{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:46:05Z","timestamp":1791243965607,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":2294,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81100639"],"award-info":[{"award-number":["81100639"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["U1205025"],"award-info":[{"award-number":["U1205025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270978"],"award-info":[{"award-number":["81270978"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81000367"],"award-info":[{"award-number":["81000367"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81070713"],"award-info":[{"award-number":["81070713"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds","award":["2012121049"],"award-info":[{"award-number":["2012121049"]}]},{"name":"Fundamental Research Funds","award":["2011121063"],"award-info":[{"award-number":["2011121063"]}]},{"name":"Natural Science Foundation of Fujian Province of China","award":["2010D023"],"award-info":[{"award-number":["2010D023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.ajpath.2013.05.025","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T03:00:52Z","timestamp":1373598052000},"page":"786-795","source":"Crossref","is-referenced-by-count":60,"title":["Notch Signal Regulates Corneal Endothelial-to-Mesenchymal Transition"],"prefix":"10.1016","volume":"183","author":[{"given":"Cheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2013.05.025_bib1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4835(73)90070-5","article-title":"Recent studies on the nature and function of the corneal endothelial barrier","volume":"15","author":"Kaye","year":"1973","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajpath.2013.05.025_bib2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0161-6420(82)34746-6","article-title":"The corneal endothelium: normal and pathologic structure and function","volume":"89","author":"Waring","year":"1982","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajpath.2013.05.025_bib3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/00055735-200104000-00003","article-title":"Role of tissue growth factors in aqueous humor homeostasis","volume":"12","author":"Welge-Lussen","year":"2001","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.ajpath.2013.05.025_bib4","first-page":"2152","article-title":"Mechanisms of mitotic inhibition in corneal endothelium: contact inhibition and TGF-beta2","volume":"43","author":"Joyce","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2013.05.025_bib5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/BF00920945","article-title":"Intraocular extracellular cyclic nucleotide concentrations: the influence of vitreous surgery","volume":"231","author":"Dalma-Weiszhauz","year":"1993","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajpath.2013.05.025_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0014-4835(76)90227-X","article-title":"The corneal endothelium in\u00a0vivo: its response to mild trauma","volume":"22","author":"Sherrard","year":"1976","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajpath.2013.05.025_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jmor.1051740104","article-title":"Cell movements in a living mammalian tissue: long-term observation of individual cells in wounded corneal endothelia of cats","volume":"174","author":"Honda","year":"1982","journal-title":"J Morphol"},{"key":"10.1016\/j.ajpath.2013.05.025_bib8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.2741\/s32","article-title":"TGF beta in fibroproliferative diseases in the eye","volume":"1","author":"Saika","year":"2009","journal-title":"Front Biosci (Schol Ed)"},{"key":"10.1016\/j.ajpath.2013.05.025_bib9","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1167\/iovs.11-9102","article-title":"NF-kappaB is the transcription factor for FGF-2 that causes endothelial mesenchymal transformation in cornea","volume":"53","author":"Lee","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2013.05.025_bib10","first-page":"2272","article-title":"Inhibitory effect of blocking TGF-beta\/Smad signal on injury-induced fibrosis of corneal endothelium","volume":"14","author":"Sumioka","year":"2008","journal-title":"Mol Vis"},{"key":"10.1016\/j.ajpath.2013.05.025_bib11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1167\/iovs.07-0255","article-title":"Connexin43 knockdown accelerates wound healing but inhibits mesenchymal transition after corneal endothelial injury in\u00a0vivo","volume":"49","author":"Nakano","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2013.05.025_bib12","first-page":"663","article-title":"Corneal endothelial modulation: a factor released by leukocytes induces basic fibroblast growth factor that modulates cell shape and collagen","volume":"34","author":"Kay","year":"1993","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2013.05.025_bib13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.exer.2010.06.021","article-title":"The molecular basis of corneal transparency","volume":"91","author":"Hassell","year":"2010","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajpath.2013.05.025_bib14","first-page":"15","article-title":"Extracellular