{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:36:26Z","timestamp":1772638586925,"version":"3.50.1"},"reference-count":115,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":1290,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council of Australia","doi-asserted-by":"publisher","award":["APP1043104"],"award-info":[{"award-number":["APP1043104"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.ajpath.2016.02.017","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T22:44:34Z","timestamp":1462056274000},"page":"1511-1523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["SerpinB2 Deficiency Results in a Stratum Corneum Defect and Increased Sensitivity to Topically Applied Inflammatory Agents"],"prefix":"10.1016","volume":"186","author":[{"given":"Wayne A.","family":"Schroder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itaru","family":"Anraku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy T.","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago D.C.","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helder I.","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Major","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan J.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Suhrbier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2016.02.017_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1615\/CritRevImmunol.v31.i1.20","article-title":"The role of SerpinB2 in immunity","volume":"31","author":"Schroder","year":"2011","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib2","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.yexcr.2010.10.016","article-title":"Human papilloma virus transformed CaSki cells constitutively express high levels of functional SerpinB2","volume":"317","author":"Major","year":"2011","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2016.02.017_bib3","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s004180050318","article-title":"Differentiating cells of murine stratified squamous epithelia constitutively express plasminogen activator inhibitor type 2 (PAI-2)","volume":"110","author":"Risse","year":"1998","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib4","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1182\/blood.V86.11.4007.bloodjournal86114007","article-title":"Biological and clinical aspects of plasminogen activator inhibitor type 2","volume":"86","author":"Kruithof","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2016.02.017_bib5","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1111\/j.1742-4658.2005.04879.x","article-title":"The undecided serpin: the ins and outs of plasminogen activator inhibitor type 2","volume":"272","author":"Medcalf","year":"2005","journal-title":"FEBS J"},{"key":"10.1016\/j.ajpath.2016.02.017_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/B978-0-12-386471-0.00006-7","article-title":"Plasminogen activator inhibitor type 2: still an enigmatic serpin but a model for gene regulation","volume":"499","author":"Medcalf","year":"2011","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib7","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1111\/jth.12704","article-title":"Is plasminogen activator inhibitor type 2 really a plasminogen activator inhibitor after all?","volume":"12","author":"Gardiner","year":"2014","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.ajpath.2016.02.017_bib8","doi-asserted-by":"crossref","first-page":"437695","DOI":"10.1155\/2015\/437695","article-title":"The inflammatory actions of coagulant and fibrinolytic proteases in disease","volume":"2015","author":"Schuliga","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.ajpath.2016.02.017_bib9","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.4049\/jimmunol.1302864","article-title":"Urokinase plasminogen activator is a central regulator of macrophage three-dimensional invasion, matrix degradation, and adhesion","volume":"192","author":"Fleetwood","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib10","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/cam4.229","article-title":"Tumor cell-expressed SerpinB2 is present on microparticles and inhibits metastasis","volume":"3","author":"Schroder","year":"2014","journal-title":"Cancer Med"},{"key":"10.1016\/j.ajpath.2016.02.017_bib11","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1038\/sj.emboj.7601173","article-title":"Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice","volume":"25","author":"Lund","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.ajpath.2016.02.017_bib12","doi-asserted-by":"crossref","first-page":"564259","DOI":"10.1155\/2012\/564259","article-title":"Cell surface remodeling by plasmin: a new function for an old enzyme","volume":"2012","author":"Deryugina","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib13","doi-asserted-by":"crossref","first-page":"e16483","DOI":"10.1371\/journal.pone.0016483","article-title":"Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2016.02.017_bib14","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1161\/hs0901.095408","article-title":"Acute tissue damage after injections of thrombin and plasmin into rat striatum","volume":"32","author":"Xue","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.ajpath.2016.02.017_bib15","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jaut.2012.09.003","article-title":"A link between interferon and augmented plasmin generation in exocrine gland damage in Sjogren's syndrome","volume":"40","author":"Gliozzi","year":"2013","journal-title":"J Autoimmun"},{"key":"10.1016\/j.ajpath.2016.02.017_bib16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0002-9440(10)62285-7","article-title":"Plasminogen activation\/plasmin in rheumatoid arthritis: matrix degradation and more","volume":"166","author":"Judex","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib17","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1073\/pnas.96.2.686","article-title":"The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival","volume":"96","author":"Dougherty","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2016.02.017_bib18","doi-asserted-by":"crossref","first-page":"15240","DOI":"10.1016\/S0021-9258(18)98608-4","article-title":"The