{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:35:58Z","timestamp":1788906958058,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.ajpath.2012.05.010","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T12:33:12Z","timestamp":1340109192000},"page":"570-582","source":"Crossref","is-referenced-by-count":14,"title":["Thrombospondin-1 Mimetic Peptide ABT-898 Affects Neovascularization and Survival of Human Endometriotic Lesions in a Mouse Model"],"prefix":"10.1016","volume":"181","author":[{"given":"Diane S.","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Virani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrakant","family":"Tayade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2012.05.010_bib1","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMcp1000274","article-title":"Endometriosis","volume":"362","author":"Giudice","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2012.05.010_bib2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1056\/NEJMra0804690","article-title":"Endometriosis","volume":"360","author":"Bulun","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2012.05.010_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/228402651000200102","article-title":"Creating solutions in endometriosis: global collaboration through the World Endometriosis Research Foundation","volume":"2","author":"Adamson","year":"2010","journal-title":"J Endometriosis"},{"key":"10.1016\/j.ajpath.2012.05.010_bib4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev-physiol-012110-142158","article-title":"Endometriosis: the role of neuroangiogenesis","volume":"73","author":"Asante","year":"2011","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.ajpath.2012.05.010_bib5","first-page":"151","article-title":"Retrograde menstruation in healthy women and in patients with endometriosis","volume":"64","author":"Halme","year":"1984","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajpath.2012.05.010_bib6","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S1701-2163(16)34986-6","article-title":"Economic burden of surgically confirmed endometriosis in Canada","volume":"33","author":"Levy","year":"2011","journal-title":"J Obstet Gynaecol Can"},{"issue":"4","key":"10.1016\/j.ajpath.2012.05.010_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001300.pub2","article-title":"Laparoscopic surgery for pelvic pain associated with endometriosis","author":"Jacobson","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ajpath.2012.05.010_bib8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00404-011-1941-7","article-title":"Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment","volume":"285","author":"Petraglia","year":"2012","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.ajpath.2012.05.010_bib9","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/humupd\/8.1.84","article-title":"Endometriosis, retrograde menstruation and peritoneal inflammation in women and in baboons","volume":"8","author":"D'Hooghe","year":"2002","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajpath.2012.05.010_bib10","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/386671a0","article-title":"Mechanisms of angiogenesis","volume":"386","author":"Risau","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2012.05.010_bib11","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.ajpath.2010.12.037","article-title":"Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis","volume":"178","author":"Becker","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2012.05.010_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1161\/01.RES.85.3.221","article-title":"Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization","volume":"85","author":"Asahara","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.ajpath.2012.05.010_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.fertnstert.2005.07.1290","article-title":"Short synthetic endostatin peptides inhibit endothelial migration in vitro and endometriosis in a mouse model","volume":"85","author":"Becker","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajpath.2012.05.010_bib14","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/1933719110395406","article-title":"Effect of vascular endothelial growth factor inhibition on endometrial implant development in a murine model of endometriosis","volume":"18","author":"Ricci","year":"2011","journal-title":"Reprod Sci"},{"key":"10.1016\/j.ajpath.2012.05.010_bib15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrd1381","article-title":"Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer","volume":"3","author":"Ferrara","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.ajpath.2012.05.010_bib16","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/humrep\/dei308","article-title":"Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions","volume":"21","author":"Laschke","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ajpath.2012.05.010_bib17","doi-asserted-by":"crossref","first-page":"5905","DOI":"10.1210\/en.2010-0283","article-title":"A thrombospondin-mimetic peptide, ABT-898, suppresses angiogenesis and promotes follicular atresia in pre- and early-antral follicles in vivo","volume":"151","author":"Garside","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2012.05.010_bib18","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1210\/en.2009-0751","article-title":"Testosterone induces redistribution of forkhead box-3a and down-regulation of growth and differentiation factor 9 messenger ribonucleic acid expression at early stage of mouse folliculogenesis","volume":"151","author":"Yang","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2012.05.010_bib19","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nm0402-349","article-title":"Inducer-stimulated fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor","volume":"8","author":"Volpert","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2012.05.010_bib20","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/jcp.20904","article-title":"Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1)","volume":"210","author":"Greenaway","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2012.05.010_bib21","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1158\/1535-7163.MCT-11-0402","article-title":"ABT-898 induces tumor regression and prolongs survival in a mouse model of epithelial ovarian cancer","volume":"10","author":"Campbell","year":"2011","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.ajpath.2012.05.010_bib22","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ajpath.2010.11.037","article-title":"Endothelial progenitor cells contribute to the vascularization of endometriotic lesions","volume":"178","author":"Laschke","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2012.05.010_bib23","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1200\/JCO.2005.05.013","article-title":"Phase I safety, pharmacokinetic, and pharmacodynamic study of the thrombospondin-1-mimetic angiogenesis inhibitor ABT-510 in patients with advanced cancer","volume":"23","author":"Hoekstra","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajpath.2012.05.010_bib24","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1158\/0008-5472.CAN-06-2595","article-title":"Thrombospondin-1 peptide ABT-510 combined with valproic acid is an effective antiangiogenesis strategy in