{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T13:23:25Z","timestamp":1768742605720,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":711,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012336","name":"Major State Basic Research Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1001404"],"award-info":[{"award-number":["2017YFC1001404"]}],"id":[{"id":"10.13039\/501100012336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012336","name":"Major State Basic Research Development Program of China","doi-asserted-by":"publisher","award":["81620108013"],"award-info":[{"award-number":["81620108013"]}],"id":[{"id":"10.13039\/501100012336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012336","name":"Major State Basic Research Development Program of China","doi-asserted-by":"publisher","award":["813707341"],"award-info":[{"award-number":["813707341"]}],"id":[{"id":"10.13039\/501100012336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012336","name":"Major State Basic Research Development Program of China","doi-asserted-by":"publisher","award":["31371175"],"award-info":[{"award-number":["31371175"]}],"id":[{"id":"10.13039\/501100012336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017YFC1001404"],"award-info":[{"award-number":["2017YFC1001404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81620108013"],"award-info":[{"award-number":["81620108013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["813707341"],"award-info":[{"award-number":["813707341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371175"],"award-info":[{"award-number":["31371175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","ajp.amjpathol.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ajpath.2017.09.006","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T08:40:24Z","timestamp":1513240824000},"page":"63-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Reduced Expression of Hydrogen Sulfide\u2013Generating Enzymes Down-Regulates 15-Hydroxyprostaglandin Dehydrogenase in Chorion\u00a0during\u00a0Term and Preterm Labor"],"prefix":"10.1016","volume":"188","author":[{"given":"Qianqian","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2017.09.006_bib1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1749-6632.1997.tb48546.x","article-title":"Prostaglandins and parturition","volume":"828","author":"Challis","year":"1997","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ajpath.2017.09.006_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0952-3278(90)90164-G","article-title":"The role of prostaglandins in human parturition","volume":"39","author":"Lundin-Schiller","year":"1990","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.ajpath.2017.09.006_bib3","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S1521-6934(03)00069-5","article-title":"The role of prostaglandins in the initiation of parturition","volume":"17","author":"Olson","year":"2003","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.ajpath.2017.09.006_bib4","first-page":"1396","article-title":"Prostaglandin endoperoxide-H synthase (PGHS) activity and immuoreactive PGHS-1 and PGHS-2 levels in human amnion throughout gestation, at term, and during labor","volume":"78","author":"Teixeira","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2017.09.006_bib5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1677\/joe.0.1500497","article-title":"Localization of prostaglandin H synthase type 2 protein and mRNA in term fetal membranes and deciduas","volume":"150","author":"Gibb","year":"1996","journal-title":"J Endocrinol"},{"key":"10.1016\/j.ajpath.2017.09.006_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0262-1746(87)90107-7","article-title":"Purification of an NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from the human placenta","volume":"26","author":"Nagai","year":"1987","journal-title":"Prostaglandins Leukot Med"},{"key":"10.1016\/j.ajpath.2017.09.006_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/10409239609106581","article-title":"Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD+-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omegahydroxylase","volume":"31","author":"Okita","year":"1996","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.ajpath.2017.09.006_bib8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1159\/000294868","article-title":"Localization of 15-hydroxy prostaglandin dehydrogenase in human fetal membranes, decidua, and placenta during pregnancy","volume":"33","author":"Cheung","year":"1992","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.ajpath.2017.09.006_bib9","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1210\/jc.2004-0540","article-title":"Regulation of 15-hydroxyprostaglandin dehydrogenase (PGDH) gene activity, messenger ribonucleic acid processing, and protein abundance in the human chorion in late gestation and labor","volume":"89","author":"Johnson","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2017.09.006_bib10","first-page":"982","article-title":"Immunohistochemical localization, messenger ribonucleic acid abundance, and activity of 15-hydroxyprostaglandin dehydrogenase in placenta and fetal membranes during term and preterm labor","volume":"78","author":"Sangha","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2017.09.006_bib11","first-page":"969","article-title":"15-Hydroxyprostaglandin dehydrogenase: implications in preterm labor with and without ascending infection","volume":"82","author":"van Meir","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2017.09.006_bib12","first-page":"463","article-title":"Human fetal membrane contribution to the prevention of parturition: uterotonin degradation","volume":"78","author":"Germain","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2017.09.006_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0143-4004(96)90052-1","article-title":"Immunoreactive 15-hydroxyprostaglandin dehydrogenase (PGDH) is reduced in fetal membranes from patients at preterm delivery in the presence of infection","volume":"17","author":"Van Meir","year":"1996","journal-title":"Placenta"},{"key":"10.1016\/j.ajpath.2017.09.006_bib14","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.2174\/138920111798280956","article-title":"The role of endogenous H2S in cardiovascular physiology","volume":"12","author":"Skovgaard","year":"2011","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.ajpath.2017.09.006_bib15","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1073\/pnas.0908047106","article-title":"Hydrogen sulfide is an endogenous stimulator of