24","author":"Santin","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ajpath.2011.06.033_bib13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/16711","article-title":"Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol","volume":"397","author":"Hofmann","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2011.06.033_bib14","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1172\/JCI27702","article-title":"TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling","volume":"116","author":"Kuwahara","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2011.06.033_bib15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0140-6736(98)10363-X","article-title":"Renoprotective properties of ACE-inhibition in non-diabetic nephropathies with non-nephrotic proteinuria","volume":"354","author":"Ruggenenti","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2011.06.033_bib16","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0140-6736(05)71082-5","article-title":"Blood-pressure control for renoprotection in patients with non-diabetic chronic renal disease (REIN-2): multicentre, randomised controlled trial","volume":"365","author":"Ruggenenti","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2011.06.033_bib17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1113\/jphysiol.2006.119305","article-title":"Angiotensin II activates two cation conductances with distinct TRPC1 and TRPC6 channel properties in rabbit mesenteric artery myocytes","volume":"577","author":"Saleh","year":"2006","journal-title":"J Physiol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib18","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1038\/sj.emboj.7601417","article-title":"TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy","volume":"25","author":"Onohara","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2011.06.033_bib19","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1093\/ndt\/gfp182","article-title":"Regulation of glomerular heparanase expression by aldosterone, angiotensin II and reactive oxygen species","volume":"24","author":"van den Hoven","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ajpath.2011.06.033_bib20","first-page":"F170","article-title":"Immunohistochemical localization of ANG II AT1 receptor in adult rat kidney using a monoclonal antibody","volume":"273","author":"Harrison-Bernard","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib21","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/ki.1997.383","article-title":"Angiotensin II increases the cytosolic calcium activity in rat podocytes in culture","volume":"52","author":"Henger","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2011.06.033_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1523-1755.2000.00810.x","article-title":"Angiotensin II increases the intracellular calcium activity in podocytes of the intact glomerulus","volume":"57","author":"Nitschke","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2011.06.033_bib23","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1172\/JCI119467","article-title":"Angiotensin II depolarizes podocytes in the intact glomerulus of the rat","volume":"99","author":"Gloy","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2011.06.033_bib24","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1097\/01.ASN.0000127988.42710.A7","article-title":"Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats","volume":"15","author":"Hoffmann","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib25","doi-asserted-by":"crossref","first-page":"e6721","DOI":"10.1371\/journal.pone.0006721","article-title":"Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin","volume":"4","author":"Huby","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2011.06.033_bib26","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.devcel.2006.04.006","article-title":"Calcineurin\/NFAT signaling in osteoblasts regulates bone mass","volume":"10","author":"Winslow","year":"2006","journal-title":"Dev Cell"},{"key":"10.1016\/j.ajpath.2011.06.033_bib27","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1101\/gad.11.7.824","article-title":"Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction","volume":"11","author":"Beals","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2011.06.033_bib28","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1681\/ASN.V1481998","article-title":"Inducible podocyte-specific gene expression in transgenic mice","volume":"14","author":"Shigehara","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/ki.1992.15","article-title":"A monoclonal antibody against GBM HS induces an acute selective proteinuria in rats","volume":"41","author":"van den Born","year":"1992","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2011.06.033_bib30","doi-asserted-by":"crossref","first-page":"17832","DOI":"10.1074\/jbc.273.28.17832","article-title":"Differential expression of agrin in renal basement membranes as revealed by domain-specific antibodies","volume":"273","author":"Raats","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2011.06.033_bib31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.ki.5002291","article-title":"Podocytes in culture: past, present, and future","volume":"72","author":"Shankland","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2011.06.033_bib32","first-page":"E919","article-title":"Physiological characterization of the hypertensive transgenic rat TGR(mREN2)27","volume":"270","author":"Lee","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib33","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.semnephrol.2007.07.005","article-title":"The (pro)renin receptor and the kidney","volume":"27","author":"Ichihara","year":"2007","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1523-1755.2004.00362.x","article-title":"Activation of a local tissue angiotensin system in podocytes by mechanical strain","volume":"65","author":"Durvasula","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2011.06.033_bib35","doi-asserted-by":"crossref","first-page":"F830","DOI":"10.1152\/ajprenal.00266.2007","article-title":"Activation of a local renin angiotensin system in podocytes by glucose","volume":"294","author":"Durvasula","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib36","doi-asserted-by":"crossref","first-page":"C558","DOI":"10.1152\/ajpcell.00077.2008","article-title":"TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription","volume":"296","author":"Schlondorff","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib37","doi-asserted-by":"crossref","first-page":"F213","DOI":"10.1152\/ajprenal.90421.2008","article-title":"Inducible rodent models of acquired