{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:06:15Z","timestamp":1785765975306,"version":"3.56.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":355,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.ajpath.2013.07.026","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T03:01:06Z","timestamp":1378350066000},"page":"1679-1687","source":"Crossref","is-referenced-by-count":33,"title":["Progesterone Signaling Inhibits Cervical Carcinogenesis in Mice"],"prefix":"10.1016","volume":"183","author":[{"given":"Young A","family":"Yoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola F.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco J.","family":"DeMayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Lydon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Hyuk","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2013.07.026_bib1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc798","article-title":"Papillomaviruses and cancer: from basic studies to clinical application","volume":"2","author":"zur Hausen","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ajpath.2013.07.026_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc2982","article-title":"The molecular biology of head and neck cancer","volume":"11","author":"Leemans","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ajpath.2013.07.026_bib3","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1158\/0008-5472.CAN-12-2083","article-title":"Inactivating all three rb family pocket proteins is insufficient to initiate cervical cancer","volume":"72","author":"Shin","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.07.026_bib4","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1158\/0008-5472.CAN-09-3307","article-title":"E6-associated protein is required for human papillomavirus type 16 E6 to cause cervical cancer in mice","volume":"70","author":"Shai","year":"2010","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.07.026_bib5","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1128\/JVI.73.7.5887-5893.1999","article-title":"The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals","volume":"73","author":"Song","year":"1999","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.ajpath.2013.07.026_bib6","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1128\/JVI.70.3.1873-1881.1996","article-title":"Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene","volume":"70","author":"Herber","year":"1996","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2013.07.026_bib7","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: gLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2013.07.026_bib8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nrc1973","article-title":"How will HPV vaccines affect cervical cancer?","volume":"6","author":"Roden","year":"2006","journal-title":"Nat Rev Cancer"},{"issue":"suppl 1","key":"10.1016\/j.ajpath.2013.07.026_bib9","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/S0020-7292(06)60030-1","article-title":"Carcinoma of the cervix uteri. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer","volume":"95","author":"Quinn","year":"2006","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ajpath.2013.07.026_bib10","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0140-6736(07)61416-0","article-title":"Human papillomavirus and cervical cancer","volume":"370","author":"Schiffman","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2013.07.026_bib11","first-page":"1267","article-title":"Sensitivity of the cervical transformation zone to estrogen-induced squamous carcinogenesis","volume":"60","author":"Elson","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.07.026_bib12","first-page":"4862","article-title":"Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis","volume":"63","author":"Riley","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.07.026_bib13","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0140-6736(02)08150-3","article-title":"Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study","volume":"359","author":"Moreno","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2013.07.026_bib14","doi-asserted-by":"crossref","first-page":"9928","DOI":"10.1158\/0008-5472.CAN-08-2051","article-title":"Requirement for estrogen receptor alpha in a mouse model for human papillomavirus-associated cervical cancer","volume":"68","author":"Chung","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.07.026_bib15","doi-asserted-by":"crossref","first-page":"19467","DOI":"10.1073\/pnas.0911436106","article-title":"Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists","volume":"106","author":"Chung","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2013.07.026_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s12672-012-0125-7","article-title":"Requirement for stromal estrogen receptor alpha in cervical neoplasia","volume":"4","author":"Chung","year":"2013","journal-title":"Horm Cancer"},{"key":"10.1016\/j.ajpath.2013.07.026_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1055\/s-2005-864031","article-title":"Revealing progesterone\u2019s role in uterine and mammary gland biology: insights from the mouse","volume":"23","author":"Fernandez-Valdivia","year":"2005","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.ajpath.2013.07.026_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tem.2011.01.005","article-title":"Progesterone: the ultimate endometrial tumor suppressor","volume":"22","author":"Yang","year":"2011","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2013.07.026_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1477-7827-1-73","article-title":"Estrogen, progesterone and epithelial ovarian cancer","volume":"1","author":"Ho","year":"2003","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.ajpath.2013.07.026_bib20","doi-asserted-by":"crossref","first-page":"353297","DOI":"10.1155\/2011\/353297","article-title":"Progesterone interactions with the cervix: translational implications for term and preterm birth","volume":"2011","author":"Larsen","year":"2011","journal-title":"Infect Dis Obstet Gynecol"},{"key":"10.1016\/j.ajpath.2013.07.026_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0010-7824(95)00215-V","article-title":"Depot-medroxyprogesterone acetate (DMPA) and risk of invasive adenocarcinomas and adenosquamous carcinomas of the uterine cervix. WHO Collaborative Study of Neoplasia and Steroid Contraceptives","volume":"52","author":"Thomas","year":"1995","journal-title":"Contraception"},{"key":"10.1016\/j.ajpath.2013.07.026_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0010-7824(92)90052-U","article-title":"Depot-medroxyprogesterone acetate (DMPA) and risk of invasive squamous cell cervical cancer. The WHO Collaborative Study of Neoplasia and Steroid Contraceptives","volume":"45","year":"1992","journal-title":"Contraception"},{"key":"10.1016\/j.ajpath.2013.07.026_bib23","first-page":"419","article-title":"Depot medroxyprogesterone acetate contraception and the risk of breast and gynecologic cancer","volume":"41","author":"Kaunitz","year":"1996","journal-title":"J Reprod Med"},{"key":"10.1016\/j.ajpath.2013.07.026_bib24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0010-7824(94)00007-J","article-title":"Cervical carcinoma in situ and use of depot-medroxyprogesterone acetate (DMPA). WHO Collaborative Study of Neoplasia and Steroid Contraceptives","volume":"51","author":"Thomas","year":"1995","journal-title":"Contraception"},{"key":"10.1016\/j.ajpath.2013.07.026_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1472-6874-8-9","article-title":"Cervical dysplasia and cancer and the use of hormonal contraceptives