{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:27:02Z","timestamp":1770748022675,"version":"3.49.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":2052,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Defense, a University of Louisville Clinical & Translational Science","award":["DM090475"],"award-info":[{"award-number":["DM090475"]}]},{"name":"Kentucky Science and Engineering Foundation R&D Excellence","award":["KSEF-148-502-10-271"],"award-info":[{"award-number":["KSEF-148-502-10-271"]}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Kentucky Lions Eye Foundation"},{"name":"Kentucky Research Challenge Trust Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.ajpath.2014.01.022","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T21:10:18Z","timestamp":1395436218000},"page":"1419-1428","source":"Crossref","is-referenced-by-count":32,"title":["Role of Retinal Pigment Epithelial Cell \u03b2-Catenin Signaling in Experimental Proliferative Vitreoretinopathy"],"prefix":"10.1016","volume":"184","author":[{"given":"Kazuhiko","family":"Umazume","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rintaro","family":"Tsukahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LanHsin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan P.","family":"Fernandez de Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry J.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Tamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2014.01.022_bib1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.bbadis.2012.12.007","article-title":"Strategies for anti-fibrotic therapies","volume":"1832","author":"Rosenbloom","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2014.01.022_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0161-6420(83)34588-7","article-title":"The classification of retinal detachment with proliferative vitreoretinopathy","volume":"90","year":"1983","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajpath.2014.01.022_bib3","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/S0161-6420(97)30167-5","article-title":"Post-traumatic proliferative vitreoretinopathy. The epidemiologic profile, onset, risk factors, and visual outcome","volume":"104","author":"Cardillo","year":"1997","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ajpath.2014.01.022_bib4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1350-9462(01)00023-4","article-title":"Proliferative vitreoretinopathy: risk factors and pathobiology","volume":"21","author":"Pastor","year":"2002","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ajpath.2014.01.022_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1350-9462(98)00024-X","article-title":"Matrix and the retinal pigment epithelium in proliferative retinal disease","volume":"18","author":"Hiscott","year":"1999","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ajpath.2014.01.022_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1350-9462(97)00007-4","article-title":"Risk factors for proliferative vitreoretinopathy","volume":"17","author":"Nagasaki","year":"1998","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ajpath.2014.01.022_bib7","first-page":"1794","article-title":"Cell proliferation in human epiretinal membranes: characterization of cell types and correlation with disease condition and duration","volume":"17","author":"Oberstein","year":"2011","journal-title":"Mol Vis"},{"key":"10.1016\/j.ajpath.2014.01.022_bib8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/sj.eye.6700194","article-title":"Proliferative vitreoretinopathy-developments in adjunctive treatment and retinal pathology","volume":"16","author":"Charteris","year":"2002","journal-title":"Eye"},{"key":"10.1016\/j.ajpath.2014.01.022_bib9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00417-009-1082-x","article-title":"Involvement of M\u00fcller glial cells in epiretinal membrane formation","volume":"247","author":"Bringmann","year":"2009","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajpath.2014.01.022_bib10","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/bjo.62.11.737","article-title":"Pathogenesis and classification of massive periretinal proliferation","volume":"62","author":"Machemer","year":"1978","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajpath.2014.01.022_bib11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.preteyeres.2004.07.001","article-title":"The role of M\u00fcller cells in fibrocontractive retinal disorders","volume":"24","author":"Guidry","year":"2005","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.ajpath.2014.01.022_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2174\/187153008783928343","article-title":"Epithelial-mesenchymal transition as a therapeutic target for prevention of ocular tissue fibrosis","volume":"8","author":"Saika","year":"2008","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"10.1016\/j.ajpath.2014.01.022_bib13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1136\/bjo.74.7.393","article-title":"Variation in epiretinal membrane components with clinical duration of the proliferative tissue","volume":"74","author":"Morino","year":"1990","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.ajpath.2014.01.022_bib14","first-page":"269","article-title":"Population and proportion of component cells in preretinal membranes","volume":"30","author":"Yamashita","year":"1986","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.ajpath.2014.01.022_bib15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1001\/archopht.1997.01100150239014","article-title":"Pathogenic mechanisms in proliferative vitreoretinopathy","volume":"115","author":"Campochiaro","year":"1997","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.ajpath.2014.01.022_bib16","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1167\/iovs.09-4725","article-title":"Epithelial-mesenchymal transition and proliferation of retinal pigment epithelial cells initiated upon loss of cell-cell contact","volume":"51","author":"Tamiya","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2014.01.022_bib17","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2014.01.022_bib18","first-page":"2062","article-title":"Epithelial-mesenchymal transition