{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:46:26Z","timestamp":1790401586517,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":508,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MT14104"],"award-info":[{"award-number":["MT14104"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.ajpath.2011.11.037","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T08:23:42Z","timestamp":1326788622000},"page":"1028-1039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"title":["Plasmodium falciparum Histones Induce Endothelial Proinflammatory Response and Barrier Dysfunction"],"prefix":"10.1016","volume":"180","author":[{"given":"Mark R.","family":"Gillrie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Channe","family":"Gowda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shevaun P.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Monestier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Tinh","family":"Hien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P.J.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2011.11.037_bib1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrmicro2110","article-title":"Malaria parasite proteins that remodel the host erythrocyte","volume":"7","author":"Maier","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ajpath.2011.11.037_bib2","doi-asserted-by":"crossref","first-page":"C1231","DOI":"10.1152\/ajpcell.1999.276.6.C1231","article-title":"Molecular mechanisms of cytoadherence in malaria","volume":"276","author":"Ho","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ajpath.2011.11.037_bib3","first-page":"35","article-title":"Antibodies against phosphatidylinositol and inositol monophosphate specifically inhibit tumour necrosis factor induction by malaria exoantigens","volume":"76","author":"Bate","year":"1992","journal-title":"Immunology"},{"key":"10.1016\/j.ajpath.2011.11.037_bib4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1084\/jem.177.1.145","article-title":"Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites","volume":"177","author":"Schofield","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2011.11.037_bib5","doi-asserted-by":"crossref","first-page":"8606","DOI":"10.1074\/jbc.M413541200","article-title":"Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity","volume":"280","author":"Krishnegowda","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2011.11.037_bib6","doi-asserted-by":"crossref","first-page":"8617","DOI":"10.1074\/jbc.M413539200","volume":"280","author":"Zhu","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2011.11.037_bib7","doi-asserted-by":"crossref","first-page":"e1000559","DOI":"10.1371\/journal.ppat.1000559","article-title":"Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases","volume":"5","author":"Shio","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2011.11.037_bib8","doi-asserted-by":"crossref","first-page":"e6510","DOI":"10.1371\/journal.pone.0006510","article-title":"Malarial hemozoin is a Nalp3 inflammasome activating danger signal","volume":"4","author":"Dostert","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2011.11.037_bib9","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/eji.200939996","article-title":"Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome","volume":"40","author":"Reimer","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ajpath.2011.11.037_bib10","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1073\/pnas.0608745104","article-title":"Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9","volume":"104","author":"Parroche","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2011.11.037_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1084\/jem.20041836","article-title":"Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin","volume":"201","author":"Coban","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2011.11.037_bib12","doi-asserted-by":"crossref","unstructured":"Gowda NM, Wu X, Gowda DC: The nucleosome (histone-DNA complex) is the TLR9-specific immunostimulatory component of Plasmodium falciparum that activates DCs. PLoS One 6:e20398","DOI":"10.1371\/journal.pone.0020398"},{"key":"10.1016\/j.ajpath.2011.11.037_bib13","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature06116","article-title":"Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide","volume":"449","author":"Lande","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2011.11.037_bib14","doi-asserted-by":"crossref","first-page":"5208","DOI":"10.4049\/jimmunol.0713552","article-title":"Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid","volume":"183","author":"Griffith","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2011.11.037_bib15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2011.11.037_bib16","doi-asserted-by":"crossref","first-page":"e1000013","DOI":"10.1371\/journal.ppat.1000013","article-title":"Plasmodium-induced inflammation by uric acid","volume":"4","author":"Orengo","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2011.11.037_bib17","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1084\/jem.20071393","article-title":"Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis [Erratum appeared in J Exp Med 2008;205:1509]","volume":"205","author":"Ye","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2011.11.037_bib18","first-page":"1921","article-title":"Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection","volume":"119","author":"Andonegui","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2011.11.037_bib19","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/eji.200939929","article-title":"Divergent roles of Toll-like receptor 2 in response to lipoteichoic acid and Staphylococcus aureus in vivo","volume":"40","author":"Gillrie","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ajpath.2011.11.037_bib20","first-page":"1477","article-title":"Systemic endothelial activation occurs in both mild and severe malaria","volume":"152","author":"Turner","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2011.11.037_bib21","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1086\/315078","article-title":"Cytokine expression in the brain in human cerebral malaria","volume":"180","author":"Brown","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2011.11.037_bib22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4269\/ajtmh.2001.64.207","article-title":"Blood-brain barrier function in cerebral malaria in Malawian children","volume":"64","author":"Brown","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ajpath.2011.11.037_bib23","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1056\/NEJM196810032791402","article-title":"Acute pulmonary edema in