in Jamaican women","volume":"8","author":"McFarlane-Anderson","year":"2008","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.ajpath.2013.07.026_bib26","first-page":"505","article-title":"Invasive cervical cancer and depot-medroxyprogesterone acetate. WHO Collaborative Study of Neoplasia and Steroid Contraceptives","volume":"63","author":"Thomas","year":"1985","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.ajpath.2013.07.026_bib27","doi-asserted-by":"crossref","first-page":"489.e1","DOI":"10.1016\/j.ajog.2009.01.030","article-title":"Depot-medroxyprogesterone acetate and combined oral contraceptive use and cervical neoplasia among women with oncogenic human papillomavirus infection","volume":"200","author":"Harris","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ajpath.2013.07.026_bib28","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1210\/me.2002-0169","article-title":"A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development","volume":"16","author":"Ismail","year":"2002","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.ajpath.2013.07.026_bib29","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1095\/biolreprod64.1.272","article-title":"Regulation of progesterone receptors and decidualization in uterine stroma of the estrogen receptor-alpha knockout mouse","volume":"64","author":"Kurita","year":"2001","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajpath.2013.07.026_bib30","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nm1598","article-title":"Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan","volume":"13","author":"Roberts","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2013.07.026_bib31","doi-asserted-by":"crossref","first-page":"7316","DOI":"10.1038\/sj.onc.1206937","article-title":"Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling","volume":"22","author":"Clarke","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2013.07.026_bib32","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.tem.2010.03.005","article-title":"Estrogen and ERalpha: culprits in cervical cancer?","volume":"21","author":"Chung","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2013.07.026_bib33","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1530\/eje.0.1510503","article-title":"Dose-response of estrogen on bone versus the uterus in ovariectomized mice","volume":"151","author":"Modder","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.ajpath.2013.07.026_bib34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0304-3835(96)04221-8","article-title":"Rapid and high yield induction of endometrial adenocarcinomas in CD-1 mice by a single intrauterine administration of N-ethyl-N-nitrosourea combined with chronic 17 beta-estradiol treatment","volume":"104","author":"Takahashi","year":"1996","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ajpath.2013.07.026_bib35","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1530\/REP-06-0302","article-title":"Circulating hormones and estrous stage predict cellular and stromal remodeling in murine uterus","volume":"133","author":"Wood","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.ajpath.2013.07.026_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.16.1.1-17.2003","article-title":"Human papillomavirus and cervical cancer","volume":"16","author":"Burd","year":"2003","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ajpath.2013.07.026_bib37","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1095\/biolreprod.109.081513","article-title":"Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse","volume":"82","author":"Franco","year":"2010","journal-title":"Biol Reprod"},{"key":"10.1016\/j.ajpath.2013.07.026_bib38","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1096\/fj.10-175349","article-title":"WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse","volume":"25","author":"Franco","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2013.07.026_bib39","series-title":"Endocrinology: An Integrated Approach","first-page":"217","author":"Nussey","year":"2001"},{"key":"10.1016\/j.ajpath.2013.07.026_bib40","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1048-891X.2004.14529.x","article-title":"Estrogen receptor, progesterone receptor, and bcl-2 are markers with prognostic significance in CIN III","volume":"14","author":"Fonseca-Moutinho","year":"2004","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ajpath.2013.07.026_bib41","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.ygyno.2004.06.013","article-title":"Cervical intraepithelial neoplasia: prognosis by combined LOH analysis of multiple loci","volume":"94","author":"ELhamidi","year":"2004","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajpath.2013.07.026_bib42","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/ijc.2910480410","article-title":"Estrogen and progesterone receptors in cervical human papillomavirus related lesions","volume":"48","author":"Monsonego","year":"1991","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2013.07.026_bib43","first-page":"153","article-title":"Estrogen and progesterone receptor expression in HPV-positive and HPV-negative cervical carcinomas","volume":"26","author":"Kwasniewska","year":"2011","journal-title":"Oncol Rep"},{"key":"10.1016\/j.ajpath.2013.07.026_bib44","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1210\/en.2005-0016","article-title":"Identification of murine uterine genes regulated in a ligand-dependent manner by the progesterone receptor","volume":"146","author":"Jeong","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2013.07.026_bib45","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/dbio.2001.0458","article-title":"Epithelial-stromal tissue interaction in paramesonephric (Mullerian) epithelial differentiation","volume":"240","author":"Kurita","year":"2001","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2013.07.026_bib46","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1126\/science.1197454","article-title":"The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2","volume":"331","author":"Li","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2013.07.026_bib47","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nm1401","article-title":"Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation","volume":"12","author":"Ferby","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2013.07.026_bib48","doi-asserted-by":"crossref","first-page":"8677","DOI":"10.1073\/pnas.0903632106","article-title":"Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease","volume":"106","author":"Jeong","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2013.07.026_bib49","doi-asserted-by":"crossref","first-page":"5180","DOI":"10.1038\/onc.2012.22","article-title":"Cyclin E drives human keratinocyte growth into differentiation","volume":"31","author":"Freije","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2013.07.026_bib50","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.4161\/cc.22529","article-title":"The mysterious human epidermal cell cycle, or an oncogene-induced differentiation checkpoint","volume":"11","author":"Gandarillas","year":"2012","journal-title":"Cell Cycle"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013005488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013005488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T06:03:16Z","timestamp":1596434596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944013005488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0002944013005488"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2013.07.026","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}