{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:05:33Z","timestamp":1758042333857,"version":"3.44.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":1717,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Science Research","award":["20590385"],"award-info":[{"award-number":["20590385"]}]},{"name":"Young Scientists","award":["23790379"],"award-info":[{"award-number":["23790379"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for Promotion of Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tokai University School of Medicine research"}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.ajpath.2014.12.015","type":"journal-article","created":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T09:33:08Z","timestamp":1423906388000},"page":"958-968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aberrant Activation of Atypical Protein Kinase C in Carbon Tetrachloride\u2013Induced Oxidative Stress Provokes a Disturbance of Cell Polarity and Sealing of Bile Canalicular Lumen"],"prefix":"10.1016","volume":"185","author":[{"given":"Yosuke","family":"Horikoshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanae","family":"Kitatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Toriumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahoko","family":"Fukunishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Matsura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Takekoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2014.12.015_bib1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00795-003-0220-5","article-title":"Regulation of the blood-biliary barrier: interaction between gap and tight junctions in hepatocytes","volume":"36","author":"Kojima","year":"2003","journal-title":"Med Electron Microsc"},{"key":"10.1016\/j.ajpath.2014.12.015_bib2","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1056\/NEJM199810223391707","article-title":"Molecular pathogenesis of cholestasis","volume":"339","author":"Trauner","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2014.12.015_bib3","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/hep.1840010612","article-title":"Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis","volume":"1","author":"Ludwig","year":"1981","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2014.12.015_bib4","first-page":"93","article-title":"The morphologic characteristics of intercellular junctions between normal human liver cells and cells from patients with extrahepatic cholestasis","volume":"100","author":"Robenek","year":"1980","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib5","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1053\/jhep.2001.25086","article-title":"Alterations in tight junctions differ between primary biliary cirrhosis and primary sclerosing cholangitis","volume":"33","author":"Sakisaka","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2014.12.015_bib6","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1242\/jcs.02898","article-title":"The PAR-aPKC system: lessons in polarity","volume":"119","author":"Suzuki","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2014.12.015_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrc3169","article-title":"Epithelial cell polarity, stem cells and cancer","volume":"12","author":"Martin-Belmonte","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.ajpath.2014.12.015_bib8","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1242\/jcs.043174","article-title":"Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells","volume":"122","author":"Horikoshi","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2014.12.015_bib9","doi-asserted-by":"crossref","first-page":"R126","DOI":"10.1016\/j.cub.2010.12.003","article-title":"Molecular regulation of lumen morphogenesis","volume":"21","author":"Datta","year":"2011","journal-title":"Curr Biol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib10","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/gut.2007.133132","article-title":"Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis","volume":"57","author":"Wapenaar","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2014.12.015_bib11","first-page":"2483","article-title":"Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation","volume":"127","author":"Wang","year":"2014","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2014.12.015_bib12","doi-asserted-by":"crossref","first-page":"e4194","DOI":"10.1371\/journal.pone.0004194","article-title":"An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms","volume":"4","author":"Hirose","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2014.12.015_bib13","doi-asserted-by":"crossref","first-page":"e74871","DOI":"10.1371\/journal.pone.0074871","article-title":"Citral is renoprotective for focal segmental glomerulosclerosis by inhibiting oxidative stress and apoptosis and activating Nrf2 pathway in mice","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2014.12.015_bib14","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1046\/j.1365-2443.2002.00590.x","article-title":"Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells","volume":"7","author":"Nagai-Tamai","year":"2002","journal-title":"Genes Cells"},{"key":"10.1016\/j.ajpath.2014.12.015_bib15","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0960-9822(03)00244-6","article-title":"Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity","volume":"13","author":"Yamanaka","year":"2003","journal-title":"Curr Biol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib16","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1177\/002215549904700601","article-title":"Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue","volume":"47","author":"Schnell","year":"1999","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.ajpath.2014.12.015_bib17","first-page":"62","article-title":"Carbon tetrachloride induced proliferation of tight junctions in the rat liver as revealed by freeze-fracturing","volume":"20","author":"Robenek","year":"1979","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib18","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1096\/fasebj.8.15.8001741","article-title":"Novel mechanisms in chemically induced hepatotoxicity","volume":"8","author":"Mehendale","year":"1994","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2014.12.015_bib19","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1096\/fasebj.6.2.1537462","article-title":"Oxidative and reductive metabolism by cytochrome P450 2E1","volume":"6","author":"Koop","year":"1992","journal-title":"FASEB J"},{"key":"10.1016\/j.ajpath.2014.12.015_bib20","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0891-5849(99)00087-8","article-title":"Persistent oxidative stress in human colorectal carcinoma, but not in adenoma","volume":"27","author":"Kondo","year":"1999","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ajpath.2014.12.015_bib21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1083\/jcb.19.1.139","article-title":"Liver parenchymal cell injury, I: initial alterations of the cell following poisoning with carbon