{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T22:39:03Z","timestamp":1779057543257,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":1473,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MPO 136782"],"award-info":[{"award-number":["MPO 136782"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA117930"],"award-info":[{"award-number":["CA117930"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ajpath.2015.08.007","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T12:39:28Z","timestamp":1445776768000},"page":"3202-3210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2"],"prefix":"10.1016","volume":"185","author":[{"given":"Xiaohong T.","family":"Gan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkatesh","family":"Rajapurohitam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Bairwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xilan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey T.-Y.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa F.W.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhito","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay-Uwe","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris","family":"Karmazyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2015.08.007_bib1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1172\/JCI0215644","article-title":"JAK-STAT signaling in human disease","volume":"109","author":"Schindler","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2015.08.007_bib2","doi-asserted-by":"crossref","first-page":"H1545","DOI":"10.1152\/ajpheart.00032.2009","article-title":"JAK redux: a second look at the regulation and role of JAKs in the heart","volume":"297","author":"Kurdi","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ajpath.2015.08.007_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0092-8674(00)81469-5","article-title":"Switching signals on or off by receptor dimerization","volume":"94","author":"Weiss","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2015.08.007_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/375247a0","article-title":"Direct stimulation of Jak\/STAT pathway by the angiotensin II AT1 receptor","volume":"375","author":"Paxton","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2015.08.007_bib5","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.4049\/jimmunol.171.7.3794","article-title":"Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus","volume":"171","author":"Lukashova","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2015.08.007_bib6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/15406580360545099","article-title":"Jak2 and Ca2+\/calmodulin are key intermediates for bradykinin B2 receptor-mediated activation of Na+\/H+ exchange in KNRK and CHO cells","volume":"1","author":"Lefler","year":"2003","journal-title":"Assay Drug Dev Technol"},{"key":"10.1016\/j.ajpath.2015.08.007_bib7","doi-asserted-by":"crossref","first-page":"H827","DOI":"10.1152\/ajpheart.00003.2006","article-title":"The JAK\/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3\u03b2","volume":"291","author":"Gross","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ajpath.2015.08.007_bib8","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/S0891-5849(01)00649-9","article-title":"Activation of JAK2 by the oxidative stress generated with oxidized low-density lipoprotein","volume":"31","author":"Mazi\u00e8re","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.ajpath.2015.08.007_bib9","doi-asserted-by":"crossref","first-page":"C1640","DOI":"10.1152\/ajpcell.1998.275.6.C1640","article-title":"Activation of the JAK-STAT pathway by reactive oxygen species","volume":"275","author":"Simon","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ajpath.2015.08.007_bib10","doi-asserted-by":"crossref","first-page":"32382","DOI":"10.1074\/jbc.274.45.32382","article-title":"Hyperglycemia enhances angiotensin II-induced janus-activated kinase\/STAT signaling in vascular smooth muscle cells","volume":"274","author":"Amiri","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2015.08.007_bib11","doi-asserted-by":"crossref","first-page":"H1291","DOI":"10.1152\/ajpheart.00181.2007","article-title":"Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation","volume":"293","author":"Banes-Berceli","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ajpath.2015.08.007_bib12","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2337\/diabetes.54.2.394","article-title":"Hyperglycemia activates JAK2 signaling pathway in human failing myocytes via angiotensin II-mediated oxidative stress","volume":"54","author":"Modesti","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.ajpath.2015.08.007_bib13","doi-asserted-by":"crossref","first-page":"30634","DOI":"10.1074\/jbc.M305008200","article-title":"High glucose augments the angiotensin II-induced activation of JAK2 in vascular smooth muscle cells via the polyol pathway","volume":"278","author":"Shaw","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2015.08.007_bib14","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1006\/jmcc.2001.1456","article-title":"Role of STAT3 in ischemic preconditioning","volume":"33","author":"Hattori","year":"2001","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.ajpath.2015.08.007_bib15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molmed.2006.12.002","article-title":"Role of the JAK-STAT pathway in myocardial injury","volume":"13","author":"Barry","year":"2007","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.ajpath.2015.08.007_bib16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.vph.2005.08.023","article-title":"Janus kinase-2 signaling mediates apoptosis in rat