in proliferative vitreoretinopathy: intermediate filament protein expression in retinal pigment epithelial cells","volume":"40","author":"Casaroli-Marano","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2014.01.022_bib19","first-page":"391","article-title":"Transdifferentiation of retinal pigment epithelial cells from epithelial to mesenchymal phenotype","volume":"36","author":"Grisanti","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2014.01.022_bib20","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/(SICI)1521-1878(199912)22:1<1021::AID-BIES6>3.0.CO;2-P","article-title":"beta-Catenin signaling and cancer","volume":"21","author":"Morin","year":"1999","journal-title":"Bioessays"},{"key":"10.1016\/j.ajpath.2014.01.022_bib21","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/BOR.0b013e32834b3309","article-title":"\u03b2-Catenin signaling: a novel mediator of fibrosis and potential therapeutic target","volume":"23","author":"Lam","year":"2011","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.ajpath.2014.01.022_bib22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1158\/1535-7163.MCT-07-2063","article-title":"A small-molecule inhibitor of Tcf\/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities","volume":"7","author":"Handeli","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.ajpath.2014.01.022_bib23","doi-asserted-by":"crossref","first-page":"e23000","DOI":"10.1371\/journal.pone.0023000","article-title":"Silymarin targets beta-catenin signaling in blocking migration\/invasion of human melanoma cells","volume":"6","author":"Vaid","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.ajpath.2014.01.022_bib24","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1167\/iovs.12-10418","article-title":"Inhibition of PVR with a tyrosine kinase inhibitor, dasatinib, in the swine","volume":"54","author":"Umazume","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2014.01.022_bib25","doi-asserted-by":"crossref","first-page":"17901","DOI":"10.1074\/jbc.M111635200","article-title":"Wnt signaling controls the phosphorylation status of beta-catenin","volume":"277","author":"van Noort","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2014.01.022_bib26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In\u00a0vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in\u00a0vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ajpath.2014.01.022_bib27","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1167\/iovs.09-3621","article-title":"Differential effects of TGFbeta and vitreous on the transformation of retinal pigment epithelial cells","volume":"50","author":"Parapuram","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2014.01.022_bib28","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.cellbio.042308.113318","article-title":"Cell motility and mechanics in three-dimensional collagen matrices","volume":"26","author":"Grinnell","year":"2010","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.ajpath.2014.01.022_bib29","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1074\/jbc.274.2.918","article-title":"Differences in the regulation of fibroblast contraction of floating versus stressed collagen matrices","volume":"274","author":"Grinnell","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2014.01.022_bib30","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.exer.2007.08.014","article-title":"Collagen gel contraction by ARPE-19 cells is mediated by a FAK-Src dependent pathway","volume":"85","author":"Morales","year":"2007","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajpath.2014.01.022_bib31","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1006\/exer.2001.1079","article-title":"Vitreous-induced modulation of integrins in retinal pigment epithelial cells: effects of fibroblast growth factor-2","volume":"73","author":"Meitinger","year":"2001","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.ajpath.2014.01.022_bib32","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0014-4827(87)90014-0","article-title":"Scrape-loading and dye transfer. A rapid and simple technique to study gap junctional intercellular communication","volume":"168","author":"el-Fouly","year":"1987","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2014.01.022_bib33","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nprot.2009.33","article-title":"A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells","volume":"4","author":"Sonoda","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ajpath.2014.01.022_bib34","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1167\/iovs.12-9768","article-title":"Proliferative vitreoretinopathy in the swine\u2013a new model","volume":"53","author":"Umazume","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2014.01.022_bib35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00417-011-1617-9","article-title":"The parameters of the porcine eyeball","volume":"249","author":"Sanchez","year":"2011","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.ajpath.2014.01.022_bib36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0002-9394(14)76695-4","article-title":"An updated classification of retinal detachment with proliferative vitreoretinopathy","volume":"112","author":"Machemer","year":"1991","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.ajpath.2014.01.022_bib37","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1242\/jcs.111.12.1741","article-title":"Identification of connexin43 as a functional target for Wnt signalling","volume":"111","author":"van der Heyden","year":"1998","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2014.01.022_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev Cell"},{"key":"10.1016\/j.ajpath.2014.01.022_bib39","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/labinvest.2011.201","article-title":"Wnt signaling induces epithelial-mesenchymal transition with proliferation in ARPE-19 cells upon loss of contact inhibition","volume":"92","author":"Chen","year":"2012","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2014.01.022_bib40","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1038\/emboj.2012.150","article-title":"The many faces and functions of \u03b2-catenin","volume":"31","author":"Valenta","year":"2012","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2014.01.022_bib41","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1167\/iovs.11-7442","article-title":"Expression of PDGFR\u03b1 is a determinant of the PVR potential of ARPE19 cells","volume":"52","author":"Lei","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2014.01.022_bib42","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.bbamcr.2011.06.009","article-title":"Thrombin activation of PI3K\/PDK1\/Akt signaling promotes cyclin D1 upregulation and RPE cell proliferation","volume":"1813","author":"Parrales","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2014.01.022_bib43","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1016\/j.ajpath.2011.08.043","article-title":"A novel strategy to develop therapeutic approaches to prevent proliferative vitreoretinopathy","volume":"179","author":"Pennock","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2014.01.022_bib44","first-page":"3091","article-title":"Activation and role of MAP kinase-dependent pathways in retinal pigment epithelial cells: ERK and RPE cell proliferation","volume":"43","author":"Hecquet","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2014.01.022_bib45","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbamem.2011.12.031","article-title":"Regulation of connexin expression by transcription factors and epigenetic mechanisms","volume":"1828","author":"Oyamada","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"Suppl 3","key":"10.1016\/j.ajpath.2014.01.022_bib46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2362.2000.0300s3021.x","article-title":"11Beta-hydroxysteroid-dehydrogenase isoforms: tissue distribution and implications for clinical medicine","volume":"30","author":"Diederich","year":"2000","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.ajpath.2014.01.022_bib47","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ab.2009.04.038","article-title":"Cell-based assay for screening 11beta-hydroxysteroid dehydrogenase 1 inhibitors","volume":"392","author":"Cho","year":"2009","journal-title":"Anal Biochem"},{"key":"10.1016\/j.ajpath.2014.01.022_bib48","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0039-128X(95)00201-Z","article-title":"11 beta-hydroxysteroid dehydrogenases of the choriocarcinoma cell line JEG-3 and their inhibition by glycyrrhetinic acid and other natural substances","volume":"61","author":"Gomez-Sanchez","year":"1996","journal-title":"Steroids"},{"key":"10.1016\/j.ajpath.2014.01.022_bib49","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1210\/endo.136.12.7588309","article-title":"LLC-PK1 cells model 11 beta-hydroxysteroid dehydrogenase type 2 regulation of glucocorticoid access to renal mineralocorticoid receptors","volume":"136","author":"Leckie","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2014.01.022_bib50","first-page":"395","article-title":"Local modulation by 11beta-hydroxysteroid dehydrogenase of glucocorticoid effects on the activity of 15-hydroxyprostaglandin dehydrogenase in human chorion and placental trophoblast cells","volume":"84","author":"Patel","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2014.01.022_bib51","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1152\/physrev.00007.2003","article-title":"Plasma membrane channels formed by connexins: their regulation and functions","volume":"83","author":"Saez","year":"2003","journal-title":"Physiol Rev"},{"key":"10.1016\/j.ajpath.2014.01.022_bib52","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/BJ20082319","article-title":"Connexin43 phosphorylation: structural changes and biological effects","volume":"419","author":"Solan","year":"2009","journal-title":"Biochem J"},{"key":"10.1016\/j.ajpath.2014.01.022_bib53","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1096\/fj.10-155291","article-title":"Connexon-mediated cell adhesion drives microtissue self-assembly","volume":"25","author":"Bao","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2014.01.022_bib54","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/glia.20728","article-title":"Adhesive properties of connexin hemichannels","volume":"56","author":"Cotrina","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.ajpath.2014.01.022_bib55","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.bbamem.2011.11.016","article-title":"Channel-independent influence of connexin 43 on cell migration","volume":"1818","author":"Kameritsch","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2014.01.022_bib56","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1524-475X.2003.11616.x","article-title":"Role for gap junctional intercellular communications in wound repair","volume":"11","author":"Ehrlich","year":"2003","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.ajpath.2014.01.022_bib57","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/jcb.20852","article-title":"Gap junction communications influence upon fibroblast synthesis of type I collagen and fibronectin","volume":"98","author":"Ehrlich","year":"2006","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.ajpath.2014.01.022_bib58","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1167\/iovs.12-10774","article-title":"Wnt signaling promotes M\u00fcller cell proliferation and survival after injury","volume":"54","author":"Liu","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.ajpath.2014.01.022_bib59","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/stem.268","article-title":"beta-Catenin signaling increases in proliferating NG2+ progenitors and astrocytes during post-traumatic gliogenesis in the adult brain","volume":"28","author":"White","year":"2010","journal-title":"Stem Cells"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944014000960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944014000960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T19:15:02Z","timestamp":1648667702000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944014000960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0002944014000960"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2014.01.022","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}