efficiency of the uncleaved secretion signal in the plasminogen activator inhibitor type 2 protein can be enhanced by point mutations that increase its hydrophobicity","volume":"266","author":"von Heijne","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.02.017_bib19","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.yexcr.2015.02.006","article-title":"The sGC activator inhibits the proliferation and migration, promotes the apoptosis of human pulmonary arterial smooth muscle cells via the up regulation of plasminogen activator inhibitor-2","volume":"332","author":"Zhang","year":"2015","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2016.02.017_bib20","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.1365-3024.2010.01241.x","article-title":"SerpinB2 deficiency modulates Th1Th2 responses after schistosome infection","volume":"32","author":"Schroder","year":"2010","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib21","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.4049\/jimmunol.0902187","article-title":"A physiological function of inflammation-associated SerpinB2 is regulation of adaptive immunity","volume":"184","author":"Schroder","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib22","doi-asserted-by":"crossref","first-page":"e57343","DOI":"10.1371\/journal.pone.0057343","article-title":"Induction of SerpinB2 and Th1\/Th2 modulation by SerpinB2 during lentiviral infections in\u00a0vivo","volume":"8","author":"Major","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2016.02.017_bib23","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.4049\/jimmunol.1200293","article-title":"SerpinB2 is critical to Th2 immunity against enteric nematode infection","volume":"190","author":"Zhao","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.coph.2013.05.008","article-title":"Microparticles are novel effectors of immunity","volume":"13","author":"Norling","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib25","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2007.07.009","article-title":"NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta","volume":"130","author":"Greten","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2016.02.017_bib26","doi-asserted-by":"crossref","first-page":"16079","DOI":"10.1073\/pnas.1306556110","article-title":"TLR-induced PAI-2 expression suppresses IL-1beta processing via increasing autophagy and NLRP3 degradation","volume":"110","author":"Chuang","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2016.02.017_bib27","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1158\/0008-5472.CAN-07-5850","article-title":"SerpinB2 protection of retinoblastoma protein from calpain enhances tumor cell survival","volume":"68","author":"Tonnetti","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2016.02.017_bib28","first-page":"970","article-title":"Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice","volume":"61","author":"Zhou","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2016.02.017_bib29","doi-asserted-by":"crossref","first-page":"E177","DOI":"10.1073\/pnas.1119296109","article-title":"TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2\/serpinB2 and transglutaminase 2","volume":"109","author":"Delhase","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2016.02.017_bib30","doi-asserted-by":"crossref","first-page":"43164","DOI":"10.1074\/jbc.M111.245647","article-title":"Association of plasminogen activator inhibitor type 2 (PAI-2) with proteasome within endothelial cells activated with inflammatory stimuli","volume":"286","author":"Boncela","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.02.017_bib31","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1046\/j.1523-1747.2001.01310.x","article-title":"Retinoic acid upregulates the plasminogen activator system in human epidermal keratinocytes","volume":"116","author":"Braungart","year":"2001","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00269356","article-title":"Expression of plasminogen activator inhibitor type 2 in\u00a0normal and psoriatic epidermis","volume":"101","author":"Lyons-Giordano","year":"1994","journal-title":"Histochemistry"},{"key":"10.1016\/j.ajpath.2016.02.017_bib33","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/08916939608995339","article-title":"Plasminogen activation in bullous pemphigoid immunohistology reveals urokinase type plasminogen activator, its receptor and plasminogen activator inhibitor type-2 in lesional epidermis","volume":"23","author":"Schaefer","year":"1996","journal-title":"Autoimmunity"},{"key":"10.1016\/j.ajpath.2016.02.017_bib34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1365-2133.1996.tb16223.x","article-title":"Plasminogen activator inhibitor type-2 in the lesional epidermis of lupus erythematosus","volume":"134","author":"Bechtel","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib35","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1365-2133.2005.07109.x","article-title":"Plasminogen activator inhibitor-2 is expressed in different types of congenital ichthyosis: in\u00a0vivo evidence for its cross-linking into the cornified cell envelope by transglutaminase-1","volume":"154","author":"Oji","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib36","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0967-2109(00)00028-4","article-title":"Lower levels of PAI-2 may contribute to impaired healing in venous ulcers: a preliminary study","volume":"8","author":"Stacey","year":"2000","journal-title":"Cardiovasc Surg"},{"key":"10.1016\/j.ajpath.2016.02.017_bib37","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.0906-6705.2004.00222.x","article-title":"High plasminogen activator inhibitor type 2 expression is a hallmark of scleroderma fibroblasts