cardiomyocytes","volume":"43","author":"Mascareno","year":"2005","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.ajpath.2015.08.007_bib17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/01.CIR.104.3.325","article-title":"JAK\/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion","volume":"104","author":"Mascareno","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ajpath.2015.08.007_bib18","doi-asserted-by":"crossref","first-page":"e41612","DOI":"10.1371\/journal.pone.0041612","article-title":"The obesity-related peptide leptin sensitizes cardiac mitochondria to calcium-induced permeability transition pore opening and apoptosis","volume":"7","author":"Martinez-Abundis","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2015.08.007_bib19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0092-8674(00)81168-X","article-title":"Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis","volume":"93","author":"Neubauer","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2015.08.007_bib20","series-title":"Guide for the Care and Use of Laboratory Animals,\u00a07th Edition","year":"1996"},{"key":"10.1016\/j.ajpath.2015.08.007_bib21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/gene.20063","article-title":"Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice","volume":"40","author":"Krempler","year":"2004","journal-title":"Genesis"},{"key":"10.1016\/j.ajpath.2015.08.007_bib22","doi-asserted-by":"crossref","first-page":"12929","DOI":"10.1073\/pnas.2134694100","article-title":"Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age","volume":"100","author":"Jacoby","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2015.08.007_bib23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.yjmcc.2015.06.019","article-title":"Prolonged Cre expression driven by the \u03b1-myosin heavy chain promoter can be cardiotoxic","volume":"86","author":"Pugach","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.ajpath.2015.08.007_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1089\/hum.2015.018","article-title":"The current and future landscape of SERCA gene therapy for heart failure: a clinical perspective","volume":"26","author":"Hayward","year":"2015","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.ajpath.2015.08.007_bib25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.5483\/BMBRep.2013.46.5.077","article-title":"SERCA2a: a prime target for modulation of cardiac contractility during heart failure","volume":"46","author":"Park","year":"2013","journal-title":"BMB Rep"},{"issue":"Suppl 1","key":"10.1016\/j.ajpath.2015.08.007_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00794072","article-title":"Calcium handling proteins in the failing human heart","volume":"92","author":"Hasenfuss","year":"1997","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.ajpath.2015.08.007_bib27","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm1151","article-title":"Phospholamban: a crucial regulator of cardiac contractility","volume":"4","author":"MacLennan","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2015.08.007_bib28","doi-asserted-by":"crossref","first-page":"28470","DOI":"10.1074\/jbc.273.43.28470","article-title":"Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice","volume":"273","author":"Sato","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2015.08.007_bib29","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/cvr\/cvt024","article-title":"\u2018Ryanopathy\u2019: causes and manifestations of RyR2 dysfunction in heart failure","volume":"98","author":"Belevych","year":"2013","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.ajpath.2015.08.007_bib30","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1039\/c2mb25120e","article-title":"Impaired JAK2-induced activation of STAT3 in failing human myocytes","volume":"8","author":"Cambi","year":"2012","journal-title":"Mol Biosyst"},{"key":"10.1016\/j.ajpath.2015.08.007_bib31","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1593\/neo.111112","article-title":"The Jak2 inhibitor, G6, alleviates Jak2-V617F-mediated myeloproliferative neoplasia by providing significant therapeutic efficacy to the bone marrow","volume":"13","author":"Kirabo","year":"2011","journal-title":"Neoplasia"},{"key":"10.1016\/j.ajpath.2015.08.007_bib32","doi-asserted-by":"crossref","first-page":"e105568","DOI":"10.1371\/journal.pone.0105568","article-title":"The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in\u00a0vitro and in\u00a0vivo","volume":"9","author":"Baskin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2015.08.007_bib33","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1517\/14656566.2014.913024","article-title":"Janus kinase inhibitors for the treatment of myeloproliferative neoplasms","volume":"15","author":"Rosenthal","year":"2014","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.ajpath.2015.08.007_bib34","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ajpath.2013.04.007","article-title":"Loss of Jak2 impairs endothelial function by attenuating Raf-1\/MEK1\/Sp-1 signaling along with altered eNOS activities","volume":"183","author":"Yang","year":"2013","journal-title":"Am J Pathol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944015004952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944015004952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T07:02:51Z","timestamp":1576220571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944015004952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0002944015004952"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2015.08.007","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2015.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}