{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:34:41Z","timestamp":1788870881945,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI078985"],"award-info":[{"award-number":["AI078985"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA098428"],"award-info":[{"award-number":["CA098428"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA022443"],"award-info":[{"award-number":["CA022443"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA141583"],"award-info":[{"award-number":["CA141583"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.ajpath.2013.10.013","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T01:53:14Z","timestamp":1389405194000},"page":"530-540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Recurrence of Cervical Cancer in Mice after Selective Estrogen Receptor Modulator Therapy"],"prefix":"10.1016","volume":"184","author":[{"given":"Megan E.","family":"Spurgeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Hyuk","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2013.10.013_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Walboomers","year":"1999","journal-title":"J Pathol"},{"issue":"Suppl 10","key":"10.1016\/j.ajpath.2013.10.013_bib2","doi-asserted-by":"crossref","first-page":"K1","DOI":"10.1016\/j.vaccine.2008.05.064","article-title":"Epidemiology and natural history of human papillomavirus infections and type-specific implications in cervical neoplasia","volume":"26","author":"Bosch","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.ajpath.2013.10.013_bib3","unstructured":"WHO\/IARC: WHO\/IARC World Cancer Report, 2008. International Agency for Research on Cancer, Lyon, France. Available online at http:\/\/www.iarc.fr\/en\/publications\/pdfs-online\/wcr\/2008\/index.php"},{"key":"10.1016\/j.ajpath.2013.10.013_bib4","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0140-6736(07)61416-0","article-title":"Human papillomavirus and cervical cancer","volume":"370","author":"Schiffman","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2013.10.013_bib5","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0140-6736(02)08151-5","article-title":"Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control study","volume":"359","author":"Munoz","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2013.10.013_bib6","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0140-6736(02)08150-3","article-title":"Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study","volume":"359","author":"Moreno","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2013.10.013_bib7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ygyno.2012.11.003","article-title":"The role of co-factors in the progression from human papillomavirus infection to cervical cancer","volume":"128","author":"Luhn","year":"2013","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajpath.2013.10.013_bib8","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/S0140-6736(07)61684-5","article-title":"Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies","volume":"370","author":"Appleby","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ajpath.2013.10.013_bib9","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.tem.2010.03.005","article-title":"Estrogen and ERalpha: culprits in cervical cancer?","volume":"21","author":"Chung","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2013.10.013_bib10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/gye.15.5.335.340","article-title":"Relationship between estradiol 16 alpha-hydroxylation and human papillomavirus infection in cervical cell transformation","volume":"15","author":"Salazar","year":"2001","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.ajpath.2013.10.013_bib11","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1158\/1055-9965.EPI-11-0753","article-title":"Endogenous sex steroids and risk of cervical carcinoma: results from the EPIC study","volume":"20","author":"Rinaldi","year":"2011","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.ajpath.2013.10.013_bib12","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1073\/pnas.93.7.2930","article-title":"Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice","volume":"93","author":"Arbeit","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2013.10.013_bib13","first-page":"1267","article-title":"Sensitivity of the cervical transformation zone to estrogen-induced squamous carcinogenesis","volume":"60","author":"Elson","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.10.013_bib14","first-page":"4862","article-title":"Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis","volume":"63","author":"Riley","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.10.013_bib15","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1158\/0008-5472.CAN-11-3085","article-title":"Cervical cancers require the continuous expression of the human papillomavirus type 16 E7 oncoprotein even in the presence of the viral E6 oncoprotein","volume":"72","author":"Jabbar","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.10.013_bib16","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1073\/pnas.0409883102","article-title":"Estrogen contributes to the onset, persistence, and malignant progression of cervical cancer in a human papillomavirus-transgenic mouse model","volume":"102","author":"Brake","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2013.10.013_bib17","doi-asserted-by":"crossref","first-page":"19467","DOI":"10.1073\/pnas.0911436106","article-title":"Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists","volume":"106","author":"Chung","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2013.10.013_bib18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s12672-012-0125-7","article-title":"Requirement for stromal estrogen receptor alpha in cervical neoplasia","volume":"4","author":"Chung","year":"2013","journal-title":"Horm Cancer"},{"key":"10.1016\/j.ajpath.2013.10.013_bib19","doi-asserted-by":"crossref","first-page":"9928","DOI":"10.1158\/0008-5472.CAN-08-2051","article-title":"Requirement for estrogen receptor alpha in a mouse model for human papillomavirus-associated cervical cancer","volume":"68","author":"Chung","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2013.10.013_bib20","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1128\/jvi.70.3.1873-1881.1996","article-title":"Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene","volume":"70","author":"Herber","year":"1996","journal-title":"J Virol"},{"key":"10.1016\/j.ajpath.2013.10.013_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/viro.1999.0106","article-title":"Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis","volume":"267","author":"Song","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.ajpath.2013.10.013_bib22","first-page":"8173","article-title":"Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer","volume":"63","author":"Brake","year":"2003","journal-title":"Cancer Res"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013007256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944013007256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:03:26Z","timestamp":1762081406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944013007256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0002944013007256"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2013.10.013","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recurrence of Cervical Cancer in Mice after Selective Estrogen Receptor Modulator Therapy","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2013.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2013.11.005","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}