{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:42:38Z","timestamp":1770842558836,"version":"3.50.1"},"reference-count":66,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":895,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.ajpath.2017.03.007","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T15:00:10Z","timestamp":1494342010000},"page":"1537-1550","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["miR-21 Promotes Fibrogenesis in Peritoneal Dialysis"],"prefix":"10.1016","volume":"187","author":[{"given":"Melisa","family":"Lopez-Anton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Lambie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Lopez-Cabrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus P.","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Ruiz-Carpio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Bartosova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betti","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Stone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-9044","authenticated-orcid":false,"given":"Robert","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2925-4779","authenticated-orcid":false,"given":"Nicholas","family":"Topley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6050-0435","authenticated-orcid":false,"given":"Timothy","family":"Bowen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2017.03.007_bib1","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1681\/ASN.2006111292","article-title":"Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions","volume":"18","author":"Aroeira","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib2","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/labinvest.2014.91","article-title":"MicroRNA-29b inhibits peritoneal fibrosis in a mouse model of peritoneal dialysis","volume":"94","author":"Yu","year":"2014","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2017.03.007_bib3","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1681\/ASN.2010111197","article-title":"Blocking TGF-\u03b21 protects the peritoneal membrane from dialysate-induced damage","volume":"22","author":"Loureiro","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib4","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa020809","article-title":"Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells","volume":"348","author":"Y\u00e1\u00f1ez-M\u00f3","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2017.03.007_bib5","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1681\/ASN.2013101079","article-title":"Lineage tracing reveals distinctive fates for mesothelial cells and submesothelial fibroblasts during peritoneal injury","volume":"25","author":"Chen","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/path.4119","article-title":"MicroRNAs, transforming growth factor beta-1, and tissue fibrosis","volume":"229","author":"Bowen","year":"2013","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1681\/ASN.2004060436","article-title":"Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum","volume":"16","author":"Margetts","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib8","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1681\/ASN.V12102029","article-title":"Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function","volume":"12","author":"Margetts","year":"2001","journal-title":"J Am Soc Nephrol"},{"issue":"Suppl 2","key":"10.1016\/j.ajpath.2017.03.007_bib9","doi-asserted-by":"crossref","first-page":"ii2","DOI":"10.1093\/ndt\/gfl183","article-title":"Epithelial-to-mesenchymal transition of the mesothelial cell: its role in the response of the peritoneum to dialysis","volume":"21","author":"Selgas","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.ajpath.2017.03.007_bib10","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","article-title":"A mammalian microRNA expression atlas based on small RNA library sequencing","volume":"129","author":"Landgraf","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2017.03.007_bib11","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nrg2628","article-title":"Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications","volume":"10","author":"Brown","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ajpath.2017.03.007_bib12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrclinonc.2011.76","article-title":"MicroRNAs in body fluids: the mix of hormones and biomarkers","volume":"8","author":"Cortez","year":"2011","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib13","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cell.2009.04.021","article-title":"Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model","volume":"137","author":"Kota","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2017.03.007_bib14","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1093\/nar\/gkr254","article-title":"Characterization of extracellular circulating microRNA","volume":"39","author":"Turchinovich","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2017.03.007_bib15","doi-asserted-by":"crossref","first-page":"929806","DOI":"10.1155\/2015\/929806","article-title":"microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis","volume":"2015","author":"Lopez-Anton","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.ajpath.2017.03.007_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1155\/2012\/737169","article-title":"Relation between microRNA expression in peritoneal dialysis effluent and peritoneal transport characteristics","volume":"33","author":"Chen","year":"2012","journal-title":"Dis Markers"},{"key":"10.1016\/j.ajpath.2017.03.007_bib17","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.ajpath.2013.05.019","article-title":"miR-30a negatively regulates TGF-\u03b21-induced epithelial-mesenchymal transition and peritoneal fibrosis by targeting Snai1","volume":"183","author":"Zhou","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib18","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1242\/jcs.01004","article-title":"The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation","volume":"117","author":"Ohkubo","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ajpath.2017.03.007_bib19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ygyno.2004.12.043","article-title":"Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level","volume":"97","author":"Kurrey","year":"2005","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib20","doi-asserted-by":"crossref","first-page":"673096","DOI":"10.1155\/2012\/673096","article-title":"miRNA589 regulates epithelial-mesenchymal transition in human peritoneal mesothelial