{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:03:51Z","timestamp":1769583831682,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.ajpath.2013.01.015","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T14:46:07Z","timestamp":1362581167000},"page":"1832-1842","source":"Crossref","is-referenced-by-count":20,"title":["Protective Roles of Epithelial Cells in the Survival of Adult T-Cell Leukemia\/Lymphoma Cells"],"prefix":"10.1016","volume":"182","author":[{"given":"Yukiko","family":"Miyatake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 L.A.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Ali","family":"Jarboui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utano","family":"Tomaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Teshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Kasahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2013.01.015_bib1","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1073\/pnas.77.12.7415","article-title":"Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma","volume":"77","author":"Poiesz","year":"1980","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2013.01.015_bib2","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1073\/pnas.79.6.2031","article-title":"Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease","volume":"79","author":"Yoshida","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2013.01.015_bib3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T-cell leukemia: clinical and hematologic features of 16 cases","volume":"50","author":"Uchiyama","year":"1977","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.01.015_bib4","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/j.1365-4632.2010.04568.x","article-title":"Cutaneous manifestations associated with HTLV-1 infection","volume":"49","author":"Bittencourt","year":"2010","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib5","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1349-7006.2007.00456.x","article-title":"Pathological features of diseases associated with human T-cell leukemia virus type I","volume":"98","author":"Ohshima","year":"2007","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ajpath.2013.01.015_bib6","doi-asserted-by":"crossref","first-page":"750","DOI":"10.3390\/v3060750","article-title":"Controversies in targeted therapy of adult T cell leukemia\/lymphoma: ON target or OFF target effects?","volume":"3","author":"Nasr","year":"2011","journal-title":"Viruses"},{"key":"10.1016\/j.ajpath.2013.01.015_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1742-4690-2-64","article-title":"Silencing of human T-cell leukemia virus type I gene transcription by epigenetic mechanisms","volume":"2","author":"Taniguchi","year":"2005","journal-title":"Retrovirology"},{"key":"10.1016\/j.ajpath.2013.01.015_bib8","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1182\/blood.V85.7.1865.bloodjournal8571865","article-title":"Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells","volume":"85","author":"Furukawa","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.01.015_bib9","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1128\/JVI.65.3.1628-1633.1991","article-title":"Human T-cell leukemia-lymphoma virus type I (HTLV-I) expression in fresh peripheral blood mononuclear cells from patients with tropical spastic paraparesis\/HTLV-I-associated myelopathy","volume":"65","author":"Gessain","year":"1991","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s12185-008-0207-z","article-title":"Adhesion-dependent growth of primary adult T cell leukemia cells with down-regulation of HTLV-I p40Tax protein: a novel in\u00a0vitro model of the growth of acute ATL cells","volume":"88","author":"Nagai","year":"2008","journal-title":"Int J Hematol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib11","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1128\/JVI.02564-08","article-title":"Stromal cell-mediated suppression of human T-cell leukemia virus type 1 expression in\u00a0vitro and in\u00a0vivo by type I interferon","volume":"83","author":"Kinpara","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.virol.2006.07.002","article-title":"Histone acetyltransferase (HAT) activity of p300 modulates human T lymphotropic virus type 1 p30II-mediated repression of LTR transcriptional activity","volume":"354","author":"Michael","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.ajpath.2013.01.015_bib13","doi-asserted-by":"crossref","first-page":"7241","DOI":"10.1038\/sj.onc.1205701","article-title":"The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression","volume":"21","author":"Ego","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2013.01.015_bib14","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1182\/blood-2006-03-013235","article-title":"Histone deacetylase inhibitors increase virus gene expression but decrease CD8+ cell antiviral function in HTLV-1 infection","volume":"108","author":"Mosley","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.01.015_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2141.1996.00305.x","article-title":"Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in\u00a0vitro","volume":"92","author":"Panayiotidis","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib16","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1182\/blood.V91.7.2387","article-title":"Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells","volume":"91","author":"Lagneaux","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.01.015_bib17","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1182\/blood.V96.8.2655","article-title":"Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1","volume":"96","author":"Burger","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.01.015_bib18","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1182\/blood-2008-11-189308","article-title":"Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice","volume":"114","author":"Kawaguchi","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.01.015_bib19","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1083\/jcb.121.5.1141","article-title":"Epiligrin, a