{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:09:20Z","timestamp":1790838560509,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":2325,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["01GS0850"],"award-info":[{"award-number":["01GS0850"]}]},{"name":"German Federal Ministry of Education and Research","award":["01GS0851"],"award-info":[{"award-number":["01GS0851"]}]},{"name":"German Federal Ministry of Education and Research","award":["01GS0852"],"award-info":[{"award-number":["01GS0852"]}]},{"name":"German Federal Ministry of Education and Research","award":["01GS0868"],"award-info":[{"award-number":["01GS0868"]}]},{"name":"Infrafrontier","award":["01KX1012"],"award-info":[{"award-number":["01KX1012"]}]},{"name":"OSTEOPATH","award":["01EC1006B"],"award-info":[{"award-number":["01EC1006B"]}]},{"name":"German Center for Diabetes Research"},{"name":"EU ANABONOS","award":["LSH-2002-2.1.4-3"],"award-info":[{"award-number":["LSH-2002-2.1.4-3"]}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.ajpath.2013.04.027","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T05:01:20Z","timestamp":1371618080000},"page":"352-368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["An ENU Mutagenesis-Derived Mouse Model with a Dominant Jak1 Mutation Resembling Phenotypes of Systemic Autoimmune Disease"],"prefix":"10.1016","volume":"183","author":[{"given":"Sibylle","family":"Sabrautzki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Janas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Lorenz-Depiereux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Calzada-Wack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Aguilar-Pimentel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Rathkolb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thure","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Cohrs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Diener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Gailus-Durner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk H.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"H\u00f6fler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Ollert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim M.","family":"Strom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhard","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Neff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hrab\u011b de Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2013.04.027_bib1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1086\/428480","article-title":"Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus","volume":"76","author":"Sigurdsson","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajpath.2013.04.027_bib2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007260","article-title":"The immunogenetic architecture of autoimmune disease","volume":"4","author":"Goris","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/1523-1747.ep12298305","article-title":"Spontaneous autoimmune skin lesions of MRL\/n mice: autoimmune disease-prone genetic background in relation to Fas-defect MRL\/1pr mice","volume":"107","author":"Furukawa","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib4","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.4049\/jimmunol.158.12.6019","article-title":"Functional dissection of systemic lupus erythematosus using congenic mouse strains","volume":"158","author":"Morel","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.it.2009.06.003","article-title":"Induction of autoimmunity by pristane and other naturally occurring hydrocarbons","volume":"30","author":"Reeves","year":"2009","journal-title":"Trends Immunol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/301527a0","article-title":"A severe combined immunodeficiency mutation in the mouse","volume":"301","author":"Bosma","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2013.04.027_bib7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/oxfordjournals.jhered.a108625","article-title":"Motheaten, an immunodeficient mutant of the mouse, I: genetics and pathology","volume":"66","author":"Green","year":"1975","journal-title":"J Hered"},{"key":"10.1016\/j.ajpath.2013.04.027_bib8","first-page":"2401","article-title":"A new mutant hairless mouse with lymph node hyperplasia and late onset of autoimmune pathology","volume":"27","author":"Massironi","year":"1994","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.ajpath.2013.04.027_bib9","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1182\/blood-2005-09-3556","article-title":"Mutation of mouse Mayp\/Pstpip2 causes a macrophage autoinflammatory disease","volume":"107","author":"Grosse","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.04.027_bib10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4049\/jimmunol.1100657","article-title":"A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis","volume":"188","author":"Alli","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib11","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/jid.2011.463","article-title":"A mouse model of vitiligo with focused epidermal depigmentation requires IFN-\u03b3 for autoreactive CD8+ T-cell accumulation in the skin","volume":"132","author":"Harris","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/path.4023","article-title":"Genetic identification and functional validation of Fc\u03b3RIV as key molecule in autoantibody-induced tissue