{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:23:49Z","timestamp":1792290229511,"version":"4.4.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":352,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA025566"],"award-info":[{"award-number":["DA025566"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA015913"],"award-info":[{"award-number":["AA015913"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH65151"],"award-info":[{"award-number":["MH65151"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.ajpath.2012.06.018","type":"journal-article","created":{"date-parts":[[2012,8,3]],"date-time":"2012-08-03T01:15:22Z","timestamp":1343956522000},"page":"1414-1425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Glycogen Synthase Kinase 3\u03b2 Inhibition Prevents Monocyte Migration across Brain Endothelial Cells via Rac1-GTPase Suppression and Down-Regulation of Active Integrin Conformation"],"prefix":"10.1016","volume":"181","author":[{"given":"Slava","family":"Rom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shongshan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Reichenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Dykstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Servio H.","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Persidsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2012.06.018_bib1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib2","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib3","doi-asserted-by":"crossref","first-page":"14337","DOI":"10.1074\/jbc.M901178200","article-title":"Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation","volume":"284","author":"Chigaev","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2012.06.018_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1242\/jcs.018556","article-title":"Linking integrin conformation to function","volume":"122","author":"Askari","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2012.06.018_bib5","doi-asserted-by":"crossref","first-page":"6210","DOI":"10.1073\/pnas.0937423100","article-title":"Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia\/reperfusion model","volume":"100","author":"Ren","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2012.06.018_bib6","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/sj.npp.1300731","article-title":"Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs","volume":"30","author":"Gould","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ajpath.2012.06.018_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1124\/jpet.106.102863","article-title":"Glycogen synthase kinase-3 beta inhibition reduces secondary damage in experimental spinal cord trauma","volume":"318","author":"Cuzzocrea","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.ajpath.2012.06.018_bib8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/01.shk.0000209545.29671.31","article-title":"Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation","volume":"25","author":"Dugo","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.ajpath.2012.06.018_bib9","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1097\/01.CCM.0000178350.21839.44","article-title":"GSK-3beta inhibitors attenuate the organ injury\/dysfunction caused by endotoxemia in the rat","volume":"33","author":"Dugo","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ajpath.2012.06.018_bib10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/01.shk.0000238059.23837.68","article-title":"Glycogen synthase kinase 3beta as a target for the therapy of shock and inflammation","volume":"27","author":"Dugo","year":"2007","journal-title":"Shock"},{"key":"10.1016\/j.ajpath.2012.06.018_bib11","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1189\/jlb.0905539","article-title":"Wnt signaling regulates transendothelial migration of monocytes","volume":"79","author":"Tickenbrock","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib12","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4049\/jimmunol.181.1.338","article-title":"Lithium prevents and ameliorates experimental autoimmune encephalomyelitis","volume":"181","author":"De Sarno","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2353\/ajpath.2010.090671","article-title":"Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells","volume":"176","author":"Ramirez","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib14","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1161\/CIRCULATIONAHA.105.564112","article-title":"Glycogen synthase kinase-3 mediates endothelial cell activation by tumor necrosis factor-alpha","volume":"112","author":"Eto","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ajpath.2012.06.018_bib15","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/nprot.2010.76","article-title":"Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier","volume":"5","author":"Bernas","year":"2010","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ajpath.2012.06.018_bib16","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1126\/science.1206936","article-title":"The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence","volume":"334","author":"Alvarez","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2012.06.018_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/374848","article-title":"Surgical techniques for the treatment of temporal lobe epilepsy","volume":"2012","author":"Al-Otaibi","year":"2012","journal-title":"Epilepsy Res