cells","volume":"2012","author":"Zhang","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib21","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3892\/etm_2013.1281","article-title":"Changes in expression of four molecular marker proteins and one microRNA in mesothelial cells of the peritoneal dialysate effluent fluid of peritoneal dialysis patients","volume":"6","author":"Zhang","year":"2013","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.ajpath.2017.03.007_bib22","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/ki.1990.150","article-title":"Isolation, culture and characterization of human peritoneal mesothelial cells","volume":"37","author":"Stylianou","year":"1990","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2017.03.007_bib23","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1681\/ASN.2013030314","article-title":"Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival","volume":"24","author":"Lambie","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib24","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1261\/rna.939908","article-title":"Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues","volume":"14","author":"Peltier","year":"2008","journal-title":"RNA"},{"key":"10.1016\/j.ajpath.2017.03.007_bib25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ajpath.2017.03.007_bib26","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/labinvest.2012.166","article-title":"Effects of dexamethasone on the TGF-\u03b21-induced epithelial-to-mesenchymal transition in human peritoneal mesothelial cells","volume":"93","author":"Jang","year":"2013","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2017.03.007_bib27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12860-015-0055-7","article-title":"AKT regulation of mesothelial-to-mesenchymal transition in peritoneal dialysis is modulated by Smurf2 and deubiquitinating enzyme USP4","volume":"16","author":"Xiao","year":"2015","journal-title":"BMC Cell Biol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib28","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/labinvest.2015.57","article-title":"MicroRNA-129-5p modulates epithelial-to-mesenchymal transition by targeting SIP1 and SOX4 during peritoneal dialysis","volume":"95","author":"Xiao","year":"2015","journal-title":"Lab Invest"},{"key":"10.1016\/j.ajpath.2017.03.007_bib29","doi-asserted-by":"crossref","first-page":"44941","DOI":"10.1038\/srep44941","article-title":"Genomic reprograming analysis of the mesothelial to mesenchymal transition identifies biomarkers in peritoneal dialysis patients","volume":"7","author":"Ruiz-Carpio","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajpath.2017.03.007_bib30","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.ajpath.2013.12.028","article-title":"miR-192 induces G2\/M growth arrest in aristolochic acid nephropathy","volume":"184","author":"Jenkins","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib31","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2353\/ajpath.2007.060554","article-title":"The contribution of B cells to renal interstitial inflammation","volume":"170","author":"Heller","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib32","doi-asserted-by":"crossref","first-page":"W210","DOI":"10.1093\/nar\/gkq388","article-title":"Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling","volume":"38","author":"Medina","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2017.03.007_bib33","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/sj.onc.1210856","article-title":"MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer","volume":"27","author":"Asangani","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2017.03.007_bib34","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/ijc.25506","article-title":"Micro-RNA-21 regulates TGF-\u03b2-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction","volume":"128","author":"Yao","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ajpath.2017.03.007_bib35","doi-asserted-by":"crossref","first-page":"e56280","DOI":"10.1371\/journal.pone.0056280","article-title":"miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1","volume":"8","author":"Br\u00f8nnum","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2017.03.007_bib36","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.immuni.2013.10.022","article-title":"Interleukin-6 signaling drives fibrosis in unresolved inflammation","volume":"40","author":"Fielding","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.ajpath.2017.03.007_bib37","doi-asserted-by":"crossref","first-page":"W169","DOI":"10.1093\/nar\/gkt393","article-title":"DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows","volume":"41","author":"Paraskevopoulou","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2017.03.007_bib38","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/bioinformatics\/bts043","article-title":"Functional microRNA targets in protein coding sequences","volume":"28","author":"Reczko","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajpath.2017.03.007_bib39","doi-asserted-by":"crossref","first-page":"D146","DOI":"10.1093\/nar\/gku1104","article-title":"miRDB: an online resource for microRNA target prediction and functional annotations","volume":"43","author":"Wong","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2017.03.007_bib40","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/bioinformatics\/btm595","article-title":"Prediction of both conserved and nonconserved microRNA targets in animals","volume":"24","author":"Wang","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ajpath.2017.03.007_bib41","doi-asserted-by":"crossref","first-page":"R90","DOI":"10.1186\/gb-2010-11-8-r90","article-title":"Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites","volume":"11","author":"Betel","year":"2010","journal-title":"Genome Biol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib42","doi-asserted-by":"crossref","first-page":"D149","DOI":"10.1093\/nar\/gkm995","article-title":"The microRNA.org resource: targets and expression","volume":"36","author":"Betel","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2017.03.007_bib43","doi-asserted-by":"crossref","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.ajpath.2017.03.007_bib44","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.molcel.2014.02.013","article-title":"Global analyses of the effect of different cellular contexts on microRNA targeting","volume":"53","author":"Nam","year":"2014","journal-title":"Mol Cell"},{"key":"10.1016\/j.ajpath.2017.03.007_bib45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2017.03.007_bib46","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1042\/BST20120090","article-title":"Analysis