{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:07:54Z","timestamp":1762081674829,"version":"build-2065373602"},"reference-count":52,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":2447,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2012-0005753"],"award-info":[{"award-number":["2012-0005753"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.ajpath.2012.12.022","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T00:01:19Z","timestamp":1360281679000},"page":"1308-1321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Early Regulation of Viral Infection Reduces Inflammation and Rescues Mx-Positive Mice from Lethal Avian Influenza Infection"],"prefix":"10.1016","volume":"182","author":[{"given":"Min-Suk","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Hun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe Noriel Q.","family":"Pascua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Hee","family":"Baek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeok-Il","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ok-Jun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Whi","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunggee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eui-Cheol","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul-Joong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ki","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2012.12.022_bib1","doi-asserted-by":"crossref","first-page":"e1000115","DOI":"10.1371\/journal.ppat.1000115","article-title":"H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice","volume":"4","author":"Perrone","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2012.12.022_bib2","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/nature08260","article-title":"In\u00a0vitro and in\u00a0vivo characterization of new swine-origin H1N1 influenza viruses","volume":"460","author":"Itoh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2012.12.022_bib3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nature05495","article-title":"Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus","volume":"445","author":"Kobasa","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2012.12.022_bib4","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/nm1477","article-title":"Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia","volume":"12","author":"de Jong","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2012.12.022_bib5","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1128\/JVI.02336-06","article-title":"Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice","volume":"81","author":"Szretter","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib6","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1084\/jem.20061377","article-title":"Antiviral defense: interferons and beyond","volume":"203","author":"Stetson","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2012.12.022_bib7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.20506\/rst.17.1.1084","article-title":"Mx proteins: mediators of innate resistance to RNA viruses","volume":"17","author":"Haller","year":"1998","journal-title":"Rev Sci Tech"},{"key":"10.1016\/j.ajpath.2012.12.022_bib8","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.biochi.2007.04.015","article-title":"Interferon-induced Mx proteins in antiviral host defense","volume":"89","author":"Haller","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.ajpath.2012.12.022_bib9","first-page":"4518","article-title":"Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation","volume":"8","author":"Staeheli","year":"1988","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib10","first-page":"851","article-title":"Mx proteins: antiviral proteins by chance or by necessity?","volume":"2","author":"Arnheiter","year":"1990","journal-title":"New Biol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib11","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.4161\/cc.6.19.4779","article-title":"Mx1 gene protects mice against the highly lethal human H5N1 influenza virus","volume":"6","author":"Salomon","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ajpath.2012.12.022_bib12","doi-asserted-by":"crossref","first-page":"10818","DOI":"10.1128\/JVI.01116-07","article-title":"The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses","volume":"81","author":"Tumpey","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.149.3.601","article-title":"Genetically determined, interferon-dependent resistance to influenza virus in mice","volume":"149","author":"Haller","year":"1979","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2012.12.022_bib14","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1128\/jvi.66.4.2564-2569.1992","article-title":"Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle","volume":"66","author":"Pavlovic","year":"1992","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1128\/jvi.56.1.201-206.1985","article-title":"Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product","volume":"56","author":"Krug","year":"1985","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib16","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/nar\/gkh192","article-title":"Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome","volume":"32","author":"Turan","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2012.12.022_bib17","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/j.1460-2075.1992.tb05212.x","article-title":"Mechanism of human MxA protein action: variants with changed antiviral properties","volume":"11","author":"Z\u00fcrcher","year":"1992","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2012.12.022_bib18","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1128\/JVI.06156-11","article-title":"Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival","volume":"86","author":"Cilloniz","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib19","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1073\/pnas.80.7.1910","article-title":"Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus","volume":"80","author":"Horisberger","year":"1983","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2012.12.022_bib20","doi-asserted-by":"crossref","first-page":"12325","DOI":"10.1128\/JVI.01373-09","article-title":"The polymerase acidic protein gene of influenza A virus contributes to pathogenicity in a mouse model","volume":"83","author":"Song","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib21","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/S0021-9258(18)89666-1","article-title":"Polyclonal and monoclonal antibodies to the interferon-inducible protein Mx of influenza virus-resistant mice","volume":"260","author":"Staeheli","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2012.12.022_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(94)90012-4","article-title":"Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications","volume":"174","author":"Van Rooijen","year":"1994","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.ajpath.2012.12.022_bib23","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00436-008-1286-8","article-title":"Differential gene expression profiling in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products","volume":"104","author":"Pak","year":"2009","journal-title":"Parasitol Res"},{"key":"10.1016\/j.ajpath.2012.12.022_bib24","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1128\/JVI.01753-07","article-title":"Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase","volume":"82","author":"Dittmann","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib25","doi-asserted-by":"crossref","first-page":"8133","DOI":"10.1128\/JVI.00712-11","article-title":"The viral nucleoprotein determines Mx sensitivity of influenza A