{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:42:36Z","timestamp":1791265356590,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":2964,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K02 HL083957"],"award-info":[{"award-number":["K02 HL083957"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011500","name":"Research Institute, Nationwide Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.ajpath.2011.07.009","type":"journal-article","created":{"date-parts":[[2011,9,7]],"date-time":"2011-09-07T03:28:45Z","timestamp":1315366125000},"page":"2464-2474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["mdx Mice Manifest More Severe Muscle Dysfunction and Diaphragm Force Deficits than Do mdx Mice"],"prefix":"10.1016","volume":"179","author":[{"given":"Nicholas","family":"Beastrom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Macke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Canan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric K.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Penton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Kaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise R.","family":"Rodino-Klapac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.L.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Montanaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2011.07.009_bib1","series-title":"Muscle Disorders in Childhood","author":"Dubowitz","year":"1995"},{"key":"10.1016\/j.ajpath.2011.07.009_bib2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0092-8674(87)90579-4","article-title":"Dystrophin: the protein product of the Duchenne muscular dystrophy locus","volume":"51","author":"Hoffman","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2011.07.009_bib3","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/323646a0","article-title":"Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene","volume":"323","author":"Monaco","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2011.07.009_bib4","series-title":"Disease of Skeletal Muscle","first-page":"373","year":"2001"},{"key":"10.1016\/j.ajpath.2011.07.009_bib5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0960-8966(93)90110-6","article-title":"The role of the dystrophin-glycoprotein complex in the molecular pathogenesis of muscular dystrophies","volume":"3","author":"Matsumura","year":"1993","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.ajpath.2011.07.009_bib6","series-title":"Myology","first-page":"961","article-title":"Dystrophinopathies","author":"Engel","year":"2004"},{"key":"10.1016\/j.ajpath.2011.07.009_bib7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/NEN.0b013e3181e9a34b","article-title":"Targeting fibrosis in Duchenne muscular dystrophy","volume":"69","author":"Zhou","year":"2010","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.ajpath.2011.07.009_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2174\/1874467210902010110","article-title":"Personalised genetic intervention for Duchenne muscular dystrophy: antisense oligomers and exon skipping","volume":"2","author":"Mitrpant","year":"2009","journal-title":"Curr Mol Pharmacol"},{"key":"10.1016\/j.ajpath.2011.07.009_bib9","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/WCO.0b013e32832fd487","article-title":"Emerging genetic therapies to treat Duchenne muscular dystrophy","volume":"22","author":"Nelson","year":"2009","journal-title":"Current Opin Neurol"},{"key":"10.1016\/j.ajpath.2011.07.009_bib10","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1017\/S1462399409001100","article-title":"Emerging strategies for cell and gene therapy of the muscular dystrophies","volume":"11","author":"Muir","year":"2009","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.ajpath.2011.07.009_bib11","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/mt.sj.6300145","article-title":"Stem and progenitor cells in skeletal muscle development, maintenance, and therapy","volume":"15","author":"Peault","year":"2007","journal-title":"Mol Ther"},{"key":"10.1016\/j.ajpath.2011.07.009_bib12","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.molmed.2007.10.003","article-title":"New therapies for Duchenne muscular dystrophy: challenges, prospects and clinical trials","volume":"13","author":"Cossu","year":"2007","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.ajpath.2011.07.009_bib13","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1073\/pnas.81.4.1189","article-title":"X chromosome-linked muscular dystrophy (mdx) in the mouse","volume":"81","author":"Bulfield","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2011.07.009_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0022-510X(93)90130-Q","article-title":"Age-related changes in replication of myogenic cells in mdx mice: quantitative autoradiographic studies","volume":"119","author":"McGeachie","year":"1993","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.ajpath.2011.07.009_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0022-510X(94)00276-T","article-title":"mdx mice show progressive weakness and muscle deterioration with age","volume":"129","author":"Pastoret","year":"1995","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.ajpath.2011.07.009_bib16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/ar.1092420109","article-title":"Phenotype of dystrophinopathy in old mdx mice","volume":"242","author":"Lefaucheur","year":"1995","journal-title":"Anat