{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:22:32Z","timestamp":1790346152625,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":1107,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Innovative Medizinische Forschung","award":["HA121006"],"award-info":[{"award-number":["HA121006"]}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.ajpath.2016.08.019","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T21:56:50Z","timestamp":1476914210000},"page":"3285-3296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Molecular Analysis of Hybrid Neurofibroma\/Schwannoma Identifies Common Monosomy 22 and \u03b1-T-Catenin\/CTNNA3 as a Novel Candidate Tumor Suppressor"],"prefix":"10.1016","volume":"186","author":[{"given":"Verena","family":"Stahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Nagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Fischer-Huchzermeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Oyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Schneppenheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gesk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Bohring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levan","family":"Chikobava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Gess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Senner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Harder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2016.08.019_bib1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00401-011-0928-6","article-title":"Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms","volume":"123","author":"Carroll","year":"2012","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.ajpath.2016.08.019_bib2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/PAS.0b013e31824d3155","article-title":"Hybrid neurofibroma\/schwannoma is overrepresented among schwannomatosis and neurofibromatosis patients","volume":"36","author":"Harder","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ajpath.2016.08.019_bib3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/jmg.39.5.311","article-title":"Malignant peripheral nerve sheath tumours in neurofibromatosis 1","volume":"39","author":"Evans","year":"2002","journal-title":"J Med Genet"},{"key":"10.1016\/j.ajpath.2016.08.019_bib4","article-title":"[Pathogenesis and molecular pathology of vestibular schwannoma]","author":"Brodhun","year":"2016","journal-title":"HNO"},{"key":"10.1016\/j.ajpath.2016.08.019_bib5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/path.2064","article-title":"Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1)","volume":"210","author":"Lind","year":"2006","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2016.08.019_bib6","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1093\/hmg\/9.20.3055","article-title":"Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations","volume":"9","author":"Serra","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ajpath.2016.08.019_bib7","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.1068452","article-title":"Neurofibromas in NF1: Schwann cell origin and role of tumor environment","volume":"296","author":"Zhu","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2016.08.019_bib8","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/glia.20776","article-title":"How does the Schwann cell lineage form tumors in NF1?","volume":"56","author":"Carroll","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.ajpath.2016.08.019_bib9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/363515a0","article-title":"Alteration in a new gene encoding a putative membrane-organizing protein causes neurofibromatosis type 2","volume":"363","author":"Rouleau","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2016.08.019_bib10","first-page":"826","article-title":"A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor","volume":"75","author":"Trofatter","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2016.08.019_bib11","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1101\/gad.1335605","article-title":"Membrane organization and tumorigenesis: the NF2 tumor suppressor, Merlin","volume":"19","author":"McClatchey","year":"2005","journal-title":"Genes Dev"},{"key":"10.1016\/j.ajpath.2016.08.019_bib12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0166-2236(96)10044-8","article-title":"Neurofibromatosis type 2: a new mechanism of tumor suppression","volume":"19","author":"Lutchman","year":"1996","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.ajpath.2016.08.019_bib13","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-2990.2010.01090.x","article-title":"CpG island hypermethylation of the neurofibromatosis type 2 (NF2) gene is rare in sporadic vestibular schwannomas","volume":"36","author":"Kullar","year":"2010","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.ajpath.2016.08.019_bib14","doi-asserted-by":"crossref","first-page":"e30418","DOI":"10.1371\/journal.pone.0030418","article-title":"Genetic and epigenetic alterations of the NF2 gene in sporadic vestibular schwannomas","volume":"7","author":"Lee","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2016.08.019_bib15","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1097\/MAO.0b013e318298ac79","article-title":"NF2 genetic alterations in sporadic vestibular schwannomas: clinical implications","volume":"34","author":"Lassaletta","year":"2013","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.ajpath.2016.08.019_bib16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/jmg.39.5.315","article-title":"Molecular genetic analysis of the NF2 gene in young patients with unilateral vestibular schwannomas","volume":"39","author":"Mohyuddin","year":"2002","journal-title":"J Med Genet"},{"key":"10.1016\/j.ajpath.2016.08.019_bib17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/humu.20679","article-title":"Evidence of a four-hit mechanism involving SMARCB1 and NF2 in schwannomatosis-associated schwannomas","volume":"29","author":"Sestini","year":"2008","journal-title":"Hum Mutat"},{"key":"10.1016\/j.ajpath.2016.08.019_bib18","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1212\/01.WNL.0000163982.78900.AD","article-title":"Diagnostic criteria for schwannomatosis","volume":"64","author":"MacCollin","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.ajpath.2016.08.019_bib19","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1212\/WNL.46.4.1072","article-title":"Schwannomatosis: a clinical and pathologic