tetrachloride","volume":"19","author":"Reynolds","year":"1963","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib22","doi-asserted-by":"crossref","first-page":"a001321","DOI":"10.1101\/cshperspect.a001321","article-title":"Membrane organization and dynamics in cell polarity","volume":"1","author":"Orlando","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib23","doi-asserted-by":"crossref","first-page":"6970","DOI":"10.1038\/onc.2008.347","article-title":"Polarity proteins in migration and invasion","volume":"27","author":"Etienne-Manneville","year":"2008","journal-title":"Oncogene"},{"issue":"Pt 24","key":"10.1016\/j.ajpath.2014.12.015_bib24","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1242\/jcs.110.24.3001","article-title":"Post-Golgi biosynthetic trafficking","volume":"110","author":"Keller","year":"1997","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2014.12.015_bib25","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0960-9822(98)70444-0","article-title":"Regulation of protein kinase C zeta by PI 3-kinase and PDK-1","volume":"8","author":"Chou","year":"1998","journal-title":"Curr Biol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jb\/mvg018","article-title":"Protein kinase C lambda\/iota (PKClambda\/iota): a PKC isotype essential for the development of multicellular organisms","volume":"133","author":"Suzuki","year":"2003","journal-title":"J Biochem"},{"key":"10.1016\/j.ajpath.2014.12.015_bib27","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1093\/emboj\/cdg513","article-title":"Redox regulation of PI 3-kinase signalling via inactivation of PTEN","volume":"22","author":"Leslie","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2014.12.015_bib28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/labinvest.2012.145","article-title":"Carbon tetrachloride-induced hepatic injury through formation of oxidized diacylglycerol and activation of the PKC\/NF-kappaB pathway","volume":"93","author":"Toriumi","year":"2013","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2014.12.015_bib29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ccr.2012.08.004","article-title":"Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis","volume":"22","author":"Iden","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ajpath.2014.12.015_bib30","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1242\/jcs.00032","article-title":"aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization","volume":"115","author":"Suzuki","year":"2002","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2014.12.015_bib31","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1242\/jcs.02938","article-title":"Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity","volume":"119","author":"Yamanaka","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2014.12.015_bib32","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1242\/jcs.115.12.2485","article-title":"Involvement of ASIP\/PAR-3 in the promotion of epithelial tight junction formation","volume":"115","author":"Hirose","year":"2002","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2014.12.015_bib33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0168-8278(99)80179-2","article-title":"Molecular regulation of hepatocellular transport systems in cholestasis","volume":"31","author":"Trauner","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib34","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/hep.510250522","article-title":"Endotoxin impairs biliary glutathione and HCO3- excretion and blocks the choleretic effect of nitric oxide in rat liver","volume":"25","author":"Trauner","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2014.12.015_bib35","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1136\/gut.31.8.938","article-title":"Tumour necrosis factor, cholestatic jaundice, and chronic liver disease","volume":"31","author":"Jones","year":"1990","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2014.12.015_bib36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00397920","article-title":"Severe intrahepatic cholestasis in patients treated with recombinant interleukin-2 and lymphokine-activated killer cells","volume":"115","author":"Hoffman","year":"1989","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib37","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1083\/jcb.41.3.736","article-title":"Liver parenchymal cell injury. 8. Lesions of membranous cellular components following iodoform","volume":"41","author":"Sell","year":"1969","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1289\/ehp.761513","article-title":"Structural and functional changes in acute liver injury","volume":"15","author":"Smuckler","year":"1976","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.ajpath.2014.12.015_bib39","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/019262338401200403","article-title":"Protection of hepatocytes with hyperoxia against carbon tetrachloride-induced injury","volume":"12","author":"Bernacchi","year":"1984","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib40","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.cub.2009.05.065","article-title":"Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration","volume":"19","author":"Schmoranzer","year":"2009","journal-title":"Curr Biol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib41","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.cell.2005.02.022","article-title":"Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells","volume":"121","author":"Gomes","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2014.12.015_bib42","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.cub.2011.03.029","article-title":"KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells","volume":"21","author":"Yoshihama","year":"2011","journal-title":"Curr Biol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib43","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.cub.2010.01.065","article-title":"Membrane targeting of Bazooka\/PAR-3 is mediated by direct binding to phosphoinositide lipids","volume":"20","author":"Krahn","year":"2010","journal-title":"Curr Biol"},{"key":"10.1016\/j.ajpath.2014.12.015_bib44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1247\/csf.11005","article-title":"Phosphoinositide binding by par-3 involved in par-3 localization","volume":"36","author":"Horikoshi","year":"2011","journal-title":"Cell Struct Funct"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944015000231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944015000231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:46:40Z","timestamp":1757602000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944015000231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S0002944015000231"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2014.12.015","relation":{},"ISSN":["0002-9440"],"issn-type":[{"type":"print","value":"0002-9440"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrant Activation of Atypical Protein Kinase C in Carbon Tetrachloride\u2013Induced Oxidative Stress Provokes a Disturbance of Cell Polarity and Sealing of Bile Canalicular Lumen","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2014.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}