{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:32:40Z","timestamp":1791167560198,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,19]],"date-time":"2013-10-19T00:00:00Z","timestamp":1382140800000},"content-version":"vor","delay-in-days":352,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.ajpath.2012.08.003","type":"journal-article","created":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T22:02:01Z","timestamp":1346968921000},"page":"1540-1559","source":"Crossref","is-referenced-by-count":45,"title":["Cytomegalovirus Impairs Cytotrophoblast-Induced Lymphangiogenesis and Vascular Remodeling in an in Vivo Human Placentation Model"],"prefix":"10.1016","volume":"181","author":[{"given":"Takako","family":"Tabata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Petitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June","family":"Fang-Hoover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Shiboski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2012.08.003_bib1","first-page":"269","article-title":"Congenital Cytomegalovirus Infection","author":"Britt","year":"1999"},{"key":"10.1016\/j.ajpath.2012.08.003_bib2","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1001\/jama.289.8.1008","article-title":"Maternal immunity and prevention of congenital cytomegalovirus infection","volume":"289","author":"Fowler","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.ajpath.2012.08.003_bib3","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1086\/649903","article-title":"Cytomegalovirus reinfections in healthy seroimmune women","volume":"201","author":"Ross","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2012.08.003_bib4","first-page":"135","article-title":"Congenital cytomegalovirus infection and disease","volume":"11","author":"Demmler","year":"1996","journal-title":"Adv Pediatr Infect Dis"},{"key":"10.1016\/j.ajpath.2012.08.003_bib5","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1542\/peds.110.4.762","article-title":"Predictors of hearing loss in children with symptomatic congenital cytomegalovirus infection","volume":"110","author":"Rivera","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajpath.2012.08.003_bib6","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1542\/peds.66.5.758","article-title":"Outcome of symptomatic congenital cytomegalovirus infection: results of long-term longitudinal follow-up","volume":"66","author":"Pass","year":"1980","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajpath.2012.08.003_bib7","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1001\/jama.1986.03380140074025","article-title":"Primary cytomegalovirus infection in pregnancy: incidence, transmission to fetus, and clinical outcome","volume":"256","author":"Stagno","year":"1986","journal-title":"JAMA"},{"key":"10.1016\/j.ajpath.2012.08.003_bib8","first-page":"616","article-title":"Pathology of the Human Placenta","author":"Benirschke","year":"2000"},{"key":"10.1016\/j.ajpath.2012.08.003_bib9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1471-0528.1984.tb05915.x","article-title":"A prospective study of primary cytomegalovirus infection during pregnancy: final report","volume":"91","author":"Griffiths","year":"1984","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF02894070","article-title":"Placental and fetal manifestations of cytomegalovirus infection","volume":"16","author":"Benirschke","year":"1974","journal-title":"Virchows Arch B Cell Pathol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib11","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/ajcp\/58.5.445","article-title":"Viral placentitis in congenital cytomegalovirus infection","volume":"58","author":"Monif","year":"1972","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0143-4004(89)90002-7","article-title":"Placental morphology in cytomegalovirus infection","volume":"10","author":"Garcia","year":"1989","journal-title":"Placenta"},{"key":"10.1016\/j.ajpath.2012.08.003_bib13","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1086\/507634","article-title":"Placental enlargement in women with primary maternal cytomegalovirus infection is associated with fetal and neonatal disease","volume":"43","author":"La Torre","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajpath.2012.08.003_bib14","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.2353\/ajpath.2010.091210","article-title":"Antibody treatment promotes compensation for human cytomegalovirus-induced pathogenesis and a hypoxia-like condition in placentas with congenital infection","volume":"177","author":"Maidji","year":"2010","journal-title":"Am J Pathol"},{"issue":"Pt 2","key":"10.1016\/j.ajpath.2012.08.003_bib15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/01.AOG.0000248538.03280.cf","article-title":"Cyomegalovirus-induced mirror syndrome associated with elevated levels of circulating antiangiogenic factors","volume":"109","author":"Rana","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib16","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0955-0674(98)80043-4","article-title":"Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors","volume":"10","author":"Damsky","year":"1998","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib17","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1242\/dev.120.12.3657","article-title":"Integrin switching regulates normal trophoblast invasion","volume":"120","author":"Damsky","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2012.08.003_bib18","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1172\/JCI119387","article-title":"Human cytotrophoblasts adopt a vascular phenotype as they differentiate: a strategy for successful endovascular invasion?","volume":"99","author":"Zhou","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2012.08.003_bib19","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0002-9440(10)62567-9","article-title":"Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome","volume":"160","author":"Zhou","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0012-1606(03)00449-4","article-title":"Human cytotrophoblasts promote endothelial survival and vascular remodeling through secretion of Ang2, PlGF, and VEGF-C","volume":"263","author":"Zhou","year":"2003","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib21","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1172\/JCI27306.","article-title":"Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation","volume":"116","author":"Red-Horse","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2012.08.003_bib22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1126\/science.2326636","article-title":"A class I antigen, HLA-G, expressed in human