{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:22:26Z","timestamp":1790680946607,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":1045,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"crossref","award":["CSCC FKZ 01EO1502"],"award-info":[{"award-number":["CSCC FKZ 01EO1502"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.ajpath.2016.10.005","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T10:30:18Z","timestamp":1484130618000},"page":"268-279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["A Novel Mouse Model of Staphylococcus aureus Vascular Graft Infection"],"prefix":"10.1016","volume":"187","author":[{"given":"H\u00e9l\u00e8ne","family":"Van de Vyver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp R.","family":"Bovenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Hoerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Schwegmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Tuchscherr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Niemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kursawe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Grosse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Moter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Neugebauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Kuhlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"L\u00f6ffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2016.10.005_bib1","first-page":"w13754","article-title":"Vascular graft infections","volume":"143","author":"Hasse","year":"2013","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.ajpath.2016.10.005_bib2","doi-asserted-by":"crossref","first-page":"e112947","DOI":"10.1371\/journal.pone.0112947","article-title":"Surgical and antimicrobial treatment of prosthetic vascular graft infections at different surgical sites: a retrospective study of treatment outcomes","volume":"9","author":"Erb","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2016.10.005_bib3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.medmal.2012.01.003","article-title":"Diagnosis and management of prosthetic vascular graft infections","volume":"42","author":"Legout","year":"2012","journal-title":"Med Maladies Infect"},{"key":"10.1016\/j.ajpath.2016.10.005_bib4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S1646-706X(14)70050-3","article-title":"Prosthetic vascular graft infections: a center experience","volume":"10","author":"Sousa","year":"2014","journal-title":"Angiol Cirurgia Vasc"},{"key":"10.1016\/j.ajpath.2016.10.005_bib5","first-page":"207","article-title":"Staphylococcal biofilms","volume":"322","author":"Otto","year":"2008","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.ajpath.2016.10.005_bib6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/viru.2.5.17724","article-title":"Staphylococcus aureus biofilms: properties, regulation and roles in human disease","volume":"2","author":"Archer","year":"2011","journal-title":"Virulence"},{"key":"10.1016\/j.ajpath.2016.10.005_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2015.00001","article-title":"Methicillin resistance and the biofilm phenotype in Staphylococcus aureus","volume":"5","author":"McCarthy","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.ajpath.2016.10.005_bib8","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1093\/jac\/dkq257","article-title":"Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms","volume":"65","author":"Singh","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ajpath.2016.10.005_bib9","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1128\/JCM.37.6.1771-1776.1999","article-title":"The calgary biofilm device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms","volume":"37","author":"Ceri","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ajpath.2016.10.005_bib10","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.3390\/molecules20045286","article-title":"Antibiotic discovery: combatting bacterial resistance in cells and in biofilm communities","volume":"20","author":"Penesyan","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.ajpath.2016.10.005_bib11","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ejvs.2011.12.029","article-title":"Prevention of vascular graft infections with antibiotic graft impregnation prior to implantation: in\u00a0vitro comparison between daptomycin, rifampin and nebacetin","volume":"43","author":"Bisdas","year":"2012","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ajpath.2016.10.005_bib12","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ejvs.2010.08.009","article-title":"Daptomycin and rifampin alone and in combination prevent vascular graft biofilm formation and emergence of antibiotic resistance in a subcutaneous rat pouch model of staphylococcal infection","volume":"40","author":"Cirioni","year":"2010","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ajpath.2016.10.005_bib13","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.avsg.2008.06.011","article-title":"Efficacy of collagen silver-coated polyester and Rifampin-soaked vascular grafts to resist infection from MRSA and Escherichia coli in a dog model","volume":"22","author":"Schneider","year":"2008","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.ajpath.2016.10.005_bib14","doi-asserted-by":"crossref","first-page":"e185","DOI":"10.1016\/j.jss.2010.05.029","article-title":"Prevention of early vascular graft infection using regional antibiotic release","volume":"164","author":"Kuehn","year":"2010","journal-title":"J Surg Res"},{"key":"10.1016\/j.ajpath.2016.10.005_bib15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jss.2008.06.050","article-title":"Regional antibiotic delivery for the treatment of experimental prosthetic graft infections","volume":"157","author":"Keeling","year":"2009","journal-title":"J