{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:17:38Z","timestamp":1779185858917,"version":"3.51.4"},"reference-count":61,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":621,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31400988"],"award-info":[{"award-number":["31400988"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81160144"],"award-info":[{"award-number":["81160144"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171044"],"award-info":[{"award-number":["31171044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20151BAB215015"],"award-info":[{"award-number":["20151BAB215015"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","award":["NCC1210360"],"award-info":[{"award-number":["NCC1210360"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","journals.elsevierhealth.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.ajpath.2017.12.005","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T19:35:01Z","timestamp":1517340901000},"page":"1043-1058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Chd7 Is Critical for Early T-Cell Development and Thymus Organogenesis in Zebrafish"],"prefix":"10.1016","volume":"188","author":[{"given":"Zhi-Zhi","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Long","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Ik","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Tsing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Ying","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lou-Yin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Taek","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Hwa","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Soo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4497-4686","authenticated-orcid":false,"given":"Hyung-Goo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Li","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Xing","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong A.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajpath.2017.12.005_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/sj.ejhg.5201778","article-title":"CHARGE syndrome: an update","volume":"15","author":"Sanlaville","year":"2007","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ajpath.2017.12.005_bib2","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ng1407","article-title":"Mutations in a new member of the chromodomain gene family cause CHARGE syndrome","volume":"36","author":"Vissers","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.ajpath.2017.12.005_bib3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/ajmg.a.32179","article-title":"Cranial nerve manifestations in CHARGE syndrome","volume":"146A","author":"Blake","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.ajpath.2017.12.005_bib4","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1542\/peds.2004-1970","article-title":"Olfactory evaluation in children: application to the CHARGE syndrome","volume":"116","author":"Chalouhi","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajpath.2017.12.005_bib5","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1542\/peds.108.2.e32","article-title":"Syndromic ear anomalies and renal ultrasounds","volume":"108","author":"Wang","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajpath.2017.12.005_bib6","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/ajmg.a.33323","article-title":"Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome","volume":"152A","author":"Zentner","year":"2010","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.ajpath.2017.12.005_bib7","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/jmg.2005.036061","article-title":"CHARGE syndrome: the phenotypic spectrum of mutations in the CHD7 gene","volume":"43","author":"Jongmans","year":"2006","journal-title":"J Med Genet"},{"key":"10.1016\/j.ajpath.2017.12.005_bib8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1651-2227.2008.01077.x","article-title":"T-cell immunodeficiency in CHARGE syndrome","volume":"98","author":"Chopra","year":"2009","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.ajpath.2017.12.005_bib9","doi-asserted-by":"crossref","first-page":"e871","DOI":"10.1542\/peds.2008-3400","article-title":"CHARGE (coloboma, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, ear anomalies\/deafness) syndrome and chromosome 22q11.2 deletion syndrome: a comparison of immunologic and nonimmunologic phenotypic features","volume":"123","author":"Jyonouchi","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.ajpath.2017.12.005_bib10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2249.2008.03681.x","article-title":"Mutations in CHD7 in patients with CHARGE syndrome cause T-B + natural killer cell + severe combined immune deficiency and may cause Omenn-like syndrome","volume":"153","author":"Gennery","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib11","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.humimm.2013.06.002","article-title":"CD4+ CD31+ recent thymic emigrants in CHD7 haploinsufficiency (CHARGE syndrome): a case","volume":"74","author":"Assing","year":"2013","journal-title":"Hum Immunol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib12","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1038\/ejhg.2015.7","article-title":"CHARGE syndrome: a review of the immunological aspects","volume":"23","author":"Wong","year":"2015","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.ajpath.2017.12.005_bib13","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.jaci.2016.05.035","article-title":"Rapid molecular diagnostics of severe primary immunodeficiency determined by using targeted next-generation sequencing","volume":"138","author":"Yu","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib14","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.iac.2015.07.002","article-title":"Severe combined immunodeficiency disorders","volume":"35","author":"Chinn","year":"2015","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.ajpath.2017.12.005_bib15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/jmg.2005.036160","article-title":"Phenotypic spectrum of CHARGE syndrome in fetuses with CHD7 truncating mutations correlates with expression during human development","volume":"43","author":"Sanlaville","year":"2006","journal-title":"J Med Genet"},{"key":"10.1016\/j.ajpath.2017.12.005_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"Thisse","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.ajpath.2017.12.005_bib17","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1523\/JNEUROSCI.4132-06.2007","article-title":"Stromal