{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:25:51Z","timestamp":1790281551290,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":355,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.ajpath.2013.07.029","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T10:16:35Z","timestamp":1382523395000},"page":"1654-1666","source":"Crossref","is-referenced-by-count":99,"title":["Continuous Exposure to Chrysotile Asbestos Can Cause Transformation of Human Mesothelial Cells via HMGB1 and TNF-\u03b1 Signaling"],"prefix":"10.1016","volume":"183","author":[{"given":"Fang","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Okimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Jube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Napolitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey I.","family":"Pass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozalia","family":"Laczko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"DeMay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazal","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarit","family":"Tiirikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Rinaudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Croce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haining","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Gaudino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2013.07.029_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1179\/2049396712Y.0000000016","article-title":"Mesothelioma incidence in 50 states and the District of Columbia, United States, 2003-2008","volume":"19","author":"Henley","year":"2013","journal-title":"Int J Occup Environ Health"},{"key":"10.1016\/j.ajpath.2013.07.029_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2007.10.054","article-title":"Extrapleural pneumonectomy versus pleurectomy\/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients","volume":"135","author":"Flores","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ajpath.2013.07.029_bib3","first-page":"2052","article-title":"Benign and malignant mesothelioma. DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology. ed\u00a09","author":"Pass","year":"2011"},{"key":"10.1016\/j.ajpath.2013.07.029_bib4","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S1470-2045(13)70257-2","article-title":"Asbestos is not just asbestos: an unrecognised health hazard","volume":"14","author":"Baumann","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jcp.22724","article-title":"Malignant mesothelioma: facts, myths, and hypotheses","volume":"227","author":"Carbone","year":"2012","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1053\/sonc.2002.30237","article-title":"The epidemiology of mesothelioma","volume":"29","author":"Britton","year":"2002","journal-title":"Semin Oncol"},{"issue":"4","key":"10.1016\/j.ajpath.2013.07.029_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nrc774","article-title":"Asbestos and its lethal legacy","volume":"2","author":"Tweedale","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ajpath.2013.07.029_bib8","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0140-6736(10)60251-6","article-title":"Health experts concerned over India\u2019s asbestos industry","volume":"375","author":"Burki","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2013.07.029_bib9","first-page":"851","article-title":"Epidemiology of malignant mesothelioma\u2013an outline","volume":"54","author":"McDonald","year":"2010","journal-title":"Ann Occup Hyg"},{"key":"10.1016\/j.ajpath.2013.07.029_bib10","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1749-6632.1965.tb41127.x","article-title":"Tests for carcinogenicity of asbestos","volume":"132","author":"Smith","year":"1965","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ajpath.2013.07.029_bib11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/bjc.1974.65","article-title":"The effects of the inhalation of asbestos in rats","volume":"29","author":"Wagner","year":"1974","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajpath.2013.07.029_bib12","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1093\/jnci\/52.6.1823","article-title":"Histogenesis and fine structure of peritoneal tumors produced in animals by injections of asbestos","volume":"52","author":"Davis","year":"1974","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ajpath.2013.07.029_bib13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0013-9351(83)90114-7","article-title":"Mesothelioma in pet dogs associated with exposure of their owners to asbestos","volume":"32","author":"Glickman","year":"1983","journal-title":"Environ Res"},{"key":"10.1016\/j.ajpath.2013.07.029_bib14","first-page":"312","article-title":"Peritoneale Differenzierungsst\u00f6rungen als Reaktion auf Asbest- und Asbestersatzstoffe. Tierexperimentelle Untersuchungen [Disturbances in peritoneal differentiation as a reaction to asbestos and asbestos substitutes. Experimental animal studies]","volume":"72","author":"Friemann","year":"1988","journal-title":"German. Verh Dtsch Ges Pathol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib15","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1749-6632.1988.tb30164.x","article-title":"Results of recent experimental research on the