{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T20:35:27Z","timestamp":1773347727182,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":2964,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.ajpath.2011.07.030","type":"journal-article","created":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T17:14:37Z","timestamp":1316020477000},"page":"2199-2209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Egr-1 Expression During Neointimal Development in Flow-Associated Pulmonary Hypertension"],"prefix":"10.1016","volume":"179","author":[{"given":"Michael G.","family":"Dickinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrijs","family":"Bartelds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grietje","family":"Molema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinus A.","family":"Borgdorff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibiche","family":"Boersma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janny","family":"Takens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Weij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter","family":"Wichers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannie","family":"Sietsma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf M.F.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2011.07.030_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1053\/euhj.1999.1698","article-title":"Possibilities and impossibilities in the evaluation of pulmonary vascular disease in congenital heart defects","volume":"21","author":"Berger","year":"2000","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ajpath.2011.07.030_bib2","first-page":"56","article-title":"Biopsy pathology of the pulmonary vasculature","author":"Wagenvoort","year":"1989"},{"key":"10.1016\/j.ajpath.2011.07.030_bib3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1165\/rcmb.2009-0389TR","article-title":"Reversible or irreversible remodeling in pulmonary arterial hypertension","volume":"43","author":"Sakao","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib4","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.1016\/j.jacc.2004.02.029","article-title":"Cellular and molecular pathobiology of pulmonary arterial hypertension","volume":"43","author":"Humbert","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.yjmcc.2007.09.006","article-title":"Pathogenic mechanisms of pulmonary arterial hypertension","volume":"44","author":"Chan","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib6","doi-asserted-by":"crossref","first-page":"L1013","DOI":"10.1152\/ajplung.00217.2009","article-title":"Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure","volume":"297","author":"Stenmark","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1183\/09031936.05.00015405","article-title":"The role of increased pulmonary blood flow in pulmonary arterial hypertension","volume":"26","author":"van Albada","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2011.07.030_bib8","doi-asserted-by":"crossref","first-page":"L483","DOI":"10.1152\/ajplung.00106.2009","article-title":"Gene expression profile in flow-associated pulmonary arterial hypertension with neointimal lesions","volume":"298","author":"van Albada","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib9","doi-asserted-by":"crossref","first-page":"L583","DOI":"10.1152\/ajplung.00321.2006","article-title":"Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension","volume":"293","author":"White","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1164\/ajrccm.159.2.9805075","article-title":"Role of hemodynamics in pulmonary vascular remodeling: implications for primary pulmonary hypertension","volume":"159","author":"Botney","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2011.07.030_bib11","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/01.RES.0000200177.53882.c3","article-title":"Early growth response-1 in cardiovascular pathobiology","volume":"98","author":"Khachigian","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.ajpath.2011.07.030_bib12","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1172\/JCI8592","article-title":"High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis","volume":"105","author":"McCaffrey","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2011.07.030_bib13","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1093\/nar\/gkh543","article-title":"Locked nucleic acid-modified DNA enzymes targeting early growth response-1 inhibit vascular smooth muscle cell growth","volume":"32","author":"Fahmy","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2011.07.030_bib14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/sj.gt.3302153","article-title":"Inhibition of neointimal hyperplasia after balloon injury by cis-element \u2018decoy\u2019 of early growth response gene-1 in hypercholesterolemic rabbits","volume":"11","author":"Ohtani","year":"2004","journal-title":"Gene Ther"},{"key":"10.1016\/j.ajpath.2011.07.030_bib15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/01.RES.81.4.457","article-title":"Inducible expression of Egr-1-dependent genes: a paradigm of transcriptional activation in vascular endothelium","volume":"81","author":"Khachigian","year":"1997","journal-title":"Circ Res"},{"key":"10.1016\/j.ajpath.2011.07.030_bib16","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0002-9440(10)65233-9","article-title":"Vascular smooth muscle cells express the transcriptional corepressor NAB2 in response to injury","volume":"155","author":"Silverman","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/01.ATV.19.2.281","article-title":"Fluid shear stress induction of the tissue factor promoter In vitro and in vivo is mediated by Egr-1","volume":"19","author":"Houston","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib18","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1164\/ajrccm.157.5.9709050","article-title":"Pulmonary artery remodeling differs in hypoxia- and monocrotaline-induced