{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:31:38Z","timestamp":1786984298930,"version":"build-2736575974"},"reference-count":65,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":711,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK045227"],"award-info":[{"award-number":["DK045227"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ajpath.2017.09.010","type":"journal-article","created":{"date-parts":[[2017,10,14]],"date-time":"2017-10-14T16:16:08Z","timestamp":1507997768000},"page":"149-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone"],"prefix":"10.1016","volume":"188","author":[{"given":"Jungeun","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9711-5522","authenticated-orcid":false,"given":"Stefano","family":"Zanotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5361-4506","authenticated-orcid":false,"given":"Bhavita","family":"Walia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Jellison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Sanjay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9154-952X","authenticated-orcid":false,"given":"Ernesto","family":"Canalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2017.09.010_bib1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1146\/annurev.immunol.19.1.595","article-title":"B cell development pathways","volume":"19","author":"Hardy","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1084\/jem.190.1.75","article-title":"B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals","volume":"190","author":"Loder","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2017.09.010_bib3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nri2656","article-title":"The follicular versus marginal zone B lymphocyte cell fate decision","volume":"9","author":"Pillai","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev.immunol.23.021704.115728","article-title":"Marginal zone B cells","volume":"23","author":"Pillai","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib5","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.4049\/jimmunol.174.8.4567","article-title":"Altered migration, recruitment, and somatic hypermutation in the early response of marginal zone B cells to T cell-dependent antigen","volume":"174","author":"Phan","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fimmu.2011.00063","article-title":"Marginal zone B-cells, a gatekeeper of innate immunity","volume":"2","author":"Zouali","year":"2011","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib7","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1128\/MCB.01285-09","article-title":"Notch and the skeleton","volume":"30","author":"Zanotti","year":"2010","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib8","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1038\/onc.2008.223","article-title":"More complicated than it looks: assembly of Notch pathway transcription complexes","volume":"27","author":"Kovall","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.ajpath.2017.09.010_bib9","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.cell.2005.12.037","article-title":"Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes","volume":"124","author":"Nam","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2017.09.010_bib10","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/30756","article-title":"Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain","volume":"393","author":"Schroeter","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2017.09.010_bib11","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2006.01.035","article-title":"Crystal structure of the CSL-Notch-mastermind ternary complex bound to DNA","volume":"124","author":"Wilson","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2017.09.010_bib12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1074-7613(00)80054-0","article-title":"Deficient T cell fate specification in mice with an induced inactivation of Notch1","volume":"10","author":"Radtke","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.ajpath.2017.09.010_bib13","doi-asserted-by":"crossref","first-page":"8637","DOI":"10.1128\/MCB.23.23.8637-8650.2003","article-title":"Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells","volume":"23","author":"Witt","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/ni793","article-title":"Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells","volume":"3","author":"Tanigaki","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib15","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S1074-7613(03)00111-0","article-title":"Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development","volume":"18","author":"Saito","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.ajpath.2017.09.010_bib16","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.4049\/jimmunol.171.6.2783","article-title":"Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells","volume":"171","author":"Witt","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib17","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1084\/jem.20132203","article-title":"Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties","volume":"211","author":"Descatoire","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2017.09.010_bib18","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1182\/blood-2010-12-325944","article-title":"CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling","volume":"118","author":"Hampel","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2017.09.010_bib19","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bone.2016.08.025","article-title":"Hajdu Cheney syndrome; report of a novel NOTCH2 mutation and treatment with denosumab","volume":"92","author":"Adami","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.ajpath.2017.09.010_bib20","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11914-016-0311-6","article-title":"Hajdu-Cheney syndrome, a disease associated with NOTCH2 