trophoblasts","volume":"248","author":"Kovats","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2012.08.003_bib23","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.4049\/jimmunol.154.8.3771","article-title":"Human placental HLA-G expression is restricted to differentiated cytotrophoblasts","volume":"154","author":"McMaster","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib24","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1084\/jem.20041214","article-title":"Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success","volume":"200","author":"Hiby","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2012.08.003_bib25","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1172\/JCI43998","article-title":"Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2","volume":"120","author":"Hiby","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2012.08.003_bib26","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.1128\/JVI.74.15.6808-6820.2000","article-title":"Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis","volume":"74","author":"Fisher","year":"2000","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib27","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1128\/JVI.78.6.2831-2840.2004","article-title":"Human cytomegalovirus interleukin-10 downregulates metalloproteinase activity and impairs endothelial cell migration and placental cytotrophoblast invasiveness in vitro","volume":"78","author":"Yamamoto-Tabata","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib28","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.placenta.2006.05.006","article-title":"Cytotrophoblasts infected with a pathogenic human cytomegalovirus strain dysregulate cell-matrix and cell-cell adhesion molecules: a quantitative analysis","volume":"28","author":"Tabata","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.ajpath.2012.08.003_bib29","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1128\/JVI.01779-09","article-title":"Activation of peroxisome proliferator-activated receptor gamma by human cytomegalovirus for de novo replication impairs migration and invasiveness of cytotrophoblasts from early placentas","volume":"84","author":"Rauwel","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jri.2011.05.003","article-title":"PPAR\u03b3 and human trophoblast differentiation","volume":"90","author":"Fournier","year":"2011","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib31","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/eji.1830260718","article-title":"An IgG-transporting Fc receptor expressed in the syncytiotrophoblast of human placenta","volume":"26","author":"Simister","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0378(97)00068-5","article-title":"Human placental Fc receptors and the transmission of antibodies from mother to fetus","volume":"37","author":"Simister","year":"1997","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib33","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2353\/ajpath.2006.050482","article-title":"Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal fc receptor-mediated transcytosis","volume":"168","author":"Maidji","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib34","doi-asserted-by":"crossref","first-page":"10026","DOI":"10.1128\/JVI.00710-10","article-title":"The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry","volume":"84","author":"Feire","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib35","doi-asserted-by":"crossref","first-page":"15470","DOI":"10.1073\/pnas.0406821101","article-title":"Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain","volume":"101","author":"Feire","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2012.08.003_bib36","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nature01818","article-title":"Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus","volume":"424","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2012.08.003_bib37","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nm1236","article-title":"Integrin \u03b1v\u03b23 is a coreceptor for human cytomegalovirus","volume":"11","author":"Wang","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2012.08.003_bib38","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1086\/422330","article-title":"Viral and bacterial pathogens at the maternal-fetal interface","volume":"190","author":"McDonagh","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2012.08.003_bib39","doi-asserted-by":"crossref","first-page":"13301","DOI":"10.1128\/JVI.77.24.13301-13314.2003","article-title":"Human cytomegalovirus transmission from the uterus to the placenta correlates with the presence of pathogenic bacteria and maternal immunity","volume":"77","author":"Pereira","year":"2003","journal-title":"J Virol"},{"issue":"Suppl 4","key":"10.1016\/j.ajpath.2012.08.003_bib40","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.jcv.2009.10.004","article-title":"Cytomegalovirus-specific, high-avidity IgG with neutralizing activity in maternal circulation enriched in the fetal bloodstream","volume":"46","author":"Nozawa","year":"2009","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib41","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1128\/JVI.02748-06","article-title":"Developmental regulation of human cytomegalovirus receptors in cytotrophoblasts correlates with distinct replication sites in the placenta","volume":"81","author":"Maidji","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib42","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1073\/pnas.90.1.104","article-title":"Human cytomegalovirus in a SCID-hu mouse: thymic epithelial cells are prominent targets of viral replication","volume":"90","author":"Mocarski","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2012.08.003_bib43","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/infdis\/171.6.1599","article-title":"Dramatic interstrain differences in the replication of human cytomegalovirus in SCID-hu mice","volume":"171","author":"Brown","year":"1995","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2012.08.003_bib44","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1128\/JVI.70.1.78-83.1996","article-title":"Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains","volume":"70","author":"Cha","year":"1996","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib45","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1128\/JVI.79.4.2115-2123.2005","article-title":"Human cytomegalovirus genes in the 15-kilobase region are required for viral replication in implanted human tissues in SCID mice","volume":"79","author":"Wang","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib46","doi-asserted-by":"crossref","first-page":"18153","DOI":"10.1073\/pnas.0509201102","article-title":"Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism","volume":"102","author":"Wang","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2012.08.003_bib47","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1128\/JVI.05354-11","article-title":"Mutational