{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:48:36Z","timestamp":1791272916118,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":1382,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ajp.amjpathol.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.ajpath.2015.10.024","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T03:15:16Z","timestamp":1454642116000},"page":"652-658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":321,"title":["Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014"],"prefix":"10.1016","volume":"186","author":[{"given":"Dianna L.","family":"Ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Al Hosani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Kelly","family":"Keating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan I.","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen G.","family":"Metcalfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suxiang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar N.","family":"Alami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia M.","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mowafaq Ali","family":"Mutei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Abdel-Wareth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Uyeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Swerdlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Barakat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif R.","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2015.10.024_bib1","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1056\/NEJMoa1211721","article-title":"Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia","volume":"367","author":"Zaki","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2015.10.024_bib2","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1401505","article-title":"Evidence for camel-to-human transmission of MERS coronavirus","volume":"370","author":"Azhar","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2015.10.024_bib3","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1473-3099(13)70690-X","article-title":"Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation","volume":"14","author":"Haagmans","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ajpath.2015.10.024_bib4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1056\/NEJMoa1306742","article-title":"Hospital outbreak of Middle East respiratory syndrome coronavirus","volume":"369","author":"Assiri","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2015.10.024_bib5","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/cid\/ciu359","article-title":"Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description","volume":"59","author":"Al-Abdallat","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajpath.2015.10.024_bib6","article-title":"Middle East respiratory syndrome coronavirus (MERS-CoV\u2013Summary of Current Situation","year":"2015","journal-title":"Lit Update Risk Assess"},{"key":"10.1016\/j.ajpath.2015.10.024_bib7","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S1473-3099(13)70204-4","article-title":"Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study","volume":"13","author":"Assiri","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ajpath.2015.10.024_bib8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ijid.2014.09.003","article-title":"Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia","volume":"29","author":"Saad","year":"2014","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.ajpath.2015.10.024_bib9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.7326\/M13-2486","article-title":"Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection","volume":"160","author":"Arabi","year":"2014","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.ajpath.2015.10.024_bib10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature12005","article-title":"Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC","volume":"495","author":"Raj","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2015.10.024_bib11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/jmp.12096","article-title":"Evaluation of pigtail macaques as a model for the effects of copper intrauterine devices on HIV infection","volume":"43","author":"Engel","year":"2014","journal-title":"J Med Primatol"},{"key":"10.1016\/j.ajpath.2015.10.024_bib12","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1086\/589753","article-title":"Pathology and pathogenesis of fatal Bordetella pertussis infection in infants","volume":"47","author":"Paddock","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajpath.2015.10.024_bib13","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3201\/eid1905.130057","article-title":"Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus","volume":"19","author":"Cotten","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.ajpath.2015.10.024_bib14","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"ClustalW and ClustalX version 2 (2007)","volume":"23","author":"Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajpath.2015.10.024_bib15","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/bioinformatics\/17.8.754","article-title":"MRBAYES: Bayesian inference of phylogenetic trees","volume":"17","author":"Huelsenbeck","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajpath.2015.10.024_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1128\/JCM.02533-13","article-title":"Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus","volume":"52","author":"Lu","year":"2014","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ajpath.2015.10.024_bib17","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1164\/rccm.201305-0954LE","article-title":"Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs","volume":"188","author":"Hocke","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2015.10.024_bib18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jcv.2014.07.002","article-title":"Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases","volume":"61","author":"Poissy","year":"2014","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ajpath.2015.10.024_bib19","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1473-3099(13)70154-3","article-title":"Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection","volume":"13","author":"Drosten","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ajpath.2015.10.024_bib20","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1371\/journal.pmed.0030027","article-title":"Time course and cellular localization of SARS-CoV nucleoprotein and RNA in lungs from fatal cases of SARS","volume":"3","author":"Nicholls","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.ajpath.2015.10.024_bib21","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S2213-2600(14)70158-4","article-title":"Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study","volume":"2","author":"Chan","year":"2014","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.ajpath.2015.10.024_bib22","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus","volume":"426","author":"Li","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2015.10.024_bib23","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/path.1570","article-title":"Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis","volume":"203","author":"Hamming","year":"2004","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2015.10.024_bib24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.virol.2007.09.045","article-title":"SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells","volume":"372","author":"Mossel","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.ajpath.2015.10.024_bib25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.humpath.2004.11.006","article-title":"Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan","volume":"36","author":"Shieh","year":"2005","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ajpath.2015.10.024_bib26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1084\/jem.20050828","article-title":"Multiple organ infection and the pathogenesis of SARS","volume":"202","author":"Gu","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2015.10.024_bib27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012","volume":"39","author":"Dellinger","year":"2013","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ajpath.2015.10.024_bib28","doi-asserted-by":"crossref","first-page":"e343","DOI":"10.1371\/journal.pmed.0030343","article-title":"SARS: systematic review of treatment effects","volume":"3","author":"Stockman","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.ajpath.2015.10.024_bib29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13054-015-0764-5","article-title":"Do corticosteroids reduce the mortality of influenza A (H1N1) infection? A meta-analysis","volume":"19","author":"Zhang","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.ajpath.2015.10.024_bib30","article-title":"Clinical management of severe acute respiratory infection when Middle East respiratory syndrome coronavirus (MERS-CoV) infection is suspected","year":"2015","journal-title":"Interim Guidance"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944015006471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944015006471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T20:22:27Z","timestamp":1634502147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944015006471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0002944015006471"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2015.10.024","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726143953.793535746","asserted-by":"object"}]},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2015.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}