{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:47:25Z","timestamp":1761490045855,"version":"3.44.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":1229,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31301217","2014BAI02B01","2015BAI08B02","2011BAI15B02","11KJB180010"],"award-info":[{"award-number":["31301217","2014BAI02B01","2015BAI08B02","2011BAI15B02","11KJB180010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["31301217","2014BAI02B01","2015BAI08B02","2011BAI15B02","11KJB180010"],"award-info":[{"award-number":["31301217","2014BAI02B01","2015BAI08B02","2011BAI15B02","11KJB180010"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["31301217","2014BAI02B01","2015BAI08B02","2011BAI15B02","11KJB180010"],"award-info":[{"award-number":["31301217","2014BAI02B01","2015BAI08B02","2011BAI15B02","11KJB180010"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.ajpath.2016.04.009","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T04:15:11Z","timestamp":1468210511000},"page":"2117-2128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Gastric Bypass Surgery Reverses Diabetic Phenotypes in Bdnf-Deficient Mice"],"prefix":"10.1016","volume":"186","author":[{"given":"Shujun","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anying","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2016.04.009_bib1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05488","article-title":"Abdominal obesity and metabolic syndrome","volume":"444","author":"Despres","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2016.04.009_bib2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nature05487","article-title":"Mechanisms linking obesity with cardiovascular disease","volume":"444","author":"Van Gaal","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2016.04.009_bib3","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1073\/pnas.0812600106","article-title":"Human gut microbiota in obesity and after gastric bypass","volume":"106","author":"Zhang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2016.04.009_bib4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.tem.2010.01.006","article-title":"Mechanisms facilitating weight loss and resolution of type 2 diabetes following bariatric surgery","volume":"21","author":"Karra","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2016.04.009_bib5","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1007\/s00125-013-3055-1","article-title":"Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass","volume":"56","author":"Dirksen","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.ajpath.2016.04.009_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ijo.2010.132","article-title":"Changes in neurohormonal gut peptides following bariatric surgery","volume":"35","author":"Ochner","year":"2011","journal-title":"Int J Obes"},{"key":"10.1016\/j.ajpath.2016.04.009_bib7","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.physbeh.2009.03.012","article-title":"Metabolic surgery and gut hormones - a review of bariatric entero-humoral modulation","volume":"97","author":"Ashrafian","year":"2009","journal-title":"Physiol Behav"},{"key":"10.1016\/j.ajpath.2016.04.009_bib8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1507\/endocrj.K10E-077","article-title":"The role of gut hormones and the hypothalamus in appetite","volume":"57","author":"Suzuki","year":"2010","journal-title":"Endocr J"},{"key":"10.1016\/j.ajpath.2016.04.009_bib9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.ajpath.2016.04.009_bib10","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ajpath.2016.04.009_bib11","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nm.2885","article-title":"Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase","volume":"18","author":"Talukdar","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2016.04.009_bib12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis\u00a0regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2016.04.009_bib13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nature13135","article-title":"FXR is a molecular target for the effects of vertical sleeve gastrectomy","volume":"509","author":"Ryan","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2016.04.009_bib14","doi-asserted-by":"crossref","first-page":"178ra41","DOI":"10.1126\/scitranslmed.3005687","article-title":"Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity","volume":"5","author":"Liou","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ajpath.2016.04.009_bib15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of human gut microbiome correlates with metabolic markers","volume":"500","author":"Le Chatelier","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2016.04.009_bib16","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.2337\/db10-0253","article-title":"Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and\u00a0low-grade inflammation markers","volume":"59","author":"Furet","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.ajpath.2016.04.009_bib17","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1136\/gut.2010.234708","article-title":"Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk","volume":"60","author":"Li","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2016.04.009_bib18","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/ijo.2008.260","article-title":"Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents","volume":"33","author":"Nadal","year":"2009","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.ajpath.2016.04.009_bib19","doi-asserted-by":"crossref","first-page":"e12191","DOI":"10.1371\/journal.pone.0012191","article-title":"High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse","volume":"5","author":"Ding","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2016.04.009_bib20","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.2337\/db11-0194","article-title":"Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance","volume":"60","author":"Lee","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.ajpath.2016.04.009_bib21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1152\/physiolgenomics.00093.2007","article-title":"Disruption of a novel regulatory locus results in decreased Bdnf expression, obesity, and type 2 diabetes in