{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:05:23Z","timestamp":1789689923376,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":1656,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.ajpath.2015.02.006","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T01:05:59Z","timestamp":1428282359000},"page":"1740-1748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Molecular Evidence for Antigen Drive in the Natural History of Mantle Cell Lymphoma"],"prefix":"10.1016","volume":"185","author":[{"given":"Aliki","family":"Xochelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley-Ann","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Agathangelidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Stalika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Karypidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotini","family":"Marantidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba Navarro","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgos","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Supikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Groenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Boudjogra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Sundstrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurilio","family":"Ponzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana Skuhrova","family":"Francova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achilles","family":"Anagnostopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarka","family":"Pospisilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Papadaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Tzovaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Ghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Pott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Davi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Rosenquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Hadzidimitriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysoula","family":"Belessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Stamatopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2015.02.006_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.biochem.76.061705.090740","article-title":"Molecular mechanisms of antibody somatic hypermutation","volume":"76","author":"Di Noia","year":"2007","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.ajpath.2015.02.006_bib2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0065-2776(06)94006-1","article-title":"Evolution of the immunoglobulin heavy chain class switch recombination mechanism","volume":"94","author":"Chaudhuri","year":"2007","journal-title":"Adv Immunol"},{"key":"10.1016\/j.ajpath.2015.02.006_bib3","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1182\/blood-2012-08-449744","article-title":"IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions","volume":"120","author":"Patten","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib4","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/ajh.23176","article-title":"Mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and clinical management","volume":"87","author":"Vose","year":"2012","journal-title":"Am J Hematol"},{"key":"10.1016\/j.ajpath.2015.02.006_bib5","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1038\/leu.2012.72","article-title":"Non-nodal type of mantle cell lymphoma is a specific biological and clinical subgroup of the disease","volume":"26","author":"Royo","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.ajpath.2015.02.006_bib6","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1172\/JCI61272","article-title":"Molecular pathogenesis of mantle cell lymphoma","volume":"122","author":"Jares","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2015.02.006_bib7","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1182\/blood-2002-11-3456","article-title":"Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations","volume":"101","author":"Camacho","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib8","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1182\/blood-2003-05-1383","article-title":"VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome","volume":"102","author":"Kienle","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib9","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1182\/blood-2002-06-1864","article-title":"A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease","volume":"101","author":"Orchard","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib10","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/modpathol.2008.199","article-title":"Hypermutation in mantle cell lymphoma does not indicate a clinical or biological subentity","volume":"22","author":"Schraders","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1016\/j.ajpath.2015.02.006_bib11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1034\/j.1600-0609.2002.01662.x","article-title":"Somatic hypermutation and V(H) gene usage in mantle cell lymphoma","volume":"68","author":"Thorselius","year":"2002","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.ajpath.2015.02.006_bib12","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1182\/blood-2002-11-3479","article-title":"Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma","volume":"101","author":"Walsh","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib13","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1182\/blood-2011-03-343434","article-title":"Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases","volume":"118","author":"Hadzidimitriou","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.semcancer.2011.09.009","article-title":"Unlocking the secrets of immunoglobulin receptors in mantle cell lymphoma: implications for the origin and selection of the malignant cells","volume":"21","author":"Agathangelidis","year":"2011","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.ajpath.2015.02.006_bib15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.semcancer.2013.07.006","article-title":"Antigen selection in B-cell lymphomas\u2013tracing the evidence","volume":"23","author":"Sutton","year":"2013","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.ajpath.2015.02.006_bib16","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1158\/0008-5472.CAN-12-1615","article-title":"Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features","volume":"72","author":"Navarro","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2015.02.006_bib17","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1182\/blood-2011-11-391474","article-title":"Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma","volume":"119","author":"Kridel","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1056\/NEJMoa1306220","article-title":"Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma","volume":"369","author":"Wang","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2015.02.006_bib19","unstructured":"Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds): WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. ed 