pulmonary hypertension","volume":"157","author":"van Suylen","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2011.07.030_bib19","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.271.5254.1427","article-title":"Egr-1-induced endothelial gene expression: a common theme in vascular injury","volume":"271","author":"Khachigian","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2011.07.030_bib20","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1172\/JCI1404","article-title":"Fluid shear stress activation of Egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1\/2 Mitogen-activated protein kinase pathway","volume":"11","author":"Schwachtgen","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2011.07.030_bib21","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1161\/01.ATV.17.10.2280","article-title":"Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shear-stress response element in the PDGF A-chain promoter","volume":"17","author":"Khachigian","year":"1997","journal-title":"Arterioscl Thromb Vasc Biol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib22","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1152\/jappl.2000.88.6.2303","article-title":"Pulmonary expression of early growth response-1: biphasic time course and effect of oxygen concentration","volume":"88","author":"Yan","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib23","doi-asserted-by":"crossref","first-page":"L422","DOI":"10.1152\/ajplung.90293.2008","article-title":"Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling","volume":"295","author":"Nozik-Grayck","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib24","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1152\/japplphysiol.00821.2004","article-title":"Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts","volume":"98","author":"Banks","year":"2005","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib25","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1165\/rcmb.2008-0470OC","article-title":"Early growth response-1 suppresses epidermal growth factor receptor\u2013mediated airway hyperresponsiveness and lung remodeling in mice","volume":"41","author":"Kramer","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/jcp.10178","article-title":"Regulation of life and death by the zinc finger transcription factor Egr-1","volume":"193","author":"Thiel","year":"2002","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib27","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1073\/pnas.92.15.6873","article-title":"Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription","volume":"92","author":"Russo","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2011.07.030_bib28","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1164\/rccm.200610-1559OC","article-title":"Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension","volume":"176","author":"Sanchez","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2011.07.030_bib29","doi-asserted-by":"crossref","first-page":"H2021","DOI":"10.1152\/ajpheart.00919.2001","article-title":"Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary hypertension in rats","volume":"283","author":"Ikeda","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib30","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.jacc.2009.04.006","article-title":"Inflammation, growth factors, and pulmonary vascular remodeling","volume":"54","author":"Hassoun","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ajpath.2011.07.030_bib31","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1164\/ajrccm.160.4.9810058","article-title":"Increased expression of mast cell chymase in the lungs of patients with congenital heart disease associated with early pulmonary vascular disease","volume":"160","author":"Hamada","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2011.07.030_bib32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1164\/rccm.200707-1037OC","article-title":"Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension","volume":"178","author":"Perros","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2011.07.030_bib33","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/15215","article-title":"New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury","volume":"5","author":"Santiago","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2011.07.030_bib34","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/hh2001.097867","article-title":"Catalytic oligodeoxynucleotides define a key regulatory role for early growth response factor-1 in the porcine model of coronary in-stent restenosis","volume":"89","author":"Lowe","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.ajpath.2011.07.030_bib35","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/jcb.21145","article-title":"Suppression of growth factor expression and human vascular smooth muscle cell growth by small interfering RNA targeting EGR-1","volume":"100","author":"Fahmy","year":"2007","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.ajpath.2011.07.030_bib36","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0002-9440(10)65189-9","article-title":"Vascular smooth muscle cell proliferation and regrowth after injury in vitro is dependent upon NGFI-A\/Egr-1","volume":"155","author":"Santiago","year":"1999","journal-title":"Am J Pathol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011007528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011007528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:31:29Z","timestamp":1757601089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944011007528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0002944011007528"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.07.030","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Egr-1 Expression During Neointimal Development in Flow-Associated Pulmonary Hypertension","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.07.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}