component of epithelial basement membranes, is an adhesive ligand for alpha 3 beta 1 positive T lymphocytes","volume":"121","author":"Wayner","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib20","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.exphem.2005.06.024","article-title":"KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity","volume":"33","author":"Suck","year":"2005","journal-title":"Exp Hematol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1742-4690-3-20","article-title":"Functional analysis of human T lymphotropic virus type 2 Tax proteins","volume":"3","author":"Sheehy","year":"2006","journal-title":"Retrovirology"},{"key":"10.1016\/j.ajpath.2013.01.015_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1152\/japplphysiol.00011.2003","article-title":"Exercise-induced changes to in\u00a0vitro T-lymphocyte mitogen responses using CFSE","volume":"95","author":"Green","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib23","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.ajpath.2013.01.015_bib24","first-page":"4266","article-title":"Sp3, but not Sp1, mediates the transcriptional activation of the p21\/WAF1\/Cip1 gene promoter by histone deacetylase inhibitor","volume":"59","author":"Sowa","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.01.015_bib25","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","article-title":"The epithelial-mesenchymal transition generates cells with properties of stem cells","volume":"133","author":"Mani","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2013.01.015_bib26","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1128\/MCB.6.11.3614","article-title":"Coding sequence and growth regulation of the human vimentin gene","volume":"6","author":"Ferrari","year":"1986","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib27","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1038\/emboj.2011.211","article-title":"Direct reprogramming of stem cell properties in colon cancer cells by CD44","volume":"30","author":"Su","year":"2011","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2013.01.015_bib28","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1083\/jcb.200812060","article-title":"Acetylation and activation of STAT3 mediated by nuclear translocation of CD44","volume":"185","author":"Lee","year":"2009","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S1074-7613(03)00272-3","article-title":"Stress management: MHC class I and class I like molecules as reporters of cellular stress","volume":"19","author":"Gleimer","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.ajpath.2013.01.015_bib30","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nri2604","article-title":"Oncogenic stress sensed by the immune system: role of natural killer cell receptors","volume":"9","author":"Raulet","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib31","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.285.5428.727","article-title":"Activation of NK cells and T cells by NKG2D, a receptor for stress inducible MICA","volume":"285","author":"Bauer","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2013.01.015_bib32","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1093\/jnci\/92.15.1210","article-title":"Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells","volume":"92","author":"Marks","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ajpath.2013.01.015_bib33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.it.2011.04.001","article-title":"Histone deacetylases as regulators of inflammation and immunity","volume":"32","author":"Shakespear","year":"2011","journal-title":"Trends Immunol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.canlet.2008.06.005","article-title":"Histone deacetylase inhibitors and genomic instability","volume":"274","author":"Eot-Houllier","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ajpath.2013.01.015_bib35","doi-asserted-by":"crossref","first-page":"346972","DOI":"10.1155\/2012\/346972","article-title":"Hyaluronan regulates cell behavior: a potential niche matrix for stem cells","volume":"2012","author":"Solis","year":"2012","journal-title":"Biochem Res Int"},{"key":"10.1016\/j.ajpath.2013.01.015_bib36","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.leukres.2011.05.011","article-title":"Involvement of osteopontin and its signaling molecule CD44 in clinicopathological features of adult T cell leukemia","volume":"35","author":"Chagan-Yasutan","year":"2011","journal-title":"Leuk Res"},{"key":"10.1016\/j.ajpath.2013.01.015_bib37","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1200\/JCO.2006.10.2434","article-title":"Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma","volume":"25","author":"Olsen","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajpath.2013.01.015_bib38","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1182\/blood-2010-10-312603","article-title":"Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma","volume":"117","author":"Piekarz","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.01.015_bib39","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.leukres.2007.05.026","article-title":"Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected T-cells via blockade of signaling by nuclear factor kappaB","volume":"32","author":"Nishioka","year":"2008","journal-title":"Leuk Res"},{"key":"10.1016\/j.ajpath.2013.01.015_bib40","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/leu.2010.315","article-title":"LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia\/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway","volume":"25","author":"Hasegawa","year":"2011","journal-title":"Leukemia"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013000990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013000990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T08:38:30Z","timestamp":1595493510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944013000990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0002944013000990"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2013.01.015","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}