in\u00a0vitro","volume":"13","author":"Kessler-Becker","year":"2004","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.7547\/0980345","article-title":"Role of tissue-type plasminogen activator in salicylic acid-induced sloughing of human corn tissue","volume":"98","author":"Heda","year":"2008","journal-title":"J Am Podiatr Med Assoc"},{"key":"10.1016\/j.ajpath.2016.02.017_bib39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jdermsci.2010.04.012","article-title":"Role of plasminogen activator inhibitor-2 (PAI-2) in keratinocyte differentiation","volume":"59","author":"Jang","year":"2010","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.ajpath.2016.02.017_bib40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.biolcel.2003.09.007","article-title":"Plasminogen activator inhibitor 2: expression and role in differentiation of epidermal keratinocyte","volume":"96","author":"Lian","year":"2004","journal-title":"Biol Cell"},{"key":"10.1016\/j.ajpath.2016.02.017_bib41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-0625.1994.tb00052.x","article-title":"Calcium modulates the expression of urokinase plasminogen activator and plasminogen activator inhibitor 2 by human keratinocytes","volume":"3","author":"Lyons-Giordano","year":"1994","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib42","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1046\/j.1523-1747.1999.00466.x","article-title":"Suppression of keratinocyte proliferation by plasminogen activator inhibitor-2","volume":"112","author":"Hibino","year":"1999","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib43","doi-asserted-by":"crossref","first-page":"18267","DOI":"10.1073\/pnas.1420159112","article-title":"Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression","volume":"111","author":"Rushworth","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2016.02.017_bib44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1006\/excr.1996.0061","article-title":"Plasminogen activator inhibitor type-2 (PAI-2) in human keratinocytes regulates pericellular urokinase-type plasminogen activator","volume":"223","author":"Reinartz","year":"1996","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2016.02.017_bib45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1083\/jcb.201409032","article-title":"FOXO1 differentially regulates both normal and diabetic wound healing","volume":"209","author":"Zhang","year":"2015","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/(SICI)1097-4652(200002)182:2<281::AID-JCP17>3.0.CO;2-D","article-title":"Evidence for intracellular cleavage of plasminogen activator inhibitor type 2 (PAI-2) in normal epidermal keratinocytes","volume":"182","author":"Risse","year":"2000","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib47","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/excr.1995.1064","article-title":"Plasminogen activator inhibitor type 2: an intracellular keratinocyte differentiation product that is incorporated into the cornified envelope","volume":"217","author":"Jensen","year":"1995","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2016.02.017_bib48","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.1074\/jbc.272.18.12035","article-title":"S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes","volume":"272","author":"Robinson","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.02.017_bib49","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1016\/j.bbamcr.2013.06.010","article-title":"Cell death by cornification","volume":"1833","author":"Eckhart","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2016.02.017_bib50","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1242\/jcs.114.17.3069","article-title":"Assembly of the epidermal cornified cell envelope","volume":"114","author":"Kalinin","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2016.02.017_bib51","first-page":"Unit 4.2","article-title":"Contact hypersensitivity","volume":"ch 4","author":"Gaspari","year":"2001","journal-title":"Curr Protoc Immunol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib52","doi-asserted-by":"crossref","first-page":"6862","DOI":"10.1128\/JVI.03364-13","article-title":"CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis","volume":"88","author":"Poo","year":"2014","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib53","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nri3150","article-title":"Early immune events in the induction of allergic contact dermatitis","volume":"12","author":"Kaplan","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0463.2011.02832.x","article-title":"Immunological mechanisms of contact hypersensitivity in mice","volume":"120","author":"Christensen","year":"2012","journal-title":"APMIS"},{"key":"10.1016\/j.ajpath.2016.02.017_bib55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/iid3.16","article-title":"The role of neutrophils and G-CSF in DNFB-induced contact hypersensitivity in mice","volume":"2","author":"Christensen","year":"2014","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.ajpath.2016.02.017_bib56","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1046\/j.1365-2133.1998.02021.x","article-title":"Plasminogen activator inhibitor type 2 is expressed in keratinocytes during re-epithelialization of epidermal defects","volume":"138","author":"Bechtel","year":"1998","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib57","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/bjc.1994.407","article-title":"Cleaved intracellular plasminogen activator inhibitor 2 in human myeloleukaemia cells is a marker of apoptosis","volume":"70","author":"Jensen","year":"1994","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ajpath.2016.02.017_bib58","doi-asserted-by":"crossref","first-page":"e7703","DOI":"10.1371\/journal.pone.0007703","article-title":"Mechanism of dinitrochlorobenzene-induced dermatitis in mice: role of specific antibodies in pathogenesis","volume":"4","author":"Zhang","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2016.02.017_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jat.830","article-title":"Induced