{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:42:31Z","timestamp":1790260951574,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T00:00:00Z","timestamp":1442361600000},"content-version":"vor","delay-in-days":350,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.ajpath.2014.06.008","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T09:00:49Z","timestamp":1407488449000},"page":"2816-2827","source":"Crossref","is-referenced-by-count":32,"title":["CREB-Induced Inflammation Is Important for Malignant Mesothelioma Growth"],"prefix":"10.1016","volume":"184","author":[{"given":"Catherine M.","family":"Westbom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian B.","family":"MacPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Yasewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill M.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacie L.","family":"Beuschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey I.","family":"Pass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela M.","family":"Vacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2014.06.008_bib1","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1056\/NEJM198906293202604","article-title":"Asbestos-related diseases","volume":"320","author":"Mossman","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2014.06.008_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1053\/sonc.2002.30227","article-title":"The pathogenesis of mesothelioma","volume":"29","author":"Carbone","year":"2002","journal-title":"Semin Oncol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib3","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1183\/09031936.00037310","article-title":"Valproate-doxorubicin: promising therapy for progressing mesothelioma. A phase II study","volume":"37","author":"Scherpereel","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ajpath.2014.06.008_bib5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.lungcan.2009.08.007","article-title":"Results of systemic pemetrexed-based combination chemotherapy versus cytoreductive surgery and hyperthermic intraperitoneal cisplatin and doxorubicin on survival in malignant peritoneal mesothelioma","volume":"66","author":"Saxena","year":"2009","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ajpath.2014.06.008_bib6","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.ajpath.2012.12.028","article-title":"New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas","volume":"182","author":"Mossman","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/cgt.2013.1","article-title":"Gene therapy for malignant mesothelioma: current prospects and challenges","volume":"20","author":"Tagawa","year":"2013","journal-title":"Cancer Gene Ther"},{"key":"10.1016\/j.ajpath.2014.06.008_bib8","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1158\/1078-0432.CCR-12-3202","article-title":"Extracellular signal-regulated kinase 5: a potential therapeutic target for malignant mesotheliomas","volume":"19","author":"Shukla","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2014.06.008_bib9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/1476-4598-9-314","article-title":"Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin","volume":"9","author":"Shukla","year":"2010","journal-title":"Mol Cancer"},{"key":"10.1016\/j.ajpath.2014.06.008_bib10","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/ijc.25763","article-title":"ERK2 is essential for the growth of human epithelioid malignant mesotheliomas","volume":"129","author":"Shukla","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2014.06.008_bib11","first-page":"1041","article-title":"Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions","volume":"119","author":"Impey","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2014.06.008_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1615\/CritRevOncog.v16.i1-2.50","article-title":"CREB and leukemogenesis","volume":"16","author":"Cho","year":"2011","journal-title":"Crit Rev Oncog"},{"key":"10.1016\/j.ajpath.2014.06.008_bib13","first-page":"357","article-title":"Elevated p-CREB-2 (ser 245) expression is potentially associated with carcinogenesis and development of breast carcinoma","volume":"5","author":"Fan","year":"2012","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.ajpath.2014.06.008_bib14","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.1158\/0008-5472.CAN-07-5376","article-title":"Cyclic AMP response element-binding protein overexpression: a feature associated with negative prognosis in never smokers with non-small cell lung cancer","volume":"68","author":"Seo","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2014.06.008_bib15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.semcancer.2010.12.007","article-title":"Transcriptional control of melanoma metastasis: the importance of the tumor microenvironment","volume":"21","author":"Braeuer","year":"2011","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib16","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.2353\/ajpath.2009.090400","article-title":"Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis","volume":"175","author":"Shukla","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib17","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1128\/MCB.20.4.1436-1447.2000","article-title":"Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics","volume":"20","author":"Dickson","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib18","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0003-4975(95)00045-M","article-title":"Characteristics of nine newly derived mesothelioma cell lines","volume":"59","author":"Pass","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.ajpath.2014.06.008_bib19","first-page":"3199","article-title":"Characterization of a human malignant mesothelioma cell line (H-MESO-1): a biphasic solid and ascitic tumor model","volume":"47","author":"Reale","year":"1987","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2014.06.008_bib20","unstructured":"Campbell WJ, Huggins CW, Wylie AG: Chemical and physical characterization of amosite, chrysotile, crocidolite, and nonfibrous tremolite for oral ingestion studies In US Bureau of Mines Report of Investigations Washington, DC: National Institute of Environmental Health Sciences; 1980"},{"key":"10.1016\/j.ajpath.2014.06.008_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1743-8977-10-39","article-title":"Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells","volume":"10","author":"Hillegass","year":"2013","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1165\/ajrcmb.17.3.2991","article-title":"Novel cell imaging techniques show induction of apoptosis and proliferation in mesothelial cells by asbestos","volume":"17","author":"Goldberg","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib23","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1158\/0008-5472.CAN-06-2389","article-title":"A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in\u00a0vivo