{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:00:44Z","timestamp":1785333644500,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":2964,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK54927"],"award-info":[{"award-number":["DK54927"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL075316"],"award-info":[{"award-number":["HL075316"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL091464"],"award-info":[{"award-number":["HL091464"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL57244"],"award-info":[{"award-number":["HL57244"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.ajpath.2011.07.019","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T12:16:12Z","timestamp":1315311372000},"page":"2210-2219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Acid Sphingomyelinase Gene Deficiency Ameliorates the Hyperhomocysteinemia-Induced Glomerular Injury in Mice"],"prefix":"10.1016","volume":"179","author":[{"given":"Krishna M.","family":"Boini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori P.","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine M.","family":"Abais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin L.","family":"Poklis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip B.","family":"Hylemon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin-Lan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2011.07.019_bib1","first-page":"S11","article-title":"Homocysteinemia and vascular disease in end-stage renal disease","volume":"57","author":"Dennis","year":"1996","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.ajpath.2011.07.019_bib2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1161\/HYPERTENSIONAHA.108.115675","article-title":"Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats","volume":"53","author":"Yi","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.ajpath.2011.07.019_bib3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1523-1755.2004.00795.x","article-title":"Activation of mesangial cell MAPK in response to homocysteine","volume":"66","author":"Ingram","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2011.07.019_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/sj.ki.5001517","article-title":"Inhibition of ceramide-redox signaling pathway blocks glomerular injury in hyperhomocysteinemic rats","volume":"70","author":"Yi","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2011.07.019_bib5","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.freeradbiomed.2010.01.029","article-title":"Protection of podocytes from hyperhomocysteinemia-induced injury by deletion of the gp91phox gene","volume":"48","author":"Zhang","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ajpath.2011.07.019_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/ars.2008.2073","article-title":"H2S protects against methionine-induced oxidative stress in brain endothelial cells","volume":"11","author":"Tyagi","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.ajpath.2011.07.019_bib7","doi-asserted-by":"crossref","first-page":"F189","DOI":"10.1152\/ajprenal.00272.2010","article-title":"Folic acid supplementation inhibits NADPH oxidase-mediated superoxide anion production in the kidney","volume":"300","author":"Hwang","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.ajpath.2011.07.019_bib8","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000110876","article-title":"Mechanisms of homocysteine-induced glomerular injury and sclerosis","volume":"28","author":"Yi","year":"2008","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.ajpath.2011.07.019_bib9","first-page":"1688","article-title":"Hyperhomocysteinemia: association with renal transsulfuration and redox signaling in rats","volume":"45","author":"Li","year":"2007","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.ajpath.2011.07.019_bib10","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1089\/ars.2007.1750","article-title":"Vascular oxidant stress and inflammation in hyperhomocysteinemia","volume":"9","author":"Papatheodorou","year":"2007","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.ajpath.2011.07.019_bib11","first-page":"F587","article-title":"Identification of gene family of caspases in rat kidney and altered expression in ischemia-reperfusion injury","volume":"274","author":"Kaushal","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ajpath.2011.07.019_bib12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0002-9343(00)00311-9","article-title":"Apoptotic mechanisms in acute renal failure","volume":"108","author":"Ueda","year":"2000","journal-title":"Am J Med"},{"key":"10.1016\/j.ajpath.2011.07.019_bib13","doi-asserted-by":"crossref","first-page":"19943","DOI":"10.1074\/jbc.272.32.19943","article-title":"Tissue-specific pattern of stress kinase activation in ischemic\/reperfused heart and kidney","volume":"272","author":"Yin","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2011.07.019_bib14","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.2353\/ajpath.2009.081036","article-title":"Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain","volume":"174","author":"Zhang","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2011.07.019_bib15","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.2337\/db10-0912","article-title":"Targeting ceramide synthesis to reverse insulin resistance","volume":"59","author":"Schmitz-Peiffer","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.ajpath.2011.07.019_bib16","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.2337\/db09-1293","article-title":"Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption","volume":"59","author":"Ussher","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.ajpath.2011.07.019_bib17","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jalz.2010.03.014","article-title":"Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss","volume":"6","author":"Mielke","year":"2010","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ajpath.2011.07.019_bib18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2007.01.002","article-title":"Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance","volume":"5","author":"Holland","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajpath.2011.07.019_bib19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.plipres.2005.11.002","article-title":"Ceramides in insulin resistance and lipotoxicity","volume":"45","author":"Summers","year":"2006","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.ajpath.2011.07.019_bib20","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/sj.embor.7400208","article-title":"The complex life of simple sphingolipids","volume":"5","author":"Futerman","year":"2004","journal-title":"EMBO Rep"},{"key":"10.1016\/j.ajpath.2011.07.019_bib21","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1126\/science.1082504","article-title":"Tumor response to radiotherapy regulated by endothelial cell apoptosis","volume":"300","author":"Garcia-Barros","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2011.07.019_bib22","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1096\/fj.08-108043","article-title":"The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases","volume":"22","author":"Smith","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2011.07.019_bib23","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1038\/sj.onc.1206540","article-title":"Ceramide-mediated clustering is required for CD95-DISC