{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:50:58Z","timestamp":1790031058972,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":986,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270926"],"award-info":[{"award-number":["81270926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81471068"],"award-info":[{"award-number":["81471068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.ajpath.2016.12.013","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T06:22:26Z","timestamp":1488867746000},"page":"808-818","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Activation of Constitutive Androstane Receptor Prevents Cholesterol Gallstone Formation"],"prefix":"10.1016","volume":"187","author":[{"given":"Shihai","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangying","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyun","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2016.12.013_bib1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.bbadis.2010.12.021","article-title":"Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease","volume":"1812","author":"Claudel","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ajpath.2016.12.013_bib2","doi-asserted-by":"crossref","first-page":"48275","DOI":"10.1074\/jbc.M310223200","article-title":"ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion","volume":"278","author":"Graf","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.12.013_bib3","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1074\/jbc.M411080200","article-title":"Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion","volume":"280","author":"Yu","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.12.013_bib4","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0092-8674(93)90380-9","article-title":"Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease","volume":"75","author":"Smit","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2016.12.013_bib5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.cmet.2015.01.007","article-title":"MAFG is a transcriptional repressor of bile acid synthesis and metabolism","volume":"21","author":"de Aguiar Vallim","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajpath.2016.12.013_bib6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1534-5807(02)00154-5","article-title":"Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis","volume":"2","author":"Kerr","year":"2002","journal-title":"Dev Cell"},{"key":"10.1016\/j.ajpath.2016.12.013_bib7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis","volume":"2","author":"Inagaki","year":"2005","journal-title":"Cell Metab"},{"key":"10.1016\/j.ajpath.2016.12.013_bib8","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1073\/pnas.0509592103","article-title":"Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor","volume":"103","author":"Inagaki","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2016.12.013_bib9","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1194\/jlr.R900012-JLR200","article-title":"Bile acid transporters","volume":"50","author":"Dawson","year":"2009","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2016.12.013_bib10","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1053\/j.gastro.2011.02.055","article-title":"PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts","volume":"140","author":"He","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2016.12.013_bib11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/35038112","article-title":"The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism","volume":"407","author":"Wei","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2016.12.013_bib12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2174\/1389200054633899","article-title":"CAR, the continuously advancing receptor, in drug metabolism and disease","volume":"6","author":"Qatanani","year":"2005","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.ajpath.2016.12.013_bib13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jhep.2010.10.029","article-title":"Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice","volume":"55","author":"Sberna","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2016.12.013_bib14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/toxsci\/kfw054","article-title":"Activation of constitutive androstane receptor (CAR) in mice results in maintained biliary excretion of bile acids despite a marked decrease of bile acids in liver","volume":"151","author":"Lickteig","year":"2016","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.ajpath.2016.12.013_bib15","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1161\/ATVBAHA.110.222497","article-title":"Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice","volume":"31","author":"Sberna","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ajpath.2016.12.013_bib16","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nm1785","article-title":"Hepatic insulin resistance directly promotes formation of cholesterol gallstones","volume":"14","author":"Biddinger","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2016.12.013_bib17","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-2275(20)40677-7","article-title":"Critical tables for calculating the cholesterol saturation of native bile","volume":"19","author":"Carey","year":"1978","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2016.12.013_bib18","doi-asserted-by":"crossref","first-page":"15482","DOI":"10.1074\/jbc.275.20.15482","article-title":"Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4","volume":"275","author":"Yu","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.12.013_bib19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.12.013_bib20","doi-asserted-by":"crossref","first-page":"e6843","DOI":"10.1371\/journal.pone.0006843","article-title":"Circadian dysregulation disrupts bile acid homeostasis","volume":"4","author":"Ma","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2016.12.013_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.ajpath.2016.12.013_bib22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/hq0102.102588","article-title":"Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL\/6J mice","volume":"22","author":"Miyake","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.ajpath.2016.12.013_bib23","doi-asserted-by":"crossref","first-page":"22250","DOI":"10.1074\/jbc.M314111200","article-title":"Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice","volume":"279","author":"Assem","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.12.013_bib24","doi-asserted-by":"crossref","first-page":"25984","DOI":"10.1074\/jbc.M109.016808","article-title":"The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity","volume":"284","author":"Gao","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.12.013_bib25","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/hep.22175","article-title":"Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization","volume":"47","author":"Uppal","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2016.12.013_bib26","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.20784","article-title":"CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice","volume":"42","author":"Wagner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2016.12.013_bib27","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1194\/jlr.M700374-JLR200","article-title":"Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice","volume":"49","author":"Masson","year":"2008","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2016.12.013_bib28","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1194\/jlr.M500115-JLR200","article-title":"ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile","volume":"46","author":"Langheim","year":"2005","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2016.12.013_bib29","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1016\/S0022-2275(20)32430-5","article-title":"Phenotypic characterization of lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice. Pathophysiology of biliary lipid secretion","volume":"40","author":"Wang","year":"1999","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2016.12.013_bib30","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1194\/jlr.M700330-JLR200","article-title":"Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine","volume":"48","author":"Kim","year":"2007","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2016.12.013_bib31","doi-asserted-by":"crossref","first-page":"14537","DOI":"10.1074\/jbc.M510713200","article-title":"Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid\/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha","volume":"281","author":"Miao","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.12.013_bib32","doi-asserted-by":"crossref","first-page":"41334","DOI":"10.1074\/jbc.M112.421834","article-title":"Nuclear receptors HNF4alpha and LRH-1 cooperate in regulating Cyp7a1 in\u00a0vivo","volume":"287","author":"Kir","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.12.013_bib33","doi-asserted-by":"crossref","first-page":"45062","DOI":"10.1074\/jbc.M307145200","article-title":"Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity","volume":"278","author":"Guo","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2016.12.013_bib34","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1194\/jlr.M800226-JLR200","article-title":"The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress","volume":"50","author":"Maglich","year":"2009","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2016.12.013_bib35","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1002\/hep.21158","article-title":"Mrp4-\/- mice have an impaired cytoprotective response in obstructive cholestasis","volume":"43","author":"Mennone","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2016.12.013_bib36","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/nm1138","article-title":"Prevention of cholesterol gallstone disease by FXR agonists in a mouse model","volume":"10","author":"Moschetta","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2016.12.013_bib37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/j.gastro.2004.03.059","article-title":"Estrogen receptor alpha, but not beta, plays a major role in 17beta-estradiol-induced murine cholesterol gallstones","volume":"127","author":"Wang","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2016.12.013_bib38","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1194\/jlr.M059121","article-title":"Estrogen induces two distinct cholesterol crystallization pathways by activating ERalpha and GPR30 in female mice","volume":"56","author":"de Bari","year":"2015","journal-title":"J Lipid Res"},{"key":"10.1016\/j.ajpath.2016.12.013_bib39","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/hep.20512","article-title":"Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice","volume":"41","author":"Uppal","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2016.12.013_bib40","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.addr.2010.07.006","article-title":"Functional crosstalk of CAR-LXR and ROR-LXR in drug metabolism and lipid metabolism","volume":"62","author":"Xiao","year":"2010","journal-title":"Adv Drug Deliv Rev"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017300639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017300639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T07:56:02Z","timestamp":1658735762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944017300639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0002944017300639"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2016.12.013","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727390475.793550831","asserted-by":"object"}]},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of Constitutive Androstane Receptor Prevents Cholesterol Gallstone Formation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2016.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}