carcinogenicity of natural and modified asbestos","volume":"534","author":"Minardi","year":"1988","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ajpath.2013.07.029_bib16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3200\/AEOH.63.2.71-75","article-title":"Orally ingested chrysotile asbestos affects rat lungs and pleura","volume":"63","author":"Hasanoglu","year":"2008","journal-title":"Arch Environ Occup Health"},{"key":"10.1016\/j.ajpath.2013.07.029_bib17","first-page":"589","article-title":"Asbestos use and carcinogenicity in Germany and a comparison with animal studies","volume":"38","author":"Pott","year":"1994","journal-title":"Ann Occup Hyg"},{"key":"10.1016\/j.ajpath.2013.07.029_bib18","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1093\/aje\/154.6.538","article-title":"Cancer mortality among workers exposed to amphibole-free chrysotile asbestos","volume":"154","author":"Yano","year":"2001","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib19","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1164\/ajrccm.157.5.9707141","article-title":"Mechanisms in the pathogenesis of asbestosis and silicosis","volume":"157","author":"Mossman","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2013.07.029_bib20","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1111\/j.1349-7006.2011.02087.x","article-title":"Asbestos surface provides a niche for oxidative modification","volume":"102","author":"Nagai","year":"2011","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ajpath.2013.07.029_bib21","doi-asserted-by":"crossref","first-page":"12611","DOI":"10.1073\/pnas.1006542107","article-title":"Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation","volume":"107","author":"Yang","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2013.07.029_bib22","doi-asserted-by":"crossref","first-page":"10397","DOI":"10.1073\/pnas.0604008103","article-title":"TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis","volume":"103","author":"Yang","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2013.07.029_bib23","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/modpathol.2011.144","article-title":"Epithelial-mesenchymal transition in malignant mesothelioma","volume":"25","author":"Fassina","year":"2012","journal-title":"Mod Pathol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0463.2012.02931.x","article-title":"Expression of snail, twist, and Zeb1 in malignant mesothelioma","volume":"121","author":"Merikallio","year":"2013","journal-title":"APMIS"},{"key":"10.1016\/j.ajpath.2013.07.029_bib25","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.canlet.2011.01.009","article-title":"Epithelial-to-mesenchymal transition, cell polarity and stemness-associated features in malignant pleural mesothelioma","volume":"302","author":"Casarsa","year":"2011","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ajpath.2013.07.029_bib26","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.ejcb.2009.08.002","article-title":"Blood monocytes stimulate migration of human pancreatic carcinoma cells in\u00a0vitro: the role of tumour necrosis factor-alpha","volume":"88","author":"Baran","year":"2009","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib27","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ccr.2009.03.016","article-title":"Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion","volume":"15","author":"Wu","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ajpath.2013.07.029_bib28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00441-005-0002-6","article-title":"Molecular characterization of soluble factors from human menstrual effluent that induce epithelial to mesenchymal transitions in mesothelial cells","volume":"322","author":"Demir","year":"2005","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.ajpath.2013.07.029_bib29","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1159\/000320485","article-title":"High-mobility group box protein 1: a novel mediator of inflammatory-induced renal epithelial-mesenchymal transition","volume":"32","author":"Lynch","year":"2010","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib30","doi-asserted-by":"crossref","first-page":"L1427","DOI":"10.1152\/ajplung.00075.2007","article-title":"The role of the receptor for advanced glycation end-products in lung fibrosis","volume":"293","author":"He","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib31","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2013.07.029_bib32","doi-asserted-by":"crossref","first-page":"10938","DOI":"10.1158\/0008-5472.CAN-05-1947","article-title":"Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease","volume":"65","author":"Bellovin","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.07.029_bib33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/35000025","article-title":"The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression","volume":"2","author":"Cano","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib34","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nrc1276","article-title":"Cell adhesion and signalling by cadherins and Ig-CAMs in cancer","volume":"4","author":"Cavallaro","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ajpath.2013.07.029_bib35","doi-asserted-by":"crossref","first-page":"E72","DOI":"10.1038\/ncb0402-e72","article-title":"E-cadherin