{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:29:09Z","timestamp":1792225749885,"version":"4.4.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":2447,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"crossref","award":["MFAG6211"],"award-info":[{"award-number":["MFAG6211"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"crossref","award":["IG9153"],"award-info":[{"award-number":["IG9153"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Italian Ministry of University and Research"},{"name":"University of Torino"},{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.ajpath.2012.12.023","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T00:02:03Z","timestamp":1360281723000},"page":"1367-1378","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":252,"title":["Autophagic Degradation Contributes to Muscle Wasting in Cancer Cachexia"],"prefix":"10.1016","volume":"182","author":[{"given":"Fabio","family":"Penna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domiziana","family":"Costamagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Pin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Camperi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Fanzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena M.","family":"Chiarpotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Cavallini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Bonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco M.","family":"Baccino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Costelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2012.12.023_bib1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/sj.bjc.6603280","article-title":"The views and practice of oncologists towards nutritional support in patients receiving chemotherapy","volume":"95","author":"Spiro","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajpath.2012.12.023_bib2","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1172\/JCI117929","article-title":"Muscle protein waste in tumor-bearing rats is effectively antagonized by a beta 2-adrenergic agonist (clenbuterol): role of the ATP-ubiquitin-dependent proteolytic pathway","volume":"95","author":"Costelli","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2012.12.023_bib3","doi-asserted-by":"crossref","first-page":"R1518","DOI":"10.1152\/ajpregu.2001.280.5.R1518","article-title":"Increased muscle ubiquitin mRNA levels in gastric cancer patients","volume":"280","author":"Bossola","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0955-0674(98)80068-9","article-title":"Delivery of proteins and organelles to the vacuole from the cytoplasm","volume":"10","author":"Scott","year":"1998","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1247\/csf.27.431","article-title":"Diversity of signaling controls of macroautophagy in mammalian cells","volume":"27","author":"Petiot","year":"2002","journal-title":"Cell Struct Funct"},{"key":"10.1016\/j.ajpath.2012.12.023_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.nu.15.070195.000421","article-title":"Whole-body protein turnover in humans: past, present, and future","volume":"15","author":"Waterlow","year":"1995","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.ajpath.2012.12.023_bib7","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1091\/mbc.e03-09-0704","article-title":"In\u00a0vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker","volume":"15","author":"Mizushima","year":"2004","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ajpath.2012.12.023_bib8","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1083\/jcb.201006098","article-title":"Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice","volume":"191","author":"Paul","year":"2010","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib9","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.biocel.2005.02.029","article-title":"Lysosomal proteolysis in skeletal muscle","volume":"37","author":"Bechet","year":"2005","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib10","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cmet.2007.11.004","article-title":"FoxO3 coordinately activates protein degradation by the autophagic\/lysosomal and proteasomal pathways in atrophying muscle cells","volume":"6","author":"Zhao","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajpath.2012.12.023_bib11","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmet.2007.11.001","article-title":"FoxO3 controls autophagy in skeletal muscle in\u00a0vivo","volume":"6","author":"Mammucari","year":"2007","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajpath.2012.12.023_bib12","first-page":"E996","article-title":"Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma","volume":"268","author":"Baracos","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/abbi.1993.1479","article-title":"Cancer cachexia, malnutrition, and tissue protein turnover in experimental animals","volume":"306","author":"Tessitore","year":"1993","journal-title":"Arch Biochem Biophys"},{"issue":"Pt 1","key":"10.1016\/j.ajpath.2012.12.023_bib14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1042\/bj2990071","article-title":"Pharmacological interference with tissue hypercatabolism in tumour-bearing rats","volume":"299","author":"Tessitore","year":"1994","journal-title":"Biochem J"},{"key":"10.1016\/j.ajpath.2012.12.023_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/bj3600143","article-title":"Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting","volume":"360","author":"Deval","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.ajpath.2012.12.023_bib16","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1042\/cs1020353","article-title":"Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy","volume":"102","author":"Jagoe","year":"2002","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.ajpath.2012.12.023_bib17","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/ijc.24784","article-title":"Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice","volume":"126","author":"Asp","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2012.12.023_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1042\/BJ20112024","article-title":"Myostatin