injury","volume":"228","author":"Kasperkiewicz","year":"2012","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib13","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.bcp.2006.04.013","article-title":"Jaks and cytokine receptors: an intimate relationship","volume":"72","author":"Haan","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib14","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.4049\/jimmunol.178.5.2623","article-title":"The JAK-STAT signaling pathway: input and output integration","volume":"178","author":"Murray","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib15","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1182\/blood-2009-09-245498","article-title":"ALL-associated JAK1 mutations confer hypersensitivity to the antiproliferative effect of type I interferon","volume":"115","author":"Hornakova","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.04.027_bib16","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3324\/haematol.2010.036350","article-title":"Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors","volume":"96","author":"Hornakova","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.ajpath.2013.04.027_bib17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.semcdb.2008.07.002","article-title":"JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies","volume":"19","author":"Vainchenker","year":"2008","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib18","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s00335-012-9397-z","article-title":"New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis","volume":"23","author":"Sabrautzki","year":"2012","journal-title":"Mamm Genome"},{"key":"10.1016\/j.ajpath.2013.04.027_bib19","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/78146","article-title":"Genome-wide, large-scale production of mutant mice by ENU mutagenesis","volume":"25","author":"Hrabe de Angelis","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajpath.2013.04.027_bib20","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00335-011-9328-4","article-title":"Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters","volume":"22","author":"Aigner","year":"2011","journal-title":"Mamm Genome"},{"key":"10.1016\/j.ajpath.2013.04.027_bib21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1258\/0023677021911740","article-title":"Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units","volume":"36","author":"Nicklas","year":"2002","journal-title":"Lab Anim"},{"key":"10.1016\/j.ajpath.2013.04.027_bib22","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00335-012-9415-1","article-title":"Innovations in phenotyping of mouse models in the German Mouse Clinic","volume":"23","author":"Fuchs","year":"2012","journal-title":"Mamm Genome"},{"key":"10.1016\/j.ajpath.2013.04.027_bib23","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nmeth0605-403","article-title":"Introducing the German Mouse Clinic: open access platform for standardized phenotyping","volume":"2","author":"Gailus-Durner","year":"2005","journal-title":"Nat Methods"},{"key":"10.1016\/j.ajpath.2013.04.027_bib24","doi-asserted-by":"crossref","first-page":"e38310","DOI":"10.1371\/journal.pone.0038310","article-title":"Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system","volume":"7","author":"Staropoli","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2013.04.027_bib25","first-page":"993","article-title":"Silver impregnation of reticulum in paraffin sections","volume":"13","author":"G\u00f6m\u00f6ri","year":"1937","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib26","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1242\/jcs.02798","article-title":"Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species","volume":"119","author":"Ateghang","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2013.04.027_bib27","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s003350010104","article-title":"The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes","volume":"11","author":"Rathkolb","year":"2000","journal-title":"Mamm Genome"},{"key":"10.1016\/j.ajpath.2013.04.027_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00335-005-0119-7","article-title":"Genotype-specific environmental impact on the variance of blood values in inbred and F1 hybrid mice","volume":"17","author":"Klempt","year":"2006","journal-title":"Mamm Genome"},{"key":"10.1016\/j.ajpath.2013.04.027_bib29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cyto.a.21015","article-title":"SPICE: exploration and analysis of post-cytometric complex multivariate datasets","volume":"79","author":"Roederer","year":"2011","journal-title":"Cytometry A"},{"key":"10.1016\/j.ajpath.2013.04.027_bib30","doi-asserted-by":"crossref","first-page":"W496","DOI":"10.1093\/nar\/gki430","article-title":"ARTS: a web-based tool for the set-up of high-throughput genome-wide mapping panels for the SNP genotyping of mouse mutants","volume":"33","author":"Klaften","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2013.04.027_bib31","doi-asserted-by":"crossref","first-page":"R82","DOI":"10.1186\/gb-2009-10-8-r82","article-title":"Whole genome sequencing of a single Bos taurus animal for single nucleotide polymorphism discovery","volume":"10","author":"Eck","year":"2009","journal-title":"Genome Biol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib32","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1101\/gr.078212.108","article-title":"Mapping short DNA sequencing reads and calling variants using mapping quality scores","volume":"18","author":"Li","year":"2008","journal-title":"Genome