changes in total serum IgE concentration in the brown Norway rat: potential for identification of chemical respiratory allergens","volume":"22","author":"Warbrick","year":"2002","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib60","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1038\/sj.jid.5700819","article-title":"Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity","volume":"127","author":"Watanabe","year":"2007","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib61","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1046\/j.1523-1747.1998.00223.x","article-title":"Localization of plasminogen activator inhibitor type 2 (PAI-2) in hair and nail: implications for terminal differentiation","volume":"110","author":"Lavker","year":"1998","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib62","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/ni.1654","article-title":"Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence","volume":"9","author":"Gan","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib63","first-page":"350","article-title":"Evidence for serpinB2-independent protection from TNF-alpha-induced apoptosis","volume":"312","author":"Fish","year":"2006","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ajpath.2016.02.017_bib64","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/abbs\/36.1.42","article-title":"Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1","volume":"36","author":"Fan","year":"2004","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.ajpath.2016.02.017_bib65","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1002\/art.34631","article-title":"Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis","volume":"64","author":"Nakaya","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.ajpath.2016.02.017_bib66","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1038\/jid.2014.229","article-title":"Newly discovered olfactory receptors in epidermal keratinocytes are associated with proliferation, migration, and re-epithelialization of keratinocytes","volume":"134","author":"Denda","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib67","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/jid.2014.273","article-title":"A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4","volume":"134","author":"Busse","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib68","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/mabi.201100443","article-title":"Construction of a microstructured collagen membrane mimicking the papillary dermis architecture and guiding keratinocyte morphology and gene expression","volume":"12","author":"Lammers","year":"2012","journal-title":"Macromol Biosci"},{"key":"10.1016\/j.ajpath.2016.02.017_bib69","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/BF00993231","article-title":"Olfactory recognition of nonhosts aspen and birch by conifer bark beetles Tomicus piniperda and Hylurgops palliatus","volume":"18","author":"Schroeder","year":"1992","journal-title":"J\u00a0Chem Ecol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib70","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s13273-010-0011-8","article-title":"Gene expression profiling in the human keratinocyte cell line, hacat exposed to urushiol isolated from sap of Korean lacquer tree (Rhus verniciflua Stokes)","volume":"6","author":"Park","year":"2010","journal-title":"Mol Cell Toxicol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib71","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/cea.12495","article-title":"Pathogenesis of atopic dermatitis","volume":"45","author":"Peng","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.ajpath.2016.02.017_bib72","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00403-012-1313-6","article-title":"Transepidermal water loss in young and aged healthy humans: a systematic review and meta-analysis","volume":"305","author":"Kottner","year":"2013","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.ajpath.2016.02.017_bib73","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/1523-1747.ep12345425","article-title":"Differential expression of urokinase-type plasminogen activator, its receptor, and inhibitors in\u00a0mouse skin after exposure to a tumor-promoting phorbol ester","volume":"106","author":"Lund","year":"1996","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib74","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000210960","article-title":"Mouse skin inflammation induced by multiple topical applications of 12-O-tetradecanoylphorbol-13-acetate","volume":"4","author":"Stanley","year":"1991","journal-title":"Skin Pharmacol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib75","doi-asserted-by":"crossref","first-page":"7722","DOI":"10.1073\/pnas.78.12.7722","article-title":"Skin tumor promotion by phorbol esters is a two-stage process","volume":"78","author":"Furstenberger","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2016.02.017_bib76","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3390\/cancers2020436","article-title":"Molecular mechanisms of mouse skin tumor promotion","volume":"2","author":"Rundhaug","year":"2010","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ajpath.2016.02.017_bib77","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/carcin\/4.7.857","article-title":"A subpopulation of cultured human keratinocytes which is resistant to the induction of terminal differentiation-related changes by phorbol, 12-myristate, 13-acetate: evidence for an increase in the resistant population following transformation","volume":"4","author":"Parkinson","year":"1983","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ajpath.2016.02.017_bib78","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/prca.201300081","article-title":"Proteases and proteomics: cutting to the core of human skin pathologies","volume":"8","author":"de Veer","year":"2014","journal-title":"Proteomics Clin