{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:26Z","timestamp":1789715006137,"version":"4.0.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":925,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["PO1AIO81678"],"award-info":[{"award-number":["PO1AIO81678"]}]},{"name":"NIH","award":["R21AA020846"],"award-info":[{"award-number":["R21AA020846"]}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.ajpath.2017.01.021","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T10:00:20Z","timestamp":1492077620000},"page":"1356-1367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Toll-Like Receptor 4\u2013Independent Carbon Tetrachloride\u2013Induced Fibrosis and Lipopolysaccharide-Induced Acute Liver Injury in Mice"],"prefix":"10.1016","volume":"187","author":[{"given":"Sudhir","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva Kumar","family":"Shanmukhappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrashekhar R.","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2017.01.021_bib1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1136\/gut.19.10.935","article-title":"Portal and systemic bacteraemia and endotoxaemia in liver disease","volume":"19","author":"Triger","year":"1978","journal-title":"Gut"},{"key":"10.1016\/j.ajpath.2017.01.021_bib2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/hep.1840080207","article-title":"Endotoxin levels measured by a chromogenic assay in portal, hepatic and peripheral venous blood in patients with cirrhosis","volume":"8","author":"Lumsden","year":"1988","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2017.01.021_bib3","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/39622","article-title":"Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection","volume":"389","author":"Jack","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2017.01.021_bib4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s12072-010-9219-x","article-title":"The role of lipopolysaccharide\/toll-like receptor 4\u00a0signaling in chronic liver diseases","volume":"4","author":"Soares","year":"2010","journal-title":"Hepatol Int"},{"key":"10.1016\/j.ajpath.2017.01.021_bib5","doi-asserted-by":"crossref","first-page":"949157","DOI":"10.1155\/2012\/949157","article-title":"Innate immune cells in liver inflammation","volume":"2012","author":"Liaskou","year":"2012","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.ajpath.2017.01.021_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jlb.64.1.25","article-title":"LPS-binding proteins and receptors","volume":"64","author":"Fenton","year":"1998","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib7","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1073\/pnas.88.10.4148","article-title":"Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages","volume":"88","author":"Weinstein","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2017.01.021_bib8","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1126\/science.7914033","article-title":"A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells","volume":"265","author":"Han","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2017.01.021_bib9","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.4049\/jimmunol.153.12.5760","article-title":"LPS induces selective translocation of protein kinase C-\u03b2 in LPS-responsive mouse macrophages, but not in LPS-nonresponsive mouse macrophages","volume":"153","author":"Shinji","year":"1994","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib10","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.4049\/jimmunol.156.11.4457","article-title":"Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages","volume":"156","author":"Sanghera","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib11","doi-asserted-by":"crossref","first-page":"G256","DOI":"10.1152\/ajpgi.00550.2001","article-title":"Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation","volume":"283","author":"Su","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib12","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1073\/pnas.90.6.2380","article-title":"Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide","volume":"90","author":"Ferrero","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Suppl","key":"10.1016\/j.ajpath.2017.01.021_bib13","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1111\/jgh.1998.13.s1.39","article-title":"The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury","volume":"13","author":"Thurman","year":"1998","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib14","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.4049\/jimmunol.160.6.2570","article-title":"The induction of acute phase proteins by lipopolysaccharide uses a novel pathway that is CD14-independent","volume":"160","author":"Haziot","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib15","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2017.01.021_bib16","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.4049\/jimmunol.176.4.2522","article-title":"Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4","volume":"176","author":"Campbell","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib17","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2017.01.021_bib18","series-title":"Molecular pathology of liver diseases","first-page":"53","article-title":"Hepatic stellate cells","author":"Gandhi","year":"2010"},{"key":"10.1016\/j.ajpath.2017.01.021_bib19","series-title":"Stellate cells in health and disease","first-page":"227","article-title":"Stellate cells in