matrix components in retrocorneal fibrous membrane in comparison to corneal endothelium and Descemet\u2019s membrane","volume":"6","author":"Leung","year":"2000","journal-title":"Mol Vis"},{"key":"10.1016\/j.ajpath.2013.05.025_bib15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.brainresbull.2009.10.019","article-title":"Induction of corneal myofibroblasts by lens-derived transforming growth factor beta1 (TGFbeta1): a transgenic mouse model","volume":"81","author":"Reneker","year":"2010","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.ajpath.2013.05.025_bib16","first-page":"822","article-title":"Retrocorneal fibrous membrane","volume":"11","author":"Michels","year":"1972","journal-title":"Invest Ophthalmol"},{"key":"10.1016\/j.ajpath.2013.05.025_bib17","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ajo.2010.03.011","article-title":"Retrocorneal membranes: a comparative immunohistochemical analysis of keratocytic, endothelial, and epithelial origins","volume":"150","author":"Jakobiec","year":"2010","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajpath.2013.05.025_bib18","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1097\/01.ico.0000136666.63870.18","article-title":"Human corneal endothelial cell proliferation: potential for use in regenerative medicine","volume":"23","author":"Joyce","year":"2004","journal-title":"Cornea"},{"key":"10.1016\/j.ajpath.2013.05.025_bib19","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1096\/fj.04-3035fje","article-title":"Functional human corneal endothelial cell sheets harvested from temperature-responsive culture surfaces","volume":"20","author":"Sumide","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2013.05.025_bib20","first-page":"2427","article-title":"Corneal endothelial modulation: bFGF as direct mediator and corneal endothelium modulation factor as inducer","volume":"35","author":"Kay","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2013.05.025_bib21","first-page":"2326","article-title":"Fibroblast growth factor 2 uses distinct signaling pathways for cell proliferation and cell shape changes in corneal endothelial cells","volume":"37","author":"Gu","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2013.05.025_bib22","doi-asserted-by":"crossref","first-page":"32325","DOI":"10.1074\/jbc.M405208200","article-title":"FGF-2 induced by interleukin-1 beta through the action of phosphatidylinositol 3-kinase mediates endothelial mesenchymal transformation in corneal endothelial cells","volume":"279","author":"Lee","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2013.05.025_bib23","first-page":"624","article-title":"FGF-2 induced reorganization and disruption of actin cytoskeleton through PI 3-kinase, Rho, and Cdc42 in corneal endothelial cells","volume":"9","author":"Lee","year":"2003","journal-title":"Mol Vis"},{"key":"10.1016\/j.ajpath.2013.05.025_bib24","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.exer.2006.04.007","article-title":"FGF-2-mediated signal transduction during endothelial mesenchymal transformation in corneal endothelial cells","volume":"83","author":"Lee","year":"2006","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajpath.2013.05.025_bib25","first-page":"2018","article-title":"Myofibroblast transformation of cat corneal endothelium by transforming growth factor-beta1, -beta2, and -beta3","volume":"39","author":"Petroll","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2013.05.025_bib26","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1167\/iovs.05-0818","article-title":"Regulatory role of FGF-2 on type I collagen expression during endothelial mesenchymal transformation","volume":"46","author":"Ko","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2013.05.025_bib27","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1161\/01.RES.0000124300.76171.C9","article-title":"Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation","volume":"94","author":"Noseda","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.ajpath.2013.05.025_bib28","doi-asserted-by":"crossref","first-page":"718","DOI":"10.4161\/cc.3.6.949","article-title":"Notch and epithelial-mesenchyme transition in development and tumor progression: another turn of the screw","volume":"3","author":"Grego-Bessa","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ajpath.2013.05.025_bib29","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1084\/jem.20071082","article-title":"Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin","volume":"204","author":"Leong","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2013.05.025_bib30","first-page":"200","article-title":"Type I collagen and fibronectin synthesis by retrocorneal fibrous membrane","volume":"22","author":"Kay","year":"1982","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2013.05.025_bib31","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1167\/iovs.06-1126","article-title":"A novel method of isolation, preservation, and expansion of human corneal endothelial