Appl"},{"key":"10.1016\/j.ajpath.2016.02.017_bib79","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1472-6750-9-43","article-title":"The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity","volume":"9","author":"Cochran","year":"2009","journal-title":"BMC Biotechnol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib80","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1189\/jlb.0104023","article-title":"Urokinase-deficient and urokinase receptor-deficient mice have impaired neutrophil antimicrobial activation in\u00a0vitro","volume":"76","author":"Gyetko","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib81","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/jid.2009.133","article-title":"Epidermal barrier dysfunction in atopic dermatitis","volume":"129","author":"Cork","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib82","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/j.1365-2133.1993.tb00254.x","article-title":"Immunohistochemical characterization of the plasminogen activator system in psoriatic epidermis","volume":"128","author":"Gissler","year":"1993","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib83","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1467-2494.2007.00386.x","article-title":"Profiling of serine protease activities in human stratum corneum and detection of a stratum corneum tryptase-like enzyme","volume":"29","author":"Voegeli","year":"2007","journal-title":"Int J Cosmet Sci"},{"key":"10.1016\/j.ajpath.2016.02.017_bib84","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1242\/jcs.096289","article-title":"Confluence switch signaling regulates ECM composition and the plasmin proteolytic cascade in keratinocytes","volume":"125","author":"Botta","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2016.02.017_bib85","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1089\/wound.2013.0512","article-title":"SERPINE1: a molecular switch in the proliferation-migration dichotomy in wound-\u201cactivated\u201d keratinocytes","volume":"3","author":"Simone","year":"2014","journal-title":"Adv Wound Care"},{"key":"10.1016\/j.ajpath.2016.02.017_bib86","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1046\/j.1523-1747.2003.12404.x","article-title":"Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization","volume":"121","author":"Kielar","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib87","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/sj.cdd.4401781","article-title":"How many ways to die? how many different models of cell death?","volume":"12 Suppl 2","author":"Melino","year":"2005","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.ajpath.2016.02.017_bib88","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1038\/sj.onc.1204403","article-title":"Global analysis of differential gene expression after transformation with the v-H-ras oncogene in a murine tumor model","volume":"20","author":"Brem","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2016.02.017_bib89","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.1016\/S0021-9258(18)83192-1","article-title":"Effects of cellular transformation on expression of plasminogen activator inhibitors 1 and 2: evidence for independent regulation","volume":"264","author":"Cohen","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.02.017_bib90","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0167-4781(00)00041-5","article-title":"The novel anti-tumour agent oxamflatin differentially regulates urokinase and plasminogen activator inhibitor type 2 expression and inhibits urokinase-mediated proteolytic activity","volume":"1492","author":"Dear","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2016.02.017_bib91","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1158\/0008-5472.CAN-03-3898","article-title":"The nuclear factor kappaB subunits RelA\/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation","volume":"64","author":"Hanson","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2016.02.017_bib92","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nature06973","article-title":"Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype","volume":"453","author":"McMurray","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2016.02.017_bib93","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s001090000116","article-title":"Induction of putative tumor-suppressing genes in Rat-1 fibroblasts by oncogenic Raf-1 as evidenced by robot-assisted complex hybridization","volume":"78","author":"Heinrich","year":"2000","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.ajpath.2016.02.017_bib94","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1091\/mbc.e03-11-0807","article-title":"The transcriptional response to Raf activation is almost completely dependent on mitogen-activated protein kinase kinase activity and shows a major autocrine component","volume":"15","author":"Schulze","year":"2004","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.ajpath.2016.02.017_bib95","first-page":"143","article-title":"Adenovirus E1A orchestrates the urokinase-plasminogen activator system and upregulates PAI-2 expression, supporting a tumor suppressor effect","volume":"28","author":"Fernandez-Soria","year":"2006","journal-title":"Int J Oncol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib96","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ydbio.2005.10.041","article-title":"TAp63alpha induces AP-2gamma as an early event in epidermal morphogenesis","volume":"289","author":"Koster","year":"2006","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib97","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0268-9499(05)80028-1","article-title":"Localization and characterization of a retinoic acid response-like element in the plasminogen activator inhibitor-2 gene promoter","volume":"8","author":"Schuster","year":"1994","journal-title":"Fibrinolysis"},{"key":"10.1016\/j.ajpath.2016.02.017_bib98","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.cellsig.2007.01.013","article-title":"Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling","volume":"19","author":"Schroder","year":"2007","journal-title":"Cell