and Hakai: signalling, remodeling or destruction?","volume":"4","author":"Pece","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib36","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/excr.1996.0183","article-title":"The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts","volume":"225","author":"Reynolds","year":"1996","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2013.07.029_bib37","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ceb.2005.08.009","article-title":"The regulation of cadherin-mediated adhesion by tyrosine phosphorylation\/dephosphorylation of beta-catenin","volume":"17","author":"Lilien","year":"2005","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib38","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/beta-catenin signaling and disease","volume":"149","author":"Clevers","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2013.07.029_bib39","first-page":"4547","article-title":"Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin","volume":"63","author":"Uematsu","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.07.029_bib40","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/path.1458","article-title":"Cadherins, catenins and APC in pleural malignant mesothelioma","volume":"201","author":"Abutaily","year":"2003","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib41","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/dc.20281","article-title":"The expression pattern of beta-catenin in mesothelial proliferative lesions and its diagnostic utilities","volume":"33","author":"Dai","year":"2005","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib42","doi-asserted-by":"crossref","first-page":"10214","DOI":"10.1073\/pnas.170207097","article-title":"Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity","volume":"97","author":"Bocchetta","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2013.07.029_bib43","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1289\/ehp.021101003","article-title":"Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species","volume":"110","author":"Xu","year":"2002","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ajpath.2013.07.029_bib44","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/cm.20151","article-title":"Intracellular protein binding to asbestos induces aneuploidy in human lung fibroblasts","volume":"63","author":"MacCorkle","year":"2006","journal-title":"Cell Motil Cytoskeleton"},{"key":"10.1016\/j.ajpath.2013.07.029_bib45","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1177\/1947601910395580","article-title":"Tissue tropism of SV40 transformation of human cells: role of the viral regulatory region and of cellular oncogenes","volume":"1","author":"Zhang","year":"2010","journal-title":"Genes Cancer"},{"key":"10.1016\/j.ajpath.2013.07.029_bib46","doi-asserted-by":"crossref","first-page":"13618","DOI":"10.1073\/pnas.1105887108","article-title":"Erionite exposure in North Dakota and Turkish villages with mesothelioma","volume":"108","author":"Carbone","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.ajpath.2013.07.029_bib47","first-page":"13","article-title":"Persistent inflammatory pathways associated with early onset myocardial infarction in a medicated multiethnic Hawaiian cohort","volume":"2011","author":"Szauter","year":"2011","journal-title":"Biochem Insights"},{"key":"10.1016\/j.ajpath.2013.07.029_bib48","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijheh.2005.01.015","article-title":"Short, thin asbestos fibers contribute to the development of human malignant mesothelioma: pathological evidence","volume":"208","author":"Suzuki","year":"2005","journal-title":"Int J Hyg Environ Health"},{"key":"10.1016\/j.ajpath.2013.07.029_bib49","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1158\/0008-5472.CAN-11-3481","article-title":"Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma","volume":"72","author":"Jube","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.07.029_bib50","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.annepidem.2011.05.010","article-title":"Mesothelioma from chrysotile asbestos: update","volume":"21","author":"Kanarek","year":"2011","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.ajpath.2013.07.029_bib51","first-page":"821","article-title":"Economic aspects of mesothelioma. Malignant Mesothelioma: Advances in Pathogenesis, Diagnosis, and Translational Therapies","author":"Lagnese","year":"2005"},{"key":"10.1016\/j.ajpath.2013.07.029_bib52","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1080\/08958370390241713","article-title":"The biopersistence of Canadian chrysotile asbestos following inhalation","volume":"15","author":"Bernstein","year":"2003","journal-title":"Inhal Toxicol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013005531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013005531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T08:27:47Z","timestamp":1539246467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944013005531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0002944013005531"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2013.07.029","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}