Res"},{"key":"10.1016\/j.ajpath.2013.04.027_bib33","doi-asserted-by":"crossref","first-page":"6132","DOI":"10.1074\/jbc.273.11.6132","article-title":"Autoregulation of the Stat3 gene through cooperation with a cAMP-responsive element-binding protein","volume":"273","author":"Ichiba","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2013.04.027_bib34","doi-asserted-by":"crossref","first-page":"20423","DOI":"10.1073\/pnas.0910371106","article-title":"Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling","volume":"106","author":"Pflegerl","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2013.04.027_bib35","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/j.1460-2075.1995.tb07128.x","article-title":"A major role for the protein tyrosine kinase JAK1 in the JAK\/STAT signal transduction pathway in response to interleukin-6","volume":"14","author":"Guschin","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2013.04.027_bib36","doi-asserted-by":"crossref","first-page":"22574","DOI":"10.1074\/jbc.M907658199","article-title":"Phosphorylation of human gp130 at Ser-782 adjacent to the Di-leucine internalization motif: effects on expression and signaling","volume":"275","author":"Gibson","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2013.04.027_bib37","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1126\/science.8511589","article-title":"IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase","volume":"260","author":"Murakami","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2013.04.027_bib38","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.3748\/wjg.v17.i11.1400","article-title":"Nodular regenerative hyperplasia: evolving concepts on underdiagnosed cause of portal hypertension","volume":"17","author":"Hartleb","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib39","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1432-1033.1991.tb16438.x","article-title":"Post-transcriptional regulation of the transferrin receptor and 4F2 antigen heavy chain mRNA during growth activation of spleen cells","volume":"202","author":"Teixeira","year":"1991","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.ajpath.2013.04.027_bib40","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/stem.5530120502","article-title":"The activation antigen CD69","volume":"12","author":"Ziegler","year":"1994","journal-title":"Stem Cells"},{"key":"10.1016\/j.ajpath.2013.04.027_bib41","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.bcp.2011.12.024","article-title":"The many faces of Janus kinase","volume":"83","author":"Seavey","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib42","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1084\/jem.20072182","article-title":"Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia","volume":"205","author":"Flex","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2013.04.027_bib43","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/nature03546","article-title":"A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera","volume":"434","author":"James","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2013.04.027_bib44","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1182\/blood-2005-05-1889","article-title":"Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2","volume":"106","author":"Kralovics","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.04.027_bib45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00062752-200701000-00009","article-title":"JAK-2 mutations and their relevance to myeloproliferative disease","volume":"14","author":"Levine","year":"2007","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib46","doi-asserted-by":"crossref","first-page":"9414","DOI":"10.1073\/pnas.0811761106","article-title":"JAK mutations in high-risk childhood acute lymphoblastic leukemia","volume":"106","author":"Mullighan","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2013.04.027_bib47","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0092-8674(00)81166-6","article-title":"Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses","volume":"93","author":"Rodig","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2013.04.027_bib48","first-page":"271694","article-title":"Murine models of systemic lupus erythematosus","volume":"2011","author":"Perry","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib49","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.autrev.2005.01.006","article-title":"Animal models of spontaneous and drug-induced cutaneous lupus erythematosus","volume":"4","author":"Furukawa","year":"2005","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.ajpath.2013.04.027_bib50","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1177\/0961203310369681","article-title":"Autoantibodies to double-stranded DNA: intermethod comparison between four commercial immunoassays and a research biosensor-based device","volume":"19","author":"Fiegel","year":"2010","journal-title":"Lupus"},{"key":"10.1016\/j.ajpath.2013.04.027_bib51","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1177\/0961203312444771","article-title":"Male versus female lupus: a comparison of ethnicity, clinical features, serology and outcome over a 30 year period","volume":"21","author":"Renau","year":"2012","journal-title":"Lupus"},{"key":"10.1016\/j.ajpath.2013.04.027_bib52","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3899\/jrheum.090194","article-title":"Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus","volume":"37","author":"Cash","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib53","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/ar3349","article-title":"Cytokine