Treatment"},{"key":"10.1016\/j.ajpath.2012.06.018_bib18","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.4049\/jimmunol.180.3.1854","article-title":"Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes","volume":"180","author":"Ramirez","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib19","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1523\/JNEUROSCI.4628-11.2012","article-title":"Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions","volume":"32","author":"Ramirez","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.ajpath.2012.06.018_bib20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10753-008-9070-6","article-title":"LPS and poly I: C induce chromatin modifications at a novel upstream region of the IL-23 p19 promoter","volume":"31","author":"Garrett","year":"2008","journal-title":"Inflammation"},{"key":"10.1016\/j.ajpath.2012.06.018_bib21","doi-asserted-by":"crossref","first-page":"9454","DOI":"10.1523\/JNEUROSCI.5796-09.2010","article-title":"Dyad of CD40\/CD40 ligand fosters neuroinflammation at the blood-brain barrier and is regulated via JNK signaling: implications for HIV-1 encephalitis","volume":"30","author":"Ramirez","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.ajpath.2012.06.018_bib22","doi-asserted-by":"crossref","first-page":"10287","DOI":"10.1074\/jbc.272.15.10287","article-title":"VLA-4 integrin cross-linking on human monocytic THP-1 cells induces tissue factor expression by a mechanism involving mitogen-activated protein kinase","volume":"272","author":"McGilvray","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2012.06.018_bib23","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2353\/ajpath.2008.070076","article-title":"Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells","volume":"172","author":"Yamamoto","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib24","doi-asserted-by":"crossref","first-page":"48670","DOI":"10.1074\/jbc.M103194200","article-title":"Real time analysis of the affinity regulation of alpha 4-integrin: the physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation","volume":"276","author":"Chigaev","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2012.06.018_bib25","doi-asserted-by":"crossref","first-page":"6828","DOI":"10.4049\/jimmunol.178.11.6828","article-title":"Regulation of cell adhesion by affinity and conformational unbending of alpha4beta1 integrin","volume":"178","author":"Chigaev","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib26","doi-asserted-by":"crossref","first-page":"32435","DOI":"10.1074\/jbc.M404387200","article-title":"Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents: \u201cinside-out\u201d signaling is independent of and additive to reduction-regulated integrin activation","volume":"279","author":"Chigaev","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2012.06.018_bib27","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3109\/13550289909021287","article-title":"Model systems for studies of leukocyte migration across the blood - brain barrier","volume":"5","author":"Persidsky","year":"1999","journal-title":"J Neurovirol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib28","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/89624","article-title":"Structure of GSK3beta reveals a primed phosphorylation mechanism","volume":"8","author":"ter Haar","year":"2001","journal-title":"Nat Struct Biol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib29","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1479-5876-8-128","article-title":"Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque","volume":"8","author":"Dwivedi","year":"2010","journal-title":"J Transl Med"},{"key":"10.1016\/j.ajpath.2012.06.018_bib30","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.yexcr.2010.12.007","article-title":"Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers","volume":"317","author":"Alon","year":"2011","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2012.06.018_bib31","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1091\/mbc.e04-12-1049","article-title":"Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1","volume":"16","author":"Garcia-Bernal","year":"2005","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ajpath.2012.06.018_bib32","doi-asserted-by":"crossref","first-page":"950","DOI":"10.4049\/jimmunol.150.3.950","article-title":"Cross-linking of CD14 molecules on monocytes results in a CD11\/CD18- and ICAM-1-dependent adherence to cytokine-stimulated human endothelial cells","volume":"150","author":"Beekhuizen","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib33","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1242\/jcs.004366","article-title":"Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis","volume":"120","author":"Jovceva","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2012.06.018_bib34","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/31729","article-title":"Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase","volume":"393","author":"Arber","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2012.06.018_bib35","doi-asserted-by":"crossref","first-page":"C178","DOI":"10.1152\/ajpcell.00273.2007","article-title":"The role of VASP in regulation of cAMP- and Rac 1-mediated endothelial barrier stabilization","volume":"294","author":"Schlegel","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib36","doi-asserted-by":"crossref","first-page":"C453","DOI":"10.1152\/ajpcell.00360.2008","article-title":"VASP is involved in cAMP-mediated Rac 1 activation in microvascular endothelial cells","volume":"296","author":"Schlegel","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cvr\/cvq093","article-title":"Vasodilator-stimulated phosphoprotein: crucial for activation of Rac1 in endothelial barrier