Signal"},{"key":"10.1016\/j.ajpath.2016.02.017_bib99","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/carcin\/bgr207","article-title":"14-3-3sigma and p63 play opposing roles in epidermal tumorigenesis","volume":"32","author":"Li","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ajpath.2016.02.017_bib100","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1101\/gad.214577.113","article-title":"Mule\/Huwe1\/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc\/Miz1-mediated down-regulation of p21 and p15","volume":"27","author":"Inoue","year":"2013","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2016.02.017_bib101","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1038\/onc.2014.398","article-title":"Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA","volume":"34","author":"Hayashi","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2016.02.017_bib102","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/mc.22303","article-title":"Keratinocyte p38delta loss inhibits Ras-induced tumor formation, while systemic p38delta loss enhances skin inflammation in the early phase of chemical carcinogenesis in mouse skin","volume":"55","author":"Kiss","year":"2015","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.ajpath.2016.02.017_bib103","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1158\/0008-5472.CAN-08-4455","article-title":"p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice","volume":"69","author":"Schindler","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2016.02.017_bib104","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/mc.20127","article-title":"Differential gene expression in epidermis of mice sensitive and resistant to phorbol ester skin tumor promotion","volume":"44","author":"Riggs","year":"2005","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.ajpath.2016.02.017_bib105","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.4049\/jimmunol.1402608","article-title":"Cutting edge: NF-kappaB p65 and c-Rel control epidermal development and immune homeostasis in the skin","volume":"194","author":"Grinberg-Bleyer","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib106","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1158\/0008-5472.CAN-03-2399","article-title":"Helicobacter pylori induces plasminogen activator inhibitor 2 in gastric epithelial cells through nuclear factor-kappaB and RhoA: implications for invasion and apoptosis","volume":"64","author":"Varro","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2016.02.017_bib107","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1046\/j.1432-1327.1999.00552.x","article-title":"Plasminogen activator inhibitor type-2 (PAI-2) gene transcription requires a novel NF-kappaB-like transcriptional regulatory motif","volume":"263","author":"Mahony","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.ajpath.2016.02.017_bib108","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/jid.2014.353","article-title":"SERPINB3\/B4 contributes to early inflammation and barrier dysfunction in an experimental murine model of atopic dermatitis","volume":"135","author":"Sivaprasad","year":"2015","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib109","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.ajhg.2013.09.015","article-title":"Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis","volume":"93","author":"Kubo","year":"2013","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ajpath.2016.02.017_bib110","doi-asserted-by":"crossref","first-page":"R107","DOI":"10.1186\/gb-2007-8-6-r107","article-title":"Large-scale identification of human genes implicated in epidermal barrier function","volume":"8","author":"Toulza","year":"2007","journal-title":"Genome Biol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib111","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1038\/sj.jid.5700902","article-title":"Gene expression time course in the human skin during elicitation of allergic contact dermatitis","volume":"127","author":"Pedersen","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib112","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jaci.2014.05.048","article-title":"Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis","volume":"134","author":"Elias","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib113","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jaci.2012.07.012","article-title":"Progressive activation of T(H)2\/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis","volume":"130","author":"Gittler","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib114","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.jaci.2010.12.1124","article-title":"Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities","volume":"127","author":"Suarez-Farinas","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2016.02.017_bib115","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.jaci.2009.09.031","article-title":"Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis","volume":"124","author":"Guttman-Yassky","year":"2009","journal-title":"J Allergy Clin Immunol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944016300669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944016300669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T12:40:57Z","timestamp":1655642457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944016300669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":115,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0002944016300669"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2016.02.017","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SerpinB2 Deficiency Results in a Stratum Corneum Defect and Increased Sensitivity to Topically Applied Inflammatory Agents","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2016.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}