mutations","volume":"14","author":"Canalis","year":"2016","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.ajpath.2017.09.010_bib21","first-page":"595","article-title":"Acro-osteolysis","volume":"94","author":"Cheney","year":"1965","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"10.1016\/j.ajpath.2017.09.010_bib22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1259\/0007-1285-21-241-42","article-title":"Cranio-skeletal dysplasia","volume":"21","author":"Hajdu","year":"1948","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/ejhg.2011.125","article-title":"Serpentine fibula polycystic kidney syndrome is part of the phenotypic spectrum of Hajdu-Cheney syndrome","volume":"20","author":"Gray","year":"2012","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ajpath.2017.09.010_bib24","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ng.778","article-title":"Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis","volume":"43","author":"Isidor","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajpath.2017.09.010_bib25","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/humu.21546","article-title":"Mutations in NOTCH2 in families with Hajdu-Cheney syndrome","volume":"32","author":"Majewski","year":"2011","journal-title":"Hum Mutat"},{"key":"10.1016\/j.ajpath.2017.09.010_bib26","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ng.779","article-title":"Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss","volume":"43","author":"Simpson","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajpath.2017.09.010_bib27","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s00198-013-2298-5","article-title":"Mutations in NOTCH2 in patients with Hajdu-Cheney syndrome","volume":"24","author":"Zhao","year":"2013","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.ajpath.2017.09.010_bib28","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/j.1349-7006.2009.01130.x","article-title":"Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma","volume":"100","author":"Lee","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ajpath.2017.09.010_bib29","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1084\/jem.20120904","article-title":"The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development","volume":"209","author":"Rossi","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2017.09.010_bib30","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1084\/jem.20120910","article-title":"Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma","volume":"209","author":"Kiel","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2017.09.010_bib31","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1074\/jbc.M115.685453","article-title":"Hajdu Cheney mouse mutants exhibit osteopenia, increased osteoclastogenesis and bone resorption","volume":"291","author":"Canalis","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2017.09.010_bib32","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1210\/er.2016-1002","article-title":"Notch signaling and the skeleton","volume":"37","author":"Zanotti","year":"2016","journal-title":"Endocr Rev"},{"key":"10.1016\/j.ajpath.2017.09.010_bib33","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/nature08878","article-title":"Therapeutic antibody targeting of individual Notch receptors","volume":"464","author":"Wu","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2017.09.010_bib34","doi-asserted-by":"crossref","first-page":"e9094","DOI":"10.1371\/journal.pone.0009094","article-title":"Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors","volume":"5","author":"Aste-Amezaga","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2017.09.010_bib35","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1210\/en.2016-1787","article-title":"An antibody to Notch2 reverses the osteopenic phenotype of Hajdu-Cheney mutant male mice","volume":"158","author":"Canalis","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.ajpath.2017.09.010_bib36","first-page":"634","article-title":"The half-lives of IgG subclasses and specific antibodies in patients with primary immunodeficiency who are receiving intravenously administered immunoglobulin","volume":"112","author":"Mankarious","year":"1988","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.ajpath.2017.09.010_bib37","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/jbmr.2591","article-title":"Inhibition of notch signaling during mouse incisor renewal leads to enamel defects","volume":"31","author":"Jheon","year":"2016","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.ajpath.2017.09.010_bib38","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/hep.27566","article-title":"Differential effects of targeting Notch receptors in a mouse model of liver cancer","volume":"61","author":"Huntzicker","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.ajpath.2017.09.010_bib39","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nature15715","article-title":"Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung","volume":"528","author":"Lafkas","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2017.09.010_bib40","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1093\/nar\/30.9.2089","article-title":"Effect of primary and secondary structure of oligodeoxyribonucleotides on the fluorescent properties of conjugated dyes","volume":"30","author":"Nazarenko","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2017.09.010_bib41","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1093\/nar\/30.9.e37","article-title":"Multiplex quantitative PCR using self-quenched primers labeled with a single fluorophore","volume":"30","author":"Nazarenko","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2017.09.010_bib42","doi-asserted-by":"crossref","first-page":"21879","DOI":"10.1016\/S0021-9258(19)36694-3","article-title":"Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system","volume":"267","author":"Akazawa","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2017.09.010_bib43","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/nar\/28.2.655","article-title":"3\u2032-minor groove binder-DNA probes increase sequence specificity at PCR extension temperatures","volume":"28","author":"Kutyavin","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ajpath.2017.09.010_bib44","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nmeth.1318","article-title":"Enzymatic