Rec"},{"key":"10.1016\/j.ajpath.2011.07.009_bib17","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/352536a0","article-title":"The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy","volume":"352","author":"Stedman","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2011.07.009_bib18","doi-asserted-by":"crossref","DOI":"10.1096\/fj.06-7353com","article-title":"Dystrophin-deficient mdx mice display a reduced life span and are susceptible to spontaneous rhabdomyosarcoma","volume":"21","author":"Chamberlain","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2011.07.009_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-510X(87)90219-X","article-title":"Muscular dystrophy in the mdx mouse: histopathology of the soleus and extensor digitorum longus muscles","volume":"80","author":"Carnwath","year":"1987","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.ajpath.2011.07.009_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00687043","article-title":"Skeletal muscle pathology in X chromosome-linked muscular dystrophy (mdx) mouse","volume":"69","author":"Tanabe","year":"1986","journal-title":"Acta Neuropathol (Berl)"},{"issue":"Pt 2","key":"10.1016\/j.ajpath.2011.07.009_bib21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/brain\/110.2.269","article-title":"The mutant mdx: inherited myopathy in the mouse","volume":"110","author":"Torres","year":"1987","journal-title":"Brain"},{"key":"10.1016\/j.ajpath.2011.07.009_bib22","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/mus.880070903","article-title":"Muscle development in mdx mutant mice","volume":"7","author":"Dangain","year":"1984","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ajpath.2011.07.009_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0022-510X(93)90027-V","article-title":"Muscular weakness in the mdx mouse","volume":"120","author":"Muntoni","year":"1993","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.ajpath.2011.07.009_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2008.03.008","article-title":"Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy","volume":"31","author":"Grounds","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.ajpath.2011.07.009_bib25","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/mus.21211","article-title":"Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measures","volume":"39","author":"Spurney","year":"2009","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ajpath.2011.07.009_bib26","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1073\/pnas.86.4.1292","article-title":"Recovery of Induced Mutations for X Chromosome-Linked Muscular Dystrophy in Mice","volume":"86","author":"Chapman","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2011.07.009_bib27","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1006\/bbrc.1997.7328","article-title":"Targeted disruption of exon 52 in the mouse dystrophin gene induced muscle degeneration similar to that observed in Duchenne muscular dystrophy","volume":"238","author":"Araki","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2011.07.009_bib28","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.2353\/ajpath.2010.090887","article-title":"Genetic background affects properties of satellite cells and mdx phenotypes","volume":"176","author":"Fukada","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2011.07.009_bib29","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/hmg\/5.8.1149","article-title":"Differential expression of dystrophin isoforms in strains of mdx mice with different mutations","volume":"5","author":"Im","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ajpath.2011.07.009_bib30","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1203\/00006450-199207000-00025","article-title":"The frequency of revertants in mdx mouse genetic models for Duchenne muscular dystrophy","volume":"32","author":"Danko","year":"1992","journal-title":"Pediatr Res"},{"key":"10.1016\/j.ajpath.2011.07.009_bib31","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00335-005-0053-8","article-title":"The influence of muscle type and dystrophin deficiency on murine expression profiles","volume":"16","author":"Haslett","year":"2005","journal-title":"Mamm Genome"},{"key":"10.1016\/j.ajpath.2011.07.009_bib32","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/mus.20436","article-title":"Nutritional therapy improves function and complements corticosteroid intervention in mdx mice","volume":"33","author":"Payne","year":"2006","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ajpath.2011.07.009_bib33","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nature07414","article-title":"Sarcolemma-localized nNOS is required to maintain activity after mild exercise","volume":"456","author":"Kobayashi","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2011.07.009_bib34","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999","article-title":"Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation","volume":"19","author":"Carter","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.ajpath.2011.07.009_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.0021-8782.2001.00008.x","article-title":"Evans Blue Dye as an in vivo marker of myofibre damage: optimising parameters for detecting initial myofibre membrane permeability","volume":"200","author":"Hamer","year":"2002","journal-title":"J Anat"},{"key":"10.1016\/j.ajpath.2011.07.009_bib36","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1172\/JCI39845","article-title":"Latent TGF-beta-binding protein 4 modifies