Surg Res"},{"key":"10.1016\/j.ajpath.2016.10.005_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature16057","article-title":"Novel antibody\u2013antibiotic conjugate eliminates intracellular S. aureus","volume":"527","author":"Lehar","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2016.10.005_bib17","first-page":"Unit-1B.1","article-title":"Growing and analyzing static biofilms","volume":"Chapter 1","author":"Merritt","year":"2005","journal-title":"Curr Protoc Microbiol"},{"key":"10.1016\/j.ajpath.2016.10.005_bib18","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/35086581","article-title":"Natural conjugative plasmids induce bacterial biofilm development","volume":"412","author":"Ghigo","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2016.10.005_bib19","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/j.1365-2672.2012.05264.x","article-title":"Development and application of a polymicrobial, in\u00a0vitro, wound biofilm model","volume":"112","author":"Woods","year":"2012","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.ajpath.2016.10.005_bib20","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1128\/AEM.03065-09","article-title":"New device for high-throughput viability screening of flow biofilms","volume":"76","author":"Benoit","year":"2010","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.ajpath.2016.10.005_bib21","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.tim.2013.06.002","article-title":"The in\u00a0vivo biofilm","volume":"21","author":"Bjarnsholt","year":"2013","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.ajpath.2016.10.005_bib22","doi-asserted-by":"crossref","first-page":"e1004870","DOI":"10.1371\/journal.ppat.1004870","article-title":"Sigma factor SigB is crucial to mediate Staphylococcus aureus adaptation during chronic infections","volume":"11","author":"Tuchscherr","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2016.10.005_bib23","doi-asserted-by":"crossref","first-page":"O538","DOI":"10.1111\/1469-0691.12526","article-title":"Fluorescence in situ hybridization for identification of microorganisms in acute chorioamnionitis","volume":"9","author":"Schmiedel","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ajpath.2016.10.005_bib24","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3389\/fmicb.2015.00416","article-title":"SarA based novel therapeutic candidate against Staphylococcus aureus associated with vascular graft infections","volume":"6","author":"Arya","year":"2015","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ajpath.2016.10.005_bib25","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1128\/AAC.03869-14","article-title":"Oral administration of the broad-spectrum antibiofilm compound Toremifene inhibits Candida albicans and Staphylococcus aureus biofilm formation in\u00a0vivo","volume":"58","author":"De Cremer","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ajpath.2016.10.005_bib26","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1128\/AAC.48.8.3162-3164.2004","article-title":"Temporin A soaking in combination with intraperitoneal Linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides","volume":"48","author":"Giacometti","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ajpath.2016.10.005_bib27","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ejvs.2009.11.023","article-title":"Prevention of primary vascular graft infection with silver-coated polyester graft in a porcine model","volume":"39","author":"Gao","year":"2010","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ajpath.2016.10.005_bib28","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s10096-010-1008-x","article-title":"Brief report: biomarkers of aortic vascular prosthetic graft infection in a porcine model with Staphylococcus aureus","volume":"29","author":"Langerhuus","year":"2010","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ajpath.2016.10.005_bib29","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.jvs.2007.06.023","article-title":"Prevention of Staphylococcus aureus graft infection by a new gelatin-sealed vascular graft prebonded with antibiotics","volume":"46","author":"Javerliat","year":"2007","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.ajpath.2016.10.005_bib30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/153857440503900505","article-title":"Graft infectivity of rifampin and silver-bonded polyester grafts to MRSA contamination","volume":"39","author":"Schmacht","year":"2005","journal-title":"Vasc Endovasc Surg"},{"key":"10.1016\/j.ajpath.2016.10.005_bib31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nri2017","article-title":"Humanized mice in translational biomedical research","volume":"7","author":"Schultz","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2016.10.005_bib32","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1161\/CIRCULATIONAHA.107.714170","article-title":"Modified prosthetic vascular conduits","volume":"117","author":"Kapadia","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.ajpath.2016.10.005_bib33","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1128\/iai.60.7.2976-2985.1992","article-title":"Histopathological and serological progression of experimental Staphylococcus aureus arthritis","volume":"60","author":"Bremell","year":"1992","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2016.10.005_bib34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10334-014-0466-z","article-title":"Velocity mapping of the aortic flow at 9.4 T in healthy mice and mice with induced heart failure using time-resolved three-dimensional phase-contrast MRI (4D PC MRI)","volume":"28","author":"Bovenkamp","year":"2015","journal-title":"MAGMA"},{"key":"10.1016\/j.ajpath.2016.10.005_bib35","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1099\/00221287-144-9-2459","article-title":"Fluorescence