of urinary microRNAs in chronic kidney disease","volume":"40","author":"Beltrami","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.ajpath.2017.03.007_bib47","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1681\/ASN.V132470","article-title":"Morphologic changes in the peritoneal membrane of patients with renal disease","volume":"13","author":"Williams","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib48","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1053\/j.ajkd.2013.01.031","article-title":"Current status and practical use of effluent biomarkers in peritoneal dialysis patients","volume":"62","author":"Lopes Barreto","year":"2013","journal-title":"Am J Kidney Dis"},{"issue":"Suppl 3","key":"10.1016\/j.ajpath.2017.03.007_bib49","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1177\/089686080802803s19","article-title":"Icodextrin and intraperitoneal inflammation","volume":"28","author":"Moriishi","year":"2008","journal-title":"Perit Dial Int"},{"key":"10.1016\/j.ajpath.2017.03.007_bib50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cca.2013.12.003","article-title":"Peritoneal dialysis and inflammation","volume":"430","author":"Velloso","year":"2014","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.ajpath.2017.03.007_bib51","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1172\/JCI17129","article-title":"Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation","volume":"112","author":"McLoughlin","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2017.03.007_bib52","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ki.1993.36","article-title":"Human peritoneal mesothelial cells synthesize interleukin-6: induction by IL-1 beta and TNF alpha","volume":"43","author":"Topley","year":"1993","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2017.03.007_bib53","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/ki.1996.430","article-title":"Superinduction of IL-6 synthesis in human peritoneal mesothelial cells is related to the induction and stabilization of IL-6 mRNA","volume":"50","author":"Witowski","year":"1996","journal-title":"Kidney Int"},{"key":"10.1016\/j.ajpath.2017.03.007_bib54","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1182\/blood-2007-03-081133","article-title":"Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer","volume":"110","author":"L\u00f6ffler","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2017.03.007_bib55","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.toxlet.2015.06.011","article-title":"The IL-6\/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes","volume":"237","author":"Lu","year":"2015","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.ajpath.2017.03.007_bib56","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.molcel.2010.07.023","article-title":"STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer","volume":"39","author":"Iliopoulos","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.ajpath.2017.03.007_bib57","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1158\/0008-5472.CAN-14-2147","article-title":"High-mobility group box 1 promotes hepatocellular carcinoma progression through miR-21-mediated matrix metalloproteinase activity","volume":"75","author":"Chen","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.ajpath.2017.03.007_bib58","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.3892\/or.2014.3114","article-title":"STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in\u00a0vitro and in\u00a0vivo","volume":"31","author":"Zhou","year":"2014","journal-title":"Oncol Rep"},{"key":"10.1016\/j.ajpath.2017.03.007_bib59","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.bbrc.2004.07.198","article-title":"Fgf18 is required for embryonic lung alveolar development","volume":"322","author":"Usui","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2017.03.007_bib60","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1152\/physiolgenomics.00034.2011","article-title":"Profiling target genes of FGF18 in the postnatal mouse lung: possible relevance for alveolar development","volume":"43","author":"Franco-Montoya","year":"2011","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.ajpath.2017.03.007_bib61","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1182\/blood-2011-05-353482","article-title":"Regulation of fibrinolysis by S100A10 in\u00a0vivo","volume":"118","author":"Surette","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2017.03.007_bib62","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1042\/bj20021069","article-title":"Matrilin-2 interacts with itself and with other extracellular matrix proteins","volume":"367","author":"Piecha","year":"2002","journal-title":"Biochem J"},{"key":"10.1016\/j.ajpath.2017.03.007_bib63","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.bbrc.2008.02.128","article-title":"DeltaNp63\/BMP-7-dependent expression of matrilin-2 is involved in keratinocyte migration in response to wounding","volume":"369","author":"Ichikawa","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ajpath.2017.03.007_bib64","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.canlet.2008.05.047","article-title":"The autocrine human secreted PDZ domain-containing protein 2 (sPDZD2) induces senescence or quiescence of prostate, breast and liver cancer cells via transcriptional activation of p53","volume":"271","author":"Tam","year":"2008","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ajpath.2017.03.007_bib65","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/jcp.24229","article-title":"p53 regulates epithelial-mesenchymal transition induced by transforming growth factor \u03b2","volume":"228","author":"Term\u00e9n","year":"2013","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.ajpath.2017.03.007_bib66","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/sj.embor.embor804","article-title":"Proteolytic cleavage of PDZD2 generates a secreted peptide containing two PDZ domains","volume":"4","author":"Yeung","year":"2003","journal-title":"EMBO Rep"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017300391?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017300391?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T11:01:26Z","timestamp":1659006086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944017300391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":66,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S0002944017300391"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.03.007","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-21 Promotes Fibrogenesis in Peritoneal Dialysis","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}