{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T18:59:48Z","timestamp":1766516388777,"version":"3.44.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":348,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56-AI097679-01A","R01-GM102146"],"award-info":[{"award-number":["R56-AI097679-01A","R01-GM102146"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.ajpath.2014.10.005","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T01:30:30Z","timestamp":1417656630000},"page":"446-461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Type I Interferon Contributes to Noncanonical Inflammasome Activation, Mediates Immunopathology, and Impairs Protective Immunity during Fatal Infection with Lipopolysaccharide-Negative Ehrlichiae"],"prefix":"10.1016","volume":"185","author":[{"given":"Qin","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather L.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie J.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahed","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2014.10.005_bib1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0025-7125(03)00093-2","article-title":"Human ehrlichioses","volume":"86","author":"Olano","year":"2002","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.ajpath.2014.10.005_bib2","first-page":"785","article-title":"Human monocytic and granulocytic ehrlichioses. Discovery and diagnosis of emerging tick-borne infections and the critical role of the pathologist","volume":"121","author":"Walker","year":"1997","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.ajpath.2014.10.005_bib3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0002-9343(93)90302-6","article-title":"Ehrlichiosis presenting as a life-threatening illness with features of the toxic shock syndrome","volume":"95","author":"Fichtenbaum","year":"1993","journal-title":"Am J Med"},{"key":"10.1016\/j.ajpath.2014.10.005_bib4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fcimb.2011.00022","article-title":"Ehrlichia chaffeensis tandem repeat proteins and Ank200 are type 1 secretion system substrates related to the repeats-in-toxin exoprotein family","volume":"1","author":"Wakeel","year":"2011","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib5","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1128\/IAI.00198-07","article-title":"Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in Ehrlichia-induced immunopathology in murine ehrlichiosis","volume":"75","author":"Ismail","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2014.10.005_bib6","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.4049\/jimmunol.172.3.1786","article-title":"Overproduction of TNF-alpha by CD8+ type 1 cells and down-regulation of IFN-gamma production by CD4+ Th1 cells contribute to toxic shock-like syndrome in an animal model of\u00a0fatal monocytotropic ehrlichiosis","volume":"172","author":"Ismail","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib7","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1128\/IAI.74.3.1846-1856.2006","article-title":"Role of tumor necrosis factor alpha (TNF-alpha) and interleukin-10 in the pathogenesis of severe murine monocytotropic ehrlichiosis: increased resistance of TNF receptor p55- and p75-deficient mice to fatal ehrlichial infection","volume":"74","author":"Ismail","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2014.10.005_bib8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2172-13-26","article-title":"Immune mediators of protective and pathogenic immune responses in patients with mild and fatal human monocytotropic ehrlichiosis","volume":"13","author":"Ismail","year":"2012","journal-title":"BMC Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib9","doi-asserted-by":"crossref","first-page":"4856","DOI":"10.1128\/IAI.00246-06","article-title":"An intradermal environment promotes a protective type-1 response against lethal systemic monocytotropic ehrlichial infection","volume":"74","author":"Stevenson","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2014.10.005_bib10","doi-asserted-by":"crossref","first-page":"766","DOI":"10.2353\/ajpath.2010.091110","article-title":"Natural killer cells promote tissue injury and systemic inflammatory responses during fatal Ehrlichia-induced toxic shock-like syndrome","volume":"177","author":"Stevenson","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib11","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1128\/IAI.01242-07","article-title":"Regulatory roles of CD1d-restricted NKT cells in the induction of toxic shock-like syndrome in an animal model of fatal ehrlichiosis","volume":"76","author":"Stevenson","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2014.10.005_bib12","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.4049\/jimmunol.1100092","article-title":"The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria","volume":"187","author":"Ghose","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib13","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1128\/IAI.01409-12","article-title":"Neutrophils mediate immunopathology and negatively regulate protective immune responses during fatal bacterial infection-induced toxic shock","volume":"81","author":"Yang","year":"2013","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2014.10.005_bib14","doi-asserted-by":"crossref","first-page":"e58514","DOI":"10.1371\/journal.pone.0058514","article-title":"TLR2 and Nod2 mediate resistance or susceptibility to fatal intracellular Ehrlichia infection in murine models of ehrlichiosis","volume":"8","author":"Chattoraj","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2014.10.005_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mib.2012.11.008","article-title":"Inflammasomes and host defenses against bacterial infections","volume":"16","author":"Vladimer","year":"2013","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib16","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1126\/science.1229010","article-title":"Immunology. Orchestrating inflammasomes","volume":"337","author":"Franchi","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2014.10.005_bib17","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev-immunol-031210-101405","article-title":"The inflammasome NLRs in immunity, inflammation, and associated diseases","volume":"29","author":"Davis","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib18","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature03408","article-title":"Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections","volume":"434","author":"Mattner","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2014.10.005_bib19","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3389\/fimmu.2013.00486","article-title":"Licensing adaptive immunity by NOD-like