angiogenesis","volume":"106","author":"Papapetropoulos","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2017.09.006_bib16","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1089\/ars.2011.4351","article-title":"Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury","volume":"17","author":"Wallace","year":"2012","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.ajpath.2017.09.006_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1385\/MN:26:1:013","article-title":"Hydrogen sulfide as a neuromodulator","volume":"26","author":"Kimura","year":"2002","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.ajpath.2017.09.006_bib18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1477-7827-7-10","article-title":"The endogenous production of hydrogen sulphide in intrauterine tissues","volume":"7","author":"Patel","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.ajpath.2017.09.006_bib19","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.ajpath.2013.01.001","article-title":"Reduced cystathionine gamma-lyase and increased miR-21 expression are associated with increased vascular resistance in growth-restricted pregnancies: hydrogen sulfide as a placental vasodilator","volume":"182","author":"Cindrova-Davies","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2017.09.006_bib20","doi-asserted-by":"crossref","first-page":"e23788","DOI":"10.1371\/journal.pone.0023788","article-title":"Expression of cystathionine beta-synthase and cystathionine gamma-lyase in human pregnant myometrium and their roles in the control of uterine contractility","volume":"6","author":"You","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2017.09.006_bib21","doi-asserted-by":"crossref","first-page":"e0152838","DOI":"10.1371\/journal.pone.0152838","article-title":"Hydrogen sulfide delays LPS-induced preterm birth in mice via anti-inflammatory pathways","volume":"11","author":"Liu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2017.09.006_bib22","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1210\/endo-118-4-1567","article-title":"Purification, characterization, and in\u00a0vitro differentiation of cytotrophoblasts from human term placentae","volume":"118","author":"Kliman","year":"1986","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2017.09.006_bib23","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1210\/en.2006-1212","article-title":"Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts","volume":"148","author":"Gao","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2017.09.006_bib24","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394C(T) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ajpath.2017.09.006_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1054\/plef.1999.0117","article-title":"Cytokine-induced coordinate expression of enzymes of prostaglandin biosynthesis and metabolism: 15-hydroxyprostaglandin dehydrogenase","volume":"62","author":"Mitchell","year":"2000","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.ajpath.2017.09.006_bib26","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0092-8674(01)00616-X","article-title":"MicroRNAs: tiny regulators with great potential","volume":"107","author":"Ambros","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2017.09.006_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/path.2463","article-title":"Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition","volume":"217","author":"Montenegro","year":"2009","journal-title":"J Pathol"},{"key":"10.1016\/j.ajpath.2017.09.006_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.placenta.2016.01.019","article-title":"MiR 20a,-20b and -200c are involved in hydrogen sulfide stimulation of VEGF production in human placental trophoblasts","volume":"39","author":"Hu","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.ajpath.2017.09.006_bib29","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1210\/jc.2002-021710","article-title":"Mechanism of cortisol\/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term","volume":"88","author":"Patel","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajpath.2017.09.006_bib30","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.ajpath.2015.03.021","article-title":"Expression of 15-hydroxyprostaglandin dehydrogenase in human chorion is associated with peroxisome proliferator-activated receptor isoform expression in term labor","volume":"185","author":"He","year":"2015","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2017.09.006_bib31","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.ajpath.2013.01.033","article-title":"Reduced expression of 15-hydroxy prostaglandin dehydrogenase during labour is associated with decreased PR-B whilst increased PR-A and GR expression in chorion","volume":"182","author":"Li","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2017.09.006_bib32","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1530\/REP-16-0549","article-title":"Endogenous hydrogen sulfide contributes to uterine quiescence during pregnancy","volume":"153","author":"You","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.ajpath.2017.09.006_bib33","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1038\/ncomms5107","article-title":"Dysregulation of hydrogen sulphide metabolism impairs oviductal transport of embryos","volume":"5","author":"Ning","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.ajpath.2017.09.006_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.placenta.2017.02.012","article-title":"MiR133b is involved in endogenous hydrogen sulfide suppression of sFlt-1 production in human placenta","volume":"52","author":"Hu","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.ajpath.2017.09.006_bib35","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1089\/ars.2013.5604","article-title":"Sulfhydration of p66Shc at cysteine59 mediates the antioxidant effect\u00a0of hydrogen sulfide","volume":"21","author":"Xie","year":"2014","journal-title":"Antioxid Redox Signal"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017306041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017306041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T23:55:49Z","timestamp":1617234949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944017306041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0002944017306041"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.09.006","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced Expression of Hydrogen Sulfide\u2013Generating Enzymes Down-Regulates 15-Hydroxyprostaglandin Dehydrogenase in Chorion\u00a0during\u00a0Term and Preterm Labor","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}