muscular dystrophy in mice","volume":"119","author":"Heydemann","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2011.07.009_bib37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jns.2007.08.029","article-title":"Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice","volume":"264","author":"Zhou","year":"2008","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.ajpath.2011.07.009_bib38","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1096\/fj.09-129833","article-title":"Imatinib attenuates skeletal muscle dystrophy in mdx mice","volume":"23","author":"Huang","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2011.07.009_bib39","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0009-9120(96)00003-6","article-title":"A simplified method for the analysis of hydroxyproline in biological tissues","volume":"29","author":"Reddy","year":"1996","journal-title":"Clin Biochem"},{"key":"10.1016\/j.ajpath.2011.07.009_bib40","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1172\/JCI30556","article-title":"Interplay of IKK\/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy","volume":"117","author":"Acharyya","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2011.07.009_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3000692","article-title":"A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy","volume":"2","author":"Chandrasekharan","year":"2010","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ajpath.2011.07.009_bib42","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2119\/molmed.2010.00263","article-title":"Peptide-based inhibition of NF-kappaB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy","volume":"17","author":"Peterson","year":"2011","journal-title":"Mol Med"},{"key":"10.1016\/j.ajpath.2011.07.009_bib43","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1242\/dev.01169","article-title":"Rescue of enzyme deficiency in embryonic diaphragm in a mouse model of metabolic myopathy: pompe disease","volume":"131","author":"Rucker","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2011.07.009_bib44","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1152\/jappl.1994.77.5.2434","article-title":"Effects of N-acetylcysteine on in vitro diaphragm function are temperature dependent","volume":"77","author":"Diaz","year":"1994","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.ajpath.2011.07.009_bib45","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1152\/jappl.1990.69.5.1740","article-title":"Temperature dependence of rat diaphragm muscle contractility and fatigue","volume":"69","author":"Prezant","year":"1990","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.ajpath.2011.07.009_bib46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1479-5876-5-45","article-title":"A translational approach for limb vascular delivery of the micro-dystrophin gene without high volume or high pressure for treatment of Duchenne muscular dystrophy","volume":"5","author":"Rodino-Klapac","year":"2007","journal-title":"J Transl Med"},{"key":"10.1016\/j.ajpath.2011.07.009_bib47","doi-asserted-by":"crossref","first-page":"C476","DOI":"10.1152\/ajpcell.00456.2008","article-title":"Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild type mice","volume":"296","author":"Martin","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2011.07.009_bib48","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1128\/JVI.76.2.791-801.2002","article-title":"Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity","volume":"76","author":"Rabinowitz","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2011.07.009_bib49","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0960-8966(97)00052-7","article-title":"Improved adenoviral vectors for gene therapy of Duchenne muscular dystrophy","volume":"7","author":"Hauser","year":"1997","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.ajpath.2011.07.009_bib50","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.nmd.2007.01.011","article-title":"Myostatin does not regulate cardiac hypertrophy or fibrosis","volume":"17","author":"Cohn","year":"2007","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.ajpath.2011.07.009_bib51","doi-asserted-by":"crossref","first-page":"C1138","DOI":"10.1152\/ajpcell.1998.274.4.C1138","article-title":"Contractile function and low-intensity exercise effects of old dystrophic (mdx) mice","volume":"274","author":"Hayes","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ajpath.2011.07.009_bib52","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0024-3205(78)90529-5","article-title":"Bone length and muscle weight in mice subjected to genetic selection for the relative length of the tibia and radius","volume":"22","author":"Hooper","year":"1978","journal-title":"Life Sci"},{"key":"10.1016\/j.ajpath.2011.07.009_bib53","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.nmd.2007.02.005","article-title":"Strength and corticosteroid responsiveness of mdx mice is unchanged by RAG2 gene knockout","volume":"17","author":"Golumbek","year":"2007","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.ajpath.2011.07.009_bib54","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jor.20781","article-title":"Systemic human minidystrophin gene transfer improves functions and life span of dystrophin and dystrophin\/utrophin-deficient mice","volume":"27","author":"Wang","year":"2009","journal-title":"J Orthop Res"},{"key":"10.1016\/j.ajpath.2011.07.009_bib55","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/(SICI)1097-4598(200004)23:4<521::AID-MUS10>3.0.CO;2-8","article-title":"Clenbuterol