cell-derived factor-1 antagonizes slit\/robo signaling in\u00a0vivo","volume":"27","author":"Chalasani","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.ajpath.2017.12.005_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nri1590","article-title":"The zebrafish: a new model of T-cell and thymic development","volume":"5","author":"Langenau","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.dci.2011.12.013","article-title":"Regulatory mechanisms of thymus and T cell development","volume":"39","author":"Ma","year":"2013","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib20","doi-asserted-by":"crossref","first-page":"e31650","DOI":"10.1371\/journal.pone.0031650","article-title":"Role of Chd7 in zebrafish: a model for CHARGE syndrome","volume":"7","author":"Patten","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ajpath.2017.12.005_bib21","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.devcel.2015.07.011","article-title":"Irf4 regulates the choice between T lymphoid-primed progenitor and myeloid lineage fates during embryogenesis","volume":"34","author":"Wang","year":"2015","journal-title":"Dev Cell"},{"key":"10.1016\/j.ajpath.2017.12.005_bib22","doi-asserted-by":"crossref","first-page":"25353","DOI":"10.1074\/jbc.M112.349126","article-title":"Live imaging reveals differing roles of macrophages and neutrophils during zebrafish tail fin regeneration","volume":"287","author":"Li","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ajpath.2017.12.005_bib23","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1002\/eji.201545814","article-title":"FOXN1 in thymus organogenesis and development","volume":"46","author":"Vaidya","year":"2016","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib24","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/ni1064","article-title":"Functional evidence for a single endodermal origin for the thymic epithelium","volume":"5","author":"Gordon","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib25","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1006\/dbio.1996.0341","article-title":"A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm","volume":"180","author":"Lee","year":"1996","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib26","doi-asserted-by":"crossref","first-page":"E244","DOI":"10.1371\/journal.pbio.0020244","article-title":"An integrin-dependent role of pouch endoderm in hyoid cartilage development","volume":"2","author":"Crump","year":"2004","journal-title":"PLoS Biol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/dbio.2000.9842","article-title":"The endoderm plays an important role in patterning the segmented pharyngeal region in zebrafish (Danio rerio)","volume":"225","author":"Piotrowski","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib28","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ydbio.2008.12.019","article-title":"Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos","volume":"327","author":"Griffith","year":"2009","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib29","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.4049\/jimmunol.181.9.6101","article-title":"An epithelial progenitor pool regulates thymus growth","volume":"181","author":"Jenkinson","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib30","doi-asserted-by":"crossref","first-page":"10555","DOI":"10.1073\/pnas.1005129107","article-title":"Mouse and zebrafish Hoxa3 orthologues have nonequivalent in\u00a0vivo protein function","volume":"107","author":"Chen","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ajpath.2017.12.005_bib31","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nature08733","article-title":"CHD7 cooperates with PBAF to control multipotent neural crest formation","volume":"463","author":"Bajpai","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ajpath.2017.12.005_bib32","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cell.2009.04.017","article-title":"Evolution of genetic networks underlying the emergence of thymopoiesis in vertebrates","volume":"138","author":"Bajoghli","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ajpath.2017.12.005_bib33","doi-asserted-by":"crossref","first-page":"e1002348","DOI":"10.1371\/journal.pgen.1002348","article-title":"Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence","volume":"7","author":"Nowell","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1016\/j.ajpath.2017.12.005_bib34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3389\/fimmu.2013.00187","article-title":"FOXN1: a master regulator gene of thymic epithelial development program","volume":"4","author":"Romano","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib35","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1242\/dev.103614","article-title":"Regeneration of the aged thymus by a single transcription factor","volume":"141","author":"Bredenkamp","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2017.12.005_bib36","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1182\/blood-2011-03-342097","article-title":"Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells","volume":"118","author":"Zook","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ajpath.2017.12.005_bib37","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/ncb3023","article-title":"An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts","volume":"16","author":"Bredenkamp","year":"2014","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib38","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.modgep.2006.01.011","article-title":"Bmp4 and Noggin expression during early thymus and parathyroid organogenesis","volume":"6","author":"Patel","year":"2006","journal-title":"Gene Expr Patterns"},{"key":"10.1016\/j.ajpath.2017.12.005_bib39","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ydbio.2011.10.022","article-title":"Modulation of Bmp4 signalling in the epithelial-mesenchymal interactions that take place in early thymus and parathyroid development in avian embryos","volume":"361","author":"Neves","year":"2012","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib40","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/eji.201646553","article-title":"A novel Foxn1eGFP\/+ mouse model identifies Bmp4-induced maintenance of Foxn1 expression and thymic epithelial progenitor populations","volume":"47","author":"Barsanti","year":"2017","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib41","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.4049\/jimmunol.175.8.5213","article-title":"BMP signaling