disturbances in systemic lupus erythematosus","volume":"13","author":"Jacob","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.ajpath.2013.04.027_bib54","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1191\/0961203305lu2134oa","article-title":"Anti-cytokine therapy in systemic lupus erythematosus","volume":"14","author":"Smolen","year":"2005","journal-title":"Lupus"},{"key":"10.1016\/j.ajpath.2013.04.027_bib55","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1056\/NEJM197907053010102","article-title":"Immune interferon in the circulation of patients with autoimmune disease","volume":"301","author":"Hooks","year":"1979","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2013.04.027_bib56","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2133.1987.tb04111.x","article-title":"Serum interferon in systemic lupus erythematosus","volume":"117","author":"Shi","year":"1987","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib57","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1002\/art.23023","article-title":"Deficiency of the type I interferon receptor protects mice from experimental lupus","volume":"56","author":"Nacionales","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ajpath.2013.04.027_bib58","doi-asserted-by":"crossref","first-page":"e41414","DOI":"10.1371\/journal.pone.0041414","article-title":"Constitutive phosphorylation of interferon receptor A-associated signaling proteins in systemic lupus erythematosus","volume":"7","author":"Ramirez-Velez","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2013.04.027_bib59","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/09612033707076513","article-title":"Unique hepatic imaging features in a patient with nodular regenerative hyperplasia of the liver associating with systemic lupus erythematosus","volume":"16","author":"Leung","year":"2007","journal-title":"Lupus"},{"key":"10.1016\/j.ajpath.2013.04.027_bib60","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4103\/0377-4929.77319","article-title":"Liver pathology in collagen vascular disorders highlighting the vascular changes within portal tracts","volume":"54","author":"Vaiphei","year":"2011","journal-title":"Indian J Pathol Microbiol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib61","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1034\/j.1600-0676.2000.020005366.x","article-title":"The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver","volume":"20","author":"Matsumoto","year":"2000","journal-title":"Liver"},{"key":"10.1016\/j.ajpath.2013.04.027_bib62","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/0046-8177(92)90033-Y","article-title":"The liver in systemic lupus erythematosus: pathologic analysis of 52 cases and review of Japanese Autopsy Registry Data","volume":"23","author":"Matsumoto","year":"1992","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib63","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/ard.45.2.167","article-title":"Systemic lupus erythematosus and nodular regenerative hyperplasia of the liver","volume":"45","author":"Klemp","year":"1986","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.ajpath.2013.04.027_bib64","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1093\/emboj\/17.19.5588","article-title":"Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver","volume":"17","author":"Maione","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2013.04.027_bib65","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/01926230701230296","article-title":"A comprehensive antibody panel for immunohistochemical analysis of formalin-fixed, paraffin-embedded hematopoietic neoplasms of mice: analysis of mouse specific and human antibodies cross-reactive with murine tissue","volume":"35","author":"Kunder","year":"2007","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib66","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1182\/blood.V100.1.246","article-title":"Bethesda proposals for classification of lymphoid neoplasms in mice","volume":"100","author":"Morse","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.04.027_bib67","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.4049\/jimmunol.141.9.3043","article-title":"Production of B cell-stimulating factors by B cells in patients with systemic lupus erythematosus","volume":"141","author":"Tanaka","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib68","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/art.1780340305","article-title":"In\u00a0vitro regulation of B cell differentiation by interleukin-6 and soluble CD23 in systemic lupus erythematosus B cell subpopulations and antigen-induced normal B cells","volume":"34","author":"Klashman","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ajpath.2013.04.027_bib69","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/intimm\/3.3.273","article-title":"Age-associated increase in interleukin 6 in MRL\/lpr mice","volume":"3","author":"Tang","year":"1991","journal-title":"Int Immunol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib70","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3109\/08916939309077367","article-title":"Differential sensitivity to interleukins of CD5+ and CD5\u2013anti-DNA antibody-producing B cells in murine lupus","volume":"14","author":"Kanno","year":"1993","journal-title":"Autoimmunity"},{"key":"10.1016\/j.ajpath.2013.04.027_bib71","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.4049\/jimmunol.158.9.4211","article-title":"Distribution