mapping of pUL131A of human cytomegalovirus emphasizes its central role for endothelial cell tropism","volume":"86","author":"Schuessler","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib48","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00705-005-0696-5","article-title":"Human cytomegalovirus UL131A, UL130 and UL128 genes are highly conserved among field isolates","volume":"151","author":"Baldanti","year":"2006","journal-title":"Arch Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib49","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1099\/vir.0.83523-0","article-title":"Human cytomegalovirus serum neutralizing antibodies block virus infection of endothelial\/epithelial cells, but not fibroblasts, early during primary infection","volume":"89","author":"Gerna","year":"2008","journal-title":"J Gen Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib50","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1128\/JVI.01809-09","article-title":"Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH\/gL\/UL128-131A complex","volume":"84","author":"Macagno","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib51","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1099\/0022-1317-82-6-1429","article-title":"In vitro selection of human cytomegalovirus variants unable to transfer virus and virus products from infected cells to polymorphonuclear leukocytes and to grow in endothelial cells","volume":"82","author":"Revello","year":"2001","journal-title":"J Gen Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib52","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.113.2.437","article-title":"92-kD type IV collagenase mediates invasion of human cytotrophoblasts","volume":"113","author":"Librach","year":"1991","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib53","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1126\/science.2971269","article-title":"The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function","volume":"241","author":"McCune","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2012.08.003_bib54","first-page":"101","article-title":"Monoclonal Antibody Production","author":"Dondero","year":"1990"},{"key":"10.1016\/j.ajpath.2012.08.003_bib55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0042-6822(84)90331-3","article-title":"Polymorphism of human cytomegalovirus glycoproteins characterized by monoclonal antibodies","volume":"139","author":"Pereira","year":"1984","journal-title":"Virology"},{"key":"10.1016\/j.ajpath.2012.08.003_bib56","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1172\/JCI60387","article-title":"Integrin \u03b19\u03b21 in airway smooth muscle suppresses exaggerated airway narrowing","volume":"122","author":"Chen","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2012.08.003_bib57","first-page":"157","article-title":"Optimization of the Tetrazolium Dye (MTT) Colorimetric Assay for Cellular Growth and Viability","volume":"Vol. 716","author":"Sylvester","year":"2011"},{"key":"10.1016\/j.ajpath.2012.08.003_bib58","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00441-010-1098-x","article-title":"Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney","volume":"343","author":"Lee","year":"2011","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ajpath.2012.08.003_bib59","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0002-9440(10)64985-1","article-title":"The adhesion molecule CEACAM1 (CD66a, C-CAM, BGP) is specifically expressed by the extravillous intermediate trophoblast","volume":"156","author":"Bamberger","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib60","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1172\/JCI119388","article-title":"Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype: one cause of defective endovascular invasion in this syndrome?","volume":"99","author":"Zhou","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2012.08.003_bib61","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1242\/dev.01971","article-title":"EPHB4 regulates chemokine-evoked trophoblast responses: a mechanism for incorporating the human placenta into the maternal circulation","volume":"132","author":"Red-Horse","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2012.08.003_bib62","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0092-8674(00)81436-1","article-title":"Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4","volume":"93","author":"Wang","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2012.08.003_bib63","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature09002","article-title":"Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis","volume":"465","author":"Wang","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2012.08.003_bib64","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1749-6632.2003.tb03211.x","article-title":"The human placenta remodels the uterus by using a combination of molecules that govern vasculogenesis or leukocyte extravasation","volume":"995","author":"Zhou","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ajpath.2012.08.003_bib65","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1099\/vir.0.025395-0","article-title":"Human cytomegalovirus productively infects lymphatic endothelial cells and induces a secretome that promotes angiogenesis and lymphangiogenesis through interleukin-6 and granulocyte-macrophage colony-stimulating factor","volume":"92","author":"Fiorentini","year":"2010","journal-title":"J Gen Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib66","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jcv.2006.06.006","article-title":"hCMV induced IL-6 release in trophoblast and trophoblast like cells","volume":"37","author":"Halwachs-Baumann","year":"2006","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib67","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jcv.2005.08.011","article-title":"Patterns of human cytomegalovirus infection in term placentas: a preliminary analysis","volume":"35","author":"McDonagh","year":"2006","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib68","doi-asserted-by":"crossref","first-page":"10330","DOI":"10.1128\/JVI.79.16.10330-10338.2005","article-title":"Human cytomegalovirus UL131 open reading frame is required for epithelial cell tropism","volume":"79","author":"Wang","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib69","doi-asserted-by":"crossref","first-page":"e1001256","DOI":"10.1371\/journal.ppat.1001256","article-title":"HCMV spread and cell tropism are determined by distinct virus