4. WHO Classification of Tumours, vol 2. Lyon, France: IARC Press, 2008"},{"key":"10.1016\/j.ajpath.2015.02.006_bib20","doi-asserted-by":"crossref","first-page":"D1006","DOI":"10.1093\/nar\/gkn838","article-title":"IMGT, the international ImMunoGeneTics information system","volume":"37","author":"Lefranc","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2015.02.006_bib21","doi-asserted-by":"crossref","first-page":"W503","DOI":"10.1093\/nar\/gkn316","article-title":"IMGT\/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis","volume":"36","author":"Brochet","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2015.02.006_bib22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2119\/molmed.2013.00042","article-title":"Temporal dynamics of clonal evolution in chronic lymphocytic leukemia with stereotyped IGHV4-34\/IGKV2-30 antigen receptors: longitudinal immunogenetic evidence","volume":"19","author":"Sutton","year":"2013","journal-title":"Mol Med"},{"key":"10.1016\/j.ajpath.2015.02.006_bib23","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1182\/blood-2009-05-221309","article-title":"Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen","volume":"114","author":"Sutton","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib24","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/leu.2010.90","article-title":"Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukemia alludes to antigen-driven clonal evolution","volume":"24","author":"Kostareli","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.ajpath.2015.02.006_bib25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bcmd.2009.12.005","article-title":"Activation-induced cytidine deaminase splicing patterns in chronic lymphocytic leukemia","volume":"44","author":"Marantidou","year":"2010","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.ajpath.2015.02.006_bib26","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","article-title":"Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia","volume":"94","author":"Damle","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib27","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","article-title":"Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia","volume":"94","author":"Hamblin","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib28","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1182\/blood-2007-07-099564","article-title":"Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis","volume":"111","author":"Murray","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib29","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/leu.2012.3","article-title":"Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications","volume":"26","author":"Bikos","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.ajpath.2015.02.006_bib30","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1182\/blood-2003-05-1632","article-title":"Mantle cell lymphoma with t(11;14) and unmutated or mutated VH genes expresses AID and undergoes isotype switch events","volume":"103","author":"Babbage","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib31","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1182\/blood-2004-09-3473","article-title":"Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients","volume":"105","author":"Guikema","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib32","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/path.1961","article-title":"Immunoglobulin class-switch recombination occurs in mantle cell lymphomas","volume":"209","author":"Klapper","year":"2006","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2015.02.006_bib33","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1182\/blood-2010-05-284984","article-title":"The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia","volume":"117","author":"Herishanu","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib34","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2119\/molmed.2011.00480","article-title":"Distinct innate immunity pathways to activation and tolerance in subgroups of chronic lymphocytic leukemia with distinct immunoglobulin receptors","volume":"18","author":"Ntoufa","year":"2012","journal-title":"Mol Med"},{"key":"10.1016\/j.ajpath.2015.02.006_bib35","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/leu.2012.44","article-title":"The miR-17 approximately 92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes","volume":"26","author":"Bomben","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.ajpath.2015.02.006_bib36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/MOH.0000000000000057","article-title":"Do mantle cell lymphomas have an 'Achilles heel'?","volume":"21","author":"Saba","year":"2014","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.ajpath.2015.02.006_bib37","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/ni1086","article-title":"Separate domains of AID are required for somatic hypermutation and class-switch recombination","volume":"5","author":"Shinkura","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2015.02.006_bib38","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1182\/blood-2008-03-145995","article-title":"Alternative splicing regulates activation-induced cytidine deaminase (AID): implications for suppression of AID mutagenic activity in normal and malignant B cells","volume":"112","author":"Wu","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib39","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1182\/blood-2008-08-175265","article-title":"AID splice variants lack deaminase activity","volume":"113","author":"van Maldegem","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib40","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1182\/blood-2003-05-1585","article-title":"Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone","volume":"102","author":"Albesiano","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib41","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1182\/blood-2002-09-2906","article-title":"High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia","volume":"101","author":"McCarthy","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2015.02.006_bib42","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1182\/blood-2002-10-3175","article-title":"Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation","volume":"101","author":"Oppezzo","year":"2003","journal-title":"Blood"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944015001388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944015001388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T06:58:57Z","timestamp":1576220337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944015001388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0002944015001388"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2015.02.006","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular Evidence for Antigen Drive in the Natural History of Mantle Cell Lymphoma","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2015.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}