receptors","volume":"4","author":"Liu","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib20","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nature11012","article-title":"NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells","volume":"484","author":"Eisenbarth","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2014.10.005_bib21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1586\/erv.11.189","article-title":"Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants","volume":"11","author":"Olive","year":"2012","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.ajpath.2014.10.005_bib22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen recognition by the innate immune system","volume":"30","author":"Kumar","year":"2011","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/1040841X.2012.706249","article-title":"Recognition of bacterial infection by innate immune sensors","volume":"39","author":"Kumar","year":"2013","journal-title":"Crit Rev Microbiol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature11351","article-title":"Rapid induction of inflammatory lipid mediators by the inflammasome in\u00a0vivo","volume":"490","author":"von Moltke","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2014.10.005_bib25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","article-title":"Activation and regulation of the inflammasomes","volume":"13","author":"Latz","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib26","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ni.2231","article-title":"Sensing and reacting to microbes through the inflammasomes","volume":"13","author":"Franchi","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib27","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ni.2550","article-title":"Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome","volume":"14","author":"Misawa","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib29","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1100\/2011\/212680","article-title":"Role of the inflammasome, IL-1beta, and IL-18 in bacterial infections","volume":"11","author":"Sahoo","year":"2011","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.ajpath.2014.10.005_bib30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-62703-523-1_7","article-title":"Detection of pyroptosis by measuring released lactate dehydrogenase activity","volume":"1040","author":"Rayamajhi","year":"2013","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.mib.2013.04.004","article-title":"Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection","volume":"16","author":"Aachoui","year":"2013","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ni.2237","article-title":"Regulation of inflammasome signaling","volume":"13","author":"Rathinam","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4161\/auto.3655","article-title":"Autophagic elimination of intracellular parasites: convergent induction by IFN-gamma and CD40 ligation?","volume":"3","author":"Yap","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.ajpath.2014.10.005_bib34","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nature07383","article-title":"Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production","volume":"456","author":"Saitoh","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2014.10.005_bib35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2014.10.005_bib36","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cell.2012.07.007","article-title":"TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by Gram-negative bacteria","volume":"150","author":"Rathinam","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2014.10.005_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.ajpath.2014.10.005_bib38","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1084\/jem.20091746","article-title":"Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma","volume":"207","author":"Rayamajhi","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2014.10.005_bib39","doi-asserted-by":"crossref","first-page":"34474","DOI":"10.1074\/jbc.M112.401406","article-title":"Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-beta (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens","volume":"287","author":"Gurung","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2014.10.005_bib40","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","author":"Ivashkiv","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib41","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mib.2005.12.003","article-title":"Ehrlichia subversion of host innate responses","volume":"9","author":"Rikihisa","year":"2006","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib42","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1084\/jem.20101664","article-title":"Type I interferon: friend or foe?","volume":"207","author":"Trinchieri","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2014.10.005_bib43","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1128\/IAI.01564-13","article-title":"Type I interferons promote severe disease in a mouse model of lethal ehrlichiosis","volume":"82","author":"Zhang","year":"2014","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2014.10.005_bib44","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1126\/science.7535475","article-title":"Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme","volume":"267","author":"Kuida","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2014.10.005_bib45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1574-6968.2002.tb11038.x","article-title":"Current status of immune mechanisms of killing of intracellular microorganisms","volume":"207","author":"Ismail","year":"2002","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.ajpath.2014.10.005_bib46","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1196\/annals.1355.070","article-title":"Balancing protective immunity and immunopathology: a unifying model of monocytotropic ehrlichiosis","volume":"1063","author":"Ismail","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ajpath.2014.10.005_bib47","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature13157","article-title":"Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases","volume":"509","author":"Meunier","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2014.10.005_bib48","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.4049\/jimmunol.165.9.4917","article-title":"A subset of NKT cells that lacks the NK1.1 marker, expresses CD1d molecules, and autopresents the alpha-galactosylceramide antigen","volume":"165","author":"Hameg","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib49","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.4049\/jimmunol.171.11.5913","article-title":"Control of NKT cell differentiation by tissue-specific microenvironments","volume":"171","author":"Yang","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib50","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1128\/IAI.00007-07","article-title":"Differential interaction of dendritic cells with Rickettsia conorii: impact on host susceptibility to murine spotted fever rickettsiosis","volume":"75","author":"Fang","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2014.10.005_bib51","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1128\/IAI.01293-07","article-title":"Protective