study","volume":"46","author":"MacCollin","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.ajpath.2016.08.019_bib20","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/ng.2855","article-title":"Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas","volume":"46","author":"Piotrowski","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajpath.2016.08.019_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1212\/WNL.0000000000001129","article-title":"Mutations in LZTR1 add to the complex heterogeneity of schwannomatosis","volume":"84","author":"Smith","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.ajpath.2016.08.019_bib22","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/ejhg.2014.220","article-title":"Expanding the mutational spectrum of LZTR1 in schwannomatosis","volume":"23","author":"Paganini","year":"2015","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ajpath.2016.08.019_bib23","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00401-014-1311-1","article-title":"Whole exome sequencing reveals that the majority of schwannomatosis cases remain unexplained after excluding SMARCB1 and LZTR1 germline variants","volume":"128","author":"Hutter","year":"2014","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.ajpath.2016.08.019_bib24","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/gim.2014.39","article-title":"A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis","volume":"16","author":"Zhang","year":"2014","journal-title":"Genet Med"},{"key":"10.1016\/j.ajpath.2016.08.019_bib25","unstructured":"WHO Classification of Tumours of the Central Nervous System. Edited by Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. Lyon, France: IARC, 2016"},{"key":"10.1016\/j.ajpath.2016.08.019_bib26","unstructured":"WHO Classification of Tumours of Soft Tissue and Bone. Edited by Fletcher CDM, Bridge JA, Hogendoorn P, Mertens F. Lyon, France: IARC,\u00a02013"},{"key":"10.1016\/j.ajpath.2016.08.019_bib27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2353\/jmoldx.2006.050083","article-title":"FISH analysis for the detection of lymphoma-associated chromosomal abnormalities in routine paraffin-embedded tissue","volume":"8","author":"Ventura","year":"2006","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.ajpath.2016.08.019_bib28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/gcc.20729","article-title":"Clinical and molecular features in patients with atypical teratoid rhabdoid tumor or malignant rhabdoid tumor","volume":"49","author":"Kordes","year":"2010","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.ajpath.2016.08.019_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0165-0270(97)00146-5","article-title":"Cold jet: a method to obtain pure Schwann cell cultures without the need for cytotoxic, apoptosis-inducing drug treatment","volume":"78","author":"Jirsova","year":"1997","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.ajpath.2016.08.019_bib30","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/gcc.20443","article-title":"Alpha-T-catenin (CTNNA3) displays tumour specific monoallelic expression in urothelial carcinoma of the bladder","volume":"46","author":"Meehan","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.ajpath.2016.08.019_bib31","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1093\/hmg\/ddm244","article-title":"Genetic association of CTNNA3 with late-onset Alzheimer's disease in females","volume":"16","author":"Miyashita","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ajpath.2016.08.019_bib32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2222.2008.03117.x","article-title":"Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis","volume":"39","author":"Kim","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.ajpath.2016.08.019_bib33","first-page":"39","article-title":"Expression of E-cadherin-catenin complex in human benign schwannomas","volume":"17","author":"Hasegawa","year":"2002","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.ajpath.2016.08.019_bib34","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1046\/j.1365-2559.2002.01392.x","article-title":"Abnormal alpha-catenin expression in invasive breast cancer correlates with poor patient survival","volume":"40","author":"Nakopoulou","year":"2002","journal-title":"Histopathology"},{"key":"10.1016\/j.ajpath.2016.08.019_bib35","doi-asserted-by":"crossref","first-page":"ra33","DOI":"10.1126\/scisignal.2001823","article-title":"alpha-Catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1","volume":"4","author":"Silvis","year":"2011","journal-title":"Sci Signal"},{"key":"10.1016\/j.ajpath.2016.08.019_bib36","doi-asserted-by":"crossref","first-page":"21883","DOI":"10.1074\/jbc.M001929200","article-title":"alpha-Catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin*T-cell factor*DNA complex","volume":"275","author":"Giannini","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.08.019_bib37","doi-asserted-by":"crossref","first-page":"C747","DOI":"10.1152\/ajpcell.00433.2003","article-title":"Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions","volume":"286","author":"Gottardi","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.ajpath.2016.08.019_bib38","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1242\/jcs.114.17.3177","article-title":"alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion","volume":"114","author":"Janssens","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2016.08.019_bib39","doi-asserted-by":"crossref","first-page":"pt6","DOI":"10.1126\/scisignal.2002314","article-title":"Merlin\/NF2 functions upstream of the nuclear E3 ubiquitin ligase CRL4DCAF1 to suppress oncogenic gene expression","volume":"4","author":"Cooper","year":"2011","journal-title":"Sci Signal"},{"key":"10.1016\/j.ajpath.2016.08.019_bib40","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1111\/j.1600-0625.2009.01017.x","article-title":"Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 1","volume":"19","author":"Arima","year":"2010","journal-title":"Exp Dermatol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944016303789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944016303789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T19:39:57Z","timestamp":1657481997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944016303789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0002944016303789"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2016.08.019","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular Analysis of Hybrid Neurofibroma\/Schwannoma Identifies Common Monosomy 22 and \u03b1-T-Catenin\/CTNNA3 as a Novel Candidate Tumor Suppressor","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2016.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}