assembly of DNA molecules up to several hundred kilobases","volume":"6","author":"Gibson","year":"2009","journal-title":"Nat Methods"},{"key":"10.1016\/j.ajpath.2017.09.010_bib45","doi-asserted-by":"crossref","first-page":"17660","DOI":"10.1074\/jbc.M311032200","article-title":"Src kinase activity is essential for osteoclast function","volume":"279","author":"Miyazaki","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2017.09.010_bib46","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1073\/pnas.92.14.6414","article-title":"Alterations in Notch signaling in neoplastic lesions of the human cervix","volume":"92","author":"Zagouras","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2017.09.010_bib47","doi-asserted-by":"crossref","first-page":"36745","DOI":"10.1074\/jbc.M110.124628","article-title":"The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival","volume":"285","author":"Adapala","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2017.09.010_bib48","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/jcb.24779","article-title":"Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b","volume":"115","author":"Adapala","year":"2014","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.ajpath.2017.09.010_bib49","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/ni.3657","article-title":"Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10","volume":"18","author":"Hammad","year":"2017","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib50","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1084\/jem.20091990","article-title":"ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in\u00a0vivo","volume":"207","author":"Gibb","year":"2010","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2017.09.010_bib51","first-page":"593","article-title":"Regulation of the size of the recirculating B cell pool of adult rats","volume":"186","author":"Lortan","year":"1985","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib52","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cellsig.2016.01.016","article-title":"Notch2 signaling promotes osteoclast resorption via activation of PYK2","volume":"28","author":"Jin","year":"2016","journal-title":"Cell Signal"},{"key":"10.1016\/j.ajpath.2017.09.010_bib53","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/76882","article-title":"Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response","volume":"1","author":"Guinamard","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib54","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1084\/jem.20020805","article-title":"A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation","volume":"196","author":"Clayton","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.ajpath.2017.09.010_bib55","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.etp.2006.01.007","article-title":"Lymphomas and leukemias in mice","volume":"57","author":"Ward","year":"2006","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.ajpath.2017.09.010_bib56","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1172\/JCI45976","article-title":"The cautionary tale of side effects of chronic Notch1 inhibition","volume":"121","author":"Ryeom","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2017.09.010_bib57","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/19083","article-title":"A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain","volume":"398","author":"De Strooper","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2017.09.010_bib58","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ccr.2013.02.020","article-title":"Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch?","volume":"23","author":"Ilagan","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ajpath.2017.09.010_bib59","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ccr.2013.03.001","article-title":"Interweaving the strands: beta-catenin, an HIV co-receptor, and Schwann cell tumors","volume":"23","author":"Largaespada","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ajpath.2017.09.010_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellsig.2015.10.006","article-title":"Beyond gamma-secretase activity: the multifunctional nature of presenilins in cell signalling pathways","volume":"28","author":"Duggan","year":"2016","journal-title":"Cell Signal"},{"key":"10.1016\/j.ajpath.2017.09.010_bib61","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature08543","article-title":"Direct inhibition of the NOTCH transcription factor complex","volume":"462","author":"Moellering","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2017.09.010_bib62","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1074\/jbc.M800170200","article-title":"Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3","volume":"283","author":"Li","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2017.09.010_bib63","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nature05313","article-title":"Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis","volume":"444","author":"Ridgway","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2017.09.010_bib64","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.1038\/nature08751","article-title":"Chronic DLL4 blockade induces vascular neoplasms","volume":"463","author":"Yan","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2017.09.010_bib65","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1084\/jem.20131026","article-title":"IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity","volume":"210","author":"Simonetti","year":"2013","journal-title":"J Exp Med"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017306168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017306168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T13:04:18Z","timestamp":1659618258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944017306168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0002944017306168"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.09.010","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}