populations","volume":"7","author":"Scrivano","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2012.08.003_bib70","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1099\/vir.0.81921-0","article-title":"Role of human cytomegalovirus UL131A in cell type-specific virus entry and release","volume":"87","author":"Adler","year":"2006","journal-title":"J Gen Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib71","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ydbio.2006.06.020","article-title":"A role for the L-selectin adhesion system in mediating cytotrophoblast emigration from the placenta","volume":"298","author":"Prakobphol","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib72","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1161\/01.ATV.0000148547.70187.89","article-title":"Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas\/FasL interactions","volume":"25","author":"Ashton","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib73","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1073\/pnas.141108798","article-title":"A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation","volume":"98","author":"Skaletskaya","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2012.08.003_bib74","doi-asserted-by":"crossref","first-page":"7126","DOI":"10.1128\/JVI.73.9.7126-7131.1999","article-title":"Human cytomegalovirus UL36 protein is dispensable for viral replication in cultured cells","volume":"73","author":"Patterson","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib75","doi-asserted-by":"crossref","first-page":"12536","DOI":"10.1073\/pnas.96.22.12536","article-title":"A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2","volume":"96","author":"Goldmacher","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2012.08.003_bib76","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.virol.2003.07.003","article-title":"Differential function and expression of the viral inhibitor of caspase 8-induced apoptosis (vICA) and the viral mitochondria-localized inhibitor of apoptosis (vMIA) cell death suppressors conserved in primate and rodent cytomegaloviruses","volume":"316","author":"McCormick","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.ajpath.2012.08.003_bib77","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/JVI.77.1.631-641.2003","article-title":"Disruption of mitochondrial networks by the human cytomegalovirus UL37 gene product viral mitochondrion-localized inhibitor of apoptosis","volume":"77","author":"McCormick","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib78","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1099\/vir.0.80379-0","article-title":"Human cytomegalovirus proteins encoded by UL37 exon 1 protect infected fibroblasts against virus-induced apoptosis and are required for efficient virus replication","volume":"85","author":"Reboredo","year":"2004","journal-title":"J Gen Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib79","doi-asserted-by":"crossref","first-page":"19117","DOI":"10.1073\/pnas.0609353103","article-title":"Human cytomegalovirus pUL37x1 induces the release of endoplasmic reticulum calcium stores","volume":"103","author":"Sharon-Friling","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2012.08.003_bib80","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1093\/emboj\/20.17.4762","article-title":"Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C\/D receptor VEGFR-3","volume":"20","author":"Makinen","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2012.08.003_bib81","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/sj.jp.7211357","article-title":"Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant","volume":"25","author":"Sampath","year":"2005","journal-title":"J Perinatol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib82","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0146-0005(05)80056-4","article-title":"Infectious causes of hydrops fetalis","volume":"19","author":"Barron","year":"1995","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib83","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/84651","article-title":"Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3","volume":"7","author":"Makinen","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2012.08.003_bib84","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature07083","article-title":"Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation","volume":"454","author":"Tammela","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2012.08.003_bib85","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1084\/jem.20062596","article-title":"Functionally specialized junctions between endothelial cells of lymphatic vessels","volume":"204","author":"Baluk","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2012.08.003_bib86","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1182\/blood-2010-06-291245","article-title":"IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin","volume":"117","author":"Botto","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2012.08.003_bib87","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/jmv.21293","article-title":"Detection of cytomegalovirus, parvovirus B19 and herpes simplex viruses in cases of intrauterine fetal death: association with pathological findings","volume":"80","author":"Syridou","year":"2008","journal-title":"J Med Virol"},{"key":"10.1016\/j.ajpath.2012.08.003_bib88","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1093\/infdis\/jir121","article-title":"Human cytomegalovirus infection is detected frequently in stillbirths and is associated with fetal thrombotic vasculopathy","volume":"203","author":"Iwasenko","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2012.08.003_bib89","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1093\/infdis\/jir126","article-title":"Have we overlooked congenital cytomegalovirus infection as a cause of stillbirth?","volume":"203","author":"Pereira","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2012.08.003_bib90","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1067\/mpd.2001.112061","article-title":"Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection","volume":"138","author":"Noyola","year":"2001","journal-title":"J Pediatr"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944012005883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944012005883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T12:19:59Z","timestamp":1687695599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944012005883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":90,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0002944012005883"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2012.08.003","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.723819030.793527212","asserted-by":"object"}]},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}