falciparum malaria: a clinicopathological correlation","volume":"279","author":"Brooks","year":"1968","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2011.11.037_bib24","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1086\/497697","article-title":"Lung injury in uncomplicated and severe falciparum malaria: a longitudinal study in Papua, Indonesia","volume":"192","author":"Maguire","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2011.11.037_bib25","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1182\/blood-2007-04-084582","article-title":"Src-family kinase dependent disruption of endothelial barrier function by Plasmodium falciparum merozoite proteins","volume":"110","author":"Gillrie","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2011.11.037_bib26","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1084\/jem.108.6.925","article-title":"Bactericidal action of histone","volume":"108","author":"Hirsch","year":"1958","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2011.11.037_bib27","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2011.11.037_bib28","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/nm.2053","article-title":"Extracellular histones are major mediators of death in sepsis","volume":"15","author":"Xu","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2011.11.037_bib29","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1086\/315016","article-title":"The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria","volume":"180","author":"Day","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2011.11.037_bib30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1056\/NEJM199607113350202","article-title":"A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria","volume":"335","author":"Tran","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2011.11.037_bib31","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/0161-5890(93)90153-3","article-title":"Structure and binding properties of monoclonal antibodies to core histones from autoimmune mice","volume":"30","author":"Monestier","year":"1993","journal-title":"Mol Immunol"},{"key":"10.1016\/j.ajpath.2011.11.037_bib32","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1182\/blood.V96.6.2292","article-title":"Synergism of multiple adhesion molecules in mediating cytoadherence of Plasmodium falciparum-infected erythrocytes to microvascular endothelial cells under flow","volume":"96","author":"Yipp","year":"2000","journal-title":"Blood"},{"issue":"Pt 5","key":"10.1016\/j.ajpath.2011.11.037_bib33","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1017\/S0031182096008621","article-title":"The histones of Plasmodium falciparum: identification, purification and a possible role in the pathology of malaria","volume":"114","author":"Longhurst","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.ajpath.2011.11.037_bib34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.gene.2005.10.022","article-title":"The malaria parasite Plasmodium falciparum histones: organization, expression, and acetylation","volume":"369","author":"Miao","year":"2006","journal-title":"Gene"},{"key":"10.1016\/j.ajpath.2011.11.037_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1475-2875-7-45","article-title":"Concentration and purification by magnetic separation of the erythrocytic stages of all human Plasmodium species","volume":"7","author":"Ribaut","year":"2008","journal-title":"Malar J"},{"key":"10.1016\/j.ajpath.2011.11.037_bib36","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1086\/598856","article-title":"Quantitative detection of Plasmodium falciparum DNA in saliva, blood, and urine","volume":"199","author":"Nwakanma","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2011.11.037_bib37","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1086\/301800","article-title":"Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis","volume":"62","author":"Lo","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajpath.2011.11.037_bib38","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1515\/CCLM.2001.095","article-title":"Nucleosomes in serum as a marker for cell death","volume":"39","author":"Holdenrieder","year":"2001","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.ajpath.2011.11.037_bib39","doi-asserted-by":"crossref","unstructured":"Semeraro F, Ammollo CT, Morrissey JH, Dale GL, Friese P, Esmon NL, Esmon CT: Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood 118:1952\u20131961","DOI":"10.1182\/blood-2011-03-343061"},{"key":"10.1016\/j.ajpath.2011.11.037_bib40","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/elps.1150060305","article-title":"Isoelectric focusing of monoclonal immunoglobulin G, A and M followed by detection with the avidin-biotin system","volume":"6","author":"Chiodi","year":"1985","journal-title":"Electrophoresis"},{"key":"10.1016\/j.ajpath.2011.11.037_bib41","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1182\/blood-2006-09-003004","article-title":"The cytoprotective protein C pathway","volume":"109","author":"Mosnier","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2011.11.037_bib42","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJM200103083441001","article-title":"Efficacy and safety of recombinant human activated protein C for severe sepsis","volume":"344","author":"Bernard","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2011.11.037_bib43","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1097\/01.CCM.0000074719.40109.95","article-title":"Elevated nucleosome levels in systemic inflammation and sepsis","volume":"31","author":"Zeerleder","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajpath.2011.11.037_bib44","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1042\/BST0360221","article-title":"Host response to cytoadherence in Plasmodium falciparum","volume":"36","author":"Chakravorty","year":"2008","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.ajpath.2011.11.037_bib45","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1086\/512083","article-title":"Plasmodium falciparum-infected erythrocytes decrease the integrity of human blood-brain barrier endothelial cell monolayers","volume":"195","author":"Tripathi","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2011.11.037_bib46","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.ijpara.2007.02.006","article-title":"Altered phenotype and gene transcription in endothelial cells, induced by Plasmodium falciparum-infected red blood cells: pathogenic or protective?","volume":"37","author":"Chakravorty","year":"2007","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.ajpath.2011.11.037_bib47","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1182\/blood-2009-06-226415","article-title":"Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated inflammatory pathways in human cerebral endothelium","volume":"114","author":"Tripathi","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2011.11.037_bib48","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/jcbfm.2010.121","article-title":"Metabolic acidosis induced by Plasmodium falciparum intraerythrocytic stages alters blood-brain barrier integrity","volume":"31","author":"Zougb\u00e9d\u00e9","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.ajpath.2011.11.037_bib49","doi-asserted-by":"crossref","first-page":"e1001021","DOI":"10.1371\/journal.ppat.1001021","article-title":"Plasmodium falciparum adhesion on human brain microvascular endothelial cells involves transmigration-like cup formation and induces opening of intercellular junctions","volume":"6","author":"Jambou","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2011.11.037_bib50","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1086\/373992","article-title":"Plasmodium falciparum\u2013infected erythrocyte adhesion induces caspase activation and apoptosis in human endothelial cells","volume":"187","author":"Pino","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2011.11.037_bib51","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1086\/528988","article-title":"Rho kinase inhibition in severe malaria: thwarting parasite-induced collateral damage to endothelia","volume":"197","author":"Taoufiq","year":"2008","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2011.11.037_bib52","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.molbiopara.2008.09.003","article-title":"Soluble factors from Plasmodium falciparum-infected erythrocytes induce apoptosis in human brain vascular endothelial and neuroglia cells","volume":"162","author":"Wilson","year":"2008","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.ajpath.2011.11.037_bib53","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2249.1992.tb05867.x","article-title":"Glomerular immune deposits in murine lupus models may contain histones","volume":"90","author":"Schmiedeke","year":"1992","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ajpath.2011.11.037_bib54","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/1097-0215(20010320)95:2<114::AID-IJC1020>3.0.CO;2-Q","article-title":"Nucleosomes in serum of patients with benign and malignant diseases [Erratum appeared in Int J Cancer 2001, 95:398]","volume":"95","author":"Holdenrieder","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2011.11.037_bib55","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1101\/gr.101063.109","article-title":"Nucleosome landscape and control of transcription in the human malaria parasite","volume":"20","author":"Ponts","year":"2010","journal-title":"Genome Res"},{"key":"10.1016\/j.ajpath.2011.11.037_bib56","doi-asserted-by":"crossref","first-page":"e10252","DOI":"10.1371\/journal.pone.0010252","article-title":"A moonlighting function of Plasmodium falciparum histone 3, mono-methylated at lysine 9?","volume":"5","author":"Luah","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2011.11.037_bib57","doi-asserted-by":"crossref","first-page":"e204","DOI":"10.1371\/journal.pmed.0020204","article-title":"Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2 [Erratum appeared in PLoS Med 2005;2:390]","volume":"2","author":"Dondorp","year":"2005","journal-title":"PLoS Med"},{"key":"10.1016\/j.ajpath.2011.11.037_bib58","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/0035-9203(92)90141-X","article-title":"The effects of multiplication and synchronicity on the vascular distribution of parasites in falciparum malaria","volume":"86","author":"White","year":"1992","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.ajpath.2011.11.037_bib59","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.immunol.021908.132603","article-title":"HMGB1 and RAGE in inflammation and cancer","volume":"28","author":"Sims","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ajpath.2011.11.037_bib60","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.mvr.2010.11.010","article-title":"HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption","volume":"81","author":"Wolfson","year":"2011","journal-title":"Microvasc Res"},{"key":"10.1016\/j.ajpath.2011.11.037_bib61","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1182\/blood-2002-05-1300","article-title":"Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells","volume":"101","author":"Fiuza","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2011.11.037_bib62","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.parint.2007.11.005","article-title":"High mobility group box (HMGB) proteins of Plasmodium falciparum: DNA binding proteins with pro-inflammatory activity","volume":"57","author":"Kumar","year":"2008","journal-title":"Parasitol Int"},{"key":"10.1016\/j.ajpath.2011.11.037_bib63","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1067\/mcp.2002.128148","article-title":"Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis","volume":"72","author":"Macias","year":"2002","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.ajpath.2011.11.037_bib64","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/0310057X1003800421","article-title":"The use of drotrecogin alfa in severe falciparum malaria","volume":"38","author":"Robak","year":"2010","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.ajpath.2011.11.037_bib65","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1365-2044.2006.04752.x","article-title":"Drotrecogin alfa (activated) in severe falciparum malaria","volume":"61","author":"Kendrick","year":"2006","journal-title":"Anaesthesia"},{"key":"10.1016\/j.ajpath.2011.11.037_bib66","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/0310057X0703500320","article-title":"The use of activated protein C in severe Plasmodium falciparum malaria","volume":"35","author":"Rankin","year":"2007","journal-title":"Anaesth Intensive Care"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011011096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944011011096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:35:57Z","timestamp":1757601357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944011011096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0002944011011096"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.11.037","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasmodium falciparum Histones Induce Endothelial Proinflammatory Response and Barrier Dysfunction","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2011.11.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}