{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:39:43Z","timestamp":1790739583984,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":2172,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.ajpath.2013.09.018","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T22:45:15Z","timestamp":1384209915000},"page":"282-295","source":"Crossref","is-referenced-by-count":44,"title":["Cell Growth in Aggregates Determines Gene Expression, Proliferation, Survival, Chemoresistance, and Sensitivity to Immune Effectors in Follicular Lymphoma"],"prefix":"10.1016","volume":"184","author":[{"given":"Pauline","family":"Gravelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Jean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Familiades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Decaup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Bezombes-Cagnac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Savina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Fourni\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2013.09.018_bib1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1182\/blood-2009-01-198580","article-title":"Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations","volume":"114","author":"Leich","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.09.018_bib2","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1365-2141.2008.07528.x","article-title":"BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations","volume":"144","author":"Masir","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib3","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1053\/gast.2001.27989","article-title":"Multicellular gastric cancer spheroids recapitulate growth pattern and differentiation phenotype of human gastric carcinomas","volume":"121","author":"Mayer","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2013.09.018_bib4","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/mc.20315","article-title":"Molecular description of a 3D in\u00a0vitro model for the study of epithelial ovarian cancer (EOC)","volume":"46","author":"Zietarska","year":"2007","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.ajpath.2013.09.018_bib5","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/(SICI)1097-0215(19980316)75:6<855::AID-IJC7>3.0.CO;2-U","article-title":"Development of an intrinsic P-glycoprotein-mediated doxorubicin resistance in quiescent cell layers of large, multicellular prostate tumor spheroids","volume":"75","author":"Wartenberg","year":"1998","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2013.09.018_bib6","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1200\/JCO.2007.12.7878","article-title":"Hypoxic radiosensitization: adored and ignored","volume":"25","author":"Overgaard","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib7","first-page":"3682","article-title":"A three-dimensional tumor cell defect in activating autologous CTLs is associated with inefficient antigen presentation correlated with heat shock protein-70 down-regulation","volume":"63","author":"Dangles-Marie","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.09.018_bib8","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/sj.bjc.6603664","article-title":"Multiple mechanisms underlie defective recognition of melanoma cells cultured in three-dimensional architectures by antigen-specific cytotoxic T lymphocytes","volume":"96","author":"Feder-Mengus","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajpath.2013.09.018_bib9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/01.sla.0000189571.84213.b0","article-title":"Culture of melanoma cells in 3-dimensional architectures results in impaired immunorecognition by cytotoxic T lymphocytes specific for Melan-A\/MART-1 tumor-associated antigen","volume":"242","author":"Ghosh","year":"2005","journal-title":"Ann Surg"},{"key":"10.1016\/j.ajpath.2013.09.018_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-1-59745-443-8_8","article-title":"Generation of multicellular tumor spheroids by the hanging-drop method","volume":"140","author":"Timmins","year":"2007","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.ajpath.2013.09.018_bib11","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1074\/jbc.M512694200","article-title":"Human keratinocytes acquire cellular cytotoxicity under UV-B irradiation. Implication of granzyme B and perforin","volume":"281","author":"Hernandez-Pigeon","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2013.09.018_bib12","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1128\/MCB.20.22.8602-8612.2000","article-title":"Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis","volume":"20","author":"M\u00e9ndez","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib13","first-page":"1347","article-title":"High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations","volume":"24","author":"Jordan","year":"1996","journal-title":"Exp Hematol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib14","first-page":"562","article-title":"Assessment of proliferative and colony-forming capacity after successive in\u00a0vitro divisions of single human CD34+ cells initially isolated in G0","volume":"26","author":"Gothot","year":"1998","journal-title":"Exp Hematol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nature07968","article-title":"Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma","volume":"459","author":"Compagno","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2013.09.018_bib16","series-title":"nwCompare and AutoCompare softwares for proteomics and transcriptomics data mining\u2014application to the exploration of gene expression profiles of aggressive lymphomas. Integrative Proteomics","author":"Pont","year":"2012"},{"key":"10.1016\/j.ajpath.2013.09.018_bib17","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/pmic.200900667","article-title":"Sorting protein lists with nwCompare: a simple and fast algorithm for n-way comparison of proteomic data files","volume":"10","author":"Pont","year":"2010","journal-title":"Proteomics"},{"key":"10.1016\/j.ajpath.2013.09.018_bib18","first-page":"107","article-title":"Negative and positive regulation of HIF-1: a complex network","volume":"1755","author":"B\u00e1rdos","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2013.09.018_bib19","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","article-title":"Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1","volume":"16","author":"Forsythe","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib20","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1084\/jem.194.12.1861","article-title":"Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells","volume":"194","author":"Davis","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2013.09.018_bib21","doi-asserted-by":"crossref","first-page":"24157","DOI":"10.1016\/S0021-9258(18)35741-7","article-title":"The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B","volume":"267","author":"Laherty","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2013.09.018_bib22","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1182\/blood-2007-03-080309","article-title":"EBV LMP2A affects LMP1-mediated NF-kappaB signaling