{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:42:57Z","timestamp":1784749377919,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":2131,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["24390047"],"award-info":[{"award-number":["24390047"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.ajpath.2014.05.015","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T07:16:43Z","timestamp":1405667803000},"page":"2505-2515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Fatty Acid Binding Protein 7 Regulates Phagocytosis and Cytokine Production in Kupffer Cells during Liver Injury"],"prefix":"10.1016","volume":"184","author":[{"given":"Hirofumi","family":"Miyazaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwa","family":"Kiyohira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yasumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiteru","family":"Kagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariful","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazem","family":"Sharifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuko","family":"Tokuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Terai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Sakaida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshizo","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Owada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2014.05.015_bib1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nm.2627","article-title":"The cellular and signaling networks linking the immune system and metabolism in disease","volume":"18","author":"Osborn","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2014.05.015_bib2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib3","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2009.03.008","article-title":"Kupffer cells in non-alcoholic fatty liver disease: the emerging view","volume":"51","author":"Baffy","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib4","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2014.05.015_bib5","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1478-3231.2006.01342.x","article-title":"Role of Kupffer cells in host defense and liver disease","volume":"26","author":"Bilzer","year":"2006","journal-title":"Liver Int"},{"key":"10.1016\/j.ajpath.2014.05.015_bib6","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.3748\/wjg.v12.i46.7413","article-title":"Role of Kupffer cells in the pathogenesis of liver disease","volume":"12","author":"Kolios","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1023\/A:1020502624234","article-title":"Insights into binding of fatty acids by fatty acid binding proteins","volume":"239","author":"Hanhoff","year":"2002","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.ajpath.2014.05.015_bib8","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.1128\/MCB.22.14.5114-5127.2002","article-title":"Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription","volume":"22","author":"Tan","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib9","doi-asserted-by":"crossref","first-page":"10273","DOI":"10.1074\/jbc.M109.097907","article-title":"Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1","volume":"285","author":"Hui","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2014.05.015_bib10","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrd2589","article-title":"Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets","volume":"7","author":"Furuhashi","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.ajpath.2014.05.015_bib11","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/89076","article-title":"Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis","volume":"7","author":"Makowski","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2014.05.015_bib12","doi-asserted-by":"crossref","first-page":"12888","DOI":"10.1074\/jbc.M413788200","article-title":"The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities","volume":"280","author":"Makowski","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2014.05.015_bib13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10735-005-9005-6","article-title":"Localization of epidermal-type fatty acid binding protein in macrophages in advanced atretic follicles of adult mice","volume":"36","author":"Nourani","year":"2005","journal-title":"J Mol Histol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib14","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1016\/j.biocel.2004.03.008","article-title":"L-FABP is exclusively expressed in alveolar macrophages within the myeloid lineage: evidence for a PPARalpha-independent expression","volume":"36","author":"Schachtrup","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib15","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nature05844","article-title":"Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2","volume":"447","author":"Furuhashi","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2014.05.015_bib16","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1161\/ATVBAHA.111.225839","article-title":"Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-gamma-regulated genes","volume":"31","author":"Babaev","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib17","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00418-003-0538-z","article-title":"Localization of brain-type fatty acid-binding protein in Kupffer cells of mice and its transient decrease in response to lipopolysaccharide","volume":"119","author":"Abdelwahab","year":"2003","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00281-009-0168-1","article-title":"Immune cell-mediated liver injury","volume":"31","author":"Corazza","year":"2009","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1254\/jphs.10045FP","article-title":"Hepatoprotective effects of Sedum sarmentosum on D-galactosamine\/lipopolysaccharide-induced murine fulminant hepatic failure","volume":"114","author":"Lian","year":"2010","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.ajpath.2014.05.015_bib20","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0002-9440(10)65594-0","article-title":"Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride","volume":"153","author":"Shi","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1460-9568.2006.04855.x","article-title":"Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene","volume":"24","author":"Owada","year":"2006","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.ajpath.2014.05.015_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1476-5381.1995.tb14924.x","article-title":"Effects of macrophage depletion on the induction of histidine decarboxylase by lipopolysaccharide, interleukin 1 and tumour necrosis