is a novel tumoral factor that induces cancer cachexia","volume":"446","author":"Lokireddy","year":"2012","journal-title":"Biochem J"},{"key":"10.1016\/j.ajpath.2012.12.023_bib19","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1158\/0008-5472.CAN-10-3145","article-title":"Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner","volume":"71","author":"Cosper","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2012.12.023_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1096\/fj.10-164152","article-title":"Toll-like receptor 4 mediates lipopolysaccharide-induced muscle catabolism via coordinate activation of ubiquitin-proteasome and autophagy-lysosome pathways","volume":"25","author":"Doyle","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2012.12.023_bib21","first-page":"201","article-title":"Glucocorticoids and muscle catabolism","volume":"2","author":"Hasselgren","year":"1999","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.ajpath.2012.12.023_bib22","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1210\/en.2004-1594","article-title":"Insulin-like growth factor-I gene transfer by electroporation prevents skeletal muscle atrophy in glucocorticoid-treated rats","volume":"146","author":"Schakman","year":"2005","journal-title":"Endocrinology"},{"issue":"Suppl 1","key":"10.1016\/j.ajpath.2012.12.023_bib23","first-page":"36","article-title":"Mechanisms of muscle atrophy induced by glucocorticoids","volume":"72","author":"Schakman","year":"2009","journal-title":"Horm Res"},{"key":"10.1016\/j.ajpath.2012.12.023_bib24","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/mus.21621","article-title":"Branched-chain amino acids protect against dexamethasone-induced soleus muscle atrophy in rats","volume":"41","author":"Yamamoto","year":"2010","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ajpath.2012.12.023_bib25","doi-asserted-by":"crossref","first-page":"E729","DOI":"10.1152\/ajpendo.00060.2012","article-title":"Role of IGF-I and the TNFalpha\/NF-kappaB pathway in the induction of muscle atrogenes by acute inflammation","volume":"303","author":"Schakman","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2012.12.023_bib26","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.exger.2009.11.002","article-title":"Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise","volume":"45","author":"Wohlgemuth","year":"2010","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib27","article-title":"Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults","author":"Fry","year":"2012","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.ajpath.2012.12.023_bib28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1096\/fj.03-0251com","article-title":"Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization","volume":"18","author":"Langen","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2012.12.023_bib29","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1165\/rcmb.2006-0103OC","article-title":"Muscle wasting and impaired muscle regeneration in a murine model of chronic pulmonary inflammation","volume":"35","author":"Langen","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4161\/auto.5338","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes","volume":"4","author":"Klionsky","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.ajpath.2012.12.023_bib31","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.tcb.2010.03.002","article-title":"The Beclin 1-VPS34 complex: at the crossroads of autophagy and beyond","volume":"20","author":"Funderburk","year":"2010","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0076-6879(08)03612-4","article-title":"Monitoring autophagic degradation of p62\/SQSTM1","volume":"452","author":"Bjorkoy","year":"2009","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib33","doi-asserted-by":"crossref","first-page":"929","DOI":"10.4161\/auto.6.7.12785","article-title":"Quantitation of \u201cautophagic flux\u201d in mature skeletal muscle","volume":"6","author":"Ju","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.ajpath.2012.12.023_bib34","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1523\/JNEUROSCI.23-08-03316.2003","article-title":"Parkin binds to alpha\/beta tubulin and increases their ubiquitination and degradation","volume":"23","author":"Ren","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.ajpath.2012.12.023_bib35","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0531-5565(03)00002-0","article-title":"Ageing-related changes in the in\u00a0vivo function of rat liver macroautophagy and proteolysis","volume":"38","author":"Del Roso","year":"2003","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/cyto.2002.1036","article-title":"Anticytokine treatment prevents the increase in the activity of ATP-ubiquitin- and Ca(2+)-dependent proteolytic systems in the muscle of tumour-bearing rats","volume":"19","author":"Costelli","year":"2002","journal-title":"Cytokine"},{"key":"10.1016\/j.ajpath.2012.12.023_bib37","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1006\/bbrc.1996.0651","article-title":"Anti-TNF treatment reverts increased muscle ubiquitin gene expression in tumour-bearing rats","volume":"221","author":"Llovera","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2012.12.023_bib38","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1096\/fj.06-7537com","article-title":"TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine","volume":"21","author":"Dogra","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2012.12.023_bib39","doi-asserted-by":"crossref","first-page":"C986","DOI":"10.1152\/ajpcell.00041.2008","article-title":"TNF induction of atrogin-1\/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1\/3 signaling","volume":"295","author":"Moylan","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib40","doi-asserted-by":"crossref","first-page":"585","DOI":"10.4161\/auto.5.5.8823","article-title":"In search of an \u201cautophagomometer\u201d","volume":"5","author":"Rubinsztein","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.ajpath.2012.12.023_bib41","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/SPC.0b013e3283196ac2","article-title":"Role of the ubiquitin-proteasome pathway in muscle atrophy in cachexia","volume":"2","author":"Attaix","year":"2008","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.1016\/j.ajpath.2012.12.023_bib42","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1158\/1078-0432.CCR-06-2307","article-title":"Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome","volume":"13","author":"Acharyya","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2012.12.023_bib43","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/sj.bjc.6602780","article-title":"Expression of the ubiquitin-proteasome pathway and muscle loss in experimental cancer cachexia","volume":"93","author":"Khal","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajpath.2012.12.023_bib44","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1038\/emboj.2011.292","article-title":"C\/EBPbeta mediates tumour-induced ubiquitin ligase atrogin1\/MAFbx upregulation and muscle wasting","volume":"30","author":"Zhang","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2012.12.023_bib45","doi-asserted-by":"crossref","first-page":"555","DOI":"10.4161\/auto.7.5.15102","article-title":"TRAF6 coordinates the activation of autophagy and ubiquitin-proteasome systems in atrophying skeletal muscle","volume":"7","author":"Paul","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.ajpath.2012.12.023_bib46","doi-asserted-by":"crossref","first-page":"378","DOI":"10.4161\/auto.5633","article-title":"Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor","volume":"4","author":"Zhao","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.ajpath.2012.12.023_bib47","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4161\/auto.7.3.14487","article-title":"Selective autophagy mediated by autophagic adapter proteins","volume":"7","author":"Johansen","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.ajpath.2012.12.023_bib48","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.jacc.2010.01.075","article-title":"Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy","volume":"56","author":"Zheng","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib49","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1091\/mbc.e02-02-0114","article-title":"Role of LAMP-2 in lysosome biogenesis and autophagy","volume":"13","author":"Eskelinen","year":"2002","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ajpath.2012.12.023_bib50","doi-asserted-by":"crossref","first-page":"R1231","DOI":"10.1152\/ajpregu.90478.2008","article-title":"Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia","volume":"295","author":"Hepple","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib51","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.cmet.2009.10.008","article-title":"Autophagy is required to maintain muscle mass","volume":"10","author":"Masiero","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajpath.2012.12.023_bib52","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1053\/j.gastro.2011.04.038","article-title":"Functions of autophagy in hepatic and pancreatic physiology and disease","volume":"140","author":"Czaja","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2012.12.023_bib53","doi-asserted-by":"crossref","first-page":"4297","DOI":"10.4161\/cc.9.21.13817","article-title":"The autophagic tumor stroma model of cancer or \u201cbattery-operated tumor growth\u201d: a simple solution to the autophagy paradox","volume":"9","author":"Martinez-Outschoorn","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ajpath.2012.12.023_bib54","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1517\/14712598.2010.503773","article-title":"Anti-cytokine strategies for the treatment of cancer-related anorexia and cachexia","volume":"10","author":"Penna","year":"2010","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.ajpath.2012.12.023_bib55","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/SPC.0b013e3283311d09","article-title":"The role of cytokines in cancer cachexia","volume":"3","author":"Argiles","year":"2009","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.1016\/j.ajpath.2012.12.023_bib56","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/jcp.22821","article-title":"TWEAK causes myotube atrophy through coordinated activation of ubiquitin-proteasome system, autophagy, and caspases","volume":"227","author":"Bhatnagar","year":"2012","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2012.12.023_bib57","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1002\/ijc.25146","article-title":"Muscle atrophy in experimental cancer cachexia: is the IGF-1 signaling pathway involved?","volume":"127","author":"Penna","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2012.12.023_bib58","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s13539-011-0029-3","article-title":"IGF-1 treatment reduces weight loss and improves outcome in a rat model of cancer cachexia","volume":"2","author":"Schmidt","year":"2011","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ajpath.2012.12.023_bib59","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.devcel.2011.09.011","article-title":"The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling","volume":"21","author":"Shi","year":"2011","journal-title":"Dev Cell"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013000333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013000333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:40:38Z","timestamp":1757601638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944013000333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0002944013000333"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2012.12.023","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagic Degradation Contributes to Muscle Wasting in Cancer Cachexia","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2012.12.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}