of Ly-6C on lymphocyte subsets, I: influence of allotype on T lymphocyte expression","volume":"158","author":"Schlueter","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib72","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1089\/10799900152547885","article-title":"Type I interferon is the primary regulator of inducible Ly-6C expression on T cells","volume":"21","author":"Schlueter","year":"2001","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.ajpath.2013.04.027_bib73","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1182\/blood-2002-04-1003","article-title":"Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13","volume":"101","author":"Scofield","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.04.027_bib74","doi-asserted-by":"crossref","first-page":"11766","DOI":"10.1073\/pnas.182162399","article-title":"Evidence for a susceptibility gene (SLEH1) on chromosome 11q14 for systemic lupus erythematosus (SLE) families with hemolytic anemia","volume":"99","author":"Kelly","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2013.04.027_bib75","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1442-200X.2003.01665.x","article-title":"Hypophosphatemia in juvenile patients with systemic lupus erythematosus","volume":"45","author":"Fujiwara","year":"2003","journal-title":"Pediatr Int"},{"key":"10.1016\/j.ajpath.2013.04.027_bib76","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s12098-008-0106-6","article-title":"Familial systemic lupus erythematosus with hypercalcemia","volume":"75","author":"Kohli","year":"2008","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.ajpath.2013.04.027_bib77","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrrheum.2012.157","article-title":"The skeleton as an endocrine organ","volume":"8","author":"Digirolamo","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib78","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.beem.2011.05.010","article-title":"Vitamin D receptor (VDR)-mediated actions of 1alpha,25(OH)(2)vitamin D(3): genomic and non-genomic mechanisms","volume":"25","author":"Haussler","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2013.04.027_bib79","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/acr.20568","article-title":"Osteoporosis and fractures in systemic lupus erythematosus","volume":"64","author":"Bultink","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.ajpath.2013.04.027_bib80","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11914-012-0104-5","article-title":"Pathways for bone loss in inflammatory disease","volume":"10","author":"Braun","year":"2012","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.ajpath.2013.04.027_bib81","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1006\/cyto.2000.0747","article-title":"gp130 Cytokine family and bone cells","volume":"12","author":"Heymann","year":"2000","journal-title":"Cytokine"},{"key":"10.1016\/j.ajpath.2013.04.027_bib82","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0169-6009(08)80117-1","article-title":"Interleukin-6 inhibits bone formation in\u00a0vitro","volume":"21","author":"Hughes","year":"1993","journal-title":"Bone Miner"},{"key":"10.1016\/j.ajpath.2013.04.027_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S8756-3282(02)00915-8","article-title":"Interleukin-6 and interleukin-11 support human osteoclast formation by\u00a0a RANKL-independent mechanism","volume":"32","author":"Kudo","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.ajpath.2013.04.027_bib84","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/endo.138.9.5364","article-title":"Activation of the Janus kinase\/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation","volume":"138","author":"Bellido","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2013.04.027_bib85","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10875-007-9104-0","article-title":"Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus","volume":"27","author":"Chun","year":"2007","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib86","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1002\/art.11320","article-title":"Triplets with systemic lupus erythematosus","volume":"48","author":"Kamat","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ajpath.2013.04.027_bib87","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0560s53","article-title":"Animal models of systemic lupus erythematosus (SLE) and ex\u00a0vivo assay design for drug discovery","author":"Seavey","year":"2011","journal-title":"Curr Protoc Pharmacol"},{"key":"10.1016\/j.ajpath.2013.04.027_bib88","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"Tsokos","year":"2011","journal-title":"N Engl J Med"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013003490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013003490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:04:00Z","timestamp":1762081440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944013003490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":88,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0002944013003490"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2013.04.027","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An ENU Mutagenesis-Derived Mouse Model with a Dominant Jak1 Mutation Resembling Phenotypes of Systemic Autoimmune Disease","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2013.04.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}