maintenance","volume":"87","author":"Schlegel","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ajpath.2012.06.018_bib38","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1242\/jcs.044537","article-title":"Differential VASP phosphorylation controls remodeling of the actin cytoskeleton","volume":"122","author":"Benz","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2012.06.018_bib39","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/35060120","article-title":"Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration","volume":"3","author":"Kiosses","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib40","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1128\/IAI.05070-11","article-title":"Glycogen synthase kinase 3 activation is important for anthrax edema toxin-induced dendritic cell maturation and anthrax toxin receptor 2 expression in macrophages","volume":"79","author":"Larabee","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2012.06.018_bib41","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1440-169X.2009.01141.x","article-title":"Glycogen synthase kinase 3 in the world of cell migration","volume":"51","author":"Sun","year":"2009","journal-title":"Dev Growth Differ"},{"key":"10.1016\/j.ajpath.2012.06.018_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2005.04.023","article-title":"Rho and vascular disease","volume":"183","author":"Rolfe","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ajpath.2012.06.018_bib43","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1161\/01.ATV.0000122854.76267.5c","article-title":"Signaling in leukocyte transendothelial migration","volume":"24","author":"van Buul","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib44","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1091\/mbc.12.7.2137","article-title":"Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes","volume":"12","author":"Alblas","year":"2001","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ajpath.2012.06.018_bib45","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1111\/j.1582-4934.2009.00900.x","article-title":"Role of AKT-glycogen synthase kinase axis in monocyte activation in human beings with and without type 2 diabetes","volume":"14","author":"Nandy","year":"2010","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.ajpath.2012.06.018_bib46","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/10739680600776062","article-title":"The p110delta isoform of PI3K differentially regulates beta1 and beta2 integrin-mediated monocyte adhesion and spreading and modulates diapedesis","volume":"13","author":"Ferreira","year":"2006","journal-title":"Microcirculation"},{"key":"10.1016\/j.ajpath.2012.06.018_bib47","first-page":"201","article-title":"Alpha4beta1-integrin activation is necessary for high-efficiency T-cell subset interactions with VCAM-1 under flow","volume":"7","author":"Lim","year":"2000","journal-title":"Microcirculation"},{"key":"10.1016\/j.ajpath.2012.06.018_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0607344","article-title":"Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma","volume":"83","author":"Barthel","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1074-7613(04)00082-2","article-title":"Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction","volume":"20","author":"Salas","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.ajpath.2012.06.018_bib50","doi-asserted-by":"crossref","first-page":"359","DOI":"10.4049\/jimmunol.0803388","article-title":"Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1","volume":"183","author":"Hyun","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib51","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1016\/j.febslet.2011.04.066","article-title":"How do immune cells overcome the blood-brain barrier in multiple sclerosis?","volume":"585","author":"Larochelle","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.ajpath.2012.06.018_bib52","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.immunol.26.021607.090347","article-title":"The actin cytoskeleton in T cell activation","volume":"26","author":"Burkhardt","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib53","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4161\/cib.2.4.8614","article-title":"Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge","volume":"2","author":"Chai","year":"2009","journal-title":"Commun Integr Biol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib54","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1083\/jcb.200912014","article-title":"Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration","volume":"189","author":"Worth","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2012.06.018_bib55","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1189\/jlb.0206107","article-title":"Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant","volume":"82","author":"Eckert","year":"2007","journal-title":"J Leukoc Biol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944012004932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944012004932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:38:29Z","timestamp":1757601509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944012004932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0002944012004932"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2012.06.018","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycogen Synthase Kinase 3\u03b2 Inhibition Prevents Monocyte Migration across Brain Endothelial Cells via Rac1-GTPase Suppression and Down-Regulation of Active Integrin Conformation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2012.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}