neuroblastoma","volume":"67","author":"Yang","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2012.05.010_bib25","doi-asserted-by":"crossref","first-page":"6678","DOI":"10.1158\/1078-0432.CCR-05-0621","article-title":"Metronomic low-dose chemotherapy boosts CD95-dependent antiangiogenic effect of the thrombospondin peptide ABT-510: a complementation antiangiogenic strategy","volume":"11","author":"Yap","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2012.05.010_bib26","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1158\/1535-7163.MCT-08-0864","article-title":"ABT-510 induces tumor cell apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer","volume":"8","author":"Greenaway","year":"2009","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.ajpath.2012.05.010_bib27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.mvr.2007.04.008","article-title":"Angiogenesis and antiangiogenic therapy in endometriosis","volume":"74","author":"Becker","year":"2007","journal-title":"Microvasc Res"},{"issue":"Suppl 2","key":"10.1016\/j.ajpath.2012.05.010_bib28","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.fertnstert.2005.04.040","article-title":"Endostatin inhibits the growth of endometriotic lesions but does not affect fertility","volume":"84","author":"Becker","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajpath.2012.05.010_bib29","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1091\/mbc.E01-09-0066","article-title":"Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism","volume":"13","author":"Armstrong","year":"2002","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ajpath.2012.05.010_bib30","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1083\/jcb.200407060","article-title":"Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins [Erratum appeared in J Cell Biol 2005, 169:541]","volume":"168","author":"Short","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2012.05.010_bib31","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1200\/JCO.2002.01.033","article-title":"Mechanisms and future directions for angiogenesis-based cancer therapies","volume":"20","author":"Scappaticci","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajpath.2012.05.010_bib32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1023\/A:1009018702832","article-title":"Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: effect on human microvascular endothelial cell proliferation and angiogenesis","volume":"3","author":"Gupta","year":"1999","journal-title":"Angiogenesis"},{"key":"10.1016\/j.ajpath.2012.05.010_bib33","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2012.05.010_bib34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/humupd\/dmm006","article-title":"In vitro and in vivo approaches to study angiogenesis in the pathophysiology and therapy of endometriosis","volume":"13","author":"Laschke","year":"2007","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajpath.2012.05.010_bib35","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1215\/S1152851705000232","article-title":"The role of pericytes in blood-vessel formation and maintenance","volume":"7","author":"Bergers","year":"2005","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ajpath.2012.05.010_bib36","doi-asserted-by":"crossref","first-page":"15404","DOI":"10.1074\/jbc.M701638200","article-title":"Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake","volume":"282","author":"Isenberg","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2012.05.010_bib37","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.bcp.2007.10.025","article-title":"Differential effects of ABT-510 and a CD36-binding peptide derived from the type 1 repeats of thrombospondin-1 on fatty acid uptake, nitric oxide signaling, and caspase activation in vascular cells","volume":"75","author":"Isenberg","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ajpath.2012.05.010_bib38","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/j.fertnstert.2009.05.076","article-title":"Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes","volume":"93","author":"Bruner-Tran","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ajpath.2012.05.010_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10456-010-9195-8","article-title":"Vascular endothelial growth inhibitor (VEGI; TNFSF15) inhibits bone marrow-derived endothelial progenitor cell incorporation into Lewis lung carcinoma tumors","volume":"14","author":"Liang","year":"2011","journal-title":"Angiogenesis"},{"key":"10.1016\/j.ajpath.2012.05.010_bib40","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/humupd\/dmr023","article-title":"Vasculogenesis: a new piece of the endometriosis puzzle","volume":"17","author":"Laschke","year":"2011","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.ajpath.2012.05.010_bib41","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1002\/stem.745","article-title":"Concise review: circulating endothelial progenitor cells for vascular medicine","volume":"29","author":"Asahara","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.ajpath.2012.05.010_bib42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10456-009-9135-7","article-title":"Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature","volume":"12","author":"Ahn","year":"2009","journal-title":"Angiogenesis"},{"key":"10.1016\/j.ajpath.2012.05.010_bib43","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/nm1101-1194","article-title":"Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth","volume":"7","author":"Lyden","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2012.05.010_bib44","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.1073\/pnas.0710516105","article-title":"Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth","volume":"105","author":"Purhonen","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2012.05.010_bib45","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/ijc.24605","article-title":"Endothelial progenitor cells do not contribute to tumor endothelium in primary and metastatic tumors","volume":"125","author":"Wickersheim","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2012.05.010_bib46","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.exphem.2006.10.016","article-title":"Bone marrow-derived endothelial progenitor cells do not contribute significantly to new vessels during incisional wound healing","volume":"35","author":"Bluff","year":"2007","journal-title":"Exp Hematol"},{"key":"10.1016\/j.ajpath.2012.05.010_bib47","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature04478","article-title":"Angiogenesis in life, disease and medicine","volume":"438","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2012.05.010_bib48","first-page":"410","article-title":"Bone mass in endometriosis patients treated with GnRH agonist implant or danazol","volume":"77","author":"Dodin","year":"1991","journal-title":"Obstet Gynecol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944012003689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944012003689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T23:37:49Z","timestamp":1561851469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944012003689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0002944012003689"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2012.05.010","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}