cells","volume":"48","author":"Li","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2013.05.025_bib32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00441-011-1222-6","article-title":"Regulation of endothelial cell plasticity by TGF-beta","volume":"347","author":"van Meeteren","year":"2012","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ajpath.2013.05.025_bib33","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: cell fate control and signal integration in development","volume":"284","author":"Artavanis-Tsakonas","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2013.05.025_bib34","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/bcr2875","article-title":"Notch signaling as a therapeutic target for breast cancer treatment?","volume":"13","author":"Han","year":"2012","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.ajpath.2013.05.025_bib35","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/978-1-4614-0899-4_21","article-title":"Notch signaling and intestinal cancer","volume":"727","author":"Guilmeau","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.ajpath.2013.05.025_bib36","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.4161\/cbt.8.21.9921","article-title":"Emerging role of Notch signaling in epidermal differentiation and skin cancer","volume":"8","author":"Panelos","year":"2009","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.ajpath.2013.05.025_bib37","doi-asserted-by":"crossref","first-page":"e1167","DOI":"10.1371\/journal.pone.0001167","article-title":"Involvement of notch signaling in wound healing","volume":"2","author":"Chigurupati","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2013.05.025_bib38","first-page":"403","article-title":"Notch signaling promotes the corneal epithelium wound healing","volume":"18","author":"Lu","year":"2012","journal-title":"Mol Vis"},{"key":"10.1016\/j.ajpath.2013.05.025_bib39","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1161\/CIRCRESAHA.108.174318","article-title":"Notch signaling in cardiac development","volume":"102","author":"Niessen","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.ajpath.2013.05.025_bib40","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.devcel.2011.06.022","article-title":"Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase","volume":"21","author":"Chang","year":"2011","journal-title":"Dev Cell"},{"key":"10.1016\/j.ajpath.2013.05.025_bib41","doi-asserted-by":"crossref","first-page":"650","DOI":"10.2353\/ajpath.2010.090447","article-title":"Preventive effect of Notch signaling inhibition by a gamma-secretase inhibitor on peritoneal dialysis fluid-induced peritoneal fibrosis in rats","volume":"176","author":"Zhu","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2013.05.025_bib42","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1083\/jcb.200305112","article-title":"Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3","volume":"163","author":"Blokzijl","year":"2003","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2013.05.025_bib43","doi-asserted-by":"crossref","first-page":"19452","DOI":"10.1074\/jbc.M109.011833","article-title":"Differential regulation of transforming growth factor beta signaling pathways by Notch in human endothelial cells","volume":"284","author":"Fu","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2013.05.025_bib44","first-page":"136","article-title":"Notch induces myofibroblast differentiation of alveolar epithelial cells via transforming growth factor-{beta}-Smad3 pathway","volume":"45","author":"Aoyagi-Ikeda","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2013.05.025_bib45","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.bbamcr.2010.09.001","article-title":"Jagged\/Notch signalling is required for a subset of TGFbeta1 responses in human kidney epithelial cells","volume":"1803","author":"Nyhan","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2013.05.025_bib46","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/sj.emboj.7600069","article-title":"Integration of TGF-beta\/Smad and Jagged1\/Notch signalling in epithelial-to-mesenchymal transition","volume":"23","author":"Zavadil","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2013.05.025_bib47","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1101\/gad.276304","article-title":"Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation","volume":"18","author":"Timmerman","year":"2004","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2013.05.025_bib48","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1167\/iovs.06-1373","article-title":"A role for notch signaling in human corneal epithelial cell differentiation and proliferation","volume":"48","author":"Ma","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294401300415X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294401300415X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T06:53:46Z","timestamp":1576220026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000294401300415X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S000294401300415X"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2013.05.025","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}