{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:33:29Z","timestamp":1791660809793,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":2901,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.ajpath.2013.02.009","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T23:44:55Z","timestamp":1368575095000},"page":"2147-2154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["VEGF Induces TGF-\u03b21 Expression and Myofibroblast Transformation after Glaucoma Surgery"],"prefix":"10.1016","volume":"182","author":[{"given":"Hae-Young L.","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Kee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2013.02.009_bib1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/archopht.1983.01040010795021","article-title":"Histologic characteristics of filtering blebs in glaucomatous eyes","volume":"101","author":"Addicks","year":"1983","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajpath.2013.02.009_bib2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/archopht.1988.01060130095036","article-title":"Cellular proliferation after experimental glaucoma filtration surgery","volume":"106","author":"Jampel","year":"1988","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajpath.2013.02.009_bib3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrm809","article-title":"Myofibroblasts and mechano-regulation of connective tissue remodelling","volume":"3","author":"Tomasek","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2013.02.009_bib4","first-page":"2123","article-title":"TGF-beta-induced interleukin-6 participates in transdifferentiation of human Tenon\u2019s fibroblasts to myofibroblasts","volume":"15","author":"Seong","year":"2009","journal-title":"Mol Vis"},{"key":"10.1016\/j.ajpath.2013.02.009_bib5","first-page":"1880","article-title":"Suppression of transforming growth factor-beta effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor","volume":"16","author":"Sapitro","year":"2010","journal-title":"Mol Vis"},{"key":"10.1016\/j.ajpath.2013.02.009_bib6","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.1167\/iovs.10-6679","article-title":"Extracellular matrix elasticity modulates TGF-beta-induced p38 activation and myofibroblast transdifferentiation in human tenon fibroblasts","volume":"52","author":"Meyer-ter-Vehn","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2013.02.009_bib7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/380435a0","article-title":"Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele","volume":"380","author":"Carmeliet","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2013.02.009_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.jidsymp.5650016","article-title":"Molecular mechanisms of VEGF-A action during tissue repair","volume":"11","author":"Eming","year":"2006","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1016\/j.ajpath.2013.02.009_bib9","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.ajpath.2013.02.009_bib10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/labinvest.2008.36","article-title":"Regulation of scar formation by vascular endothelial growth factor","volume":"88","author":"Wilgus","year":"2008","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2013.02.009_bib11","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.exer.2011.08.016","article-title":"The role of different VEGF isoforms in scar formation after glaucoma filtration surgery","volume":"93","author":"Van Bergen","year":"2011","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajpath.2013.02.009_bib12","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1167\/iovs.08-2662","article-title":"Inhibition of vascular endothelial growth factor reduces scar formation after glaucoma filtration surgery","volume":"50","author":"Li","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2013.02.009_bib13","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ajo.2011.08.005","article-title":"Subconjunctival bevacizumab versus mitomycin C adjunctive to trabeculectomy","volume":"153","author":"Nilforushan","year":"2012","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajpath.2013.02.009_bib14","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1038\/sj.emboj.7601421","article-title":"Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney","volume":"25","author":"Boutet","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2013.02.009_bib15","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.bbrc.2005.07.005","article-title":"VEGF induces proliferation, migration, and TGF-beta1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol 3-kinase","volume":"334","author":"Li","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2013.02.009_bib16","doi-asserted-by":"crossref","first-page":"33213","DOI":"10.1074\/jbc.M403758200","article-title":"Transforming growth factor-beta1 stimulates vascular endothelial growth factor 164 via mitogen-activated protein kinase kinase 3-p38alpha and p38delta mitogen-activated protein kinase-dependent pathway in murine mesangial cells","volume":"279","author":"Wang","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2013.02.009_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1001\/archopht.1993.01090020117035","article-title":"Prolonged localized tissue effects from 5-minute exposures to fluorouracil and mitomycin C","volume":"111","author":"Khaw","year":"1993","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajpath.2013.02.009_bib18","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0079-6123(08)01117-5","article-title":"Modulation of wound healing during and after glaucoma surgery","volume":"173","author":"Georgoulas","year":"2008","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.ajpath.2013.02.009_bib19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00055735-200004000-00010","article-title":"Wound healing modulation after glaucoma surgery","volume":"11","author":"Cordeiro","year":"2000","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.ajpath.2013.02.009_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1083\/jcb.122.1.103","article-title":"Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts","volume":"122","author":"Desmouliere","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2013.02.009_bib21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ceb.2007.02.015","article-title":"Negative regulation of TGF-beta receptor\/Smad signal transduction","volume":"19","author":"Itoh","year":"2007","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.ajpath.2013.02.009_bib22","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1183\/09031936.00125007","article-title":"Inhibition of VEGF blocks TGF-beta1 production through a PI3K\/Akt signalling pathway","volume":"31","author":"Lee","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2013.02.009_bib23","first-page":"1517","article-title":"Levels of vascular endothelial growth factor-A165b (VEGF-A165b) are elevated in experimental glaucoma","volume":"14","author":"Ergorul","year":"2008","journal-title":"Mol Vis"},{"key":"10.1016\/j.ajpath.2013.02.009_bib24","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0161-6420(98)92782-8","article-title":"Increased level of vascular endothelial growth factor in aqueous humor of patients with neovascular glaucoma","volume":"105","author":"Tripathi","year":"1998","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajpath.2013.02.009_bib25","article-title":"The level of vascular endothelial growth factor in Tenon\u2019s tissue and the results of glaucoma surgery","author":"Park","year":"2013","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajpath.2013.02.009_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/00055735-200104000-00011","article-title":"Modulation of wound healing after glaucoma surgery","volume":"12","author":"Khaw","year":"2001","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.ajpath.2013.02.009_bib27","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/j.ophtha.2008.06.009","article-title":"Evaluation of subconjunctival bevacizumab as an adjunct to trabeculectomy a pilot study","volume":"115","author":"Grewal","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajpath.2013.02.009_bib28","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s12325-008-0047-5","article-title":"Surgical outcome of intravitreal bevacizumab and filtration surgery in neovascular glaucoma","volume":"25","author":"Kitnarong","year":"2008","journal-title":"Adv Ther"},{"key":"10.1016\/j.ajpath.2013.02.009_bib29","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/IJG.0b013e3181d9ce12","article-title":"Combined intravitreal bevacizumab and trabeculectomy with mitomycin C versus trabeculectomy with mitomycin C alone for neovascular glaucoma","volume":"20","author":"Takihara","year":"2011","journal-title":"J Glaucoma"},{"key":"10.1016\/j.ajpath.2013.02.009_bib30","doi-asserted-by":"crossref","first-page":"6524","DOI":"10.1167\/iovs.10-5669","article-title":"Antifibrotic activity of bevacizumab on human Tenon\u2019s fibroblasts in\u00a0vitro","volume":"51","author":"O\u2019Neill","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013001867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013001867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:44:45Z","timestamp":1757601885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944013001867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0002944013001867"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2013.02.009","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VEGF Induces TGF-\u03b21 Expression and Myofibroblast Transformation after Glaucoma Surgery","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2013.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}