{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:54:46Z","timestamp":1780415686714,"version":"3.54.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":742,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ajp.amjpathol.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.ajpath.2017.08.014","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T20:48:59Z","timestamp":1505854139000},"page":"2811-2820","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Nonpathologic Infection of Macaques by an Attenuated Mycobacterial Vaccine Is Not Reactivated in the Setting of HIV Co-Infection"],"prefix":"10.1016","volume":"187","author":[{"given":"Taylor W.","family":"Foreman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley V.","family":"Veatch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denae N.","family":"LoBato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Didier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0212-9548","authenticated-orcid":false,"given":"Lara A.","family":"Doyle-Meyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasi E.","family":"Russell-Lodrigue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Lackner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin G.","family":"Kousoulas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabaana A.","family":"Khader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Kaushal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smriti","family":"Mehra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2017.08.014_bib1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1089\/jamp.2011.0931","article-title":"Pulmonary vaccine delivery: a realistic approach?","volume":"25","author":"Tonnis","year":"2012","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"10.1016\/j.ajpath.2017.08.014_bib2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.tibtech.2010.12.009","article-title":"New developments in dry powder pulmonary vaccine delivery","volume":"29","author":"Sou","year":"2011","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.ajpath.2017.08.014_bib3","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1164\/rccm.201304-0803OC","article-title":"S100A8\/A9 Proteins Mediate Neutrophilic Inflammation and Lung Pathology during Tuberculosis","volume":"188","author":"Gopal","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2017.08.014_bib4","first-page":"712","article-title":"CXCR5+ T helper cells mediate protective immunity against tuberculosis","volume":"123","author":"Slight","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2017.08.014_bib5","doi-asserted-by":"crossref","first-page":"8533","DOI":"10.1038\/ncomms9533","article-title":"Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis","volume":"6","author":"Kaushal","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2017.08.014_bib6","doi-asserted-by":"crossref","first-page":"E5636","DOI":"10.1073\/pnas.1611987113","article-title":"CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection","volume":"113","author":"Foreman","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2017.08.014_bib7","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.4172\/2161-1068.1000e108","article-title":"Faithful Experimental Models of Human Infection","volume":"2","author":"Kaushal","year":"2012","journal-title":"Mycobact Dis"},{"key":"10.1016\/j.ajpath.2017.08.014_bib8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1600-0684.2012.00536.x","article-title":"The non-human primate model of tuberculosis","volume":"41","author":"Kaushal","year":"2012","journal-title":"J Med Primatol"},{"key":"10.1016\/j.ajpath.2017.08.014_bib9","doi-asserted-by":"crossref","first-page":"e1002607","DOI":"10.1371\/journal.ppat.1002607","article-title":"Vaccines against tuberculosis: where are we and where do we need to go?","volume":"8","author":"Ottenhoff","year":"2012","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ajpath.2017.08.014_bib10","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1016\/j.vaccine.2011.04.066","article-title":"Extended safety and efficacy studies of a live attenuated double leucine and pantothenate auxotroph of Mycobacterium tuberculosis as a vaccine candidate","volume":"29","author":"Sampson","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.ajpath.2017.08.014_bib11","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1128\/IAI.72.5.3031-3037.2004","article-title":"Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs","volume":"72","author":"Sampson","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.ajpath.2017.08.014_bib12","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1016\/j.vaccine.2009.05.050","article-title":"Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates","volume":"27","author":"Larsen","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.ajpath.2017.08.014_bib13","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1016\/j.vaccine.2006.05.097","article-title":"Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis","volume":"24","author":"Sambandamurthy","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.ajpath.2017.08.014_bib14","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nm765","article-title":"A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis","volume":"8","author":"Sambandamurthy","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.ajpath.2017.08.014_bib15","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.2217\/IMT.15.74","article-title":"Vaccination in patients with primary immune deficiency, secondary immune deficiency and autoimmunity with immune regulatory abnormalities","volume":"7","author":"Eibl","year":"2015","journal-title":"Immunotherapy"},{"key":"10.1016\/j.ajpath.2017.08.014_bib16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tube.2011.12.003","article-title":"BCG: myths, realities, and the need for alternative vaccine strategies","volume":"92","author":"McShane","year":"2012","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.ajpath.2017.08.014_bib17","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.1016\/j.vaccine.2007.06.045","article-title":"BCG and HIV reconsidered: moving the research agenda forward","volume":"25","author":"Hesseling","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.ajpath.2017.08.014_bib18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.vaccine.2006.07.020","article-title":"The risk of disseminated Bacille Calmette-Guerin (BCG) disease in HIV-infected children","volume":"25","author":"Hesseling","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.ajpath.2017.08.014_bib19","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1086\/499953","article-title":"Bacille Calmette-Guerin vaccine-induced disease in HIV-infected and HIV-uninfected children","volume":"42","author":"Hesseling","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ajpath.2017.08.014_bib20","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S2213-2600(15)00435-X","article-title":"Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial","volume":"3","author":"Spertini","year":"2015","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.ajpath.2017.08.014_bib21","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/infdis\/jis102","article-title":"The Mycobacterium tuberculosis stress response factor SigH is required for bacterial burden as well as immunopathology in primate lungs","volume":"205","author":"Mehra","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2017.08.014_bib22","first-page":"266","article-title":"Disseminated granulomatous disease in a simian immunodeficiency virus- and bacille