podocyte diseases","volume":"296","author":"Pippin","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib38","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s11906-007-0074-7","article-title":"Dual effects of RAS blockade on blood pressure and podocyte function","volume":"9","author":"Reiser","year":"2007","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.ajpath.2011.06.033_bib39","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1681\/ASN.2006020184","article-title":"Induction of glomerular heparanase expression in rats with adriamycin nephropathy is regulated by reactive oxygen species and the renin-angiotensin system","volume":"17","author":"Kramer","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib40","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.ki.5002075","article-title":"Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosis","volume":"71","author":"Kramer","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2011.06.033_bib41","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1681\/ASN.2006030217","article-title":"Angiotensin II type 1 receptor blockade inhibits the development and progression of HIV-associated nephropathy in a mouse model","volume":"18","author":"Hiramatsu","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib42","doi-asserted-by":"crossref","first-page":"F1214","DOI":"10.1152\/ajprenal.00162.2007","article-title":"Angiotensin II provokes podocyte injury in murine model of HIV-associated nephropathy","volume":"293","author":"Ideura","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib43","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1681\/ASN.V125941","article-title":"Blocking angiotensin II synthesis\/activity preserves glomerular nephrin in rats with severe nephrosis","volume":"12","author":"Benigni","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib44","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/sj.ki.5000060","article-title":"ACE inhibition reduces glomerulosclerosis and regenerates glomerular tissue in a model of progressive renal disease","volume":"69","author":"Remuzzi","year":"2006","journal-title":"Kidney Int"},{"issue":"Suppl 9","key":"10.1016\/j.ajpath.2011.06.033_bib45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/ndt\/17.suppl_9.20","article-title":"Molecular structure and function of the slit diaphragm: expression of nephrin in proteinuric states and in developing glomeruli","volume":"17","author":"Kawachi","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ajpath.2011.06.033_bib46","doi-asserted-by":"crossref","first-page":"19093","DOI":"10.1073\/pnas.0606728103","article-title":"Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange","volume":"103","author":"Weissmann","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2011.06.033_bib47","doi-asserted-by":"crossref","first-page":"13861","DOI":"10.1073\/pnas.0405908101","article-title":"Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension","volume":"101","author":"Yu","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2011.06.033_bib48","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1681\/ASN.2010050522","article-title":"TRPC6 enhances angiotensin II-induced albuminuria","volume":"22","author":"Eckel","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib49","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ceca.2007.03.007","article-title":"Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes","volume":"42","author":"Gwack","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ajpath.2011.06.033_bib50","doi-asserted-by":"crossref","first-page":"ra77","DOI":"10.1126\/scisignal.2001200","article-title":"Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels","volume":"3","author":"Tian","year":"2010","journal-title":"Sci Signal"},{"key":"10.1016\/j.ajpath.2011.06.033_bib51","doi-asserted-by":"crossref","first-page":"F1241","DOI":"10.1152\/ajprenal.00376.2005","article-title":"Identification and localization of TRPC channels in the rat kidney","volume":"290","author":"Goel","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib52","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/emboj\/cdg080","article-title":"Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6","volume":"22","author":"Hoenderop","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2011.06.033_bib53","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.1073\/pnas.102596199","article-title":"Subunit composition of mammalian transient receptor potential channels in living cells","volume":"99","author":"Hofmann","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2011.06.033_bib54","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3181\/0901-RM-11","article-title":"TRPC6 up-regulation in Ang II-induced podocyte apoptosis might result from ERK activation and NF-{kappa}B translocation","volume":"234","author":"Zhang","year":"2009","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.ajpath.2011.06.033_bib55","doi-asserted-by":"crossref","first-page":"23117","DOI":"10.1074\/jbc.M611780200","article-title":"Galpha12\/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation","volume":"282","author":"Nishida","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2011.06.033_bib56","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1681\/ASN.2009121253","article-title":"Activation of NFAT signaling in podocytes causes glomerulosclerosis","volume":"21","author":"Wang","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2011.06.033_bib57","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nm.1857","article-title":"The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A","volume":"14","author":"Faul","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2011.06.033_bib58","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1172\/JCI200523371","article-title":"Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner","volume":"115","author":"Asanuma","year":"2005","journal-title":"J Clin Invest"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011006535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011006535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:01:23Z","timestamp":1762081283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944011006535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0002944011006535"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.06.033","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiotensin II Contributes to Podocyte Injury by Increasing TRPC6 Expression via an NFAT-Mediated Positive Feedback Signaling Pathway","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.06.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}