viruses","volume":"85","author":"Zimmermann","year":"2011","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib26","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.4049\/jimmunol.168.7.3195","article-title":"IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking","volume":"168","author":"Dufour","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib27","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1073\/pnas.0931259100","article-title":"PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells","volume":"100","author":"Loke","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2012.12.022_bib28","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/sj.gt.3302958","article-title":"Complete knockdown of CCR5 by lentiviral vector-expressed siRNAs and protection of transgenic macrophages against HIV-1 infection","volume":"14","author":"Anderson","year":"2007","journal-title":"Gene Ther"},{"key":"10.1016\/j.ajpath.2012.12.022_bib29","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/ni735","article-title":"B cells and professional APCs recruit regulatory T cells via CCL4","volume":"2","author":"Bystry","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib30","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1073\/pnas.91.9.3652","article-title":"Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant","volume":"91","author":"Carr","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2012.12.022_bib31","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.171.5.1797","article-title":"Neutrophil-activating properties of the melanoma growth-stimulatory activity","volume":"171","author":"Moser","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2012.12.022_bib32","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1006\/bbrc.1993.1251","article-title":"Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines","volume":"191","author":"Opdenakker","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2012.12.022_bib33","first-page":"273","article-title":"Significant involvement of CCL2 (MCP-1) in inflammatory disorders of the lung","volume":"10","author":"Rose","year":"2003","journal-title":"Microcirculation"},{"key":"10.1016\/j.ajpath.2012.12.022_bib34","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1074\/jbc.M406968200","article-title":"Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2","volume":"280","author":"Solovjov","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2012.12.022_bib35","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1146\/annurev.cellbio.22.010305.104619","article-title":"The interferon-inducible GTPases","volume":"22","author":"Martens","year":"2006","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib36","first-page":"233","article-title":"The interferon-stimulated genes: targets of direct signaling by interferons, double-stranded RNA, and viruses","volume":"316","author":"Sen","year":"2007","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib37","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.molimm.2004.11.008","article-title":"Type I interferons and the innate immune response\u2013more than just antiviral cytokines","volume":"42","author":"Smith","year":"2005","journal-title":"Mol Immunol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib38","doi-asserted-by":"crossref","first-page":"11308","DOI":"10.1128\/JVI.00691-08","article-title":"Gene expression analysis of host innate immune responses during lethal H5N1 infection in ferrets","volume":"82","author":"Cameron","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib39","doi-asserted-by":"crossref","first-page":"7613","DOI":"10.1128\/JVI.00553-10","article-title":"Lethal dissemination of H5N1 influenza virus is associated with dysregulation of inflammation and lipoxin signaling in a mouse model of infection","volume":"84","author":"Cilloniz","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib40","doi-asserted-by":"crossref","first-page":"e1000604","DOI":"10.1371\/journal.ppat.1000604","article-title":"Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes","volume":"5","author":"Cill\u00f3niz","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2012.12.022_bib41","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.immuni.2009.03.011","article-title":"Fighting the flu with inflammasome signaling","volume":"30","author":"Owen","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.ajpath.2012.12.022_bib42","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1465-9921-9-57","article-title":"The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice","volume":"9","author":"Tate","year":"2008","journal-title":"Respir Res"},{"key":"10.1016\/j.ajpath.2012.12.022_bib43","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1172\/JCI0215849","article-title":"Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury","volume":"110","author":"Belperio","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2012.12.022_bib44","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/S0002-9440(10)65068-7","article-title":"Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus","volume":"156","author":"Dawson","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib45","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1089\/jir.2010.0143","article-title":"Susceptibility to infection and inflammatory response following influenza virus (H1N1, A\/PR\/8\/34) challenge: role of macrophages","volume":"31","author":"Murphy","year":"2011","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.ajpath.2012.12.022_bib46","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1128\/JVI.00291-10","article-title":"Critical role of airway macrophages in modulating disease severity during influenza virus infection of mice","volume":"84","author":"Tate","year":"2010","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib47","doi-asserted-by":"crossref","first-page":"14933","DOI":"10.1128\/JVI.79.23.14933-14944.2005","article-title":"Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice","volume":"79","author":"Tumpey","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib48","doi-asserted-by":"crossref","first-page":"e1001304","DOI":"10.1371\/journal.ppat.1001304","article-title":"Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice","volume":"7","author":"Seo","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2012.12.022_bib49","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome","volume":"342","author":"Ware","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2012.12.022_bib50","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1089\/vim.2006.0101","article-title":"CXCR2 is required for neutrophil recruitment to the lung during influenza virus infection, but is not essential for viral clearance","volume":"20","author":"Wareing","year":"2007","journal-title":"Viral Immunol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib51","doi-asserted-by":"crossref","first-page":"6055","DOI":"10.1128\/JVI.00365-12","article-title":"Integrated clinical, pathologic, virologic, and transcriptomic analysis of H5N1 influenza virus-induced viral pneumonia in the rhesus macaque","volume":"86","author":"Shinya","year":"2012","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2012.12.022_bib52","doi-asserted-by":"crossref","first-page":"13445","DOI":"10.1128\/JVI.01682-12","article-title":"Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly","volume":"86","author":"Verhelst","year":"2012","journal-title":"J Virol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013000321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013000321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:03:40Z","timestamp":1762081420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944013000321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0002944013000321"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2012.12.022","relation":{},"ISSN":["0002-9440"],"issn-type":[{"type":"print","value":"0002-9440"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Regulation of Viral Infection Reduces Inflammation and Rescues Mx-Positive Mice from Lethal Avian Influenza Infection","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2012.12.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}