reduces degeneration of exercised or aged dystrophic (mdx) muscle","volume":"23","author":"Zeman","year":"2000","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ajpath.2011.07.009_bib56","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/mus.21527","article-title":"Use of Evans blue dye to compare limb muscles in exercised young and old mdx mice","volume":"41","author":"Wooddell","year":"2010","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ajpath.2011.07.009_bib57","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1083\/jcb.139.2.375","article-title":"Animal models for muscular dystrophy show different patterns of sarcolemmal disruption","volume":"139","author":"Straub","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2011.07.009_bib58","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.ymthe.2004.07.025","article-title":"AAV vector-mediated microdystrophin expression in a relatively small percentage of mdx myofibers improved the mdx phenotype","volume":"10","author":"Yoshimura","year":"2004","journal-title":"Mol Ther"},{"key":"10.1016\/j.ajpath.2011.07.009_bib59","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ymthe.2004.09.013","article-title":"Adeno-associated virus-mediated microdystrophin expression protects young mdx muscle from contraction-induced injury","volume":"11","author":"Liu","year":"2005","journal-title":"Mol Ther"},{"key":"10.1016\/j.ajpath.2011.07.009_bib60","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/mt.2009.254","article-title":"Persistent expression of FLAG-tagged micro dystrophin in nonhuman primates following intramuscular and vascular delivery","volume":"18","author":"Rodino-Klapac","year":"2010","journal-title":"Mol Ther"},{"key":"10.1016\/j.ajpath.2011.07.009_bib61","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nm0302-253","article-title":"Modular flexibility of dystrophin: implications for gene therapy of Duchenne muscular dystrophy","volume":"8","author":"Harper","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2011.07.009_bib62","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nbt1073","article-title":"Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart","volume":"23","author":"Wang","year":"2005","journal-title":"Nature Biotechnol"},{"key":"10.1016\/j.ajpath.2011.07.009_bib63","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1172\/JCI36612","article-title":"Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy","volume":"119","author":"Lai","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2011.07.009_bib64","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/BF00188793","article-title":"C57BL\/6 and C57BL\/10 inbred mouse strains differ at multiple loci on chromosome 4","volume":"39","author":"McClive","year":"1994","journal-title":"Immunogenetics"},{"key":"10.1016\/j.ajpath.2011.07.009_bib65","first-page":"72","article-title":"New microsatellite polymorphisms identified between C57BL\/6","volume":"43","author":"Slingsby","year":"1996","journal-title":"Immunogenetics"},{"key":"10.1016\/j.ajpath.2011.07.009_bib66","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bbr.2007.02.009","article-title":"A comparison of the behavior of C57BL\/6 and C57BL\/10 mice","volume":"179","author":"Deacon","year":"2007","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.ajpath.2011.07.009_bib67","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.physbeh.2005.06.003","article-title":"Inbred mouse strain survey of sucrose intake","volume":"85","author":"Lewis","year":"2005","journal-title":"Physiol Behav"},{"key":"10.1016\/j.ajpath.2011.07.009_bib68","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s003350010149","article-title":"Testing of SHIRPA, a mouse phenotypic assessment protocol, on Dmd(mdx) and Dmd(mdx3cv) dystrophin-deficient mice","volume":"11","author":"Rafael","year":"2000","journal-title":"Mamm Genome"},{"key":"10.1016\/j.ajpath.2011.07.009_bib69","doi-asserted-by":"crossref","first-page":"C411","DOI":"10.1152\/ajpcell.00192.2005","article-title":"Impact of sarcoglycan complex on mechanical signal transduction in murine skeletal muscle","volume":"290","author":"Barton","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2011.07.009_bib70","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.cell.2010.11.039","article-title":"Short telomeres and stem cell exhaustion model Duchenne muscular dystrophy in mdx\/mTR mice","volume":"143","author":"Sacco","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2011.07.009_bib71","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1212\/WNL.0b013e318207afeb","article-title":"SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy","volume":"76","author":"Pegoraro","year":"2011","journal-title":"Neurology"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011007279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011007279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:36:06Z","timestamp":1757601366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944011007279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":71,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0002944011007279"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.07.009","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"mdx5cv Mice Manifest More Severe Muscle Dysfunction and Diaphragm Force Deficits than Do mdx Mice","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}