is required for normal thymus development","volume":"175","author":"Bleul","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib42","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.ajpath.2012.05.006","article-title":"The mutation in Chd7 causes misexpression of Bmp4 and developmental defects in telencephalic midline","volume":"181","author":"Jiang","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib43","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.celrep.2014.07.017","article-title":"Conversion of the thymus into a bipotent lymphoid organ by replacement of FOXN1 with its paralog, FOXN4","volume":"8","author":"Swann","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.ajpath.2017.12.005_bib44","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0344-0338(00)80031-X","article-title":"Malakoplakia of the colon in an infant with severe combined immunodeficiency (SCID) and charge association","volume":"196","author":"Boudny","year":"2000","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.ajpath.2017.12.005_bib45","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/humu.22106","article-title":"A novel classification system to predict the pathogenic effects of CHD7 missense variants in CHARGE syndrome","volume":"33","author":"Bergman","year":"2012","journal-title":"Hum Mutat"},{"key":"10.1016\/j.ajpath.2017.12.005_bib46","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/000992289803700302","article-title":"CHARGE association: an update and review for the primary pediatrician","volume":"37","author":"Blake","year":"1998","journal-title":"Clin Pediatr"},{"key":"10.1016\/j.ajpath.2017.12.005_bib47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12026-008-8082-5","article-title":"Thymus transplantation in complete DiGeorge anomaly","volume":"44","author":"Markert","year":"2009","journal-title":"Immunol Res"},{"key":"10.1016\/j.ajpath.2017.12.005_bib48","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1399-3046.2007.00702.x","article-title":"Unrelated partially matched lymphocyte infusions in a patient with complete DiGeorge\/CHARGE syndrome","volume":"11","author":"Janda","year":"2007","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.ajpath.2017.12.005_bib49","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.jpedsurg.2004.07.020","article-title":"Thymic transplantation for complete DiGeorge syndrome: medical and surgical considerations","volume":"39","author":"Rice","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.ajpath.2017.12.005_bib50","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1056\/NEJM199910143411603","article-title":"Transplantation of thymus tissue in complete DiGeorge syndrome","volume":"341","author":"Markert","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajpath.2017.12.005_bib51","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12026-009-8108-7","article-title":"Immunologic reconstitution in 22q deletion (DiGeorge) syndrome","volume":"45","author":"McGhee","year":"2009","journal-title":"Immunol Res"},{"key":"10.1016\/j.ajpath.2017.12.005_bib52","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1242\/dev.059998","article-title":"Mechanisms of thymus organogenesis and morphogenesis","volume":"138","author":"Gordon","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.ajpath.2017.12.005_bib53","doi-asserted-by":"crossref","first-page":"5272","DOI":"10.4049\/jimmunol.181.8.5272","article-title":"Maintenance of thymic epithelial phenotype requires extrinsic signals in mouse and zebrafish","volume":"181","author":"Soza-Ried","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib54","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.stem.2013.04.004","article-title":"Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development","volume":"13","author":"Parent","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ajpath.2017.12.005_bib55","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4161\/cc.27118","article-title":"Direct BMP2\/4 signaling through BMP receptor IA regulates fetal thymocyte progenitor homeostasis and differentiation to CD4+CD8+ double-positive cell","volume":"13","author":"Hager-Theodorides","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ajpath.2017.12.005_bib56","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/ajmg.a.30561","article-title":"Speculations on the pathogenesis of CHARGE syndrome","volume":"133A","author":"Williams","year":"2005","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.ajpath.2017.12.005_bib57","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/tera.1420310303","article-title":"Pathologic features of the CHARGE association: support for involvement of the neural crest","volume":"31","author":"Siebert","year":"1985","journal-title":"Teratology"},{"key":"10.1016\/j.ajpath.2017.12.005_bib58","first-page":"3301","article-title":"Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice","volume":"119","author":"Randall","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajpath.2017.12.005_bib59","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ydbio.2009.12.026","article-title":"Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis","volume":"339","author":"Gordon","year":"2010","journal-title":"Dev Biol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib60","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1038\/ncb2870","article-title":"A network of epigenetic regulators guides developmental haematopoiesis in\u00a0vivo","volume":"15","author":"Huang","year":"2013","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.ajpath.2017.12.005_bib61","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1182\/blood-2017-04-780106","article-title":"CHD7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11","volume":"130","author":"Zhen","year":"2017","journal-title":"Blood"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017306697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944017306697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T07:22:41Z","timestamp":1576221761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944017306697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0002944017306697"],"URL":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.12.005","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chd7 Is Critical for Early T-Cell Development and Thymus Organogenesis in Zebrafish","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajpath.2017.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Society for Investigative Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}