formation","volume":"22","author":"Grassme","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2011.07.019_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1385\/JMN:15:2:85","article-title":"Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis","volume":"15","author":"Yu","year":"2000","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.ajpath.2011.07.019_bib25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1126\/science.1060191","article-title":"Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice","volume":"293","author":"Paris","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2011.07.019_bib26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.drup.2005.02.003","article-title":"Role of early plasma membrane events in chemotherapy-induced cell death","volume":"8","author":"Dimanche-Boitrel","year":"2005","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.ajpath.2011.07.019_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1172\/JCI16010","article-title":"Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice","volume":"111","author":"Garcia-Ruiz","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2011.07.019_bib28","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1159\/000322342","article-title":"Acid sphingomyelinase deficiency attenuates bleomycin-induced lung inflammation and fibrosis in mice","volume":"26","author":"Dhami","year":"2010","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.ajpath.2011.07.019_bib29","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1165\/rcmb.2009-0174OC","article-title":"Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis","volume":"42","author":"Becker","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2011.07.019_bib30","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nm1748","article-title":"Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis","volume":"14","author":"Teichgraber","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2011.07.019_bib31","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1124\/jpet.110.168815","article-title":"Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet","volume":"334","author":"Boini","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.ajpath.2011.07.019_bib32","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.2353\/ajpath.2010.091257","article-title":"Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis","volume":"177","author":"Moles","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2011.07.019_bib33","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/ki.2008.578","article-title":"Amitriptyline attenuates interstitial inflammation and ameliorates the progression of renal fibrosis","volume":"75","author":"Achar","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2011.07.019_bib34","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1161\/01.CIR.0000027586.64231.1B","article-title":"Effect of hyperhomocysteinemia on plasma or tissue adenosine levels and renal function","volume":"106","author":"Chen","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ajpath.2011.07.019_bib35","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/ki.1984.147","article-title":"Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats","volume":"26","author":"Raij","year":"1984","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2011.07.019_bib36","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1111\/j.1523-1755.2004.00968.x","article-title":"Homocysteine activates NADH\/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells","volume":"66","author":"Yi","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2011.07.019_bib37","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.bbalip.2010.09.001","article-title":"Visfatin-induced lipid raft redox signaling platforms and dysfunction in glomerular endothelial cells","volume":"1801","author":"Boini","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2011.07.019_bib38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0021-9673(01)01422-4","article-title":"Separation, identification and quantitation of ceramides in human cancer cells by liquid chromatography-electrospray ionization tandem mass spectrometry","volume":"949","author":"Fillet","year":"2002","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.ajpath.2011.07.019_bib39","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.bbamcr.2009.12.006","article-title":"Redox signaling via lipid raft clustering in homocysteine-induced injury of podocytes","volume":"1803","author":"Zhang","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2011.07.019_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.vascn.2004.03.004","article-title":"Approaches and methods in gene therapy for kidney disease","volume":"50","author":"van der Wouden","year":"2004","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.ajpath.2011.07.019_bib41","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/01.ATV.15.5.551","article-title":"The response-to-retention hypothesis of early atherogenesis","volume":"15","author":"Williams","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ajpath.2011.07.019_bib42","doi-asserted-by":"crossref","first-page":"23305","DOI":"10.1074\/jbc.270.40.23305","article-title":"Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines: implications for cellular proliferation and differentiation","volume":"270","author":"Coroneos","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2011.07.019_bib43","doi-asserted-by":"crossref","first-page":"10284","DOI":"10.1074\/jbc.M412348200","article-title":"Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice","volume":"280","author":"Hojjati","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2011.07.019_bib44","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1161\/CIRCRESAHA.107.169201","article-title":"Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1alpha in the renal medulla","volume":"102","author":"Li","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.ajpath.2011.07.019_bib45","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0002-9440(10)62297-3","article-title":"Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney","volume":"166","author":"Hou","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2011.07.019_bib46","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jgm.632","article-title":"An efficient gene transfer method mediated by ultrasound and microbubbles into the kidney","volume":"7","author":"Koike","year":"2005","journal-title":"J Gene Med"},{"key":"10.1016\/j.ajpath.2011.07.019_bib47","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1097\/01.ASN.0000067632.04658.B8","article-title":"Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model","volume":"14","author":"Lan","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2011.07.019_bib48","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/sj.gt.3303070","article-title":"Ultrasound-based nonviral gene delivery induces bone formation in vivo","volume":"15","author":"Sheyn","year":"2008","journal-title":"Gene Ther"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011007383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011007383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:31:36Z","timestamp":1757601096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944011007383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0002944011007383"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.07.019","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acid Sphingomyelinase Gene Deficiency Ameliorates the Hyperhomocysteinemia-Induced Glomerular Injury in Mice","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}