heterologous immunity against fatal ehrlichiosis and lack of protection following homologous challenge","volume":"76","author":"Thirumalapura","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2014.10.005_bib52","first-page":"971","article-title":"Induction of HGF and VEGF in hepatic regeneration after hepatotoxin-induced cirrhosis in mice","volume":"58","author":"Tekkesin","year":"2011","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.ajpath.2014.10.005_bib53","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1128\/IAI.00720-09","article-title":"Persistent infection contributes to heterologous protective immunity against fatal ehrlichiosis","volume":"77","author":"Thirumalapura","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2014.10.005_bib54","doi-asserted-by":"crossref","first-page":"e1003400","DOI":"10.1371\/journal.ppat.1003400","article-title":"Caspase-11 activation in response to bacterial secretion systems that access the host cytosol","volume":"9","author":"Casson","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2014.10.005_bib55","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nature11419","article-title":"Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1","volume":"490","author":"Broz","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2014.10.005_bib56","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1126\/science.1230751","article-title":"Caspase-11 protects against bacteria that escape the vacuole","volume":"339","author":"Aachoui","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2014.10.005_bib57","doi-asserted-by":"crossref","first-page":"399","DOI":"10.4161\/auto.5907","article-title":"Autophagic cell death unraveled: pharmacological inhibition of apoptosis and autophagy enables necrosis","volume":"4","author":"White","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.ajpath.2014.10.005_bib58","doi-asserted-by":"crossref","first-page":"20800","DOI":"10.1073\/pnas.1218674109","article-title":"Autophagosomes induced by a bacterial beclin 1 binding protein facilitate obligatory intracellular infection","volume":"109","author":"Niu","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2014.10.005_bib59","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.semnephrol.2013.11.008","article-title":"Autophagy and immune response in kidneys","volume":"34","author":"Leventhal","year":"2014","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib60","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2014.10.005_bib61","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.yexcr.2014.01.001","article-title":"Autophagy inhibition induces podocyte apoptosis by activating the pro-apoptotic pathway of endoplasmic reticulum stress","volume":"322","author":"Fang","year":"2014","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2014.10.005_bib62","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1242\/jcs.094573","article-title":"Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages","volume":"125","author":"Yuan","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2014.10.005_bib63","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib64","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.yexcr.2011.12.021","article-title":"Autophagy regulation in macrophages and neutrophils","volume":"318","author":"Mihalache","year":"2012","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2014.10.005_bib65","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.bbamcr.2008.07.014","article-title":"Autophagy: a lysosomal degradation pathway with a central role in health and disease","volume":"1793","author":"Eskelinen","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2014.10.005_bib66","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imm.12168","article-title":"Autophagy activation by interferon-gamma via the p38 mitogen-activated protein kinase signalling pathway is involved in macrophage bactericidal activity","volume":"141","author":"Matsuzawa","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.ajpath.2014.10.005_bib67","doi-asserted-by":"crossref","first-page":"553","DOI":"10.4161\/auto.4615","article-title":"Cytosolic LC3 ratio as a sensitive index of macroautophagy in isolated rat hepatocytes and H4-II-E cells","volume":"3","author":"Karim","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.ajpath.2014.10.005_bib68","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4161\/auto.7.10.16490","article-title":"Cleaving beclin 1 to suppress autophagy in chemotherapy-induced apoptosis","volume":"7","author":"Li","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.ajpath.2014.10.005_bib69","doi-asserted-by":"crossref","first-page":"15947","DOI":"10.1074\/jbc.M112.426791","article-title":"Caspase 1 activation is protective against hepatocyte cell death by up-regulating beclin 1 protein and mitochondrial autophagy in the setting of redox stress","volume":"288","author":"Sun","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2014.10.005_bib70","doi-asserted-by":"crossref","first-page":"967852","DOI":"10.1155\/2012\/967852","article-title":"New insight into immunity and immunopathology of Rickettsial diseases","volume":"2012","author":"Mansueto","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib71","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.1073\/pnas.1321700111","article-title":"Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS","volume":"111","author":"Pilla","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ajpath.2014.10.005_bib72","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.mib.2013.11.008","article-title":"Detection of cytosolic bacteria by inflammatory caspases","volume":"17","author":"Hagar","year":"2014","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.ajpath.2014.10.005_bib73","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.4049\/jimmunol.1301581","article-title":"Salmonella infection induces recruitment of caspase-8 to the inflammasome to modulate IL-1beta production","volume":"191","author":"Man","year":"2013","journal-title":"J Immunol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944014005975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944014005975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:45:53Z","timestamp":1757601953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944014005975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":73,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0002944014005975"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2014.10.005","relation":{},"ISSN":["0002-9440"],"issn-type":[{"type":"print","value":"0002-9440"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Type I Interferon Contributes to Noncanonical Inflammasome Activation, Mediates Immunopathology, and Impairs Protective Immunity during Fatal Infection with Lipopolysaccharide-Negative Ehrlichiae","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2014.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}