and prevents tumor recurrence after surgical resection","volume":"67","author":"Suzuki","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2014.06.008_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1749-6632.2010.05554.x","article-title":"Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model","volume":"1203","author":"Hillegass","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ajpath.2014.06.008_bib25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/wnan.54","article-title":"Assessing nanotoxicity in cells in\u00a0vitro","volume":"2","author":"Hillegass","year":"2010","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib26","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1096\/fj.05-4554fje","article-title":"Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung","volume":"20","author":"Shukla","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2014.06.008_bib27","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.ajpath.2014.06.008_bib28","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1165\/rcmb.2008-0146OC","article-title":"Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity","volume":"41","author":"Shukla","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib29","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2014.06.008_bib30","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/(SICI)1097-0215(19980413)76:2<240::AID-IJC12>3.0.CO;2-G","article-title":"Hepatocyte growth factor\/scatter factor stimulates chemotaxis and growth of malignant mesothelioma cells through c-met receptor","volume":"76","author":"Klominek","year":"1998","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2014.06.008_bib31","first-page":"4331","article-title":"Establishment and characterization of a human gastrointestinal stromal tumour (GIST) xenograft in athymic nude mice","volume":"29","author":"Revheim","year":"2009","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ajpath.2014.06.008_bib32","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.humpath.2009.12.016","article-title":"Cell adhesion molecules P-cadherin and CD24 are markers for carcinoma and dysplasia in the biliary tract","volume":"41","author":"Riener","year":"2010","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib33","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1165\/ajrcmb.26.4.4613","article-title":"Production of eosinophilic chemokines by normal pleural mesothelial cells","volume":"26","author":"Katayama","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib34","first-page":"187","article-title":"Inhibition of interleukin-8 reduces human malignant pleural mesothelioma propagation in nude mouse model","volume":"11","author":"Galffy","year":"1999","journal-title":"Oncol Res"},{"key":"10.1016\/j.ajpath.2014.06.008_bib35","first-page":"2063","article-title":"Independent expression of serum vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in patients with carcinoma and sarcoma","volume":"18","author":"Linder","year":"1998","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ajpath.2014.06.008_bib36","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1158\/1940-6207.CAPR-07-0002","article-title":"Cyclic AMP-responsive element binding protein- and nuclear factor-kappaB-regulated CXC chemokine gene expression in lung carcinogenesis","volume":"1","author":"Sun","year":"2008","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.ajpath.2014.06.008_bib37","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/aps.2012.61","article-title":"Calcium mediates high glucose-induced HIF1\u03b1 and VEGF expression in cultured rat retinal M\u00fcller cells through CaMKII-CREB pathway","volume":"33","author":"Li","year":"2012","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.ajpath.2014.06.008_bib38","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.4049\/jimmunol.1001829","article-title":"The role of the transcription factor CREB in immune function","volume":"185","author":"Wen","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2014.06.008_bib39","first-page":"4419","article-title":"Intrapleural production of interleukin 6 during mesothelioma and its modulation by gamma-interferon treatment","volume":"54","author":"Monti","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2014.06.008_bib40","doi-asserted-by":"crossref","first-page":"28975","DOI":"10.1074\/jbc.M113.483826","article-title":"cAMP response element-binding protein (CREB) and nuclear factor \u03baB mediate the tamoxifen-induced up-regulation of glutamate transporter 1 (GLT-1) in rat astrocytes","volume":"288","author":"Karki","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2014.06.008_bib41","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1872-034X.2012.01067.x","article-title":"Increased glutathione and mitogen-activated protein kinase phosphorylation are involved in the induction of doxorubicin resistance in hepatocellular carcinoma cells","volume":"43","author":"Ye","year":"2013","journal-title":"Hepatol Res"},{"key":"10.1016\/j.ajpath.2014.06.008_bib42","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.canlet.2013.04.028","article-title":"Angiopoietin2 enhances doxorubicin resistance in HepG2 cells by upregulating survivin and Ref-1 via MSK1 activation","volume":"337","author":"Li","year":"2013","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ajpath.2014.06.008_bib43","doi-asserted-by":"crossref","first-page":"e516","DOI":"10.1038\/cddis.2013.39","article-title":"Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis","volume":"4","author":"Gausdal","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ajpath.2014.06.008_bib44","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1158\/1078-0432.CCR-13-0495","article-title":"HMGB1 in cancer: good, bad, or both?","volume":"19","author":"Kang","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ajpath.2014.06.008_bib45","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jss.2011.02.026","article-title":"LPS induces HMGB1 relocation and release by activating the NF-\u03baB-CBP signal transduction pathway in the murine macrophage-like cell line RAW264.7","volume":"175","author":"Wu","year":"2012","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.ajpath.2014.06.008_bib46","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/jcb.20194","article-title":"Histone acetyltransferase activity of p300 enhances the activation of IL-18 promoter","volume":"94","author":"Sun","year":"2005","journal-title":"J Cell Biochem"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944014003630?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944014003630?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T22:53:28Z","timestamp":1538348008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944014003630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0002944014003630"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2014.06.008","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}