and survival of lymphoma cells by regulating TRAF2 expression","volume":"111","author":"Guasparri","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.09.018_bib23","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/jlb.66.6.876","article-title":"Regulation of intercellular adhesion molecule-1 (CD54) gene expression","volume":"66","author":"Roebuck","year":"1999","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib24","doi-asserted-by":"crossref","first-page":"18337","DOI":"10.1074\/jbc.271.31.18337","article-title":"Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts","volume":"271","author":"Rivard","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2013.09.018_bib25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4161\/cc.8.1.7507","article-title":"Loss of p21 CDKN1A impairs entry to quiescence and activates a DNA damage response in normal fibroblasts induced to quiescence","volume":"8","author":"Perucca","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ajpath.2013.09.018_bib26","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.exphem.2010.06.002","article-title":"Slow-cycling\/quiescence balance of hematopoietic stem cells is related\u00a0to physiological gradient of oxygen","volume":"38","author":"Guitart","year":"2010","journal-title":"Exp Hematol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1128\/MCB.23.1.359-369.2003","article-title":"Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia","volume":"23","author":"Goda","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib28","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1073\/pnas.81.5.1361","article-title":"Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4\u2032-(9-acridinylamino)-methanesulfon-m-anisidide","volume":"81","author":"Nelson","year":"1984","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2013.09.018_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10549-009-0502-2","article-title":"HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment","volume":"122","author":"Weigelt","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.ajpath.2013.09.018_bib30","first-page":"655","article-title":"Role of extracellular signal-regulated kinase (ERK)1\/2 in multicellular resistance to docetaxel in MCF-7 cells","volume":"37","author":"Jeong","year":"2010","journal-title":"Int J Oncol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/(SICI)1097-4652(199805)175:2<129::AID-JCP2>3.0.CO;2-Q","article-title":"Hypotonic Ca2+ signaling and volume regulation in proliferating and quiescent cells from multicellular spheroids","volume":"175","author":"Sauer","year":"1998","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib32","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1371\/journal.pgen.0030091","article-title":"A transcriptional program mediating entry into cellular quiescence","volume":"3","author":"Liu","year":"2007","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ajpath.2013.09.018_bib33","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/(SICI)1097-4652(200004)183:1<18::AID-JCP3>3.0.CO;2-S","article-title":"Multiple functions of p27(Kip1) and its alterations in tumor cells: a review","volume":"183","author":"Sgambato","year":"2000","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib34","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4161\/cc.3.3.710","article-title":"Cell cycle regulation in hematopoietic stem\/progenitor cells","volume":"3","author":"Ezoe","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ajpath.2013.09.018_bib35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jtbi.2011.11.009","article-title":"Modelling acidosis and the cell cycle in multicellular tumour spheroids","volume":"298","author":"Tindall","year":"2012","journal-title":"J Theor Biol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib36","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1517\/17460441.2012.708334","article-title":"The multicellular tumor spheroid model for high-throughput cancer drug discovery","volume":"7","author":"Labarbera","year":"2012","journal-title":"Expert Opin Drug Discov"},{"key":"10.1016\/j.ajpath.2013.09.018_bib37","doi-asserted-by":"crossref","first-page":"7919","DOI":"10.1074\/jbc.M010189200","article-title":"Hypoxia inhibits G1\/S transition through regulation of p27 expression","volume":"276","author":"Gardner","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2013.09.018_bib38","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1365-2141.2008.07093.x","article-title":"Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family","volume":"141","author":"Evens","year":"2008","journal-title":"Br J Haematol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib39","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1046\/j.1365-2559.2002.01357.x","article-title":"Expression of angiogenic factors and hypoxia inducible factors HIF 1, HIF 2 and CA IX in non-Hodgkin\u2019s lymphoma","volume":"40","author":"Stewart","year":"2002","journal-title":"Histopathology"},{"key":"10.1016\/j.ajpath.2013.09.018_bib40","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/leu.2011.248","article-title":"Involvement of the Syk-mTOR pathway in follicular lymphoma cell invasion and angiogenesis","volume":"26","author":"Fruchon","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.ajpath.2013.09.018_bib41","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/eji.201141870","article-title":"The gene expression profile of phosphoantigen-specific human \u03b3\u03b4 T lymphocytes is a blend of \u03b1\u03b2 T-cell and NK-cell signatures","volume":"42","author":"Pont","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ajpath.2013.09.018_bib42","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.leukres.2009.05.004","article-title":"Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFkappaB activity in Follicular Lymphoma","volume":"33","author":"Green","year":"2009","journal-title":"Leuk Res"},{"key":"10.1016\/j.ajpath.2013.09.018_bib43","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.bbamcr.2011.03.002","article-title":"Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death","volume":"1813","author":"Kuznetsov","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2013.09.018_bib44","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1182\/blood-2007-04-085092","article-title":"PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma","volume":"111","author":"Leseux","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2013.09.018_bib45","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1182\/blood-2009-04-217687","article-title":"Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy","volume":"114","author":"Ramsay","year":"2009","journal-title":"Blood"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013006743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013006743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T01:46:12Z","timestamp":1647049572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944013006743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0002944013006743"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2013.09.018","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}