factor","volume":"114","author":"Endo","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib23","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/hep.20301","article-title":"Kupffer cell-derived interleukin 10 is responsible for impaired bacterial clearance in bile duct-ligated mice","volume":"40","author":"Abe","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2014.05.015_bib24","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/hep.23337","article-title":"Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity","volume":"51","author":"Stienstra","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2014.05.015_bib25","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/nm.2048","article-title":"PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance","volume":"15","author":"Mukundan","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2014.05.015_bib26","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.freeradbiomed.2012.02.010","article-title":"P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice","volume":"52","author":"Chatterjee","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ajpath.2014.05.015_bib27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1084\/jem.165.3.657","article-title":"Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice","volume":"165","author":"Lehmann","year":"1987","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2014.05.015_bib28","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.3748\/wjg.v19.i24.3781","article-title":"Glycyrrhizic acid attenuates CCl4-induced hepatocyte apoptosis in rats via a p53-mediated pathway","volume":"19","author":"Guo","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib29","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.4049\/jimmunol.178.9.5635","article-title":"Macrophages and dendritic cells use different Axl\/Mertk\/Tyro3 receptors in clearance of apoptotic cells","volume":"178","author":"Seitz","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib30","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/sj.cdd.4402184","article-title":"Clearance of apoptotic cells by phagocytes","volume":"15","author":"Erwig","year":"2008","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.ajpath.2014.05.015_bib31","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00418-010-0754-2","article-title":"Identification of FABP7 in fibroblastic reticular cells of mouse lymph nodes","volume":"134","author":"Tokuda","year":"2010","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib32","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jhep.2007.02.003","article-title":"Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies","volume":"46","author":"Hemmann","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib33","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/hep.1840120519","article-title":"Infection of mice with lactate dehydrogenase-elevating virus destroys the subpopulation of Kupffer cells involved in receptor-mediated endocytosis of lactate dehydrogenase and other enzymes","volume":"12","author":"Smit","year":"1990","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2014.05.015_bib34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ajpath.2011.03.029","article-title":"Increased serum enzyme levels associated with kupffer cell reduction with no signs of hepatic or skeletal muscle injury","volume":"179","author":"Radi","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib35","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1172\/JCI200114122","article-title":"Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences","volume":"108","author":"Fadok","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2014.05.015_bib36","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1084\/jem.20060370","article-title":"Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells","volume":"203","author":"Greenberg","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2014.05.015_bib37","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.4049\/jimmunol.177.6.4047","article-title":"Requirements for apoptotic cell contact in regulation of macrophage responses","volume":"177","author":"Lucas","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2014.05.015_bib38","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1042\/bj2690807","article-title":"Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis","volume":"269","author":"Calder","year":"1990","journal-title":"Biochem J"},{"key":"10.1016\/j.ajpath.2014.05.015_bib39","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jnutbio.2009.02.008","article-title":"Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages","volume":"21","author":"Mullen","year":"2010","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.ajpath.2014.05.015_bib40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1620\/tjem.214.213","article-title":"Fatty acid binding protein: localization and functional significance in the brain","volume":"214","author":"Owada","year":"2008","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.ajpath.2014.05.015_bib41","doi-asserted-by":"crossref","first-page":"27045","DOI":"10.1016\/S0021-9258(19)61478-X","article-title":"Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein","volume":"275","author":"Balendiran","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2014.05.015_bib42","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s10620-010-1400-5","article-title":"Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine- and choline-deficient diet","volume":"56","author":"Kajikawa","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.ajpath.2014.05.015_bib43","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/hep.21626","article-title":"Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines","volume":"45","author":"Schmocker","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2014.05.015_bib44","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.clnu.2010.06.001","article-title":"The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease","volume":"30","author":"Shapiro","year":"2011","journal-title":"Clin Nutr"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944014003174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944014003174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:46:15Z","timestamp":1757601975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944014003174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0002944014003174"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2014.05.015","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fatty Acid Binding Protein 7 Regulates Phagocytosis and Cytokine Production in Kupffer Cells during Liver Injury","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2014.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}