hepatic immunological tolerance","author":"Gandhi","year":"2015"},{"key":"10.1016\/j.ajpath.2017.01.021_bib20","series-title":"Stellate cells in health and disease","first-page":"63","article-title":"Cytokine production and signaling in stellate cells","author":"Marra","year":"2015"},{"key":"10.1016\/j.ajpath.2017.01.021_bib21","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/jcp.20366","article-title":"Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes","volume":"204","author":"Thirunavukkarasu","year":"2005","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib22","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/sj.bjp.0704151","article-title":"Inhibition of DNA synthesis in cultured hepatocytes by endotoxin-conditioned medium of activated stellate cells is transforming growth factor-\u03b2- and nitric oxide-independent","volume":"133","author":"Uemura","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib23","doi-asserted-by":"crossref","first-page":"e82159","DOI":"10.1371\/journal.pone.0082159","article-title":"The transcriptomic response of rat hepatic stellate cells to endotoxin: implications for hepatic inflammation and immune regulation","volume":"8","author":"Harvey","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2017.01.021_bib24","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1053\/jhep.2003.50182","article-title":"Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells","volume":"37","author":"Paik","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2017.01.021_bib25","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jhep.2013.09.013","article-title":"A novel mouse model of depletion of stellate cells clarifies their role in ischemia\/reperfusion- and endotoxin-induced acute liver injury","volume":"60","author":"Stewart","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1053\/j.gastro.2014.10.008","article-title":"Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice","volume":"148","author":"Gandhi","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2017.01.021_bib27","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib28","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.4049\/jimmunol.1102460","article-title":"Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance","volume":"188","author":"Dangi","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib29","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1189\/jlb.2A0516-239R","article-title":"Hepatic stellate cells increase the immunosuppressive function of natural Foxp3+ regulatory T cells via IDO-induced AhR activation","volume":"101","author":"Kumar","year":"2017","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib30","first-page":"Unit14.24","article-title":"Measuring matrix metalloproteinase activity in macrophages and polymorphonuclear leukocytes","volume":"Chapter 14","author":"Kessenbrock","year":"2011","journal-title":"Curr Protoc Immunol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib31","series-title":"Stellate cells in health and disease","first-page":"41","article-title":"Stellate cells and hepatic fibrosis","author":"Hasegawa","year":"2015"},{"key":"10.1016\/j.ajpath.2017.01.021_bib32","series-title":"Stellate cells in health and disease","first-page":"87","article-title":"Stellate cells, portal myofibroblasts and epithelial-to-mesenchymal transition","author":"Koyama","year":"2015"},{"key":"10.1016\/j.ajpath.2017.01.021_bib33","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1038\/ncomms3823","article-title":"Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology","volume":"4","author":"Mederacke","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2017.01.021_bib34","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/hep.1840160325","article-title":"Inhibition of rat hepatic lipocyte activation in culture by interferon-gamma","volume":"16","author":"Rockey","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2017.01.021_bib35","first-page":"660","article-title":"Interferon gamma inhibits lipocyte activation and extracellular matrix mRNA expression during experimental liver injury: implications for treatment of hepatic fibrosis","volume":"42","author":"Rockey","year":"1994","journal-title":"J Investig Med"},{"key":"10.1016\/j.ajpath.2017.01.021_bib36","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1126\/science.1240248","article-title":"Noncanonical inflammasome activation by intracellular LPS independent of TLR4","volume":"341","author":"Kayagaki","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ajpath.2017.01.021_bib37","series-title":"Stellate cells in health and disease","first-page":"107","article-title":"Matrix metalloproteinases and their inhibitors","author":"Campana","year":"2015"},{"key":"10.1016\/j.ajpath.2017.01.021_bib38","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/hep.21254","article-title":"Mechanisms of endotoxin-induced nitric oxide, interleukin-6 and tumor necrosis factor-a production in activated rat hepatic stellate cells: role of p38MAPK","volume":"44","author":"Thirunavukkarasu","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2017.01.021_bib39","doi-asserted-by":"crossref","first-page":"6867","DOI":"10.1038\/sj.onc.1203219","article-title":"How NF\u03baB is activated: the role of the I\u03baB kinase (IKK) complex","volume":"18","author":"Karin","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2017.01.021_bib40","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product","volume":"162","author":"Hoshino","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib41","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","article-title":"Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components","volume":"11","author":"Takeuchi","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.ajpath.2017.01.021_bib42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1084\/jem.147.1.39","article-title":"Genetic control of endotoxic responses in mice","volume":"147","author":"Watson","year":"1978","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2017.01.021_bib43","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1172\/JCI118055","article-title":"Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation","volume":"96","author":"Bissell","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2017.01.021_bib44","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1053\/gast.2002.34234","article-title":"Impaired liver regeneration in mice by lipopolysaccharide via TNF-alpha\/kallikrein-mediated activation of latent TGF-beta","volume":"123","author":"Akita","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2017.01.021_bib45","doi-asserted-by":"crossref","first-page":"G571","DOI":"10.1152\/ajpgi.00537.2004","article-title":"Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells","volume":"289","author":"Brun","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib46","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2017.01.021_bib47","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.jhep.2009.03.007","article-title":"Signaling pathways in alcohol-induced liver inflammation","volume":"50","author":"Mandrekar","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib48","doi-asserted-by":"crossref","first-page":"e0147864","DOI":"10.1371\/journal.pone.0147864","article-title":"Hepatic deficiency of augmenter of liver regeneration exacerbates alcohol-induced liver injury and promotes fibrosis in mice","volume":"11","author":"Kumar","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2017.01.021_bib49","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1055\/s-2008-1040483","article-title":"Carbon tetrachloride hepatotoxicity: an example of free radical-mediated injury","volume":"10","author":"Williams","year":"1990","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.ajpath.2017.01.021_bib50","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2613.2009.00656.x","article-title":"Experimental mouse models for hepatocellular carcinoma research","volume":"90","author":"Heindryckx","year":"2009","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.ajpath.2017.01.021_bib51","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1053\/jhep.2003.50472","article-title":"Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression","volume":"38","author":"Canbay","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2017.01.021_bib52","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1053\/gast.2002.35953","article-title":"Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis","volume":"123","author":"Canbay","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2017.01.021_bib53","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1073\/pnas.94.20.10663","article-title":"Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses","volume":"94","author":"Shi","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2017.01.021_bib54","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1053\/gast.2002.37069","article-title":"Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15","volume":"123","author":"Hillebrandt","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ajpath.2017.01.021_bib55","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1023\/A:1018817600238","article-title":"Hepatotoxic agent thioacetamide induces biochemical and histological alterations in rat small intestine","volume":"42","author":"Ortega","year":"1997","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.ajpath.2017.01.021_bib56","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1007\/s10753-012-9465-2","article-title":"Effects of rifaximin on bacterial translocation in thioacetamide-induced liver injury in rats","volume":"35","author":"Harputluoglu","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.ajpath.2017.01.021_bib57","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/bjs.1800831007","article-title":"Intestinal barrier dysfunction in clinical and experimental obstructive jaundice and its reversal by internal biliary drainage","volume":"83","author":"Parks","year":"1996","journal-title":"Br J Surg"},{"key":"10.1016\/j.ajpath.2017.01.021_bib58","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jhep.2004.04.026","article-title":"High-fat enteral nutrition reduces endotoxin, tumor necrosis factor-alpha and gut permeability in bile duct-ligated rats subjected to hemorrhagic shock","volume":"41","author":"Luyer","year":"2004","journal-title":"J Hepatol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017301281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017301281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T03:43:19Z","timestamp":1692762199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944017301281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0002944017301281"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.01.021","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toll-Like Receptor 4\u2013Independent Carbon Tetrachloride\u2013Induced Fibrosis and Lipopolysaccharide-Induced Acute Liver Injury in Mice","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}