in situ hybridization shows spatial distribution of as yet uncultured treponemes in biopsies from digital dermatitis lesions","volume":"144","author":"Moter","year":"1998","journal-title":"Microbiology"},{"key":"10.1016\/j.ajpath.2016.10.005_bib36","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1128\/aem.56.6.1919-1925.1990","article-title":"Combination of 16S rRNA-targeted oligonucleotide probes with flow cytometry for analyzing mixed microbial populations","volume":"56","author":"Amann","year":"1990","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.ajpath.2016.10.005_bib37","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1128\/JCM.38.2.830-838.2000","article-title":"Fluorescent in situ hybridization allows rapid identification of microorganisms in blood cultures","volume":"38","author":"Kempf","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ajpath.2016.10.005_bib38","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.ijantimicag.2008.06.007","article-title":"Fluorescence in situ hybridisation (FISH) accelerates identification of Gram-positive cocci in positive blood cultures","volume":"32: Suppl 1","author":"Gescher","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ajpath.2016.10.005_bib39","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/cyto.990140205","article-title":"Optimizing fluorescent in situ hybridization with rRNA-targeted oligonucleotide probes for flow cytometric identification of microorganisms","volume":"14","author":"Wallner","year":"1993","journal-title":"Cytometry"},{"key":"10.1016\/j.ajpath.2016.10.005_bib40","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.ajpath.2012.07.005","article-title":"A novel mouse model of Staphylococcus aureus chronic osteomyelitis that closely mimics the human infection - an integrated view of disease pathogenesis","volume":"181","author":"Horst","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2016.10.005_bib41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.idc.2011.09.004","article-title":"Vascular graft infections","volume":"26","author":"Young","year":"2012","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.ajpath.2016.10.005_bib42","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejvs.2010.09.007","article-title":"In\u00a0vivo detection of Staphylococcus aureus in biofilm on vascular prostheses using non-invasive biophotonic imaging","volume":"41","author":"Lorenz","year":"2011","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.ajpath.2016.10.005_bib43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.micpath.2003.12.004","article-title":"The ability of biofilm formation does not influence virulence of Staphylococcus aureus and host response in a mouse tissue cage infection model","volume":"36","author":"Kristian","year":"2004","journal-title":"Microb Pathog"},{"key":"10.1016\/j.ajpath.2016.10.005_bib44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2334-5-91","article-title":"Systemic and local antibiotic prophylaxis in the prevention of Staphylococcus epidermidis graft infection","volume":"5","author":"Turgut","year":"2005","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ajpath.2016.10.005_bib45","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1006\/cyto.2002.0876","article-title":"Induction of cytokine production by different staphylococcal strains","volume":"19","author":"Megyeri","year":"2002","journal-title":"Cytokine"},{"key":"10.1016\/j.ajpath.2016.10.005_bib46","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1128\/IAI.68.7.3965-3970.2000","article-title":"Peptidoglycan and lipoteichoic acid from Staphylococcus aureus induce tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-10 production in both T cells and monocytes in a human whole blood model","volume":"68","author":"Wang","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2016.10.005_bib47","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1128\/IAI.01386-10","article-title":"Murine Immune response to a chronic Staphylococcus aureus biofilm infection","volume":"79","author":"Prabhakara","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2016.10.005_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/1748-6041\/3\/3\/034003","article-title":"Biofilm formation, bacterial adhesion and host response on polymeric implants \u2014 issues and prevention","volume":"3","author":"Pavithra","year":"2008","journal-title":"Biomed Mater"},{"key":"10.1016\/j.ajpath.2016.10.005_bib49","doi-asserted-by":"crossref","first-page":"153ra132","DOI":"10.1126\/scitranslmed.3004120","article-title":"Vascular catheters with a nonleaching poly-sulfobetaine surface modification reduce thrombus formation and microbial attachment","volume":"4","author":"Smith","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.ajpath.2016.10.005_bib50","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1128\/CMR.15.2.167-193.2002","article-title":"Biofilms: survival mechanisms of clinically relevant microorganisms","volume":"15","author":"Donlan","year":"2002","journal-title":"Clin Microbiol Rev"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944016304606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944016304606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T01:41:05Z","timestamp":1655862065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944016304606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0002944016304606"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2016.10.005","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Novel Mouse Model of Staphylococcus aureus Vascular Graft Infection","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2016.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}