Calmette-Guerin-infected rhesus monkey","volume":"11","author":"Chen","year":"1997","journal-title":"AIDS"},{"key":"10.1016\/j.ajpath.2017.08.014_bib23","doi-asserted-by":"crossref","first-page":"e12266","DOI":"10.1371\/journal.pone.0012266","article-title":"Transcriptional reprogramming in nonhuman primate (rhesus macaque) tuberculosis granulomas","volume":"5","author":"Mehra","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2017.08.014_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-0684.2011.00485.x","article-title":"Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus","volume":"40","author":"Mehra","year":"2011","journal-title":"J Med Primatol"},{"key":"10.1016\/j.ajpath.2017.08.014_bib25","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1164\/rccm.201408-1502OC","article-title":"The DosR regulon modulates adaptive immunity and is essential for M. tuberculosis persistence","volume":"191","author":"Mehra","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ajpath.2017.08.014_bib26","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1086\/652497","article-title":"Genetic requirements for the survival of tubercle bacilli in primates","volume":"201","author":"Dutta","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ajpath.2017.08.014_bib27","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.ajpath.2014.11.003","article-title":"LAG3 expression in active Mycobacterium tuberculosis infections","volume":"185","author":"Phillips","year":"2015","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2017.08.014_bib28","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.tube.2015.07.005","article-title":"The TB-specific CD4 T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans","volume":"95","author":"Mothe","year":"2015","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.ajpath.2017.08.014_bib29","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.tube.2015.05.012","article-title":"A tuberculosis ontology for host systems biology","volume":"95","author":"Levine","year":"2015","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.ajpath.2017.08.014_bib30","doi-asserted-by":"crossref","first-page":"8330","DOI":"10.1073\/pnas.102055799","article-title":"Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH","volume":"99","author":"Kaushal","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2017.08.014_bib31","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1128\/JB.00064-09","article-title":"Functional genomics reveals extended roles of the Mycobacterium tuberculosis stress response factor sigmaH","volume":"191","author":"Mehra","year":"2009","journal-title":"J Bacteriol"},{"key":"10.1016\/j.ajpath.2017.08.014_bib32","series-title":"Committee for the Update of the Guide for the Care and Use of Laboratory Animals; National Research Council: Guide for the Care and Use of Laboratory Animals: Eighth Edition","year":"2011"},{"key":"10.1016\/j.ajpath.2017.08.014_bib33","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.4049\/jimmunol.1400676","article-title":"Aerosol vaccination with AERAS-402 elicits robust cellular immune responses in the lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge","volume":"193","author":"Darrah","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2017.08.014_bib34","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/infdis\/jis778","article-title":"Granuloma correlates of protection against tuberculosis and mechanisms of immune modulation by Mycobacterium tuberculosis","volume":"207","author":"Mehra","year":"2013","journal-title":"J Infect Dis"},{"issue":"30","key":"10.1016\/j.ajpath.2017.08.014_bib35","first-page":"e1561","article-title":"A technique to simultaneously visualize virus-specific CD8+ T cells and virus-infected cells in situ","volume":"2009","author":"Li","year":"2009","journal-title":"J Vis Exp"},{"key":"10.1016\/j.ajpath.2017.08.014_bib36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2174\/156652407780598520","article-title":"Correlates of immune protection from tuberculosis","volume":"7","author":"Fletcher","year":"2007","journal-title":"Curr Molecular Medicine"},{"key":"10.1016\/j.ajpath.2017.08.014_bib37","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1615\/CritRevImmunol.v26.i4.30","article-title":"Mycobacterium tuberculosis-specific CD8+ T cells and their role in immunity","volume":"26","author":"Woodworth","year":"2006","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.ajpath.2017.08.014_bib38","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cell.2016.08.072","article-title":"A functional role for antibodies in tuberculosis","volume":"167","author":"Lu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2017.08.014_bib39","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1586\/14760584.6.2.213","article-title":"Pulmonary vaccine delivery","volume":"6","author":"Lu","year":"2007","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.ajpath.2017.08.014_bib40","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s11095-007-9381-6","article-title":"Preparation and in\u00a0vivo evaluation of a dry powder for inhalation of capreomycin","volume":"25","author":"Fiegel","year":"2008","journal-title":"Pharm Res"},{"key":"10.1016\/j.ajpath.2017.08.014_bib41","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1073\/pnas.0800043105","article-title":"Immunization by a bacterial aerosol","volume":"105","author":"Garcia-Contreras","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2017.08.014_bib42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/trstmh\/tru206","article-title":"Aerosol immunisation for TB: matching route of vaccination to route of infection","volume":"109","author":"Manjaly Thomas","year":"2015","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.ajpath.2017.08.014_bib43","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1128\/CVI.00394-14","article-title":"Intranasal administration of Mycobacterium bovis BCG induces superior protection against aerosol infection with Mycobacterium tuberculosis in mice","volume":"21","author":"Derrick","year":"2014","journal-title":"Clin Vaccine Immunol"},{"key":"10.1016\/j.ajpath.2017.08.014_bib44","first-page":"351","article-title":"Protection of monkeys against airborne tuberculosis by aerosol vaccination with bacillus Calmette-Guerin","volume":"107","author":"Barclay","year":"1973","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.ajpath.2017.08.014_bib45","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tube.2016.09.004","article-title":"Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populations","volume":"101","author":"Sharpe","year":"2016","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.ajpath.2017.08.014_bib46","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrmicro1211","article-title":"The success and failure of BCG - implications for a novel tuberculosis vaccine","volume":"3","author":"Andersen","year":"2005","journal-title":"Nat Rev Microbiol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017303632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017303632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:47:21Z","timestamp":1634518041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944017303632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0002944017303632"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.08.014","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonpathologic Infection of Macaques by an Attenuated Mycobacterial Vaccine Is Not Reactivated in the Setting of HIV Co-Infection","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}