mice","volume":"31","author":"Sha","year":"2007","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.ajpath.2016.04.009_bib22","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/bjs.7400","article-title":"Antidiabetic effects of duodenojejunal bypass in an experimental model of diabetes induced by a high-fat diet","volume":"98","author":"Woods","year":"2011","journal-title":"Br J Surg"},{"key":"10.1016\/j.ajpath.2016.04.009_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nm1185","article-title":"IKK-beta links inflammation to obesity-induced insulin resistance","volume":"11","author":"Arkan","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2016.04.009_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1146689","article-title":"Microbial population structures in the deep marine biosphere","volume":"318","author":"Huber","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2016.04.009_bib25","doi-asserted-by":"crossref","first-page":"e41606","DOI":"10.1371\/journal.pone.0041606","article-title":"Bacterial community shift in treated periodontitis patients revealed by ion torrent 16S rRNA gene amplicon sequencing","volume":"7","author":"Junemann","year":"2012","journal-title":"PloS ONE"},{"key":"10.1016\/j.ajpath.2016.04.009_bib26","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3949\/ccjm.77a.09135","article-title":"Bariatric surgery for type 2 diabetes: weighing the impact for obese patients","volume":"77","author":"Kashyap","year":"2010","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.ajpath.2016.04.009_bib27","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.med.051308.105148","article-title":"Metabolic surgery to treat type 2 diabetes: clinical outcomes and mechanisms of action","volume":"61","author":"Rubino","year":"2010","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.ajpath.2016.04.009_bib28","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2016.04.009_bib29","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2016.04.009_bib30","doi-asserted-by":"crossref","first-page":"20466","DOI":"10.1073\/pnas.0710335105","article-title":"Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge","volume":"104","author":"Amar","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2016.04.009_bib31","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.2337\/dc07-0349","article-title":"Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients","volume":"30","author":"Targher","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ajpath.2016.04.009_bib32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/gutjnl-2014-306748","article-title":"Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis","volume":"64","author":"Verbeek","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2016.04.009_bib33","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.celrep.2013.03.018","article-title":"Weight loss after gastric bypass surgery in human obesity remodels promoter methylation","volume":"3","author":"Barres","year":"2013","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajpath.2016.04.009_bib34","doi-asserted-by":"crossref","first-page":"199ra112","DOI":"10.1126\/scitranslmed.3006505","article-title":"Improved rodent maternal metabolism but reduced intrauterine growth after vertical sleeve gastrectomy","volume":"5","author":"Grayson","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ajpath.2016.04.009_bib35","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.2337\/db13-0856","article-title":"Duodenal-jejunal bypass and jejuectomy improve insulin sensitivityin Goto-Kakizaki diabetic rats without changes in incretins or insulin secretion","volume":"63","author":"Salinari","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.ajpath.2016.04.009_bib36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cmet.2013.11.014","article-title":"Jejunal leptin-PI3K signaling lowers glucose production","volume":"19","author":"Rasmussen","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajpath.2016.04.009_bib37","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2016.04.009_bib38","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2016.04.009_bib39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1742-2094-11-85","article-title":"Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment","volume":"11","author":"Vasconcelos","year":"2014","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.ajpath.2016.04.009_bib40","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jneuroim.2015.05.013","article-title":"Intermittent fasting modulates IgA levels in the small intestine under intense stress: a mouse model","volume":"285","author":"Lara-Padilla","year":"2015","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.ajpath.2016.04.009_bib41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.chom.2012.07.004","article-title":"Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice","volume":"12","author":"Carvalho","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ajpath.2016.04.009_bib42","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1053\/j.gastro.2011.04.052","article-title":"The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice","volume":"141","author":"Bercik","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2016.04.009_bib43","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1210\/en.2012-2151","article-title":"The gut microbiota reduces leptin sensitivity and the expression of the obesity-suppressing neuropeptides proglucagon (Gcg) and brain-derived neurotrophic factor (Bdnf) in the central nervous system","volume":"154","author":"Schele","year":"2013","journal-title":"Endocrinology"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944016301225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944016301225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:48:07Z","timestamp":1757602087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944016301225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S0002944016301225"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2016.04.009","relation":{},"ISSN":["0002-9440"],"issn-type":[{"type":"print","value":"0002-9440"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastric Bypass Surgery Reverses Diabetic Phenotypes in Bdnf-Deficient Mice","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2016.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}